LOCUS       NM_001367719            6501 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens La ribonucleoprotein 1, translational regulator
            (LARP1), transcript variant 9, mRNA.
ACCESSION   NM_001367719
VERSION     NM_001367719.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6501)
  AUTHORS   Ma,J., Dong,D., Qi,H., Li,J., Yu,H., Hu,X., Sun,L. and Shen,L.
  TITLE     LARP1, an RNA-binding protein, participates in ovarian cancer cell
            survival by regulating mitochondrial oxidative phosphorylation in
            response to the influence of the PI3K/mTOR pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167453 (2024)
   PUBMED   39111634
  REMARK    GeneRIF: LARP1, an RNA-binding protein, participates in ovarian
            cancer cell survival by regulating mitochondrial oxidative
            phosphorylation in response to the influence of the PI3K/mTOR
            pathway.
REFERENCE   2  (bases 1 to 6501)
  AUTHORS   Chettle,J., Louie,R.J., Larner,O., Best,R., Chen,K., Morris,J.,
            Dedeic,Z., Childers,A., Rogers,R.C., DuPont,B.R., Skinner,C.,
            Kury,S., Uguen,K., Planes,M., Monteil,D., Li,M., Eliyahu,A.,
            Greenbaum,L., Mor,N., Besnard,T., Isidor,B., Cogne,B., Blesson,A.,
            Comi,A., Wentzensen,I.M., Vuocolo,B., Lalani,S.R., Sierra,R.,
            Berry,L., Carter,K., Sanders,S.J. and Blagden,S.P.
  TITLE     LARP1 haploinsufficiency is associated with an autosomal dominant
            neurodevelopmental disorder
  JOURNAL   HGG Adv 5 (4), 100345 (2024)
   PUBMED   39182167
  REMARK    GeneRIF: LARP1 haploinsufficiency is associated with an autosomal
            dominant neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 6501)
  AUTHORS   Smith,B.C. and Silvers,R.
  TITLE     1H, 13C, and 15N resonance assignments of the La Motif of the human
            La-related protein 1
  JOURNAL   Biomol NMR Assign 18 (1), 111-118 (2024)
   PUBMED   38691336
  REMARK    GeneRIF: [1]H, [13]C, and [15]N resonance assignments of the La
            Motif of the human La-related protein 1.
REFERENCE   4  (bases 1 to 6501)
  AUTHORS   Bley,H., Krisp,C., Schobel,A., Hehner,J., Schneider,L., Becker,M.,
            Stegmann,C., Heidenfels,E., Nguyen-Dinh,V., Schluter,H., Gerold,G.
            and Herker,E.
  TITLE     Proximity labeling of host factor ANXA3 in HCV infection reveals a
            novel LARP1 function in viral entry
  JOURNAL   J Biol Chem 300 (5), 107286 (2024)
   PUBMED   38636657
  REMARK    GeneRIF: Proximity labeling of host factor ANXA3 in HCV infection
            reveals a novel LARP1 function in viral entry.
REFERENCE   5  (bases 1 to 6501)
  AUTHORS   Kozlov,G., Jiang,J., Rutherford,T., Noronha,A.M., Wilds,C.J. and
            Gehring,K.
  TITLE     Enhanced binding of guanylated poly(A) RNA by the LaM domain of
            LARP1
  JOURNAL   RNA Biol 21 (1), 7-16 (2024)
   PUBMED   39016322
  REMARK    GeneRIF: Enhanced binding of guanylated poly(A) RNA by the LaM
            domain of LARP1.
REFERENCE   6  (bases 1 to 6501)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   7  (bases 1 to 6501)
  AUTHORS   Burrows,C., Abd Latip,N., Lam,S.J., Carpenter,L., Sawicka,K.,
            Tzolovsky,G., Gabra,H., Bushell,M., Glover,D.M., Willis,A.E. and
            Blagden,S.P.
