LOCUS       NM_001367718            7082 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens La ribonucleoprotein 1, translational regulator
            (LARP1), transcript variant 8, mRNA.
ACCESSION   NM_001367718 XM_005268406
VERSION     NM_001367718.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7082)
  AUTHORS   Ma,J., Dong,D., Qi,H., Li,J., Yu,H., Hu,X., Sun,L. and Shen,L.
  TITLE     LARP1, an RNA-binding protein, participates in ovarian cancer cell
            survival by regulating mitochondrial oxidative phosphorylation in
            response to the influence of the PI3K/mTOR pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167453 (2024)
   PUBMED   39111634
  REMARK    GeneRIF: LARP1, an RNA-binding protein, participates in ovarian
            cancer cell survival by regulating mitochondrial oxidative
            phosphorylation in response to the influence of the PI3K/mTOR
            pathway.
REFERENCE   2  (bases 1 to 7082)
  AUTHORS   Chettle,J., Louie,R.J., Larner,O., Best,R., Chen,K., Morris,J.,
            Dedeic,Z., Childers,A., Rogers,R.C., DuPont,B.R., Skinner,C.,
            Kury,S., Uguen,K., Planes,M., Monteil,D., Li,M., Eliyahu,A.,
            Greenbaum,L., Mor,N., Besnard,T., Isidor,B., Cogne,B., Blesson,A.,
            Comi,A., Wentzensen,I.M., Vuocolo,B., Lalani,S.R., Sierra,R.,
            Berry,L., Carter,K., Sanders,S.J. and Blagden,S.P.
  TITLE     LARP1 haploinsufficiency is associated with an autosomal dominant
            neurodevelopmental disorder
  JOURNAL   HGG Adv 5 (4), 100345 (2024)
   PUBMED   39182167
  REMARK    GeneRIF: LARP1 haploinsufficiency is associated with an autosomal
            dominant neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 7082)
  AUTHORS   Smith,B.C. and Silvers,R.
  TITLE     1H, 13C, and 15N resonance assignments of the La Motif of the human
            La-related protein 1
  JOURNAL   Biomol NMR Assign 18 (1), 111-118 (2024)
   PUBMED   38691336
  REMARK    GeneRIF: [1]H, [13]C, and [15]N resonance assignments of the La
            Motif of the human La-related protein 1.
REFERENCE   4  (bases 1 to 7082)
  AUTHORS   Bley,H., Krisp,C., Schobel,A., Hehner,J., Schneider,L., Becker,M.,
            Stegmann,C., Heidenfels,E., Nguyen-Dinh,V., Schluter,H., Gerold,G.
            and Herker,E.
  TITLE     Proximity labeling of host factor ANXA3 in HCV infection reveals a
            novel LARP1 function in viral entry
  JOURNAL   J Biol Chem 300 (5), 107286 (2024)
   PUBMED   38636657
  REMARK    GeneRIF: Proximity labeling of host factor ANXA3 in HCV infection
            reveals a novel LARP1 function in viral entry.
REFERENCE   5  (bases 1 to 7082)
  AUTHORS   Kozlov,G., Jiang,J., Rutherford,T., Noronha,A.M., Wilds,C.J. and
            Gehring,K.
  TITLE     Enhanced binding of guanylated poly(A) RNA by the LaM domain of
            LARP1
  JOURNAL   RNA Biol 21 (1), 7-16 (2024)
   PUBMED   39016322
  REMARK    GeneRIF: Enhanced binding of guanylated poly(A) RNA by the LaM
            domain of LARP1.
REFERENCE   6  (bases 1 to 7082)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   7  (bases 1 to 7082)
  AUTHORS   Burrows,C., Abd Latip,N., Lam,S.J., Carpenter,L., Sawicka,K.,
            Tzolovsky,G., Gabra,H., Bushell,M., Glover,D.M., Willis,A.E. and
            Blagden,S.P.
  TITLE     The RNA binding protein Larp1 regulates cell division, apoptosis
            and cell migration
  JOURNAL   Nucleic Acids Res 38 (16), 5542-5553 (2010)
   PUBMED   20430826
REFERENCE   8  (bases 1 to 7082)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 7082)
  AUTHORS   Horke,S., Reumann,K., Schweizer,M., Will,H. and Heise,T.
