LOCUS       NM_014713               1365 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens lysosomal protein transmembrane 4 alpha (LAPTM4A),
            mRNA.
ACCESSION   NM_014713
VERSION     NM_014713.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Ji,R., Yang,H., Chen,J., Zhao,A., Chen,X. and Niu,Y.
  TITLE     The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in
            gestational diabetes mellitus
  JOURNAL   APMIS 132 (6), 465-476 (2024)
   PUBMED   38588560
  REMARK    GeneRIF: The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in
            gestational diabetes mellitus.
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Fekete,J.T. and Gyorffy,B.
  TITLE     New Transcriptomic Biomarkers of 5-Fluorouracil Resistance
  JOURNAL   Int J Mol Sci 24 (2), 1508 (2023)
   PUBMED   36675023
  REMARK    GeneRIF: New Transcriptomic Biomarkers of 5-Fluorouracil
            Resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Hirota,Y., Hayashi,M., Miyauchi,Y., Ishii,Y., Tanaka,Y. and
            Fujimoto,K.
  TITLE     LAPTM4alpha is targeted from the Golgi to late endosomes/lysosomes
            in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT
            proteins
  JOURNAL   Biochem Biophys Res Commun 556, 9-15 (2021)
   PUBMED   33836347
  REMARK    GeneRIF: LAPTM4alpha is targeted from the Golgi to late
            endosomes/lysosomes in a manner dependent on the E3 ubiquitin
            ligase Nedd4-1 and ESCRT proteins.
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Vergarajauregui,S., Martina,J.A. and Puertollano,R.
  TITLE     LAPTMs regulate lysosomal function and interact with mucolipin 1:
            new clues for understanding mucolipidosis type IV
  JOURNAL   J Cell Sci 124 (Pt 3), 459-468 (2011)
   PUBMED   21224396
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1365)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   9  (bases 1 to 1365)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   10 (bases 1 to 1365)
  AUTHORS   Hogue,D.L., Ellison,M.J., Young,J.D. and Cass,C.E.
  TITLE     Identification of a novel membrane transporter associated with
            intracellular membranes by phenotypic complementation in the yeast
            Saccharomyces cerevisiae
  JOURNAL   J Biol Chem 271 (16), 9801-9808 (1996)
   PUBMED   8621662
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR156048.1, BC093075.1 and
            CD679337.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014713.4.
            
            Summary: This gene encodes a protein that has four predicted
            transmembrane domains. The function of this gene has not yet been
            determined; however, studies in the mouse homolog suggest a role in
            the transport of small molecules across endosomal and lysosomal
            membranes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279841.1653.1, BC003158.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000175091.5/ ENSP00000175091.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               DR156048.1         434-804
            372-1362            BC093075.1         372-1362
            1363-1365           CD679337.1         605-607
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..1365
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /note="lysosomal protein transmembrane 4 alpha"
                     /db_xref="GeneID:9741"
                     /db_xref="HGNC:HGNC:6924"
                     /db_xref="MIM:618837"
     exon            1..219
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..810
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /note="membrane nucleoside transporter;
                     lysosomal-associated protein transmembrane 4 alpha; golgi
                     4-transmembrane-spanning transporter MTP"
                     /codon_start=1
                     /product="lysosomal-associated transmembrane protein 4A"
                     /protein_id="NP_055528.1"
                     /db_xref="CCDS:CCDS1696.1"
                     /db_xref="GeneID:9741"
                     /db_xref="HGNC:HGNC:6924"
                     /db_xref="MIM:618837"
                     /translation="MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMA
                     ILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAI
                     SYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSC
                     LLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMA
                     VKMPEKEPPPPYLPA"
     exon            220..340
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            341..417
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            418..540
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            541..636
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            637..735
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1365
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /note="hexamer: AATAAA"
     polyA_site      1365
                     /gene="LAPTM4A"
                     /gene_synonym="HUMORF13; LAPTM4; MBNT; Mtrp"
                     /note="major polyA site"
ORIGIN      
        1 gaagacgcgt cgttgggttt tggaggccgt gaaacagccg tttgagtttg gctgcgggtg
       61 gagaacgttt gtcaggggcc cggccaagaa ggaggcccgc ctgttacgat ggtgtccatg
      121 agtttcaagc ggaaccgcag tgaccggttc tacagcaccc ggtgctgcgg ctgttgccat
      181 gtccgcaccg ggacgatcat cctggggacc tggtacatgg tagtaaacct attgatggca
      241 attttgctga ctgtggaagt gactcatcca aactccatgc cagctgtcaa cattcagtat
      301 gaagtcatcg gtaattacta ttcgtctgag agaatggctg ataatgcctg tgttcttttt
      361 gccgtctctg ttcttatgtt tataatcagt tcaatgctgg tttatggagc aatttcttat
      421 caagtgggtt ggctgattcc attcttctgt taccgacttt ttgacttcgt cctcagttgc
      481 ctggttgcta ttagttctct cacctatttg ccaagaatca aagaatatct ggatcaacta
      541 cctgattttc cctacaaaga tgacctcctg gccttggact ccagctgcct cctgttcatt
      601 gttcttgtgt tctttgcctt attcatcatt tttaaggctt atctaattaa ctgtgtttgg
      661 aactgctata aatacatcaa caaccgaaac gtgccggaga ttgctgtgta ccctgccttt
      721 gaagcacctc ctcagtacgt tttgccaacc tatgaaatgg ccgtgaaaat gcctgaaaaa
      781 gaaccaccac ctccttactt acctgcctga agaaattctg cctttgacaa taaatcctat
      841 accagctttt tgtttgttta tgttacagaa tgctgcaatt cagggctctt caaacttgtt
      901 tgatataaaa tatgttgtct tttgtttaag catttatttt caaacactaa ggagcttttt
      961 gacatctgtt aaacgtcttt ttgttttttt gttaagtctt ttacatttta atagtttttg
     1021 aagacaatct aggttaagca agagcaaagt gccattgttt gcctttaatt ggggggtggg
     1081 aagggaaaga gggtacttgc cacatagttt cctttttaac tgcactttct ttatataatc
     1141 gtttgcattt tgttacttgc taccctgagt actttcagga agactgactt aaatattcgg
     1201 ggtgagtaag tagttgggta taagatctga acttttcatc tgcagaggca agaaaaatat
     1261 ttgacattgt gacttgactg tggaagatga tggttgcatg tttctagttt gtatatgttt
     1321 ccatctttgt gataagatga tttaataaat ctctttaaat actta
//