  TITLE     The RNA binding protein Larp1 regulates cell division, apoptosis
            and cell migration
  JOURNAL   Nucleic Acids Res 38 (16), 5542-5553 (2010)
   PUBMED   20430826
REFERENCE   8  (bases 1 to 6501)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 6501)
  AUTHORS   Horke,S., Reumann,K., Schweizer,M., Will,H. and Heise,T.
  TITLE     Nuclear trafficking of La protein depends on a newly identified
            nucleolar localization signal and the ability to bind RNA
  JOURNAL   J Biol Chem 279 (25), 26563-26570 (2004)
   PUBMED   15060081
  REMARK    GeneRIF: Nuclear trafficking of La protein depends on a newly
            identified nucleolar localization signal and the ability to bind
            RNA
REFERENCE   10 (bases 1 to 6501)
  AUTHORS   Chauvet,S., Maurel-Zaffran,C., Miassod,R., Jullien,N., Pradel,J.
            and Aragnol,D.
  TITLE     dlarp, a new candidate Hox target in Drosophila whose orthologue in
            mouse is expressed at sites of epithelium/mesenchymal interactions
  JOURNAL   Dev Dyn 218 (3), 401-413 (2000)
   PUBMED   10878606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112169.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1544379.1,
                                           SRR1803616.106148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC112169.2         146807-146943       c
            138-199             AC112169.2         113711-113772       c
            200-265             AC112169.2         113387-113452       c
            266-440             AC112169.2         111301-111475       c
            441-569             AC112169.2         110374-110502       c
            570-770             AC112169.2         110097-110297       c
            771-933             AC112169.2         109835-109997       c
            934-1078            AC112169.2         108778-108922       c
            1079-1247           AC112169.2         104338-104506       c
            1248-1417           AC112169.2         104055-104224       c
            1418-1810           AC112169.2         101698-102090       c
            1811-1934           AC112169.2         100684-100807       c
            1935-2140           AC112169.2         100352-100557       c
            2141-2247           AC112169.2         99790-99896         c
            2248-2399           AC112169.2         98065-98216         c
            2400-2544           AC112169.2         95494-95638         c
            2545-2654           AC112169.2         92741-92850         c
            2655-2782           AC112169.2         92457-92584         c
            2783-6501           AC112169.2         86492-90210         c
FEATURES             Location/Qualifiers
     source          1..6501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..6501
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="La ribonucleoprotein 1, translational regulator"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
     exon            1..137
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..199
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..265
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..440
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..2992
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="isoform 3 is encoded by transcript variant 9;
                     la-related protein 1; La ribonucleoprotein domain family
                     member 1"
                     /codon_start=1
                     /product="la-related protein 1 isoform 3"
                     /protein_id="NP_001354648.1"