  TITLE     Nuclear trafficking of La protein depends on a newly identified
            nucleolar localization signal and the ability to bind RNA
  JOURNAL   J Biol Chem 279 (25), 26563-26570 (2004)
   PUBMED   15060081
  REMARK    GeneRIF: Nuclear trafficking of La protein depends on a newly
            identified nucleolar localization signal and the ability to bind
            RNA
REFERENCE   10 (bases 1 to 7082)
  AUTHORS   Chauvet,S., Maurel-Zaffran,C., Miassod,R., Jullien,N., Pradel,J.
            and Aragnol,D.
  TITLE     dlarp, a new candidate Hox target in Drosophila whose orthologue in
            mouse is expressed at sites of epithelium/mesenchymal interactions
  JOURNAL   Dev Dyn 218 (3), 401-413 (2000)
   PUBMED   10878606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112169.2.
            
            On Dec 13, 2018 this sequence version replaced XM_005268406.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.193658.1,
                                           SRR7346977.1809901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               AC112169.2         147904-148720       c
            818-879             AC112169.2         113711-113772       c
            880-945             AC112169.2         113387-113452       c
            946-1120            AC112169.2         111301-111475       c
            1121-1249           AC112169.2         110374-110502       c
            1250-1351           AC112169.2         110196-110297       c
            1352-1514           AC112169.2         109835-109997       c
            1515-1659           AC112169.2         108778-108922       c
            1660-1828           AC112169.2         104338-104506       c
            1829-1998           AC112169.2         104055-104224       c
            1999-2391           AC112169.2         101698-102090       c
            2392-2515           AC112169.2         100684-100807       c
            2516-2721           AC112169.2         100352-100557       c
            2722-2828           AC112169.2         99790-99896         c
            2829-2980           AC112169.2         98065-98216         c
            2981-3125           AC112169.2         95494-95638         c
            3126-3235           AC112169.2         92741-92850         c
            3236-3363           AC112169.2         92457-92584         c
            3364-7082           AC112169.2         86492-90210         c
FEATURES             Location/Qualifiers
     source          1..7082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..7082
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="La ribonucleoprotein 1, translational regulator"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
     exon            1..817
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..3573
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="isoform 7 is encoded by transcript variant 8;
                     la-related protein 1; La ribonucleoprotein domain family
                     member 1"
                     /codon_start=1
                     /product="la-related protein 1 isoform 7"
                     /protein_id="NP_001354647.1"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
                     /translation="MATQVEPLLPGGATLLQAEEHGGLVRKKPPPAPEGKGEPGPNDV
                     RGGEPDGSARRPRPPCAKPHKEGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAG
                     GGAAGAAGAGRRDFVEAPPPKVNPWTKNALPPVLTTVNGQSPPEHSAPAKVVRAAVPK
                     QRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQPTRKLPPKKDMKEQEKGEGSDSK
                     ESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLASRPTRPP
                     EPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSTHFDYQFGYRK
