LOCUS       NM_001367716            6324 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens La ribonucleoprotein 1, translational regulator
            (LARP1), transcript variant 6, mRNA.
ACCESSION   NM_001367716 XM_017009283
VERSION     NM_001367716.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6324)
  AUTHORS   Ma,J., Dong,D., Qi,H., Li,J., Yu,H., Hu,X., Sun,L. and Shen,L.
  TITLE     LARP1, an RNA-binding protein, participates in ovarian cancer cell
            survival by regulating mitochondrial oxidative phosphorylation in
            response to the influence of the PI3K/mTOR pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167453 (2024)
   PUBMED   39111634
  REMARK    GeneRIF: LARP1, an RNA-binding protein, participates in ovarian
            cancer cell survival by regulating mitochondrial oxidative
            phosphorylation in response to the influence of the PI3K/mTOR
            pathway.
REFERENCE   2  (bases 1 to 6324)
  AUTHORS   Chettle,J., Louie,R.J., Larner,O., Best,R., Chen,K., Morris,J.,
            Dedeic,Z., Childers,A., Rogers,R.C., DuPont,B.R., Skinner,C.,
            Kury,S., Uguen,K., Planes,M., Monteil,D., Li,M., Eliyahu,A.,
            Greenbaum,L., Mor,N., Besnard,T., Isidor,B., Cogne,B., Blesson,A.,
            Comi,A., Wentzensen,I.M., Vuocolo,B., Lalani,S.R., Sierra,R.,
            Berry,L., Carter,K., Sanders,S.J. and Blagden,S.P.
  TITLE     LARP1 haploinsufficiency is associated with an autosomal dominant
            neurodevelopmental disorder
  JOURNAL   HGG Adv 5 (4), 100345 (2024)
   PUBMED   39182167
  REMARK    GeneRIF: LARP1 haploinsufficiency is associated with an autosomal
            dominant neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 6324)
  AUTHORS   Smith,B.C. and Silvers,R.
  TITLE     1H, 13C, and 15N resonance assignments of the La Motif of the human
            La-related protein 1
  JOURNAL   Biomol NMR Assign 18 (1), 111-118 (2024)
   PUBMED   38691336
  REMARK    GeneRIF: [1]H, [13]C, and [15]N resonance assignments of the La
            Motif of the human La-related protein 1.
REFERENCE   4  (bases 1 to 6324)
  AUTHORS   Bley,H., Krisp,C., Schobel,A., Hehner,J., Schneider,L., Becker,M.,
            Stegmann,C., Heidenfels,E., Nguyen-Dinh,V., Schluter,H., Gerold,G.
            and Herker,E.
  TITLE     Proximity labeling of host factor ANXA3 in HCV infection reveals a
            novel LARP1 function in viral entry
  JOURNAL   J Biol Chem 300 (5), 107286 (2024)
   PUBMED   38636657
  REMARK    GeneRIF: Proximity labeling of host factor ANXA3 in HCV infection
            reveals a novel LARP1 function in viral entry.
REFERENCE   5  (bases 1 to 6324)
  AUTHORS   Kozlov,G., Jiang,J., Rutherford,T., Noronha,A.M., Wilds,C.J. and
            Gehring,K.
  TITLE     Enhanced binding of guanylated poly(A) RNA by the LaM domain of
            LARP1
  JOURNAL   RNA Biol 21 (1), 7-16 (2024)
   PUBMED   39016322
  REMARK    GeneRIF: Enhanced binding of guanylated poly(A) RNA by the LaM
            domain of LARP1.
REFERENCE   6  (bases 1 to 6324)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   7  (bases 1 to 6324)
  AUTHORS   Burrows,C., Abd Latip,N., Lam,S.J., Carpenter,L., Sawicka,K.,
            Tzolovsky,G., Gabra,H., Bushell,M., Glover,D.M., Willis,A.E. and
            Blagden,S.P.
