LOCUS       NM_001170331           10123 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens LanC like family member 3 (LANCL3), transcript variant
            2, mRNA.
ACCESSION   NM_001170331
VERSION     NM_001170331.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10123)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK124915.1, AI989993.1, BG944288.1 and AC233297.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001170331.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 3' coding
            region, which results in a frameshift compared to variant 1. The
            encoded isoform (2) is longer and has a distinct C-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.321248.1, BC143528.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378619.4/ ENSP00000367882.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1313              AK124915.1         93-1405
            1314-1692           AK124915.1         1489-1867
            1693-1693           AI989993.1         201-201             c
            1694-3156           AK124915.1         1869-3331
            3157-3157           BG944288.1         30-30               c
            3158-10123          AC233297.3         143838-150803
FEATURES             Location/Qualifiers
     source          1..10123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.1"
     gene            1..10123
                     /gene="LANCL3"
                     /note="LanC like family member 3"
                     /db_xref="GeneID:347404"
                     /db_xref="HGNC:HGNC:24767"
     exon            1..783
                     /gene="LANCL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1473
                     /gene="LANCL3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lanC-like protein 3; LanC like 3; LanC lantibiotic
                     synthetase component C-like 3"
                     /codon_start=1
                     /product="lanC-like protein 3 isoform 2"
                     /protein_id="NP_001163802.1"
                     /db_xref="CCDS:CCDS55398.1"
                     /db_xref="GeneID:347404"
                     /db_xref="HGNC:HGNC:24767"
                     /translation="MDTKRCFANRFDDYQGSLLAGQCEEAVAPLVTATIERILQELPP
                     LGGGAEARGATAGASACQGGLYGGVAGVAYMLYHVSQSPLFATARERYLRSAKRLIDA
                     CARAEEWGEPDADTRAAFLLGGAGVYAVATLVYHALGRSDYVQPLGKFRALCAVCAPV
                     SFLECGSDELFVGRAGYLCAALVLKQKLAQEVLTPAQIKSICQAILDSGKQYAIKKRK
                     PFPLMYSYYGTEYLGAAHGLSSILQMLLSYHEHLKPSDRELVWQSVDFLMEQEQNCNW
                     PPELGETIERENELVHWCHGAPGIAYLFAKAYLVSKKPQYLDTCIRCGELTWQKGLLK
                     KGPGICHGVAGSAYVFLLLYRLTGNSKYIYRAQRFAQFLFTEEFKAGSRVLESIYSLY
                     EGFSGTVCFLIDLLQPNQAEFPLFSVFV"
     exon            784..907
                     /gene="LANCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1105
                     /gene="LANCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1313
                     /gene="LANCL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..10123
                     /gene="LANCL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3126..3131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LANCL3"
                     /note="hexamer: AATAAA"
