LOCUS       NM_006055               4592 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LanC like glutathione S-transferase 1 (LANCL1),
            transcript variant 1, mRNA.
ACCESSION   NM_006055
VERSION     NM_006055.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4592)
  AUTHORS   Huang,H., Tsui,Y.M., Ho,D.W., Chung,C.Y., Sze,K.M., Lee,E.,
            Cheung,G.C., Zhang,V.X., Wang,X., Lyu,X. and Ng,I.O.
  TITLE     LANCL1, a cell surface protein, promotes liver tumor initiation
            through FAM49B-Rac1 axis to suppress oxidative stress
  JOURNAL   Hepatology 79 (2), 323-340 (2024)
   PUBMED   37540188
  REMARK    GeneRIF: LANCL1, a cell surface protein, promotes liver tumor
            initiation through FAM49B-Rac1 axis to suppress oxidative stress.
REFERENCE   2  (bases 1 to 4592)
  AUTHORS   Spinelli,S., Cossu,V., Passalacqua,M., Hansen,J.B., Guida,L.,
            Magnone,M., Sambuceti,G., Marini,C., Sturla,L. and Zocchi,E.
  TITLE     The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte
            Browning and Energy Expenditure
  JOURNAL   Int J Mol Sci 24 (4), 3489 (2023)
   PUBMED   36834900
  REMARK    GeneRIF: The ABA/LANCL1/2 Hormone/Receptor System Controls
            Adipocyte Browning and Energy Expenditure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4592)
  AUTHORS   Spinelli,S., Begani,G., Guida,L., Magnone,M., Galante,D.,
            D'Arrigo,C., Scotti,C., Iamele,L., De Jonge,H., Zocchi,E. and
            Sturla,L.
  TITLE     LANCL1 binds abscisic acid and stimulates glucose transport and
            mitochondrial respiration in muscle cells via the
            AMPK/PGC-1alpha/Sirt1 pathway
  JOURNAL   Mol Metab 53, 101263 (2021)
   PUBMED   34098144
  REMARK    GeneRIF: LANCL1 binds abscisic acid and stimulates glucose
            transport and mitochondrial respiration in muscle cells via the
            AMPK/PGC-1alpha/Sirt1 pathway.
REFERENCE   4  (bases 1 to 4592)
  AUTHORS   Downey,A., Olcott,M., Spector,D., Bird,K., Ter Doest,A., Pierce,Z.,
            Quach,E., Sparks,S., Super,C., Naifeh,J., Powers,A., White,M. and
            Hensley,K.
  TITLE     Stable knockout of lanthionine synthase C-like protein-1 (LanCL1)
            from HeLa cells indicates a role for LanCL1 in redox regulation of
            deubiquitinating enzymes
  JOURNAL   Free Radic Biol Med 161, 115-124 (2020)
   PUBMED   33049334
  REMARK    GeneRIF: Stable knockout of lanthionine synthase C-like protein-1
            (LanCL1) from HeLa cells indicates a role for LanCL1 in redox
            regulation of deubiquitinating enzymes.
REFERENCE   5  (bases 1 to 4592)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 4592)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   7  (bases 1 to 4592)
  AUTHORS   Marschang,P., Brich,J., Weeber,E.J., Sweatt,J.D., Shelton,J.M.,
            Richardson,J.A., Hammer,R.E. and Herz,J.
  TITLE     Normal development and fertility of knockout mice lacking the tumor
            suppressor gene LRP1b suggest functional compensation by LRP1
  JOURNAL   Mol Cell Biol 24 (9), 3782-3793 (2004)
   PUBMED   15082773
REFERENCE   8  (bases 1 to 4592)
  AUTHORS   Mayer,H., Bauer,H. and Prohaska,R.
  TITLE     Organization and chromosomal localization of the human and mouse
            genes coding for LanC-like protein 1 (LANCL1)
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 100-104 (2001)
   PUBMED   11474189
REFERENCE   9  (bases 1 to 4592)
  AUTHORS   Bauer,H., Mayer,H., Marchler-Bauer,A., Salzer,U. and Prohaska,R.
  TITLE     Characterization of p40/GPR69A as a peripheral membrane protein
            related to the lantibiotic synthetase component C
  JOURNAL   Biochem Biophys Res Commun 275 (1), 69-74 (2000)
   PUBMED   10944443
REFERENCE   10 (bases 1 to 4592)
  AUTHORS   Mayer,H., Salzer,U., Breuss,J., Ziegler,S., Marchler-Bauer,A. and
            Prohaska,R.
  TITLE     Isolation, molecular characterization, and tissue-specific
            expression of a novel putative G protein-coupled receptor
  JOURNAL   Biochim Biophys Acta 1395 (3), 301-308 (1998)
   PUBMED   9512664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC324843.1, AC007970.3,
            Y11395.1 and BX473106.1.
            
            On May 17, 2019 this sequence version replaced NM_006055.2.
