LOCUS       NM_018407               2442 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens lysosomal protein transmembrane 4 beta (LAPTM4B),
            mRNA.
ACCESSION   NM_018407
VERSION     NM_018407.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Wang,M., Liao,J., Wang,J., Xu,M., Cheng,Y., Wei,L. and Huang,A.
  TITLE     HDAC2 promotes autophagy-associated HCC malignant progression by
            transcriptionally activating LAPTM4B
  JOURNAL   Cell Death Dis 15 (8), 593 (2024)
   PUBMED   39147759
  REMARK    GeneRIF: HDAC2 promotes autophagy-associated HCC malignant
            progression by transcriptionally activating LAPTM4B.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Wang,H., Zhou,Q., Xie,D.F., Xu,Q., Yang,T. and Wang,W.
  TITLE     LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation
            and MDSC migration: implications for HCC progression and
            sensitivity to PD-L1 monoclonal antibody therapy
  JOURNAL   Cell Death Dis 15 (2), 165 (2024)
   PUBMED   38388484
  REMARK    GeneRIF: LAPTM4B-mediated hepatocellular carcinoma stem cell
            proliferation and MDSC migration: implications for HCC progression
            and sensitivity to PD-L1 monoclonal antibody therapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Huang,Y., Peng,M., Qin,H., Li,Y., Pei,L., Liu,X. and Zhao,X.
  TITLE     LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis
  JOURNAL   Cell Signal 106, 110623 (2023)
   PUBMED   36758682
  REMARK    GeneRIF: LAPTM4B promotes AML progression through regulating
            RPS9/STAT3 axis.
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Guo,K. and Li,K.
  TITLE     Screening of four key genes in esophageal carcinoma based on TCGA
            and GEO data and verification of anti-proliferative effect of
            LAPTM4B knockdown in esophageal carcinoma cells invitro
  JOURNAL   Arch Biochem Biophys 728, 109352 (2022)
   PUBMED   35863479
  REMARK    GeneRIF: Screening of four key genes in esophageal carcinoma based
            on TCGA and GEO data and verification of anti-proliferative effect
            of LAPTM4B knockdown in esophageal carcinoma cells invitro.
REFERENCE   5  (bases 1 to 2442)
  AUTHORS   Pang,Y., Zhang,S., Yang,H. and Zhou,R.L.
  TITLE     [Serum LAPTM4B-35 protein as a novel diagnostic marker for
            hepatocellular carcinoma]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 53 (4), 710-715 (2021)
   PUBMED   34393233
  REMARK    GeneRIF: [Serum LAPTM4B-35 protein as a novel diagnostic marker for
            hepatocellular carcinoma].
REFERENCE   6  (bases 1 to 2442)
  AUTHORS   Deng,L.J., Zhang,Q.Y., Liu,B. and Zhou,R.L.
  TITLE     [Relationship between LAPTM4B gene polymorphism and susceptibility
            of lung cancer]
  JOURNAL   Beijing Da Xue Xue Bao Yi Xue Ban 37 (3), 302-305 (2005)
   PUBMED   15968325
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2442)
  AUTHORS   Kasper,G., Vogel,A., Klaman,I., Grone,J., Petersen,I., Weber,B.,
            Castanos-Velez,E., Staub,E. and Mennerich,D.
  TITLE     The human LAPTM4b transcript is upregulated in various types of
            solid tumours and seems to play a dual functional role during
            tumour progression
  JOURNAL   Cancer Lett 224 (1), 93-103 (2005)
   PUBMED   15911104
  REMARK    GeneRIF: LAPTM4b has active role in disease progression of
            malignant cells and is involved in cell proliferation and multidrug
            resistance
REFERENCE   8  (bases 1 to 2442)
  AUTHORS   Liu,X.R., Zhou,R.L., Zhang,Q.Y., Zhang,Y., Jin,Y.Y., Lin,M.,
            Rui,J.A. and Ye,D.X.