                     /db_xref="CCDS:CCDS93807.1"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
                     /translation="MKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNK
                     HKWVPLQIDMKPEVPREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVAPPTPAWQ
                     PEIKPEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGY
                     RKFDGVEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERD
                     FFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRREEPE
                     KWPLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLK
                     TLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLPQQLPSQQLMSK
                     DQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEESDYEIDDRDVNKILIVTQTPHYMRR
                     HPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVN
                     MISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTV
                     PESPNYRNTRTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLE
                     SHVGWVMDSREHRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELLKENGFTQ
                     HVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKE
                     GYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAK
                     NLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHSVVAGGGGGEGRKRCPSQSSSR
                     PAAMISQPPTPPTGQPVREDAKWTSQHSNTQTLGK"
     exon            441..569
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..770
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..933
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1078
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1247
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1417
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1810
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1934
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2140
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2247
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2399
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2544
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2654
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2782
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..6501
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6479..6484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="hexamer: AATAAA"
     polyA_site      6501
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="major polyA site"
ORIGIN      
        1 attcctctgc agccgggaca acgtggtgcc tccccgcgcg gggagcggca tgtgactgcc
       61 gaccggcgct ccgcgagtcc tccctctccc tcctccgcgt tttggtcctt ttggaccgtg
      121 cccctttccg gggggagaac actctgctcc agccaaggtg gtgagggcag ctgttcctaa
      181 acagcgcaaa ggcagcaagg ttggtgactt tggagatgca atcaattggc ccacacctgg
      241 agagatagcc cacaagagtg ttcagccaca gtcccacaag cctcagccta cccgtaaact
      301 gccacccaag aaggacatga aggaacagga gaaaggagaa gggagtgata gtaaggagag
      361 tccaaaaacc aaatcagatg aatcagggga ggaaaagaat ggagatgagg attgccagcg
      421 aggcgggcag aagaagaaag gaaacaaaca caagtgggtt ccattacaaa tagacatgaa
      481 gcctgaagtg cccagagaga aactggcttc acgccccact cgcccaccgg agcctagaca
      541 catacctgcc aatcgcggag agatcaaagg gtctgagtct gccacctacg tgcccgtggc
      601 cccccccacc ccagcctggc aaccagagat caaaccggag cctgcctggc acgaccagga
      661 tgagacatcg agtgtgaaga gtgatggggc tggtggggcg cgggcttcct tccgtggccg
      721 tggacggggg cgtggtcgcg gccggggacg cggccggggt ggcactcgaa cccattttga
      781 ctaccagttt ggctaccgaa agtttgatgg tgtggagggg cctcgtacgc ccaagtacat