            
            Summary: This gene encodes a loosely associated peripheral membrane
            protein related to the LanC family of bacterial membrane-associated
            proteins involved in the biosynthesis of antimicrobial peptides.
            This protein may play a role as a peptide-modifying enzyme
            component in eukaryotic cells. Previously considered a member of
            the G-protein-coupled receptor superfamily, this protein is now in
            the LanC family. Multiple alternatively spliced variants, encoding
            the same protein, have been identified. [provided by RefSeq, Nov
            2008].
            
            Transcript Variant: Transcript Variant: This variant (1) represents
            the longest transcript. Variants 1, 2 and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11395.1, SRR11853565.17494.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450366.7/ ENSP00000393597.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               DC324843.1         9-110
            103-135             AC007970.3         46340-46372
            136-3647            Y11395.1           84-3595
            3648-3648           AC007970.3         90802-90802
            3649-4373           Y11395.1           3596-4320
            4374-4546           AC007970.3         91528-91700
            4547-4592           BX473106.1         21-66               c
FEATURES             Location/Qualifiers
     source          1..4592
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4592
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /note="LanC like glutathione S-transferase 1"
                     /db_xref="GeneID:10314"
                     /db_xref="HGNC:HGNC:6508"
                     /db_xref="MIM:604155"
     exon            1..140
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            141..237
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1356
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /EC_number="2.5.1.18"
                     /note="G protein-coupled receptor 69A; LanC (bacterial
                     lantibiotic synthetase component); LanC like 1; LanC
                     (bacterial lantibiotic synthetase component C)-like 1;
                     lanC-like protein 1; 40 kDa erythrocyte membrane protein;
                     LanC lantibiotic synthetase component C-like 1"
                     /codon_start=1
                     /product="glutathione S-transferase LANCL1"
                     /protein_id="NP_006046.1"
                     /db_xref="CCDS:CCDS2392.1"
                     /db_xref="GeneID:10314"
                     /db_xref="HGNC:HGNC:6508"
                     /db_xref="MIM:604155"
                     /translation="MAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELL
                     QQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKR
                     SITFLCGDAGPLAVAAVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIY
                     ALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMYEWYQEYYVGAA
                     HGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWC
                     HGAPGVIYMLIQAYKVFREEKYLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLT
                     LYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKA
                     RFPAFEL"
     exon            238..355
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            356..563
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            564..699
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            700..846
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1029
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1206
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1279
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..4592
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4570..4575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /note="hexamer: AATAAA"
     polyA_site      4592
                     /gene="LANCL1"
                     /gene_synonym="GPR69A; p40"
                     /note="major polyA site"
ORIGIN      
        1 ggtaaaatag cccttctgtt actgtccggg gctgcggggt gagaggccag ggccgagaag
       61 ggcttcagga cgcgggaggc gcacttgctt caagtcgcgg gcgtgggaac ggggttgcaa
      121 aacggggcct ctttgtccgg gcttgcttcc ggcgtcatgg ctcaaagggc cttcccgaat
      181 ccttatgctg attataacaa atccctggcc gaaggctact ttgatgctgc cgggaggctg
      241 actcctgagt tctcacaacg cttgaccaat aagattcggg agcttcttca gcaaatggag