     polyA_site      3157
                     /gene="LANCL3"
     regulatory      10103..10108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LANCL3"
                     /note="hexamer: AATAAA"
     polyA_site      10123
                     /gene="LANCL3"
                     /note="major polyA site"
ORIGIN      
        1 actcgggagc ctcgcggcag cccggcgccc cacttggcca tccgctcctt gcccgcctcc
       61 tcttgtcacc tcccgtctca tccttctcgc tccttccccg ccgcatacac cggcatccga
      121 gtgcctcaga gagccggagg tggtgtgcgg ggctgcaggg cacgacttca agcggtcctc
      181 agctccgcac tagggggcac gggcaacagc atggacacca agcgctgctt cgccaatcgc
      241 ttcgatgact accagggcag cctgctggcg ggccagtgtg aggaggcggt ggcgcccttg
      301 gtcaccgcca ccatcgagcg catcctccag gagcttcccc cactcggggg cggcgcggag
      361 gcccgagggg cgacggcggg ggctagcgcc tgccaggggg ggctttatgg cggcgtggcc
      421 ggagtggcgt atatgctcta ccacgtctcg cagagcccgc ttttcgccac ggcccgggaa
      481 cgctacctgc gctcggctaa gcgcctcatc gacgcgtgcg cccgcgctga ggagtggggc
      541 gaaccggacg ccgacacccg cgccgccttc ctgctcgggg gcgcgggcgt gtacgccgtg
      601 gccacgctcg tataccacgc cctgggccgg tccgactacg tgcagccgct gggcaagttc
      661 cgggctctgt gtgccgtctg cgcgccggtc tccttcctgg agtgcggctc cgacgagctg
      721 ttcgtgggcc gcgcgggtta cctgtgtgcc gcgctggtgc tcaagcagaa actcgcccag
      781 gaggtgctga ctccagcaca gatcaagtca atttgtcagg caattctgga ctctgggaag
      841 cagtatgcca taaagaagag gaaaccattc cccctgatgt attcttacta tggaaccgaa
      901 tacttggggg cagctcacgg cttgtcgtct attcttcaga tgcttctttc ttaccatgag
      961 catctcaagc cctcagatcg ggaattggta tggcagagcg tggactttct catggaacag
     1021 gaacaaaact gcaactggcc acctgagctc ggcgagacca tcgagagaga gaatgagctg
     1081 gtgcactggt gccatggcgc tccaggaatt gcctatctgt ttgccaaagc ttatctggtt
     1141 tccaagaaac cgcagtacct ggacacatgt attcggtgtg gggaactcac atggcagaaa
     1201 ggcctgctaa agaaggggcc tgggatttgc catggagtag ccggcagtgc ctatgtcttc
     1261 ctgctgctgt accggctcac gggaaactct aaatacatct accgagctca aaggtttgct
     1321 caattcttat ttaccgagga attcaaggcc ggttctcggg tccttgaaag tatatacagc
     1381 ttgtatgaag gcttctctgg gacagtgtgc tttctgattg acctgctgca gcccaatcag
     1441 gctgaattcc cactcttcag cgtctttgtt tagaaggctc tatcttccac tgtggccctg
     1501 cagagatccc ctgagccaag ccgaggcagt ttccacataa gccacattca atggtatcgc
     1561 aaccatgagc cttaacattg ccatcagaag gaaggaatca ggcaggtgaa ggcaacatga
     1621 tgccagattt gagaaaggat ctgcaaaata aagataccac aattcatctt aaaactgcag
     1681 agatttaatg tgtcagggaa tagatgtgaa acaagggatc ataggaaaag gggaaagaga
     1741 aatgatctgt ttttcagtta tgacatagaa aaccaaactg caagtgtaga ctatgacaaa
     1801 aaatacacta atacctttgc aatctgaatg agaatttgac catttgtgtg tgccctctac
     1861 ccttaaattc agaaataaag acaataaaaa attaaaataa ttgcccagct gaaaactgct
     1921 atgaggaatg gattgtcagg ttgctgaagt ataaaaataa actcttggtt gtcctgtgct
     1981 tatacttatt gaaatttatg gtttttactg agcaaagata tttgcatatg aatctctatt
     2041 tttttcatta ccctgggcaa tttaaagaaa tcatatcata gcgtagttca gatactaaaa
     2101 tttgaagttt ccttaggccc tagaacatct cttttcctgg ttcctttttt ttcctcaaag
     2161 ctcaattaga atagcaaaat ttataagcta gtaaacttat actatagcaa gtgttgctgt
     2221 aaagtgtttt tctccatagg aagtgtgaac tgtgtattgt ctattgttag taattttaaa
     2281 aatgccttta tgtacataat cttgatggag ctattagctg aactataaaa tatgctcttg
