LOCUS       NM_133642               4753 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens LARGE xylosyl- and glucuronyltransferase 1 (LARGE1),
            transcript variant 2, mRNA.
ACCESSION   NM_133642
VERSION     NM_133642.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4753)
  AUTHORS   Botti-Lodovico,Y., Nair,P., Nosamiefan,D., Stremlau,M.,
            Schaffner,S., Agignoae,S.V., Aiyepada,J.O., Ajogbasile,F.V.,
            Akpede,G.O., Alhasan,F., Andersen,K.G., Asogun,D.A., Ayodeji,O.O.,
            Badiane,A.S., Barnes,K., Bauer,M.R., Bell-Kareem,A., Benard,M.E.,
            Benevolence,E.O., Blessing,O., Boehm,C.K., Boisen,M.L., Bond,N.G.,
            Branco,L.M., Butts,M.J., Carter,A., Colubri,A., Deme,A.B.,
            DeRuff,K.C., Diedhiou,Y., Edamhande,A.P., Elhamoumi,S., Engel,E.J.,
            Eromon,P., Fallah,M., Folarin,O.A., Fry,B., Garry,R., Gaye,A.,
            Gbakie,M., Gevao,S.M., Gionet,G., Gladden-Young,A., Goba,A.,
            Gomis,J.F., Happi,A.N., Houghton,M., Ihekwuazu,C., Iruolagbe,C.O.,
            Jackson,J., Jalloh,S., Johnson,J., Kanneh,L., Kayode,A.,
            Kemball,M., Kingsley,O.C., Koroma,V., Kotliar,D., Mehta,S.,
            Metsky,H.C., Michael,A., Mirhashemi,M.E., Modjarrad,K., Momoh,M.,
            Myhrvold,C.A., Naregose,O.G., Ndiaye,T., Ndiaye,M., Ndiaye,A.,
            Normandin,E., Odia,I., Oguzie,J.U., Okogbenin,S.A., Okokhere,P.O.,
            Okolie,J., Olawoye,I.B., Olumade,T.J., Oluniyi,P.E., Omoregie,O.,
            Park,D.J., Paye,M.F., Petros,B., Philippakis,A.A., Priscilla,A.,
            Ricks,A., Rimoin,A., Sandi,J.D., Schieffelin,J.S., Schreiber,M.,
            Seck,M.C., Siddiqui,S., Siddle,K., Smither,A.R., Sy,M., Sy,N.,
            Tomkins-Tinch,C.H., Tomori,O., Ugwu,C., Uwanibe,J.N., Uyigue,E.A.,
            Victoria,D.I., Vinze,A., Vodzak,M.E., Welch,N., Wurie,H.I.,
            Zoumarou,D., Grant,D.S., Ndiaye,D., MacInnis,B., Sabeti,P.C. and
            Happi,C.
  TITLE     The Origins and Future of Sentinel: An Early-Warning System for
            Pandemic Preemption and Response
  JOURNAL   Viruses 13 (8), 1605 (2021)
   PUBMED   34452470
  REMARK    GeneRIF: The Origins and Future of Sentinel: An Early-Warning
            System for Pandemic Preemption and Response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4753)
  AUTHORS   Wang,M., Tao,H. and Huang,P.
  TITLE     Clinical significance of LARGE1 in progression of liver cancer and
            the underlying mechanism
  JOURNAL   Gene 779, 145493 (2021)
   PUBMED   33588034
  REMARK    GeneRIF: Clinical significance of LARGE1 in progression of liver
            cancer and the underlying mechanism.
REFERENCE   3  (bases 1 to 4753)
  AUTHORS   Walimbe,A.S., Okuma,H., Joseph,S., Yang,T., Yonekawa,T., Hord,J.M.,
            Venzke,D., Anderson,M.E., Torelli,S., Manzur,A., Devereaux,M.,
            Cuellar,M., Prouty,S., Ocampo Landa,S., Yu,L., Xiao,J., Dixon,J.E.,
            Muntoni,F. and Campbell,K.P.
