LOCUS       NM_018697               4459 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens LanC like glutathione S-transferase 2 (LANCL2), mRNA.
ACCESSION   NM_018697
VERSION     NM_018697.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4459)
  AUTHORS   Parajuli,K.R., Jung,Y. and Taichman,R.S.
  TITLE     Abscisic acid signaling through LANCL2 and PPARgamma induces
            activation of p38MAPK resulting in dormancy of prostate cancer
            metastatic cells
  JOURNAL   Oncol Rep 51 (3) (2024)
   PUBMED   38624012
  REMARK    GeneRIF: Abscisic acid signaling through LANCL2 and PPARgamma
            induces activation of p38MAPK resulting in dormancy of prostate
            cancer metastatic cells.
REFERENCE   2  (bases 1 to 4459)
  AUTHORS   Zhao,H.F., Zhou,X.M., Wang,J., Chen,F.F., Wu,C.P., Diao,P.Y.,
            Cai,L.R., Chen,L., Xu,Y.W., Liu,J., Li,Z.Y., Liu,W.L., Chen,Z.P.,
            Huang,G.D. and Li,W.P.
  TITLE     Identification of prognostic values defined by copy number
            variation, mRNA and protein expression of LANCL2 and EGFR in
            glioblastoma patients
  JOURNAL   J Transl Med 19 (1), 372 (2021)
   PUBMED   34461927
  REMARK    GeneRIF: Identification of prognostic values defined by copy number
            variation, mRNA and protein expression of LANCL2 and EGFR in
            glioblastoma patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4459)
  AUTHORS   Lou,Y., Xu,J., Zhang,Y., Zhang,W., Zhang,X., Gu,P., Zhong,H.,
            Wang,H., Lu,J. and Han,B.
  TITLE     Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung
            adenocarcinoma tumorigenesis
  JOURNAL   Cell Death Dis 12 (2), 170 (2021)
   PUBMED   33568630
  REMARK    GeneRIF: Akt kinase LANCL2 functions as a key driver in EGFR-mutant
            lung adenocarcinoma tumorigenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4459)
  AUTHORS   Leber,A., Hontecillas,R., Tubau-Juni,N., Zoccoli-Rodriguez,V.,
            Goodpaster,B. and Bassaganya-Riera,J.
  TITLE     Abscisic acid enriched fig extract promotes insulin sensitivity by
            decreasing systemic inflammation and activating LANCL2 in skeletal
            muscle
  JOURNAL   Sci Rep 10 (1), 10463 (2020)
   PUBMED   32591558
  REMARK    GeneRIF: Abscisic acid enriched fig extract promotes insulin
            sensitivity by decreasing systemic inflammation and activating
            LANCL2 in skeletal muscle.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4459)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4459)
  AUTHORS   Sturla,L., Fresia,C., Guida,L., Bruzzone,S., Scarfi,S., Usai,C.,
            Fruscione,F., Magnone,M., Millo,E., Basile,G., Grozio,A.,
            Jacchetti,E., Allegretti,M., De Flora,A. and Zocchi,E.
  TITLE     LANCL2 is necessary for abscisic acid binding and signaling in
            human granulocytes and in rat insulinoma cells
  JOURNAL   J Biol Chem 284 (41), 28045-28057 (2009)
   PUBMED   19667068
  REMARK    GeneRIF: Data show that lanthionine synthetase C-like protein
            (LANCL2) is required for abscisic acid binding on human granulocyte
            membranes and that LANCL2 is necessary for transduction of the ABA
            signal into granulocytes and rat insulinoma cells.
REFERENCE   7  (bases 1 to 4459)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Maccarrone,G., Dias-Neto,E. and Turck,C.W.
  TITLE     Prefrontal cortex shotgun proteome analysis reveals altered calcium
            homeostasis and immune system imbalance in schizophrenia
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)
   PUBMED   19165527
  REMARK    GeneRIF: Using shotgun mass spectrometry, we found this protein
            differentially expressed in the dorsolateral prefrontal cortex from
            patients with schizophrenia.