     2341 gtaaatatca ctaatttcaa agatcagggg aaccactaca aagacgtgtc atttctgcct
     2401 ttgtttggga caggcagaca ggctgaggaa gtcaccagtg attgtggaaa taattttgct
     2461 ccattttata ctattaaatg aagagatgag tgaattctgt ggttggttac cttaccttcc
     2521 aagatacagg gtccactaga aattggctgt aatactcatt gagccaagtt gtcatatcaa
     2581 attcaaccct gctgtaaaca catagaagtt gtgaaactgc ttcaagtaaa tagtggtttg
     2641 cagaacactg taggagcatc tgtcacttca ttatgcagag cataagttga tccttttcct
     2701 agaattttgt cagtggcaat tgcatatatc agattgagta ggaaattgtg tactgtataa
     2761 gacttattta aatagtcatt aaatatttgg atatattatg tgtgtgtgtg tgtgtgtgtg
     2821 tgtgtgtatg gtgtgtattc catatctatt cccatgtaaa tccaaatact tattctttat
     2881 ttcagtaatt cttaacttga atcatagact ttggaacgag ttagggaatg ctctgttgcc
     2941 taaaaagcaa acctacaagt atgttggtgt gtgtatgtgt atggaccagt ttgtttgtgt
     3001 gtgtgtgtgc tcattttgag gggacaagga tctctagcat tcataacatt ctcaaagaat
     3061 ctgaccaaag aaaggtaaca actatctttg tgtattttat gactgtgtgt gtttgcactc
     3121 attgcaataa agtaggacaa aatgattttg aaatgcatac atcttttcag cttcctgttt
     3181 catttttaca tcctcagata caaccatatc aaattggcct cagttgttca tcagtgaaaa
     3241 tgctcagttt ggggtgatac cacataaata gcagctttca gatgactccc cacattgggt
     3301 ccagaagttc tttcatatag gctgaatata ataaccatcc tatatacaga gctttatgga
     3361 acacatgcag tttttatcgt ccaagaaccc ctcaagatgt gtttggtaaa tgctccaaag
     3421 tcttacagct agaaaaggac aaaaccagga ttcaaaccca gggtttcact ttctaagttt
     3481 atttattcag tattctagac tagaatctgg ggatacaata gtgaacaaaa taaactttcc
     3541 ctcaaagcta ccttctgttt ccatttgctg ttcctttcac aattcatcct tgagacctga
     3601 aacctaaagc actcagaact gatactctag ttcattatca tatcagttcc atttctagta
     3661 acttcagaaa aacaagacca ctttcaggcc tatctgccct tttaagttct gataggtctg
     3721 atgatgatgt gctaaccatt ttgatttgtg tgtcaaatct aagcaaagac catgtttgag
     3781 tattgtcttt atgaaatgac atttcggtaa attagaaaca acaataggct tgtttagccc
     3841 ttaaacatgt tgatgaaact tttcattttc ctgaaagaat tatagatttt ggaaggtcct
     3901 cttctatatt atttttccaa gaaggggaaa acgattctta cattttgctg taggaaagtg
     3961 tggcatgtta cttcttattt aattatccaa cttgcccccc ttctctgtgg tagcattttt
     4021 aatgtagtac ttaaggctgt tgtctcttaa aggctacagg ggcattttca ccaccactag
     4081 tataacttta atattattta ctatatacag catgagcaat tataaaccct gaaggtaata
     4141 gtggaaatgt ttgaggatac attgaaatag tctctcaata atggggagac tgcattatgc
     4201 tttgatagca agacattttg gaaaccatta caactctgtg tattttgttt cattaatgta
     4261 attacatacc atctcttcca cacacacccc agaatattat acatttttat tttgcccaag
     4321 cctgtttcag tcatcagttt gtagtctttt acttccactt gtaacttgat aactgagtag
     4381 aacaggggtt tgctagagta tatttccctg tgcttcttta ggtagttgac tatgctatta
     4441 agataacagt atttgcttac tgataacttg agaaacagtc attttcttgg tctgtgctaa
     4501 attgcatctc ttccagtggc agcttatttc tttaactttt ttgacatatt aagattttaa
     4561 tcatggtaat actgaaattg tttcaaattt gaaagagcga acctcagtaa cttcaatgaa
     4621 acaaatgggt ttgtgatttc tagccatgtt aaatgaacac acaattaaaa ggaaaaccat
     4681 tagtggtgca aagagccctg tgctggaaat ctcaaagtct tgctctgcca cttttagggg
     4741 ccactgtagt aataataata atcaccctgt ctacttcaca gggttgttat aaaagttgtc
     4801 aatgataaaa tggatataag tgagtttttt aatgtgcaga tcctttatat atttaaaagg
     4861 gatgttatat tttacccact atatacatag aaaaatcatg cccagttatg acttccaata
