LOCUS       NM_006762               2177 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens lysosomal protein transmembrane 5 (LAPTM5), mRNA.
ACCESSION   NM_006762
VERSION     NM_006762.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Zhang,M.M., Liang,M.J., Zhang,D.M., Cai,J.N., Yang,Q.J., Zhao,Y.,
            Zhang,J.P. and Li,Y.L.
  TITLE     The function and mechanism of LAPTM5 in diseases
  JOURNAL   Biomed Pharmacother 178, 117237 (2024)
   PUBMED   39096616
  REMARK    GeneRIF: The function and mechanism of LAPTM5 in diseases.
            Review article
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Yang,Y., Xie,W., Qiao,X., Yang,J., Yao,D. and Zhu,D.
  TITLE     ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote
            metastasis in pancreatic ductal adenocarcinoma
  JOURNAL   Histol Histopathol 39 (6), 747-760 (2024)
   PUBMED   38018874
  REMARK    GeneRIF: ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to
            promote metastasis in pancreatic ductal adenocarcinoma.
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Pan,J., Zhang,M., Dong,L., Ji,S., Zhang,J., Zhang,S., Lin,Y.,
            Wang,X., Ding,Z., Qiu,S., Gao,D., Zhou,J., Fan,J. and Gao,Q.
  TITLE     Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib
            resistance in hepatocellular carcinoma
  JOURNAL   Autophagy 19 (4), 1184-1198 (2023)
   PUBMED   36037300
  REMARK    GeneRIF: Genome-Scale CRISPR screen identifies LAPTM5 driving
            lenvatinib resistance in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Han,S., Jin,X., Hu,T. and Chi,F.
  TITLE     LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of
            breast cancer through activating the Wnt/beta-catenin pathway
  JOURNAL   Oncol Rep 49 (3) (2023)
   PUBMED   36799186
  REMARK    GeneRIF: LAPTM5 regulated by FOXP3 promotes the malignant
            phenotypes of breast cancer through activating the Wnt/betacatenin
            pathway.
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   Wang,Y., Liu,J., Akatsu,C., Zhang,R., Zhang,H., Zhu,H., Liu,K.,
            Zhu,H.Y., Min,Q., Meng,X., Cui,C., Tang,Y., Yu,M., Li,Y., Feng,X.,
            Wei,H., Wen,Z., Ji,S., Weigert,M.G., Tsubata,T. and Wang,J.Y.
  TITLE     LAPTM5 mediates immature B cell apoptosis and B cell tolerance by
            regulating the WWP2-PTEN-AKT pathway
  JOURNAL   Proc Natl Acad Sci U S A 119 (36), e2205629119 (2022)
   PUBMED   36037365
  REMARK    GeneRIF: LAPTM5 mediates immature B cell apoptosis and B cell
            tolerance by regulating the WWP2-PTEN-AKT pathway.
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Somura,H., Iizuka,N., Tamesa,T., Sakamoto,K., Hamaguchi,T.,
            Tsunedomi,R., Yamada-Okabe,H., Sawamura,M., Eramoto,M.,
            Miyamoto,T., Hamamoto,Y. and Oka,M.
  TITLE     A three-gene predictor for early intrahepatic recurrence of
            hepatocellular carcinoma after curative hepatectomy
  JOURNAL   Oncol Rep 19 (2), 489-495 (2008)
   PUBMED   18202799
REFERENCE   7  (bases 1 to 2177)
  AUTHORS   Pak,Y., Glowacka,W.K., Bruce,M.C., Pham,N. and Rotin,D.
  TITLE     Transport of LAPTM5 to lysosomes requires association with the
            ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination
  JOURNAL   J Cell Biol 175 (4), 631-645 (2006)
   PUBMED   17116753
REFERENCE   8  (bases 1 to 2177)
  AUTHORS   Hayami,Y., Iida,S., Nakazawa,N., Hanamura,I., Kato,M., Komatsu,H.,
            Miura,I., Dave,B.J., Sanger,W.G., Lim,B., Taniwaki,M. and Ueda,R.