REFERENCE   8  (bases 1 to 4459)
  AUTHORS   Landlinger,C., Salzer,U. and Prohaska,R.
  TITLE     Myristoylation of human LanC-like protein 2 (LANCL2) is essential
            for the interaction with the plasma membrane and the increase in
            cellular sensitivity to adriamycin
  JOURNAL   Biochim Biophys Acta 1758 (11), 1759-1767 (2006)
   PUBMED   16979580
REFERENCE   9  (bases 1 to 4459)
  AUTHORS   Park,S. and James,C.D.
  TITLE     Lanthionine synthetase components C-like 2 increases cellular
            sensitivity to adriamycin by decreasing the expression of
            P-glycoprotein through a transcription-mediated mechanism
  JOURNAL   Cancer Res 63 (3), 723-727 (2003)
   PUBMED   12566319
  REMARK    GeneRIF: Lanthionine synthetase components C-like 2 increases
            cellular sensitivity to adriamycin by decreasing the expression of
            P-glycoprotein through a transcription-mediated mechanism.
REFERENCE   10 (bases 1 to 4459)
  AUTHORS   Mayer,H., Pongratz,M. and Prohaska,R.
  TITLE     Molecular cloning, characterization, and tissue-specific expression
            of human LANCL2, a novel member of the LanC-like protein family
  JOURNAL   DNA Seq 12 (3), 161-166 (2001)
   PUBMED   11762191
  REMARK    GeneRIF: cDNA cloned and characterized.  May play a role as a
            component of a peptide-modifying complex
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073347.3.
            
            On Jul 15, 2020 this sequence version replaced NM_018697.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278245.1, BC070049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254770.3/ ENSP00000254770.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-893               AC073347.3         52593-53485
            894-1011            AC073347.3         79049-79166
            1012-1219           AC073347.3         85679-85886
            1220-1367           AC073347.3         87213-87360
            1368-1514           AC073347.3         88430-88576
            1515-1697           AC073347.3         99163-99345
            1698-1874           AC073347.3         112510-112686
            1875-1947           AC073347.3         115631-115703
            1948-4459           AC073347.3         118482-120993
FEATURES             Location/Qualifiers
     source          1..4459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..4459
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /note="LanC like glutathione S-transferase 2"
                     /db_xref="GeneID:55915"
                     /db_xref="HGNC:HGNC:6509"
                     /db_xref="MIM:612919"
     exon            1..893
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     CDS             690..2042
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /note="G protein-coupled receptor 69B; LanC lantibiotic
                     synthetase component C-like 2; LanC like 2; LanC
                     (bacterial lantibiotic synthetase component C)-like 2;
                     testis-specific adriamycin sensitivity protein"
                     /codon_start=1
                     /product="lanC-like protein 2"
                     /protein_id="NP_061167.1"
                     /db_xref="CCDS:CCDS5517.1"
                     /db_xref="GeneID:55915"
                     /db_xref="HGNC:HGNC:6509"
                     /db_xref="MIM:612919"
                     /translation="MGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAA
                     EETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQTKIKDLLQQMEEGLKTADPHDCSA