  TITLE     POMK regulates dystroglycan function via LARGE1-mediated elongation
            of matriglycan
  JOURNAL   Elife 9, e61388 (2020)
   PUBMED   32975514
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4753)
  AUTHORS   Beltran,D., Anderson,M.E., Bharathy,N., Settelmeyer,T.P.,
            Svalina,M.N., Bajwa,Z., Shern,J.F., Gultekin,S.H., Cuellar,M.A.,
            Yonekawa,T., Keller,C. and Campbell,K.P.
  TITLE     Exogenous expression of the glycosyltransferase LARGE1 restores
            alpha-dystroglycan matriglycan and laminin binding in
            rhabdomyosarcoma
  JOURNAL   Skelet Muscle 9 (1), 11 (2019)
   PUBMED   31054580
  REMARK    GeneRIF: findings demonstrate that a lack of matriglycan on
            alpha-dystroglycan is a common feature in rhabdomyosarcoma due to
            the downregulation of LARGE1, and that ectopic expression of LARGE1
            can restore matriglycan modifications and the ability of
            alpha-dystroglycan to function as an extracellular matrix receptor
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4753)
  AUTHORS   Gao,G., Johnson,S.H., Vasmatzis,G., Pauley,C.E., Tombers,N.M.,
            Kasperbauer,J.L. and Smith,D.I.
  TITLE     Common fragile sites (CFS) and extremely large CFS genes are
            targets for human papillomavirus integrations and chromosome
            rearrangements in oropharyngeal squamous cell carcinoma
  JOURNAL   Genes Chromosomes Cancer 56 (1), 59-74 (2017)
   PUBMED   27636103
  REMARK    GeneRIF: Large1 gene is a target for human papillomavirus
            integrations and chromosome rearrangements in oropharyngeal
            squamous cell carcinoma.
REFERENCE   6  (bases 1 to 4753)
  AUTHORS   Longman,C., Brockington,M., Torelli,S., Jimenez-Mallebrera,C.,
            Kennedy,C., Khalil,N., Feng,L., Saran,R.K., Voit,T., Merlini,L.,
            Sewry,C.A., Brown,S.C. and Muntoni,F.
  TITLE     Mutations in the human LARGE gene cause MDC1D, a novel form of
            congenital muscular dystrophy with severe mental retardation and
            abnormal glycosylation of alpha-dystroglycan
  JOURNAL   Hum Mol Genet 12 (21), 2853-2861 (2003)
   PUBMED   12966029
REFERENCE   7  (bases 1 to 4753)
  AUTHORS   Michele,D.E., Barresi,R., Kanagawa,M., Saito,F., Cohn,R.D.,
            Satz,J.S., Dollar,J., Nishino,I., Kelley,R.I., Somer,H., Straub,V.,
            Mathews,K.D., Moore,S.A. and Campbell,K.P.
  TITLE     Post-translational disruption of dystroglycan-ligand interactions
            in congenital muscular dystrophies
  JOURNAL   Nature 418 (6896), 417-422 (2002)
   PUBMED   12140558
REFERENCE   8  (bases 1 to 4753)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 4753)
  AUTHORS   Peyrard,M., Seroussi,E., Sandberg-Nordqvist,A.C., Xie,Y.G.,
            Han,F.Y., Fransson,I., Collins,J., Dunham,I., Kost-Alimova,M.,
            Imreh,S. and Dumanski,J.P.
  TITLE     The human LARGE gene from 22q12.3-q13.1 is a new, distinct member
            of the glycosyltransferase gene family
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 598-603 (1999)
   PUBMED   9892679
REFERENCE   10 (bases 1 to 4753)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z73429.1, AL096754.1, Z68287.1,
            Z69042.1, Z70288.1, Z69943.3, AL008715.1, Z82173.2 and AL008630.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_133642.4.