                     FDGVEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFF
                     LRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRREEPEKW
                     PLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTL
                     PKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLPQQLPSQQLMSKDQ
                     DEQEELDFLFDEEMEQMDGRKNTFTAWSDEESDYEIDDRDVNKILIVTQTPHYMRRHP
                     GGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMI
                     SREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPE
                     SPNYRNTRTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESH
                     VGWVMDSREHRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELLKENGFTQHV
                     YHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGY
                     RYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNL
                     DIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHSVVAGGGGGEGRKRCPSQSSSRPA
                     AMISQPPTPPTGQPVREDAKWTSQHSNTQTLGK"
     exon            818..879
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..945
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1120
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1249
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1351
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1514
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1659
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1828
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1998
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2391
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2515
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2721
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2828
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2980
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3125
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3235
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3363
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..7082
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7060..7065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="hexamer: AATAAA"
     polyA_site      7082
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="major polyA site"
ORIGIN      
        1 gtccatattg ctgcagcccc cgagccggga agcccgggcc gccccggggg cgggggggag
       61 ggagggacgg gactagaagc ctgccgggct cggggtgggg gcgtcttgcg aggaacgggc
      121 ggggggggac gcacgcctag gaggcctgga ctgcagagtg gggggccttc ctcccccccc
      181 gccccgctag tgggcctcgg atttacggcg gctgcatcta actgggaggg ggccgcacct
      241 cgcgtgaacc ccgacccttc tctgcaggga ctggggccca gcgccccgga ggaaggcgtc
      301 gcgggcgctc tgctagccaa gttcgaggcg ggggaggcag cctcgggcgc gcccggcttc
      361 tccggggggg cgggcgcgca gatggccact caggtggagc cgctgctgcc tgggggcgcc
      421 acgctcttgc aggccgaaga gcacgggggg ctggtgagga agaagccgcc gccggcgccc
      481 gagggcaagg gcgagcccgg gccaaacgac gtccgcgggg gggagccgga cggcagcgct
      541 cggagacccc ggccgccctg cgccaagccg cacaaggagg gcaccgggca gcaggagcgc
      601 gagagcccgc ggccgctgca gctgcccggc gccgaaggcc cggccatcag cgacggggag
      661 gagggcggcg gcgagccagg cgctggcgga ggagctgccg gagccgcggg cgcggggcgc
      721 cgggacttcg tggaagcccc cccgcccaag gtgaacccgt ggactaagaa cgcattgccg
      781 ccggtcctga ccaccgtgaa cggacagtcc cccccagaac actctgctcc agccaaggtg
      841 gtgagggcag ctgttcctaa acagcgcaaa ggcagcaagg ttggtgactt tggagatgca
      901 atcaattggc ccacacctgg agagatagcc cacaagagtg ttcagccaca gtcccacaag
      961 cctcagccta cccgtaaact gccacccaag aaggacatga aggaacagga gaaaggagaa
     1021 gggagtgata gtaaggagag tccaaaaacc aaatcagatg aatcagggga ggaaaagaat
     1081 ggagatgagg attgccagcg aggcgggcag aagaagaaag gaaacaaaca caagtgggtt