     4921 agaatttcaa ccaaatagaa tctctatatg tggatgtagt gcttgaggtc tgggtcacta
     4981 gatggataaa aaccaagtgt acattttttt atattctacc accagtcctg agcacagcac
     5041 tttgcctcag aaggttctga ttcaccaaga cttactacat gggaatagac tgatttagct
     5101 caggagctcc ttttaatgca aatatttatt ttgcttgctg agaacaaagg attacagtgc
     5161 caataactca agaaaaggag caggcaagcc aggtctgtag agagaaaatg aactggaaaa
     5221 taaagtaatt ctggggtgag tttgatctgc actttaattc aagtctcaga accacgtgac
     5281 atatagtgat caaaatatac tctcaattgc atattaggcc ttcctttggg gacctgggct
     5341 atttattcag cactgtccca aattaatagc taaatgactg agcctcaaat ttgccgagcc
     5401 cgtgtaatat tggtataaat ttggcaagga aagcaaatga gaaggcaggc aaaggggtgg
     5461 gtgaggggaa gcttgctgaa gctcagtatc tcaaagtgag ttgtggatgc gtgtttaaca
     5521 ctataaagaa ccagtccatt cttacccatg agttttattg ctttctggga cctctaaccc
     5581 aggaccaccc ctgattcacc aacttctcct tcttctcctc tttaaatatt atagttcatt
     5641 gtgatatgtt tttcctgtat ctgctctatc atgtgacctc ctttcgcctg ggagggcaga
     5701 ttttctcctt atctcttcca tccatgtctg ttcttagcta agagttccag cctcagtaca
     5761 gctggattac cctttggaca gaagggcaga caacctcaag gtcagcagca acagaagttg
     5821 ggcctagtag tcagatcaca agtgagtgtg gctattcatg agaatagggt ggtggtggca
     5881 tttatcctgc ttcccctcca taaataaacc tggtaatttt atttttaatg ttacaaaaaa
     5941 agttgatgct acattaaatg ttttaccctc atccattatc ataaatctca tactggaggt
     6001 gtgatctctc ttcttgtttc tttaattgaa agtaccaatg aatcgaggcc tggtggatga
     6061 tgcctttaga gttttttgtt ttgttttgtt tttgttttct tgaatcattg aaacttgtca
     6121 tttttatcta gactcttcca caaatggcaa agtcacttat ctgcagaatt cccagaatct
     6181 tcttttgcct ttgtgcacct gctaattacc ccctctgaac tgaatttgaa aaaattaatt
     6241 aaaataaccg aatcacccat gtttttgttc ttgcagggtt tggtgagtta tgtggattaa
     6301 aagaacagac tatcctctct ctttttttgt ctttcttctc cctgtccaat actgaggaag
     6361 aagagggaga agggggtaaa gatacataag gcttaactac ccagggttat gaaaacagtt
     6421 tgcaaagtct tcctgtttgc ttcccttttg gtttttctta gtccctgtag gaaaaagttt
     6481 acccctctgt gtgcgagtgt gtgtgtgtgt gtgtgtaagt agttgagtga aaaagaatga
     6541 gactgactta aggagagtca atatcgcata tgaatcaaaa gccaacattt agctattaga
     6601 tagatctcag tgaaaggata tgttcaagct aagttgatta agtttattaa acttatttat
     6661 taagcttgac taagcttatt aaaacttctg ctaggttgaa gccattagta accatctgta
     6721 gaagataaca gccatgagtt tcacaaatac agcagcagtg tctgctagaa ttgtgctgtg
     6781 agccacgaat gcaaaccaca tatgcaattt tcaaattttc tagtagctac caaaaaggta
     6841 aaagaaaaag atgaaattaa ttttaataat gtatttgact tagccttata tatccaaaat
     6901 gatagcattt caatatgcaa tcaatataaa aacatgaatg agctatttta catttttgta
     6961 ctgagtcttc aaactctagt gtgtatttta tacttactat acatctccag tctcgaagta
     7021 gccacatttc aagtgtataa gagctgcatg tgagttggct attgtattgg acagtcccat
     7081 tcctgtttcc tagtattgat aaagtcttcc taccttcctt cgttgttatg ggagaaaatg
     7141 taaacagaac ctgcctatta cacgagagct gcaatatttc cccaaatgca gcccagcagt
     7201 accatgagct gccctgtgga aaaatttaat ctgtgattaa ataagttagg aaagttttat
     7261 tattttaccc ccttttgaag attacatggt acattaacat attaaagatt gagtaaactc
     7321 tcctgggtaa aaaaacctgt ttgacgttgt ttagttgttg agttctgtgt ctataagaat
     7381 cctagaaatt gccacaagtg tctctccata agaaaaactt tgtgttttcc tctctttctc
     7441 cactcctttt ggggcccatt tctatttatc tttgtattca gaatcacccg agagccacaa
     7501 tatctctttt gttctagaac aaccacctcc taaattgaaa ccaacagatg gctttaaagt