  TITLE     Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and
            DNA methylation in human multiple myeloma
  JOURNAL   Leukemia 17 (8), 1650-1657 (2003)
   PUBMED   12886255
  REMARK    GeneRIF: results suggest that loss of E3 gene expression might be a
            crucial event during the progression of human MM
REFERENCE   9  (bases 1 to 2177)
  AUTHORS   Seimiya,M., O-Wang,J., Bahar,R., Kawamura,K., Wang,Y., Saisho,H.
            and Tagawa,M.
  TITLE     Stage-specific expression of Clast6/E3/LAPTM5 during B cell
            differentiation: elevated expression in human B lymphomas
  JOURNAL   Int J Oncol 22 (2), 301-304 (2003)
   PUBMED   12527926
  REMARK    GeneRIF: LAPTM5 shows stage-specific expression during B cell
            differentiation. It may be involved in B cell malignancies.
REFERENCE   10 (bases 1 to 2177)
  AUTHORS   Adra,C.N., Zhu,S., Ko,J.L., Guillemot,J.C., Cuervo,A.M.,
            Kobayashi,H., Horiuchi,T., Lelias,J.M., Rowley,J.D. and Lim,B.
  TITLE     LAPTM5: a novel lysosomal-associated multispanning membrane protein
            preferentially expressed in hematopoietic cells
  JOURNAL   Genomics 35 (2), 328-337 (1996)
   PUBMED   8661146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC106897.1, D42042.1 and
            AL137857.29.
            
            On Nov 22, 2018 this sequence version replaced NM_006762.2.
            
            Summary: This gene encodes a transmembrane receptor that is
            associated with lysosomes. The encoded protein, also known as E3
            protein, may play a role in hematopoiesis. [provided by RefSeq, Feb
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51240.1, SRR1163658.68490.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294507.4/ ENSP00000294507.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-958               BC106897.1         22-979
            959-1696            D42042.1           951-1688
            1697-1697           AL137857.29        150504-150504       c
            1698-2177           D42042.1           1690-2169
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..2177
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /note="lysosomal protein transmembrane 5"
                     /db_xref="GeneID:7805"
                     /db_xref="HGNC:HGNC:29612"
                     /db_xref="MIM:601476"
     exon            1..116
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..818
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /note="lysosomal multispanning membrane protein 5;
                     lysosomal associated multispanning membrane protein 5;
                     human retinoic acid-inducible E3 protein;
                     CD40-ligand-activated specific transcripts;
                     lysosomal-associated multitransmembrane protein 5"
                     /codon_start=1
                     /product="lysosomal-associated transmembrane protein 5"
                     /protein_id="NP_006753.1"
                     /db_xref="CCDS:CCDS337.1"
                     /db_xref="GeneID:7805"
                     /db_xref="HGNC:HGNC:29612"
                     /db_xref="MIM:601476"
                     /translation="MDPRLSTVRQTCCCFNVRIATTALAIYHVIMSVLLFIEHSVEVA
                     HGKASCKLSQMGYLRIADLISSFLLITMLFIISLSLLIGVVKNREKYLLPFLSLQIMD
                     YLLCLLTLLGSYIELPAYLKLASRSRASSSKFPLMTLQLLDFCLSILTLCSSYMEVPT
                     YLNFKSMNHMNYLPSQEDMPHNQFIKMMIIFSIAFITVLIFKVYMFKCVWRCYRLIKC