  TITLE     Structure analysis and expressions of a novel tetratransmembrane
            protein, lysosoma-associated protein transmembrane 4 beta
            associated with hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 10 (11), 1555-1559 (2004)
   PUBMED   15162524
  REMARK    GeneRIF: LAPTM4B gene encoded two isoforms of tetratransmembrane
            proteins, LAPTM4B-35 and LAPTM4B-24 and expression of LAPTM4B-35
            protein is upregulated and associated with poor differentiation in
            human hepatocellular carcinoma tissues
REFERENCE   9  (bases 1 to 2442)
  AUTHORS   Shao,G.Z., Zhou,R.L., Zhang,Q.Y., Zhang,Y., Liu,J.J., Rui,J.A.,
            Wei,X. and Ye,D.X.
  TITLE     Molecular cloning and characterization of LAPTM4B, a novel gene
            upregulated in hepatocellular carcinoma
  JOURNAL   Oncogene 22 (32), 5060-5069 (2003)
   PUBMED   12902989
REFERENCE   10 (bases 1 to 2442)
  AUTHORS   With,S., Rice,T., Salinas,C. and Auld,V.
  TITLE     Fire exit is a potential four transmembrane protein expressed in
            developing Drosophila glia
  JOURNAL   Genesis 35 (3), 143-152 (2003)
   PUBMED   12640618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003357.2, AP002906.2, AY261384.1 and AI079853.1.
            
            On May 17, 2019 this sequence version replaced NM_018407.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.83949.1,
                                           SRR1803614.39238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521545.7/ ENSP00000428409.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AP003357.2         97682-98002
            322-433             AP003357.2         127247-127358
            434-507             AP003357.2         137222-137295
            508-630             AP003357.2         137952-138074
            631-729             AP003357.2         141034-141132
            730-825             AP003357.2         146952-147047
            826-1994            AP002906.2         24115-25283
            1995-2024           AY261384.1         2221-2250
            2025-2031           AI079853.1         5-11                c
            2032-2442           AP002906.2         25321-25731
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..2442
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /note="lysosomal protein transmembrane 4 beta"
                     /db_xref="GeneID:55353"
                     /db_xref="HGNC:HGNC:13646"
                     /db_xref="MIM:613296"
     exon            1..321
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..903
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /note="lysosomal associated protein transmembrane 4 beta;
                     lysosome-associated transmembrane protein 4-beta"
                     /codon_start=1
                     /product="lysosomal-associated transmembrane protein 4B"
                     /protein_id="NP_060877.4"
                     /db_xref="CCDS:CCDS6275.2"
                     /db_xref="GeneID:55353"
                     /db_xref="HGNC:HGNC:13646"
                     /db_xref="MIM:613296"
                     /translation="MKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILL
                     SALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWII
                     PFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILL
                     FISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKE
                     PPPPYVSA"
     exon            322..433
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /inference="alignment:Splign:2.1.0"
     exon            434..507
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /inference="alignment:Splign:2.1.0"
     exon            508..630
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /inference="alignment:Splign:2.1.0"