  TITLE     The RNA binding protein Larp1 regulates cell division, apoptosis
            and cell migration
  JOURNAL   Nucleic Acids Res 38 (16), 5542-5553 (2010)
   PUBMED   20430826
REFERENCE   8  (bases 1 to 6324)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 6324)
  AUTHORS   Horke,S., Reumann,K., Schweizer,M., Will,H. and Heise,T.
  TITLE     Nuclear trafficking of La protein depends on a newly identified
            nucleolar localization signal and the ability to bind RNA
  JOURNAL   J Biol Chem 279 (25), 26563-26570 (2004)
   PUBMED   15060081
  REMARK    GeneRIF: Nuclear trafficking of La protein depends on a newly
            identified nucleolar localization signal and the ability to bind
            RNA
REFERENCE   10 (bases 1 to 6324)
  AUTHORS   Chauvet,S., Maurel-Zaffran,C., Miassod,R., Jullien,N., Pradel,J.
            and Aragnol,D.
  TITLE     dlarp, a new candidate Hox target in Drosophila whose orthologue in
            mouse is expressed at sites of epithelium/mesenchymal interactions
  JOURNAL   Dev Dyn 218 (3), 401-413 (2000)
   PUBMED   10878606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008379.7 and AC112169.2.
            
            On Dec 13, 2018 this sequence version replaced XM_017009283.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.7204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC008379.7         39438-39496
            60-121              AC112169.2         113711-113772       c
            122-187             AC112169.2         113387-113452       c
            188-362             AC112169.2         111301-111475       c
            363-491             AC112169.2         110374-110502       c
            492-593             AC112169.2         110196-110297       c
            594-756             AC112169.2         109835-109997       c
            757-901             AC112169.2         108778-108922       c
            902-1070            AC112169.2         104338-104506       c
            1071-1240           AC112169.2         104055-104224       c
            1241-1633           AC112169.2         101698-102090       c
            1634-1757           AC112169.2         100684-100807       c
            1758-1963           AC112169.2         100352-100557       c
            1964-2070           AC112169.2         99790-99896         c
            2071-2222           AC112169.2         98065-98216         c
            2223-2367           AC112169.2         95494-95638         c
            2368-2477           AC112169.2         92741-92850         c
            2478-2605           AC112169.2         92457-92584         c
            2606-6324           AC112169.2         86492-90210         c
FEATURES             Location/Qualifiers
     source          1..6324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..6324
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="La ribonucleoprotein 1, translational regulator"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
     exon            1..59
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..121
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..187
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..362
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2815
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="isoform 5 is encoded by transcript variant 6;
                     la-related protein 1; La ribonucleoprotein domain family
                     member 1"
                     /codon_start=1