     7561 cttgcacttg gacatagatc ttcagaaagt accaaaatat ataccttcct cttattcttt
     7621 cagaaacggt gaacactcta aaaagatgtg ggggtgtggt gggggatatg tgaatgtgta
     7681 tatgtgtaaa caccaaatac atacagtttc ttaagtagag taatgcaatt cttgctgatg
     7741 ttttattttt atttttattt ttttattttt tttttttttt gagacggagt ctcgctctgt
     7801 cgcccaggct ggagtgcagt ggcgggatct cggctcgctg caagctccgc ctcccgggtt
     7861 cacgccattc tcctgcctca gcctcccaag tagctgggac tacaggcgcc cgccactacg
     7921 cccggctaat tttttgtatt tttagtagag acggggtttc accgttttag ccgggatggt
     7981 ctcgatctcc tgacctcgtg atccgcccgc ctcggcctcc caatattttt atattttgtg
     8041 tgtggtgaca atgtacatgc tttaatgtgt actgttctag taatatgtat gaagtagctg
     8101 tgacatagca gtcagtttta aagatacaga ctataattga ctactgtcaa tctttaacaa
     8161 gtgatctttt tgcaacttgg ttttagtggg gtctctgacg ttgtccccac aagtttcatt
     8221 ttaaaatcta tgcttaagtg gcagttacca atataattaa ttctgctgct gaatttggtt
     8281 catattgaat gtggtaaccc ttatatgtgg atatattcaa acatgtggat tgatttagat
     8341 catccgtttt gtctttgttt tttaggactt tgctatttca atattaaaga tgtcttttga
     8401 atactgtagc agcagtagaa tccctatgtt cttgaaaatg caaaatgtaa catgagttgc
     8461 acatagactc tctagcagta gaaatggaat attctaagtg cagaagtttg gttttagaat
     8521 ctgttaagga aggacggccc aatctttgaa aaggtacagc tttctcaact ttgaacatct
     8581 gggggaactc ttcttggaag tctgaatttt aatatcttta atccaatggc tctaaattaa
     8641 caaacattaa aaaatggatt tcgtagaatc aaattattag ggggagcact ttgcaaagcc
     8701 atatactggt gaatatatac tgggtcaagc accacatgtt agttttggaa tgtgtatttc
     8761 ccagcgaata gaatttactg ctccaaaaag cttttttggc ataaatcaca atacttacag
     8821 aaatataatt gtatcattga aaaaaacaaa gctcaccttc ctaatgatac atttcacaaa
     8881 ctgcacatta gggcaatttc ttacttatga ggaggtacaa agaaatactc tgtcaatata
     8941 gtataactgc ttatttcaaa ttgtatctag gaatgaataa ctactattat ttaaagtact
     9001 actgaatttt gaggaactga tcaaagaatt agtattatta ataaaattgt actatttgca
     9061 atatatttgc cttggcacaa atgcagagtt aaaaacataa aattataaaa aaaaataata
     9121 gtgattggtt gttactactt taaaatccta ctaatttcca ttagcactaa atcaaacagc
     9181 acttatctgt tgtatacaag taaaattttg aaagactcgg acacaaaatg aaaggctttt
     9241 taaaaatgtc tttgccataa caggttatat gacctcttgc taattgttat atttccttag
     9301 gggcactttg aggctctttc aaagacatct gcagcaatta ggtctaaatt tagagtagaa
     9361 tattttgcca gatattttac tatatcacaa aatgtcatac tactgtattt tataataaaa
     9421 ccaaattctc aagtattctg gtatgttaca tattaatata ccaaaacatc actttctata
     9481 agtctattat tatgtacata atatttttaa aaataatggg tattttggtc ctagtgaaaa
     9541 agtataatgc aatacatgac attaatcttt agtcaaaacc cattgaggtg tctgacaggg
     9601 aaattagcaa tcataagcta taagatatat attattttca aggacaaaat ggcaaatgat
     9661 aatacagaaa gacgtgatca ctggagcaag ttagctggtg tgcagactaa gaaggatcaa
     9721 cttgcaaatg ctcatcagaa tttagctttt gttattggtt gttctgcagg ggatagtact
     9781 agtcagttga tattgcttcc ctttcatgtg ggagtttgct cacagcccac tgcatggtat
     9841 aatgaaatct ctataagcaa gatagagtca gaagcttaga gatgcacttt atggttttta
     9901 caactgctgt tacaatgttc taaacactgt gatctttcca aatgtgtttt ctgtattcgt
     9961 tttgtactgt agaaaataat tcgctataaa ctggacttta tagtgtttaa agcgatgtta
    10021 tttattggct tattgcccct ccttataata catttatgta cagtacactt aatgtaaaac
    10081 ctgtgataat cctttgcctt aaaataaaat ctaatgctaa ata
//