                     YTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAV
                     IYHKLRSDCESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGT
                     VCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQYVGAAHGMAGIYYMLMQP
                     AAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLMQA
                     YKVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYRLTQDKKYLYR
                     ACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAIHFLSDVLGPETSRFPAFELDSSKRD
                     "
     exon            894..1011
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1219
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1367
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1514
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1697
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1874
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1947
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..4459
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2225..2230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /note="hexamer: TATAAA"
     polyA_site      2250
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
     regulatory      4430..4435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /note="hexamer: AGTAAA"
     polyA_site      4459
                     /gene="LANCL2"
                     /gene_synonym="GPR69B; TASP"
                     /note="major polyA site"
ORIGIN      
        1 atccctcgga gactagcctt gcagtgtttt agactgtttt gaaattctgt tctttagaag
       61 agattttttt tttcttctta atatcaaaca aagaactgct gctattcctt tgggctggcg
      121 cagcaggggc cggtgaaatg caggctgacg acggcgcgcc aggggctgag ctcgccccgg
      181 tcggcgacgc gcacacacct tgagtgacag cgacctcttc tctacaggtt ttccccgcgg
      241 gagcgtggcc ctagcgggcg ttcggttttc tttggaaatc gcggaggggg ctggccgggc
      301 gcagcgatcc ccaccccggg actccagccc cggccgtgcg cgtcgccgcg gacgggctct
      361 gcgggccacg gggaaggtgc gaggaggcgc gagcaggctg tgagccgctg ggcgctcccg
      421 cgagcccgct cctctccgtc gggagcaggg caaaggcgcc aggaacaggg cagaggcaca
      481 gcgcccaccg cctctgcggc cgcctgatgt gcgagcagcc cgcgacgagg cagtgcacgc
      541 tcagacgccc cgctcctccc gccagcgcgc ggcctcgctc ctcctagagg acgctctctg
      601 cgcgggccct cggaggaggc ggcggcgggg cgagctgcag cgccgggaca ggaggtttgt
      661 ccccgcccgc gcgccgtacc gcggcggaga tgggcgagac catgtcaaag aggctgaagc
      721 tccacctggg aggggaggca gaaatggagg aacgggcgtt cgtcaacccc ttcccggact
      781 acgaggccgc cgccggggcg ctgctcgcct ccggagcggc cgaagagaca ggctgtgttc
      841 gtcccccggc gaccacggat gagcccggcc tcccttttca tcaggacggg aagatcattc
      901 ataatttcat aagacggatc cagaccaaaa ttaaagatct tctgcagcaa atggaagaag
      961 ggctgaagac agctgatccc catgactgct ctgcttatac tggctggaca ggcatagccc
     1021 ttttgtacct gcagttgtac cgggtcacat gtgaccaaac ctacctgctc cgatccctgg
     1081 attacgtaaa aagaacactt cggaatctga atggccgcag ggtcaccttc ctctgtgggg
     1141 atgctggccc cctggctgtt ggagctgtga tttatcacaa actcagaagt gactgtgagt
     1201 cccaggaatg tgtcacaaaa cttttgcagc tccagagatc ggttgtctgc caagaatcag
     1261 accttcctga tgagctgctt tatggacggg caggttatct gtatgcctta ctgtacctga
     1321 acacagagat aggtccaggc accgtgtgtg agtcagctat taaagaggta gtcaatgcta
     1381 ttattgaatc gggtaagact ttgtcaaggg aagaaagaaa aacggagcgc tgcccgctgt
     1441 tgtaccagtg gcaccggaag cagtacgttg gagcagccca tggcatggct ggaatttact
     1501 atatgttaat gcagccggca gcaaaagtgg accaagaaac cttgacagaa atggtgaaac
     1561 ccagtattga ttatgtgcgc cacaaaaaat tccgatctgg gaattaccca tcatcattaa