                     /product="la-related protein 1 isoform 5"
                     /protein_id="NP_001354645.1"
                     /db_xref="CCDS:CCDS93806.1"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
                     /translation="MKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNK
                     HKWVPLQIDMKPEVPREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVAPPTPAWQ
                     PEIKPEPAWHDQDETSTHFDYQFGYRKFDGVEGPRTPKYMNNITYYFDNVSSTELYSV
                     DQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISL
                     IFAALKDSKVVEIVDEKVRRREEPEKWPLPPIVDYSQTDFSQLLNCPEFVPRQHYQKE
                     TESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPK
                     KSEESRFSHLTSLPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEE
                     SDYEIDDRDVNKILIVTQTPHYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQ
                     DLWAEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVP
                     TDALANKLFGAPEPSTIARSLPTTVPESPNYRNTRTPRTPRTPQLKDSSQTSRFYPVV
                     KEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPTVGSY
                     GCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWS
                     FFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEET
                     VKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNH
                     KRHSVVAGGGGGEGRKRCPSQSSSRPAAMISQPPTPPTGQPVREDAKWTSQHSNTQTL
                     GK"
     exon            363..491
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..593
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..756
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..901
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1070
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1240
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1633
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1757
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1963
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2070
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2222
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2367
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2477
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2605
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..6324
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6302..6307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="hexamer: AATAAA"
     polyA_site      6324
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="major polyA site"
ORIGIN      
        1 agaggctgag tcatcgctgc tgcggcgctg ccggccgtgc tgggagagca ggcgagcaga
       61 acactctgct ccagccaagg tggtgagggc agctgttcct aaacagcgca aaggcagcaa
      121 ggttggtgac tttggagatg caatcaattg gcccacacct ggagagatag cccacaagag
      181 tgttcagcca cagtcccaca agcctcagcc tacccgtaaa ctgccaccca agaaggacat
      241 gaaggaacag gagaaaggag aagggagtga tagtaaggag agtccaaaaa ccaaatcaga
      301 tgaatcaggg gaggaaaaga atggagatga ggattgccag cgaggcgggc agaagaagaa
      361 aggaaacaaa cacaagtggg ttccattaca aatagacatg aagcctgaag tgcccagaga
      421 gaaactggct tcacgcccca ctcgcccacc ggagcctaga cacatacctg ccaatcgcgg
      481 agagatcaaa gggtctgagt ctgccaccta cgtgcccgtg gcccccccca ccccagcctg
      541 gcaaccagag atcaaaccgg agcctgcctg gcacgaccag gatgagacat cgacccattt
      601 tgactaccag tttggctacc gaaagtttga tggtgtggag gggcctcgta cgcccaagta
      661 catgaacaac atcacctact actttgacaa tgtcagcagc accgagcttt acagtgtgga
      721 tcaggaactg ctcaaagact acatcaagcg ccagattgaa tactacttca gcgtggacaa