      841 gaacaacatc acctactact ttgacaatgt cagcagcacc gagctttaca gtgtggatca
      901 ggaactgctc aaagactaca tcaagcgcca gattgaatac tacttcagcg tggacaattt
      961 agagcgagac ttcttcctgc gaaggaaaat ggatgctgat ggtttcctac ccatcaccct
     1021 tattgcttcc ttccaccgag tgcaggccct taccactgac atttcactca tctttgcggc
     1081 cctaaaggac agcaaggtgg tggagatcgt tgatgagaaa gttcgtagga gggaggaacc
     1141 agaaaagtgg cctcttcccc caatagtgga ttattcacag actgatttct cccagcttct
     1201 caactgccct gaatttgttc cccgtcagca ctaccaaaag gagacagagt cggcacctgg
     1261 ctctcctcgt gcagtcaccc cagtgccaac caaaacagag gaggtcagca acctaaagac
     1321 actacccaag ggcctgtctg ccagcctgcc tgacctggat tctgagaact ggattgaagt
     1381 gaagaagagg cctcggccat ccccagcacg gcccaagaag tcagaggagt ccagattttc
     1441 ccacctgacc tctctgcctc agcagctgcc ttcccagcag ctgatgtcca aggatcagga
     1501 tgagcaagag gaactggatt ttctgtttga cgaggagatg gagcagatgg atgggcggaa
     1561 gaacaccttc actgcctggt ctgatgagga atctgactat gagattgatg acagggatgt
     1621 caacaagatc ctcattgtca cccagacacc acattacatg cgccggcacc caggggggga
     1681 ccgcacaggc aaccacacct cgcgtgccaa gatgagcgcc gaactggcca aggtcattaa
     1741 tgatggcctc ttctactatg agcaggacct gtgggctgaa aagtttgaac ctgagtattc
     1801 ccagatcaag caagaagtcg agaacttcaa aaaggtcaat atgatcagcc gggagcagtt
     1861 tgacacactg acccctgagc cccctgtgga tcccaaccag gaagttcctc ctgggccacc
     1921 tcggttccag caagttccta cggatgccct ggccaacaag ttgtttggtg ctcctgagcc
     1981 ctccaccatc gcccgctctc taccaaccac tgtcccagag tcaccaaact accgcaacac
     2041 caggacccct cgcactcccc ggacaccaca gctcaaagac tcaagccaga catcacggtt
     2101 ttacccagtg gtgaaagaag gacggacact ggatgccaag atgcctcgaa aaagaaagac
     2161 aagacacagt tcaaacccac ccttggagag ccatgtgggc tgggtgatgg attcccgtga
     2221 gcacaggccc cgtactgctt ccatcagctc cagcccctca gaagggacgc ctacagttgg
     2281 cagctatggc tgtacccctc agtcattgcc caagttccag catccttccc atgaactgct
     2341 caaggaaaat ggcttcacac aacacgtcta ccataagtat cgtaggcgct gccttaatga
     2401 gcggaaacgc ttgggcattg gccagtctca ggagatgaac acactcttcc gcttctggtc
     2461 cttcttcctc cgagatcact tcaacaaaaa gatgtatgag gagttcaagc agctggctct
     2521 ggaggacgcc aaagaaggct acagatatgg tttggagtgc ctttttcgat actacagtta
     2581 tggcctggaa aagaagttcc ggctggacat attcaaggat tttcaggagg aaacggtgaa
     2641 ggactatgaa gctggccaac tgtatgggct ggagaagttc tgggccttct tgaaatattc
     2701 caaagccaaa aatttggaca ttgaccccaa actgcaagaa tacctcggca aattccgacg
     2761 tcttgaagac ttccgagtag atccccccat gggtgaggag ggcaaccaca agcgacactc
     2821 agtggtagca ggaggtggcg gcggtgaggg caggaagcgg tgcccctccc agtcttccag
     2881 caggcctgct gccatgatca gccaaccccc tacaccaccc accggccagc ctgtccggga
     2941 agatgccaaa tggacaagcc agcactcgaa cacacagact ttgggaaagt gaaaagctcc
     3001 ttagccctgg ggcttgaggg gggaaagggg tagggtgggt aagagtccat gggggtgccc
     3061 agtcccagga aaggggacaa tgaagggaca ggcctggagt tactaggaca ggcctttgtg
     3121 ctgagtagca atgtatacac catttgggct atcagaggta cccctgggca ggagcctcta
     3181 catccccttc cccctcctct ctccatgact cttgacatcc tagcttcttc taagggggga
     3241 gggaaagggg ggagattttt atatatatat acatatatat atatcaagtt ttaaattatt
     3301 gatagttcat ctggattacc aaaatcactc tgcagccctg cccgaggcta gtaggctgca
     3361 accctggtcc ccacccctaa cctcctgctc cccctcaagc caactatgca gcccacaaga
     3421 aggccctgcg ggccccccca ttgcccagca ctgtctcata gaaggctctg gtggtacctc
     3481 tgggccccag gagcatcagc cccttgatca tctggggttt gtcatcacca tattttctcc
     3541 ctgctgttcc caccatgccc ttctgccatc ttctgggaga aggaaaccaa aggatctaaa
     3601 actggggttt gggggaaggt ttcagcctct ccccactccc cttgccccac accctttact