     1141 ccattacaaa tagacatgaa gcctgaagtg cccagagaga aactggcttc acgccccact
     1201 cgcccaccgg agcctagaca catacctgcc aatcgcggag agatcaaagg gtctgagtct
     1261 gccacctacg tgcccgtggc cccccccacc ccagcctggc aaccagagat caaaccggag
     1321 cctgcctggc acgaccagga tgagacatcg acccattttg actaccagtt tggctaccga
     1381 aagtttgatg gtgtggaggg gcctcgtacg cccaagtaca tgaacaacat cacctactac
     1441 tttgacaatg tcagcagcac cgagctttac agtgtggatc aggaactgct caaagactac
     1501 atcaagcgcc agattgaata ctacttcagc gtggacaatt tagagcgaga cttcttcctg
     1561 cgaaggaaaa tggatgctga tggtttccta cccatcaccc ttattgcttc cttccaccga
     1621 gtgcaggccc ttaccactga catttcactc atctttgcgg ccctaaagga cagcaaggtg
     1681 gtggagatcg ttgatgagaa agttcgtagg agggaggaac cagaaaagtg gcctcttccc
     1741 ccaatagtgg attattcaca gactgatttc tcccagcttc tcaactgccc tgaatttgtt
     1801 ccccgtcagc actaccaaaa ggagacagag tcggcacctg gctctcctcg tgcagtcacc
     1861 ccagtgccaa ccaaaacaga ggaggtcagc aacctaaaga cactacccaa gggcctgtct
     1921 gccagcctgc ctgacctgga ttctgagaac tggattgaag tgaagaagag gcctcggcca
     1981 tccccagcac ggcccaagaa gtcagaggag tccagatttt cccacctgac ctctctgcct
     2041 cagcagctgc cttcccagca gctgatgtcc aaggatcagg atgagcaaga ggaactggat
     2101 tttctgtttg acgaggagat ggagcagatg gatgggcgga agaacacctt cactgcctgg
     2161 tctgatgagg aatctgacta tgagattgat gacagggatg tcaacaagat cctcattgtc
     2221 acccagacac cacattacat gcgccggcac ccaggggggg accgcacagg caaccacacc
     2281 tcgcgtgcca agatgagcgc cgaactggcc aaggtcatta atgatggcct cttctactat
     2341 gagcaggacc tgtgggctga aaagtttgaa cctgagtatt cccagatcaa gcaagaagtc
     2401 gagaacttca aaaaggtcaa tatgatcagc cgggagcagt ttgacacact gacccctgag
     2461 ccccctgtgg atcccaacca ggaagttcct cctgggccac ctcggttcca gcaagttcct
     2521 acggatgccc tggccaacaa gttgtttggt gctcctgagc cctccaccat cgcccgctct
     2581 ctaccaacca ctgtcccaga gtcaccaaac taccgcaaca ccaggacccc tcgcactccc
     2641 cggacaccac agctcaaaga ctcaagccag acatcacggt tttacccagt ggtgaaagaa
     2701 ggacggacac tggatgccaa gatgcctcga aaaagaaaga caagacacag ttcaaaccca
     2761 cccttggaga gccatgtggg ctgggtgatg gattcccgtg agcacaggcc ccgtactgct
     2821 tccatcagct ccagcccctc agaagggacg cctacagttg gcagctatgg ctgtacccct
     2881 cagtcattgc ccaagttcca gcatccttcc catgaactgc tcaaggaaaa tggcttcaca
     2941 caacacgtct accataagta tcgtaggcgc tgccttaatg agcggaaacg cttgggcatt
     3001 ggccagtctc aggagatgaa cacactcttc cgcttctggt ccttcttcct ccgagatcac
     3061 ttcaacaaaa agatgtatga ggagttcaag cagctggctc tggaggacgc caaagaaggc
     3121 tacagatatg gtttggagtg cctttttcga tactacagtt atggcctgga aaagaagttc
     3181 cggctggaca tattcaagga ttttcaggag gaaacggtga aggactatga agctggccaa
     3241 ctgtatgggc tggagaagtt ctgggccttc ttgaaatatt ccaaagccaa aaatttggac
     3301 attgacccca aactgcaaga atacctcggc aaattccgac gtcttgaaga cttccgagta
     3361 gatcccccca tgggtgagga gggcaaccac aagcgacact cagtggtagc aggaggtggc
     3421 ggcggtgagg gcaggaagcg gtgcccctcc cagtcttcca gcaggcctgc tgccatgatc
     3481 agccaacccc ctacaccacc caccggccag cctgtccggg aagatgccaa atggacaagc
     3541 cagcactcga acacacagac tttgggaaag tgaaaagctc cttagccctg gggcttgagg
     3601 ggggaaaggg gtagggtggg taagagtcca tgggggtgcc cagtcccagg aaaggggaca
     3661 atgaagggac aggcctggag ttactaggac aggcctttgt gctgagtagc aatgtataca
     3721 ccatttgggc tatcagaggt acccctgggc aggagcctct acatcccctt ccccctcctc
     3781 tctccatgac tcttgacatc ctagcttctt ctaagggggg agggaaaggg gggagatttt
     3841 tatatatata tacatatata tatatcaagt tttaaattat tgatagttca tctggattac
     3901 caaaatcact ctgcagccct gcccgaggct agtaggctgc aaccctggtc cccaccccta
     3961 acctcctgct ccccctcaag ccaactatgc agcccacaag aaggccctgc gggccccccc
     4021 attgcccagc actgtctcat agaaggctct ggtggtacct ctgggcccca ggagcatcag
     4081 ccccttgatc atctggggtt tgtcatcacc atattttctc cctgctgttc ccaccatgcc