      781 tttagagcga gacttcttcc tgcgaaggaa aatggatgct gatggtttcc tacccatcac
      841 ccttattgct tccttccacc gagtgcaggc ccttaccact gacatttcac tcatctttgc
      901 ggccctaaag gacagcaagg tggtggagat cgttgatgag aaagttcgta ggagggagga
      961 accagaaaag tggcctcttc ccccaatagt ggattattca cagactgatt tctcccagct
     1021 tctcaactgc cctgaatttg ttccccgtca gcactaccaa aaggagacag agtcggcacc
     1081 tggctctcct cgtgcagtca ccccagtgcc aaccaaaaca gaggaggtca gcaacctaaa
     1141 gacactaccc aagggcctgt ctgccagcct gcctgacctg gattctgaga actggattga
     1201 agtgaagaag aggcctcggc catccccagc acggcccaag aagtcagagg agtccagatt
     1261 ttcccacctg acctctctgc ctcagcagct gccttcccag cagctgatgt ccaaggatca
     1321 ggatgagcaa gaggaactgg attttctgtt tgacgaggag atggagcaga tggatgggcg
     1381 gaagaacacc ttcactgcct ggtctgatga ggaatctgac tatgagattg atgacaggga
     1441 tgtcaacaag atcctcattg tcacccagac accacattac atgcgccggc acccaggggg
     1501 ggaccgcaca ggcaaccaca cctcgcgtgc caagatgagc gccgaactgg ccaaggtcat
     1561 taatgatggc ctcttctact atgagcagga cctgtgggct gaaaagtttg aacctgagta
     1621 ttcccagatc aagcaagaag tcgagaactt caaaaaggtc aatatgatca gccgggagca
     1681 gtttgacaca ctgacccctg agccccctgt ggatcccaac caggaagttc ctcctgggcc
     1741 acctcggttc cagcaagttc ctacggatgc cctggccaac aagttgtttg gtgctcctga
     1801 gccctccacc atcgcccgct ctctaccaac cactgtccca gagtcaccaa actaccgcaa
     1861 caccaggacc cctcgcactc cccggacacc acagctcaaa gactcaagcc agacatcacg
     1921 gttttaccca gtggtgaaag aaggacggac actggatgcc aagatgcctc gaaaaagaaa
     1981 gacaagacac agttcaaacc cacccttgga gagccatgtg ggctgggtga tggattcccg
     2041 tgagcacagg ccccgtactg cttccatcag ctccagcccc tcagaaggga cgcctacagt
     2101 tggcagctat ggctgtaccc ctcagtcatt gcccaagttc cagcatcctt cccatgaact
     2161 gctcaaggaa aatggcttca cacaacacgt ctaccataag tatcgtaggc gctgccttaa
     2221 tgagcggaaa cgcttgggca ttggccagtc tcaggagatg aacacactct tccgcttctg
     2281 gtccttcttc ctccgagatc acttcaacaa aaagatgtat gaggagttca agcagctggc
     2341 tctggaggac gccaaagaag gctacagata tggtttggag tgcctttttc gatactacag
     2401 ttatggcctg gaaaagaagt tccggctgga catattcaag gattttcagg aggaaacggt
     2461 gaaggactat gaagctggcc aactgtatgg gctggagaag ttctgggcct tcttgaaata
     2521 ttccaaagcc aaaaatttgg acattgaccc caaactgcaa gaatacctcg gcaaattccg
     2581 acgtcttgaa gacttccgag tagatccccc catgggtgag gagggcaacc acaagcgaca
     2641 ctcagtggta gcaggaggtg gcggcggtga gggcaggaag cggtgcccct cccagtcttc
     2701 cagcaggcct gctgccatga tcagccaacc ccctacacca cccaccggcc agcctgtccg
     2761 ggaagatgcc aaatggacaa gccagcactc gaacacacag actttgggaa agtgaaaagc
     2821 tccttagccc tggggcttga ggggggaaag gggtagggtg ggtaagagtc catgggggtg
     2881 cccagtccca ggaaagggga caatgaaggg acaggcctgg agttactagg acaggccttt
     2941 gtgctgagta gcaatgtata caccatttgg gctatcagag gtacccctgg gcaggagcct
     3001 ctacatcccc ttccccctcc tctctccatg actcttgaca tcctagcttc ttctaagggg
     3061 ggagggaaag gggggagatt tttatatata tatacatata tatatatcaa gttttaaatt
     3121 attgatagtt catctggatt accaaaatca ctctgcagcc ctgcccgagg ctagtaggct
     3181 gcaaccctgg tccccacccc taacctcctg ctccccctca agccaactat gcagcccaca
     3241 agaaggccct gcgggccccc ccattgccca gcactgtctc atagaaggct ctggtggtac
     3301 ctctgggccc caggagcatc agccccttga tcatctgggg tttgtcatca ccatattttc
     3361 tccctgctgt tcccaccatg cccttctgcc atcttctggg agaaggaaac caaaggatct
     3421 aaaactgggg tttgggggaa ggtttcagcc tctccccact ccccttgccc cacacccttt
     3481 actccccagc ccagagagac gctgctttta ccaggaaaga ctattgaaag atgttttatt