     3661 ccccagccca gagagacgct gcttttacca ggaaagacta ttgaaagatg ttttatttta
     3721 tttttctctg acctttccat ccttgaaaaa atggggaaaa aagaagaaaa aagacaaaat
     3781 cgaccataaa agaccaaaaa aaaaaaaaaa atcagaaaac ccccacctaa tccacagaaa
     3841 gtaatgtctt tcccctcccc ttggaatttt tgttttgttt ttggaaataa tattttttta
     3901 aaagttgcct tattgtggag cgggaatctg aaatacccaa atgcctgttt tcctcggtgg
     3961 agtcaacccg aagagctccc accttctctg gatgtgcctg ggcttggact ggctagaatc
     4021 tttctctgga ctgttgcatg tacagtgcct ccatcctgga ggcaagagag ttgggagtgg
     4081 ctcgaatcag agccgtgccc aagatatccc tgctgttgca tcgtttgaag ctgacgtcct
     4141 gtgtctgtac actgctgcca ctgttgtgtc ctcgctctgc ttgctgttgc ctcacgccag
     4201 gccccgtcct gccgtgacac ccttcatcct acccttggaa ccccaaggcc aagttggttc
     4261 aaactgttgg agaacagagt tggcctgcat ctggaacaca cttgtcctca gcttaccatc
     4321 tcctcacacc ccagagtgga aaggtgaaca cctgcagctg aggcttggaa acgtttcttg
     4381 tgttgccctg aaaaatcttt gagacctcag ggaggctctg tctctcttaa aaggtggaga
     4441 aagatgccat tctctcccta aggtctggtg gagtctcccc atcttgcata cccttctgca
     4501 agccatctat ctctgctcac tctccaattg acccgcctgg gaacaaggga tgaggaggag
     4561 ttgggggctg gggggaatcc tgccagttgg tgaagccctg tggcaggaag gtatatgtgg
     4621 acatagagta tacctgattc tctttcttca gccactgact gcttgggttg ggctgtgaat
     4681 gataatggaa tggctggagt ctgctgttgt cagaaggcag ggagggtgat gaaggactga
     4741 cccacatgga ctgggatgtg tgtcggttat gggcatgact gcacgttcac tctcagtggg
     4801 atctgggcaa catggagttc attgtcctgt tgcttactta ctgcaatgtc tttggccctc
     4861 cttttcaact ggttcctctg ttgggcccaa aggttgggag taggagacag tatcccaggc
     4921 tgacaagggc ttgcccttta ccttgggcac cttgttaatt tttagcctgt gcccttcccc
     4981 acctttgccc tcccagtggt tggtatgtgg gaagcccatc tcagttcctg tgacttcatg
     5041 tctcaaacca aggatgagcg tctggtctct gctatgatgg tggtatccga ggcctttccc
     5101 tgcccagtct ggtgcctgcc ccacattgta ccggacactg gattcctgga cccccttctc
     5161 ctttcctttc tttccttcag gtcacgcagc cctgtactgt atccagcacc acagaaacct
     5221 cagtgttttt cctctgctgg tttggggcac aaggaagcct tagggtatgg ggaaaggctg
     5281 ttattaccta gagtttactc ccaggccagg gggctgccat cttcttcaca gacatccctg
     5341 aaaggaagcc cctttggggc agggaggtga ggacttcatc tcaacatcgg ctggtggttg
     5401 gtaggggagc tttttctttt ctttcctttt tttttgtttt tgtttttgtt tttgtttttg
     5461 gtaacatgtt aggagttaat gttgcaaaga gtagtttaca tcttcacttt ctgaagacac
     5521 ttgaatttag gaccgatgta tctgtgacaa gcatgccaga agtggcaggg gccatcaggg
     5581 ctaaccactt cacacctacc atcgtcccat ggggatccaa gacctgagat aaagcaacag
     5641 cctgcccaga tccctctgtt catcctatcc cttccaaggt tggtccatgc caacataacc
     5701 tctgggcatc agacatcagc aggtctgtgt gcctcagccc tgttaagggg caggtttctc
     5761 tttagccctc ttcctgcact tgggagcaaa ggcactacca gtagagaagg gccatccagc
     5821 cgtgccccag cctggacccc tggggctcag atagaggtgc tgagcccctg tgtcaaagtt
     5881 gttaaatgtt tttgttttgt tccattgtag ctcttttttt ttttttttcc cctttcctgg
     5941 tgattgattt tacaaaagaa agtaagctgc ttagaaggcc ctggaaggga agtgaggagg
     6001 agggacaagg aagatgacta gttacggagg gtgagggttg ttttttgcca aaaagcctgg
     6061 gtagagtgat ctgaattatc tggcaccctc ctgaatggaa ccccagagta cctcctgtgt
     6121 ggaagggtcc ctggattttc cctaacaccc accctctccc ccttcagcca tgctgatggc
     6181 agagaagata agaacttgga gcccatttct cactggagag gaaaacttgt catctggctt
     6241 tgcggagaag gttccacctt acgctcgtag tacattatct ttactatgtg ctaggatatc
     6301 atatttaaaa ggacaaaaaa atgtaaaata cttgaatgag cttgtattat aacattaata
     6361 ttattgagag tatctgcttt ccaggctgaa gtgattcatt cattattcta gtcctgcttt
     6421 agtcctttgt aatttgtggt aattatgctt ttctttttaa tacaaaaaaa tgtataaaaa
     6481 taaacacttg aaaaggcaaa a
//