     4141 cttctgccat cttctgggag aaggaaacca aaggatctaa aactggggtt tgggggaagg
     4201 tttcagcctc tccccactcc ccttgcccca caccctttac tccccagccc agagagacgc
     4261 tgcttttacc aggaaagact attgaaagat gttttatttt atttttctct gacctttcca
     4321 tccttgaaaa aatggggaaa aaagaagaaa aaagacaaaa tcgaccataa aagaccaaaa
     4381 aaaaaaaaaa aatcagaaaa cccccaccta atccacagaa agtaatgtct ttcccctccc
     4441 cttggaattt ttgttttgtt tttggaaata atattttttt aaaagttgcc ttattgtgga
     4501 gcgggaatct gaaataccca aatgcctgtt ttcctcggtg gagtcaaccc gaagagctcc
     4561 caccttctct ggatgtgcct gggcttggac tggctagaat ctttctctgg actgttgcat
     4621 gtacagtgcc tccatcctgg aggcaagaga gttgggagtg gctcgaatca gagccgtgcc
     4681 caagatatcc ctgctgttgc atcgtttgaa gctgacgtcc tgtgtctgta cactgctgcc
     4741 actgttgtgt cctcgctctg cttgctgttg cctcacgcca ggccccgtcc tgccgtgaca
     4801 cccttcatcc tacccttgga accccaaggc caagttggtt caaactgttg gagaacagag
     4861 ttggcctgca tctggaacac acttgtcctc agcttaccat ctcctcacac cccagagtgg
     4921 aaaggtgaac acctgcagct gaggcttgga aacgtttctt gtgttgccct gaaaaatctt
     4981 tgagacctca gggaggctct gtctctctta aaaggtggag aaagatgcca ttctctccct
     5041 aaggtctggt ggagtctccc catcttgcat acccttctgc aagccatcta tctctgctca
     5101 ctctccaatt gacccgcctg ggaacaaggg atgaggagga gttgggggct ggggggaatc
     5161 ctgccagttg gtgaagccct gtggcaggaa ggtatatgtg gacatagagt atacctgatt
     5221 ctctttcttc agccactgac tgcttgggtt gggctgtgaa tgataatgga atggctggag
     5281 tctgctgttg tcagaaggca gggagggtga tgaaggactg acccacatgg actgggatgt
     5341 gtgtcggtta tgggcatgac tgcacgttca ctctcagtgg gatctgggca acatggagtt
     5401 cattgtcctg ttgcttactt actgcaatgt ctttggccct ccttttcaac tggttcctct
     5461 gttgggccca aaggttggga gtaggagaca gtatcccagg ctgacaaggg cttgcccttt
     5521 accttgggca ccttgttaat ttttagcctg tgcccttccc cacctttgcc ctcccagtgg
     5581 ttggtatgtg ggaagcccat ctcagttcct gtgacttcat gtctcaaacc aaggatgagc
     5641 gtctggtctc tgctatgatg gtggtatccg aggcctttcc ctgcccagtc tggtgcctgc
     5701 cccacattgt accggacact ggattcctgg acccccttct cctttccttt ctttccttca
     5761 ggtcacgcag ccctgtactg tatccagcac cacagaaacc tcagtgtttt tcctctgctg
     5821 gtttggggca caaggaagcc ttagggtatg gggaaaggct gttattacct agagtttact
     5881 cccaggccag ggggctgcca tcttcttcac agacatccct gaaaggaagc ccctttgggg
     5941 cagggaggtg aggacttcat ctcaacatcg gctggtggtt ggtaggggag ctttttcttt
     6001 tctttccttt ttttttgttt ttgtttttgt ttttgttttt ggtaacatgt taggagttaa
     6061 tgttgcaaag agtagtttac atcttcactt tctgaagaca cttgaattta ggaccgatgt
     6121 atctgtgaca agcatgccag aagtggcagg ggccatcagg gctaaccact tcacacctac
     6181 catcgtccca tggggatcca agacctgaga taaagcaaca gcctgcccag atccctctgt
     6241 tcatcctatc ccttccaagg ttggtccatg ccaacataac ctctgggcat cagacatcag
     6301 caggtctgtg tgcctcagcc ctgttaaggg gcaggtttct ctttagccct cttcctgcac
     6361 ttgggagcaa aggcactacc agtagagaag ggccatccag ccgtgcccca gcctggaccc
     6421 ctggggctca gatagaggtg ctgagcccct gtgtcaaagt tgttaaatgt ttttgttttg
     6481 ttccattgta gctctttttt tttttttttc ccctttcctg gtgattgatt ttacaaaaga
     6541 aagtaagctg cttagaaggc cctggaaggg aagtgaggag gagggacaag gaagatgact
     6601 agttacggag ggtgagggtt gttttttgcc aaaaagcctg ggtagagtga tctgaattat
     6661 ctggcaccct cctgaatgga accccagagt acctcctgtg tggaagggtc cctggatttt
     6721 ccctaacacc caccctctcc cccttcagcc atgctgatgg cagagaagat aagaacttgg
     6781 agcccatttc tcactggaga ggaaaacttg tcatctggct ttgcggagaa ggttccacct
     6841 tacgctcgta gtacattatc tttactatgt gctaggatat catatttaaa aggacaaaaa
     6901 aatgtaaaat acttgaatga gcttgtatta taacattaat attattgaga gtatctgctt
     6961 tccaggctga agtgattcat tcattattct agtcctgctt tagtcctttg taatttgtgg
     7021 taattatgct tttcttttta atacaaaaaa atgtataaaa ataaacactt gaaaaggcaa
     7081 aa
//