     3541 ttatttttct ctgacctttc catccttgaa aaaatgggga aaaaagaaga aaaaagacaa
     3601 aatcgaccat aaaagaccaa aaaaaaaaaa aaaatcagaa aacccccacc taatccacag
     3661 aaagtaatgt ctttcccctc cccttggaat ttttgttttg tttttggaaa taatattttt
     3721 ttaaaagttg ccttattgtg gagcgggaat ctgaaatacc caaatgcctg ttttcctcgg
     3781 tggagtcaac ccgaagagct cccaccttct ctggatgtgc ctgggcttgg actggctaga
     3841 atctttctct ggactgttgc atgtacagtg cctccatcct ggaggcaaga gagttgggag
     3901 tggctcgaat cagagccgtg cccaagatat ccctgctgtt gcatcgtttg aagctgacgt
     3961 cctgtgtctg tacactgctg ccactgttgt gtcctcgctc tgcttgctgt tgcctcacgc
     4021 caggccccgt cctgccgtga cacccttcat cctacccttg gaaccccaag gccaagttgg
     4081 ttcaaactgt tggagaacag agttggcctg catctggaac acacttgtcc tcagcttacc
     4141 atctcctcac accccagagt ggaaaggtga acacctgcag ctgaggcttg gaaacgtttc
     4201 ttgtgttgcc ctgaaaaatc tttgagacct cagggaggct ctgtctctct taaaaggtgg
     4261 agaaagatgc cattctctcc ctaaggtctg gtggagtctc cccatcttgc atacccttct
     4321 gcaagccatc tatctctgct cactctccaa ttgacccgcc tgggaacaag ggatgaggag
     4381 gagttggggg ctggggggaa tcctgccagt tggtgaagcc ctgtggcagg aaggtatatg
     4441 tggacataga gtatacctga ttctctttct tcagccactg actgcttggg ttgggctgtg
     4501 aatgataatg gaatggctgg agtctgctgt tgtcagaagg cagggagggt gatgaaggac
     4561 tgacccacat ggactgggat gtgtgtcggt tatgggcatg actgcacgtt cactctcagt
     4621 gggatctggg caacatggag ttcattgtcc tgttgcttac ttactgcaat gtctttggcc
     4681 ctccttttca actggttcct ctgttgggcc caaaggttgg gagtaggaga cagtatccca
     4741 ggctgacaag ggcttgccct ttaccttggg caccttgtta atttttagcc tgtgcccttc
     4801 cccacctttg ccctcccagt ggttggtatg tgggaagccc atctcagttc ctgtgacttc
     4861 atgtctcaaa ccaaggatga gcgtctggtc tctgctatga tggtggtatc cgaggccttt
     4921 ccctgcccag tctggtgcct gccccacatt gtaccggaca ctggattcct ggaccccctt
     4981 ctcctttcct ttctttcctt caggtcacgc agccctgtac tgtatccagc accacagaaa
     5041 cctcagtgtt tttcctctgc tggtttgggg cacaaggaag ccttagggta tggggaaagg
     5101 ctgttattac ctagagttta ctcccaggcc agggggctgc catcttcttc acagacatcc
     5161 ctgaaaggaa gcccctttgg ggcagggagg tgaggacttc atctcaacat cggctggtgg
     5221 ttggtagggg agctttttct tttctttcct ttttttttgt ttttgttttt gtttttgttt
     5281 ttggtaacat gttaggagtt aatgttgcaa agagtagttt acatcttcac tttctgaaga
     5341 cacttgaatt taggaccgat gtatctgtga caagcatgcc agaagtggca ggggccatca
     5401 gggctaacca cttcacacct accatcgtcc catggggatc caagacctga gataaagcaa
     5461 cagcctgccc agatccctct gttcatccta tcccttccaa ggttggtcca tgccaacata
     5521 acctctgggc atcagacatc agcaggtctg tgtgcctcag ccctgttaag gggcaggttt
     5581 ctctttagcc ctcttcctgc acttgggagc aaaggcacta ccagtagaga agggccatcc
     5641 agccgtgccc cagcctggac ccctggggct cagatagagg tgctgagccc ctgtgtcaaa
     5701 gttgttaaat gtttttgttt tgttccattg tagctctttt tttttttttt tcccctttcc
     5761 tggtgattga ttttacaaaa gaaagtaagc tgcttagaag gccctggaag ggaagtgagg
     5821 aggagggaca aggaagatga ctagttacgg agggtgaggg ttgttttttg ccaaaaagcc
     5881 tgggtagagt gatctgaatt atctggcacc ctcctgaatg gaaccccaga gtacctcctg
     5941 tgtggaaggg tccctggatt ttccctaaca cccaccctct cccccttcag ccatgctgat
     6001 ggcagagaag ataagaactt ggagcccatt tctcactgga gaggaaaact tgtcatctgg
     6061 ctttgcggag aaggttccac cttacgctcg tagtacatta tctttactat gtgctaggat
     6121 atcatattta aaaggacaaa aaaatgtaaa atacttgaat gagcttgtat tataacatta
     6181 atattattga gagtatctgc tttccaggct gaagtgattc attcattatt ctagtcctgc
     6241 tttagtcctt tgtaatttgt ggtaattatg cttttctttt taatacaaaa aaatgtataa
     6301 aaataaacac ttgaaaaggc aaaa
//