            
            Summary: This gene encodes a member of the
            N-acetylglucosaminyltransferase gene family. It encodes a
            glycosyltransferase which participates in glycosylation of
            alpha-dystroglycan, and may carry out the synthesis of glycoprotein
            and glycosphingolipid sugar chains. It may also be involved in the
            addition of a repeated disaccharide unit. The protein encoded by
            this gene is the glycotransferase that adds the final xylose and
            glucuronic acid to alpha-dystroglycan and thereby allows
            alpha-dystroglycan to bind ligands including laminin 211 and
            neurexin. Mutations in this gene cause several forms of congenital
            muscular dystrophy characterized by cognitive disability and
            abnormal glycosylation of alpha-dystroglycan. Alternative splicing
            of this gene results in multiple transcript variants that encode
            the same protein. [provided by RefSeq, May 2018].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.69942.1,
                                           SRR1660803.173083.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397394.8/ ENSP00000380549.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               Z73429.1           34189-34670         c
            483-670             AL096754.1         6814-7001           c
            671-972             Z68287.1           8885-9186           c
            973-1055            Z69042.1           12061-12143         c
            1056-1179           Z70288.1           29395-29518         c
            1180-1351           Z69943.3           9391-9562           c
            1352-1456           AL008715.1         88465-88569         c
            1457-1569           AL008715.1         40496-40608         c
            1570-1695           AL008715.1         38223-38348         c
            1696-1851           Z82173.2           31581-31736         c
            1852-2015           Z82173.2           10020-10183         c
            2016-2294           AL008630.1         58642-58920         c
            2295-2441           AL008630.1         37615-37761         c
            2442-2637           AL008630.1         31473-31668         c
            2638-4753           AL008630.1         26922-29037         c
FEATURES             Location/Qualifiers
     source          1..4753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..4753
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /note="LARGE xylosyl- and glucuronyltransferase 1"
                     /db_xref="GeneID:9215"
                     /db_xref="HGNC:HGNC:6511"
                     /db_xref="MIM:603590"
     exon            1..482
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            483..670
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             565..2835
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /note="isoform 1 is encoded by transcript variant 2;
                     acetylglucosaminyltransferase-like protein;
                     glycosyltransferase-like protein LARGE1;
                     acetylglucosaminyltransferase-like 1A; xylosyl- and
                     glucuronyltransferase LARGE1"
                     /codon_start=1
                     /product="xylosyl- and glucuronyltransferase LARGE1
                     isoform 1"
                     /protein_id="NP_598397.1"
                     /db_xref="CCDS:CCDS13912.1"
                     /db_xref="GeneID:9215"
                     /db_xref="HGNC:HGNC:6511"
                     /db_xref="MIM:603590"
                     /translation="MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSP
                     LESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTY
                     SMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSV
                     LFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSG
                     IYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDW
                     YLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLAD
                     QDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNK
                     HVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRER
                     FTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDA
                     EAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDF
                     LPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFT
                     FRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKV
                     AHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSR
                     RYGFAALKYLTAENNS"
     exon            671..972
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1055
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1179
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1351
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1456
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1569
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1695
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1851
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2015
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2294
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2441
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2637
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..4753
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4155..4160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /note="hexamer: AATAAA"
     polyA_site      4186
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /note="major polyA site"
     regulatory      4728..4733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
                     /note="hexamer: TATAAA"
     polyA_site      4753
                     /gene="LARGE1"
                     /gene_synonym="LARGE; MDC1D; MDDGA6; MDDGB6"
ORIGIN      
        1 agtctgctcc tgccccgccg ccgcgccgga gcccgggcgc ccgaagctgg gggcgcggcc
       61 gcgctcgtct cgccgggctg ttcgcgggca ggccctgccc tgaagggacg aatcggcttg
      121 gagcgcggga ggtggagtcg gccccggcgg tcgctccctg gacccaaccc gaggctgacc
      181 caggcccctg cccatgcggg gcgcccctgg ctcggaagag tcccccgggc cgggagcagc
      241 tccaggcagc ggccccggag gaagaggaag aagggacagt gctcagcttg ggggacccgg
      301 accctcgccg cggcatttgg agccgggggc agtcccgaac tctgtgcttg gcaccgccgc
      361 tccgagtagg gcagcgcctg ccgggaccct gacccggacc ccctgcgcct cgtaggcggc
      421 ggcgccgccg cgccaccctg ttcttccgtg tctccctctg cctggcggca gtcacggcca
      481 agagagtatt atgagggagg ccgaggactt catgctccgg acagagaaac ggcgctggga
      541 ttagggattg ccacttctga gaggatgctg ggaatctgca gggggagacg gaaattcttg
      601 gctgcctcgt tgagtcttct ctgcatccca gccatcacct ggatttacct gttttctggg
      661 agcttcgaag atggaaagcc cgtgtctctg tcaccgctgg agtcccaggc acacagcccc
      721 aggtacacgg cctccagcca gcgggagcgc gagagcctgg aggtgcgcat gcgcgaggtg
      781 gaggaggaga accgcgccct ccgcaggcag ctcagcctgg cccagggccg agccccatcc
      841 catcgccgag gcaaccactc caagacctac tccatggagg agggcactgg agacagcgag
      901 aaccttcggg ctggcatcgt ggcaggcaac agctccgagt gtgggcagca gccggtcgtg
      961 gagaaatgcg agacaatcca cgttgctatt gtctgcgccg gatacaatgc cagccgggat
     1021 gtcgtcaccc tggtcaaatc cgtcctgttc catagacgga accctctgca cttccacctt
     1081 attgctgact ccattgcgga gcagatcctg gccacgctct tccagacctg gatggtgccc
     1141 gctgtgcgtg tggacttcta caatgcagac gagctcaagt ctgaagtttc ctggatcccc
     1201 aataaacatt actctgggat ttatggtctg atgaagcttg tcctgaccaa gactcttcct
     1261 gccaacctgg agagagtcat cgtccttgac acggatatca cctttgccac tgacattgca
     1321 gagctgtggg ctgtgttcca caagttcaaa ggtcagcaag tcctgggctt ggtggagaac
     1381 cagagtgact ggtaccttgg aaacctgtgg aaaaatcacc gcccatggcc agcccttgga
     1441 agaggctaca acacaggggt gatcctgtta cttctggata agctgcggaa gatgaaatgg
     1501 gagcagatgt ggaggctgac cgcagagagg gagctcatgg gcatgctctc tacatcctta
     1561 gctgaccagg atattttcaa tgccgtcatc aaacaaaacc ccttccttgt gtaccagctc