                     MNSVEEKRNSKMLQKVVLPSYEEALSLPSKTPEGGPAPPPYSEV"
     exon            117..210
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     exon            211..287
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     exon            288..416
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     exon            417..539
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     exon            540..635
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     exon            636..728
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     exon            729..2177
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="LAPTM5"
                     /gene_synonym="CLAST6"
                     /note="major polyA site"
ORIGIN      
        1 agtgtctcag aggaggggac ggcagcacca tggacccccg cttgtccact gtccgccaga
       61 cctgctgctg cttcaatgtc cgcatcgcaa ccaccgccct ggccatctac catgtgatca
      121 tgagcgtctt gttgttcatc gagcactcag tagaggtggc ccatggcaag gcgtcctgca
      181 agctctccca gatgggctac ctcaggatcg ctgacctgat ctccagcttc ctgctcatca
      241 ccatgctctt catcatcagc ctgagcctac tgatcggcgt agtcaagaac cgggagaagt
      301 acctgctgcc cttcctgtcc ctgcaaatca tggactatct cctgtgcctg ctcaccctgc
      361 tgggctccta cattgagctg cccgcctacc tcaagttggc ctcccggagc cgtgctagct
      421 cctccaagtt ccccctgatg acgctgcagc tgctggactt ctgcctgagc atcctgaccc
      481 tctgcagctc ctacatggaa gtgcccacct atctcaactt caagtccatg aaccacatga
      541 attacctccc cagccaggag gatatgcctc ataaccagtt catcaagatg atgatcatct
      601 tttccatcgc cttcatcact gtccttatct tcaaggtcta catgttcaag tgcgtgtggc
      661 ggtgctacag attgatcaag tgcatgaact cggtggagga gaagagaaac tccaagatgc
      721 tccagaaggt ggtcctgccg tcctacgagg aagccctgtc tttgccatcg aagaccccag
      781 aggggggccc agcaccaccc ccatactcag aggtgtgacc ctcgccaggc cccagcccca
      841 gtgctgggag gggtggagct gcctcataat ctgctttttt gctttggtgg cccctgtggc
      901 ctgggtgggc cctcccgccc ctccctggca ggacaatctg cttgtgtctc cctcgctggc
      961 ctgctcctcc tgcagggcct gtgagctgct cacaactggg tcaacgcttt aggctgagtc
     1021 actcctcggg tctctccata attcagccca acaatgcttg gtttatttca atcagctctg
     1081 acacttgttt agacgattgg ccattctaaa gttggtgagt ttgtcaagca actatcgact
     1141 tgatcagttc agccaagcaa ctgacaaatc aaaaacccac ttgtcagttc agtaaaataa
     1201 tttggtcaaa caacagtcta ttgcattgat ttataaatag ttgtcagttc acatagcaat
     1261 ttaatcaagt aatcattaat tagttacccc ctatatataa atatatgtaa tcaatttctt
     1321 caaatagctt gcttacatga taatcaatta gccaaccatg agtcatttag aatagtgata
     1381 aatagaatac acagaatagt gatgaaattc aatttaaaaa atcacgttag cctccaaacc
     1441 atttaattca aatgaaccca tcaactggat gccaactctg gcgaatgtag gacctctgag
     1501 tggctgtata attgttaatt caaatgaaat tcatttaaac agttgacaaa ctgtcattca
     1561 acaattagct ccaggaaata acagttattt catcataaaa cagtcccttc aaacacacaa
     1621 ttgttctgct gaagagttgt catcaacaat ccaatgctca cctattcagt tgctctgtgg
     1681 tcagtgtggc tgcataacag tggattccat gaaaggagtc attttagtga tgagctgcca
     1741 gtccattccc aggccaggct gtcgctggcc atccattcag tcgattcagt cataggcgaa
     1801 tctgttctgc ccgaggcttg tggtcaagca aaaattcagc cctgaaatca ggcacatctg
     1861 ttcgttggac taaacccaca ggttagttca gtcaaagcag gcaaccccct tgtgggcact
     1921 gaccctgcca ctggggtcat ggcggttgtg gcagctgggg aggtttggcc ccaacagccc
     1981 tcctgtgcct gcttccctgt gtgtcggggt cctccaggga gctgacccag aggtggaggc
     2041 cacggaggca gggtctctgg ggactgtcgg ggggtacaga gggagaaggc tctgcaagag
     2101 ctccctggca ataccccctt gtgtaattgc tttgtgtgcg acagggagga agtttcaata
     2161 aagcagcaac aagcttc
//