     exon            631..729
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /inference="alignment:Splign:2.1.0"
     exon            730..825
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /inference="alignment:Splign:2.1.0"
     exon            826..2442
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /note="hexamer: ATTAAA"
     regulatory      2008..2013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /note="hexamer: AACAAG"
     polyA_site      2024
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /note="major polyA site"
     polyA_site      2029
                     /gene="LAPTM4B"
                     /gene_synonym="LAPTM4beta; LC27"
                     /note="major polyA site"
ORIGIN      
        1 gtccccgccg ctgcagcggt cgccttcgga gcgaagggta ccgacccggc agaagctcgg
       61 agctctcggg gtatcgagga ggcaggcccg cgggcgcacg ggcgagcggg ccgggagccg
      121 gagcggcgga ggagccggca gcagcggcgc ggcgggctcc aggcgaggcg gtcgacgctc
      181 ctgaaaactt gcgcgcgcgc tcgcgccact gcgcccggag cgatgaagat ggtcgcgccc
      241 tggacgcggt tctactccaa cagctgctgc ttgtgctgcc atgtccgcac cggcaccatc
      301 ctgctcggcg tctggtatct gatcatcaat gctgtggtac tgttgatttt attgagtgcc
      361 ctggctgatc cggatcagta taacttttca agttctgaac tgggaggtga ctttgagttc
      421 atggatgatg ccaacatgtg cattgccatt gcgatttctc ttctcatgat cctgatatgt
      481 gctatggcta cttacggagc gtacaagcaa cgcgcagcct ggatcatccc attcttctgt
      541 taccagatct ttgactttgc cctgaacatg ttggttgcaa tcactgtgct tatttatcca
      601 aactccattc aggaatacat acggcaactg cctcctaatt ttccctacag agatgatgtc
      661 atgtcagtga atcctacctg tttggtcctt attattcttc tgtttattag cattatcttg
      721 acttttaagg gttacttgat tagctgtgtt tggaactgct accgatacat caatggtagg
      781 aactcctctg atgtcctggt ttatgttacc agcaatgaca ctacggtgct gctacccccg
      841 tatgatgatg ccactgtgaa tggtgctgcc aaggagccac cgccacctta cgtgtctgcc
      901 taagccttca agtgggcgga gctgagggca gcagcttgac tttgcagaca tctgagcaat
      961 agttctgtta tttcactttt gccatgagcc tctctgagct tgtttgttgc tgaaatgcta
     1021 ctttttaaaa tttagatgtt agattgaaaa ctgtagtttt caacatatgc tttgctggaa
     1081 cactgtgata gattaactgt agaattcttc ctgtacgatt ggggatataa tgggcttcac
     1141 taaccttccc taggcattga aacttccccc aaatctgatg gacctagaag tctgcttttg
     1201 tacctgctgg gccccaaagt tgggcatttt tctctctgtt ccctctcttt tgaaaatgta
     1261 aaataaaacc aaaaatagac aactttttct tcagccattc cagcatagag aacaaaacct
     1321 tatggaaaca ggaatgtcaa ttgtgtaatc attgttctaa ttaggtaaat agaagtcctt
     1381 atgtatgtgt tacaagaatt tcccccacaa catcctttat gactgaagtt caatgacagt
     1441 ttgtgtttgg tggtaaagga ttttctccat ggcctgaatt aagaccatta gaaagcacca
     1501 ggccgtggga gcagtgacca tctgctgact gttcttgtgg atcttgtgtc cagggacatg
     1561 gggtgacatg cctcgtatgt gttagagggt ggaatggatg tgtttggcgc tgcatgggat
     1621 ctggtgcccc tcttctcctg gattcacatc cccacccagg gcccgctttt actaagtgtt
     1681 ctgccctaga ttggttcaag gaggtcatcc aactgacttt atcaagtgga attgggatat
     1741 atttgatata cttctgccta acaacatgga aaagggtttt cttttccctg caagctacat
     1801 cctactgctt tgaacttcca agtatgtcta gtcacctttt aaaatgtaaa cattttcaga
     1861 aaaatgagga ttgccttcct tgtatgcgct ttttaccttg actacctgaa ttgcaaggga
     1921 tttttatata ttcatatgtt acaaagtcag caactctcct gttggttcat tattgaatgt
     1981 gctgtaaatt aagttgtttg caattaaaac aaggtttgcc cacatccaag atgaccttgt
     2041 gattttgtgc tgattgtgtc tgaggacctt tccctccaca tatggtctgg cagatgcacc
     2101 cagttcagcc taaggagtag gctttttttt ggggggggga ggtcgggtgg gggggatttt
     2161 taatctttta attttcaaga tggttaaaat attgaaatgt ttaagtggat aactatatta
     2221 ttcataaaat gactgagtga aaactaatac actatgagat gaaaagtact tgtcagggat
     2281 tttcaagctt ttgctcaagt aattactatg aaataacaat ttctagaaat gaagaacaat
     2341 ccgtggagaa taaattacca ttggtgtggg ggaaaaaagc caaacagaag tagaaaaagg
     2401 tgtagccggc atacaaatgt tatctacagt gtatttttag at
//