     1621 ccctgcttct ggaatgtgca gctgtcagac cacacccgct ccgagcagtg ctacagagac
     1681 gtgtctgatc taaaggtcat tcactggaac tcccccaaga agctccgggt gaagaacaag
     1741 catgtggagt tttttcgcaa cctctacctg accttcctgg agtatgacgg caatcttctg
     1801 aggcgggaac tgtttggctg ccccagtgag gctgatgtca acagtgaaaa cctccagaag
     1861 cagctgtctg agctggacga ggacgacctg tgctatgagt tccggcgaga gcgcttcact
     1921 gtccaccgca cccacctgta cttcctgcac tacgagtatg agcctgcagc agacagcacg
     1981 gacgtcaccc tggtcgctca gctgtccatg gacaggctcc agatgctgga ggccatctgc
     2041 aagcactggg aggggcccat cagcctggcc ctctacctgt cagacgccga ggcccagcag
     2101 ttcctccgct acgcacaggg ctctgaggtg cttatgagcc gccacaacgt gggctaccac
     2161 atcgtgtaca aggagggcca gttctacccc gtgaacctgc tgcgcaacgt ggccatgaag
     2221 cacatcagca ctccctacat gttcctgtct gacattgact tcctgcccat gtatgggctc
     2281 tatgagtacc tcaggaagtc tgtcatccag ctcgatcttg ccaacaccaa gaaagcaatg
     2341 attgtccccg cgttcgagac actgcgctac cggctgtcct tccccaagtc aaaagcggag
     2401 ttgctgtcaa tgctggacat ggggaccctc ttcacattca ggtaccacgt ctggacgaaa
     2461 ggccacgcac ccacaaactt cgccaagtgg cggaccgcca ccacgcctta ccgggttgag
     2521 tgggaggccg attttgagcc gtatgttgtt gtgagacgtg actgcccgga gtacgaccgg
     2581 aggtttgtag gctttggctg gaacaaagtg gctcatatca tggagctgga tgtgcaggag
     2641 tatgagttca ttgtgctgcc caacgcctac atgatccaca tgcctcatgc ccccagcttc
     2701 gacattacca agttccgttc caacaagcaa taccgcatct gtctcaaaac cctcaaggaa
     2761 gagtttcagc aggacatgtc ccgccgctac ggctttgctg ccctgaaata tctcacagcc
     2821 gagaacaaca gctagcacca agaagcccac cactaggggg agacatgctg taggggaagt
     2881 gccactcgct gtttggggcc cggccttcaa attcaaaatt gagccatgct ttttcggttt
     2941 gtttttattt atctctttgg cccagccaag ctgccctcac tacagagacc ttggacaagg
     3001 atccagccag tccctctctg ccccacaacc ctgcattccc agaggttagc tatgcagccc
     3061 acctagatga gtctcttcaa gaatgggaaa tcaaggggtg acagggagta aaagggttat
     3121 catcttactg caaagccaca agatcagggc agggctttag gatgttctgg atgcttttta
     3181 ataattatgc ttcccatcat aactggggag aaagggaagt cagggttcta ggggttattc
     3241 gtcccaggaa atagaagtga aattgtcttt attaagtgaa aactttcccc tttgccctgc
     3301 aatgtagctg ggcattcaaa cggagggcaa accgatgatc taaaccaacc acttggaaaa
     3361 acccaatggg gacattgtaa ccagagggtc ctggaggtgg ggttgatggg tttccttatc
     3421 cccaaagtca ctcctgtttt gttttgtttt tctttggggg ttttgtttat ttttggggct
     3481 ggcaatccaa aatagaaaat ctgatccttt gaggctctaa aggaaaatca gctgcctcta
     3541 ccaaccaccc tctatcagca gtggcccagg aaggaggtca agcatcttcg gccgatattt
     3601 aaacatgggc agcttccttc aggatgatca ccgaggctcc cgtgactttg aactccctac
     3661 tctccagaat ccaggggcta tagcgatggg gactgcggaa ttacgagggc tggctgtttt
     3721 acaccggtca cattttctat tggcagtgac tgattcatgg gaaagggctt tgaaggaact
     3781 acttcagtgc acacacaagg tacgaacctc tcaggccttt cgaagaactt tcataattca
     3841 tgaaagccca gttctgaaga ttcacgtatc catctggaga cctacaggaa gaaagtgatt
     3901 gggttcctct ggttcttgcc tgcttcactg tggatgggaa gaggtgacaa cctcagtctc
     3961 cctttgggac ctgtccaagg gtaggcaacc accttcacct tcacacagat tgaggagaca
     4021 ctggactttt tacccatttt ctttaatctt caatattaat attgtgttta cattgatgag
     4081 aacaagagtt aatgccctac cctctgctgg gctgtttgta ttgagttgca atgtgaccag
     4141 cgaaagctgc atttaataaa tgaaagtaca gactgtttct tccccattcc cctcccactc
     4201 ttgcaggaag ctactgagac acaccttgac atagagagct aaattgcagt ggataaacag
     4261 caacttcaca ctttctgttc ccccattcta tttttctcat catttgaact ttagcctttt
     4321 ttttcccctt ttgcctgaag ttagatccca ctctgtctct aactcaaacc atcttcaagt
     4381 tttccattcc gcatctttct caacactgga gccagatgtt gtcttctacc agatgtgggc
     4441 taggagggta aatcctggta atcaattgta aagggaacat cccatccttg ggcctggtag
     4501 tcatgtggga ccctatagca atccggtttg tgagatcact cacgatgtta catgctcaag
     4561 tggatgttac acggaaattt atacaagaat taggaaaatt accattagga ctaatttttg
     4621 catagatcta gctaggctta tgtatgtatg taaatatata tgtagacaga gcatacaagt
     4681 atatagccta tatacaaagc atttataaat aaaaagtgac atatatgtat aaagcagaac
     4741 aaaaattttg aaa
//