     1621 gcaatgaaac agaccggctg gtgcactggt gccacggcgc cccgggggtc atccacatgc
     1681 tcatgcaggc gtacaaggtc tttaaggagg agaagtactt gaaagaggcc atggagtgta
     1741 gcgatgtgat ttggcagcga ggtttgctgc ggaagggcta cgggatatgc catgggactg
     1801 ctggcaacgg ctattccttc ctgtcccttt accgtctcac gcaggataag aagtacctct
     1861 accgagcttg caagtttgca gagtggtgtc tagattacgg agcacacggg tgccgcattc
     1921 ctgacagacc ctattcgctc tttgaaggca tggctggcgc tattcacttt ctctctgatg
     1981 tcctgggacc agagacatca cggtttccag catttgaact tgactcttcg aagagggatt
     2041 aaaaggtgca aaaagacaac taaaataccc atttggacca aaagccacca gattgcttag
     2101 tgcctgacac agaaacaact gggaatcctg aaagagaagc agacaccgtc acaggcccct
     2161 ctggttagac tagcatgagt gaccgaagcc atccatcaac attttctaac agcaccctca
     2221 tcaatataaa atatgacttc ttcacataca gattctctgt agtgtttgca tgtttcttgg
     2281 tgtttgttgt ctccaggtgt aagctgtttt aaatggaagg cccttctatt cctgagggct
     2341 cagagctgac catgcatgaa tgtatggcag tgtccacttt tctgtataaa atgtataaag
     2401 tggggtttct tccatattga caaatgaggg aacaggtggt gtctatcttg tatatcagaa
     2461 agattatcta gggtctatcc tagtgataat acattgtcag ccttttctgt ggcaccttcc
     2521 agatgagaat gagggagcga ccactccaag gacggacagg accagcagtt ctgcaggggc
     2581 gtgctggggt ggtttgggag tgcacagctg aacgcttccc gtttggattt tacactcacc
     2641 ttcgtgtttt aaagaagcct cagagtgcat tgcagctctg tcagggcccc attcccagca
     2701 gaggcttcag gtgctttgtg tagagtccag ggcagctgga gctttgttgg ggagacttct
     2761 ggacccaaag ggagctttcc caagaagcct ttgatggcca cactgtaggc agcagtgact
     2821 aagcactggc agttccagaa catttaccca ggtatatgtt actaaaacag gctccacctc
     2881 agtttatcaa cattataagt tactgttcta agaaaagtaa atacagttcc agatgggtta
     2941 ttgcagatta acagaaagac actcaactgg actcatgtcc ctgcaattaa acttacttca
     3001 accttttgga aagttatcaa aatctaaatt tggaatgaat gcatttccta ttttttgtct
     3061 acttttgggt gataaaaagt actagccctt atttatagat atgagaaaca taatgttcta
     3121 accaacaaca ttatggtatt tgtgtgactt ttatttgaaa aaatgtgagc agtaatttgg
     3181 gttagcctac cttcattaat tctatcacat agatttcagt ttttagaagg gtttctgtca
     3241 tcatggaaga ggtggtctgg gactaggtac ttctcgtctt gtgagctaag gcttgtgtca
     3301 tgaaagacaa gaggcctctc ttaacagccc agtccttgtc tgcaggggga ggcctgagca
     3361 tttcccagcc ccagtgtcca cacctctcag aaaagagaaa aaagaatgtc agtttaggag
     3421 aaaagcttcc tttttacttg tgtggttatg tgtggggctg gcacccgaaa tgtgtgacat
     3481 tcagcttcta aacgatgcct ggagagtctg tttgctgcag acacccttgc tcctgagtca
     3541 ttattttctt tcatgttaga ttgatgactt ctgtgaatag aaatcatcct gatcctattt
     3601 tacctggcct ccagggcctg ttgatgggct ttgcaggcag tccagcagcc cacacctgca
     3661 ggcaggatgc tgtcgtcaat gagctgaggg tagctgcttt gctgaagacc tcacacgatg
     3721 tccaatctca tccaaataac attgttccca tcctccccac ccaccacatc aaaacataac
     3781 acatcacagc actcagtaga ggtcctgcct ccccatttct caagggaagc cagtaggcaa
     3841 cacagccagc acggtgctct ccagggcagc ccctctcaga cgaggaggca gcgggtgcag
     3901 ccaggtgtct gcagagcagc cacaaaggtg gcctaggatg cgggtgtctc cccaggtgag
     3961 tccatccaca cacgtttgaa aaacactatt agtctttcta acacactgag ggaaagatta
     4021 aaatctgtgg aataaaggag gagattttat ttacagattt ttttaaaagc cacctgggtt
     4081 gacaccttcc tacttatcca ctagatgtca tcagaggtgc tgttccgtgg ttctgcatta
     4141 acccctgcct catgtctgta acatgtgaca gtaattccag ctcggtccct ccaggcaaag
     4201 gagaaacggg acttacttca caggacagag gattgacaga agtcagttta agataagtgt
     4261 ttgaatcaga tttcagtaca tctcattcat ttcttagatt tgtattcaca attgtgttct
     4321 ctaaaatgtg tctaaatttt aaaaatatgt acatgcataa tgtcatttta aaatctgaag
     4381 gaaagaattt gaagtccaca aaaagtgttt gaggttcttt ggttttgtta gtaaaagcca
     4441 gttctgtggt gatgaccta
//