      301 agaggcctga aatcagcaga ccctcgggat ggcaccggtt acactggctg ggcaggtatt
      361 gctgtgcttt acttacatct ttatgatgta tttggggacc ctgcctacct acagttagca
      421 catggctatg taaagcaaag tctgaactgc ttaaccaagc gctccatcac cttcctttgt
      481 ggggatgcag gccccctggc agtggccgct gtgctatatc acaagatgaa caatgagaag
      541 caggcagaag attgcatcac acggctaatt cacctaaata agattgatcc tcatgctcca
      601 aatgaaatgc tctatgggcg aataggctac atctatgctc ttctttttgt caataagaac
      661 tttggagtgg aaaagattcc tcaaagccat attcagcaga tttgtgaaac aattttaacc
      721 tctggagaaa acctagctag gaagagaaac ttcacggcaa agtctccact gatgtatgaa
      781 tggtaccagg aatattatgt aggggctgct catggcctgg ctggaattta ttactacctg
      841 atgcagccca gccttcaagt gagccaaggg aagttacata gtttggtcaa gcccagtgta
      901 gactacgtct gccagctgaa attcccttct ggcaattacc ctccatgtat aggtgataat
      961 cgagatctgc ttgtccattg gtgccatggc gcccctgggg taatctacat gctcatccag
     1021 gcctataagg tattcagaga ggaaaagtat ctctgtgatg cctatcagtg tgctgatgtg
     1081 atctggcaat atgggttgct gaagaaggga tatgggctgt gccacggttc tgcagggaat
     1141 gcctatgcct tcctgacact ctacaacctc acacaggaca tgaagtacct gtatagggcc
     1201 tgtaagtttg ctgaatggtg cttagagtat ggagaacatg gatgcagaac accagacacc
     1261 cctttctctc tctttgaagg aatggctgga acaatatatt tcctggctga cctgctagtc
     1321 cccacaaaag ccaggttccc tgcatttgaa ctctgaaagg atagcatgcc acctgcaact
     1381 cactgcatga ccctttctgt atattcaaac ccaagctaag tgcttccgtt gctttccaag
     1441 gaaacaaaga gtcaaactgt ggacttgatt ttgttagctt ttttcagaat ttatctttca
     1501 ttcagttccc ttccattatc atttactttt acttagaagt atccaaggaa gtcttttaac
     1561 tttaatttcc atttcttcct aaagggagag tgagtgatat gtacagtgtt ttgagattgt
     1621 atacatatat tccagaactt ggaggaaatc ttatttaagt ttatgaatat aaccatctgt
     1681 tactgttcta aaaatgttta aaagaaactc aatacagata aagataaata tgtgactatt
     1741 attgggtatt acacttcact tctctttaat atttttcctc caactggagg gcagacaatt
     1801 ttctgacttg cttttctcta ggtggttcat tttgaaaggg gacagaaata taactaaatg
     1861 cttccaggag aaaaattcca agagttacaa tctggacttg gtacctaaat atcatttttt
     1921 aaattcttga tgcctatttg gactagaggt aaacatactt tcagattggc ctgtttttgt
     1981 cggtaaggca tacagccttc agaagccaac atttttaatc aaaaacttat aaaacatgat
     2041 gatcattgtg aaaattctga gttgaaggtt agtttaagat aagctaacaa taacagtctg
     2101 tgttttctct aaaataatct gagttttttg gaactcttta tttaaatatg tgtgtttttc
     2161 agtattcaaa taagatcagg aagccaattt tctatgtatg aatatgcttt aacctaggat
     2221 ttcagtccac tctgactgac tttctaaact ttaacttggg tttttacagt gactatgcat
     2281 tagtgctgac tctttggtat aagccataaa atattttcct tcctatcaat ttatctgaac
     2341 tttggtcttt tcactaaatt gtacagtatt ctacttctgt ttaaaaaggg gagatgagaa
     2401 agggaatact atctaaccaa taacttgaac aaaaacacta aactaagcat ttaatagaaa
     2461 tgctttttat tgaggaggta ttatccagag ttcatgctta gaacaaatgc atctttgcgt
     2521 atcctagact taacaattca tcagtttctg agaccacaga atcaggtttt ccgtagtaga
     2581 taaagactct ctggtgcttc aaattctgtt caagtgtttt gactcatcag cttctactct
     2641 ttctattact gcctttgcct ggcttgtttt gtctctttgc aactgatttt gcaaaaaaaa
     2701 attgtagctt taaaataaca gggtctaagt attttaaatg tgcctatttc acagctctct
     2761 tggtcacaaa aacatgctat ttttattgga acttcaaacc aaatccccac tgagtgtgta
     2821 ctggttcctg caggtagcag tctcctatta tctcctgttt agcaccaaaa gagctaatat
     2881 tattggaaac tgacctttta aaggccactg gcagtaggat ttaaaaagca gcccactgct
     2941 cagtttccag gatcagcttc ctccttctgt cacttgtgta agttggcact accttgtgcc
     3001 tctcagattg ctgaagtgct gctggtaagc atgtgcatgc tctgcctttc ttgtgaaagt
     3061 tttcaatcag cgatatcagc acttacagta agaagtaaaa gtagtgcaca gcaaagctaa
     3121 tttgcctttg cctggggtgt tcagcttgaa agaataaagc tcatttggtt tagttaaatg
     3181 tcttactcta ctgtgcctat gcttttagct gcgttactaa gcaagggaaa aataacagtt
     3241 tctctgagcc agagaagact tgatcacagt tctccaagca tcgtgatagc aatgcttaac
     3301 cccaggaaga tttcaaggca gggagaagaa catttcaaat aagattcttg ttaacccatt
     3361 tatgcctagt gttccattat tggaatgcta agcttgtggg agtcatttac atcctactgc
     3421 tcaaagtcat tgccaaggtc tgatttttca cacaaaaaat tgcaaccccc agcataaatg
     3481 ggttagctac tgtcatcagt tagcaaattc atccacacaa acacaattag agtttggttt
     3541 ttttttaagc ttttcaaaac ttactaaact ggcacaattt tatatgtatg ctatttgttg
     3601 tatttatgct taagagcaaa aaagttttga tgggatttta aattcaggca aagcctacaa
     3661 cgctgagaca atcccctaac aacatggtag taactaaaga aacttttata ctaggcttct
     3721 tagttttaaa aggaagtggc atcattgttt cagttctagt ttgtattttt ctctcagata
     3781 tttttcttct ttaaaaatct ttcccagaag ttggttccta gaaaactcaa taccatcatc
     3841 tcttatctct atacagggac taggtaataa aaccttcaaa ggttgtcaaa ggtcatcaag
     3901 cagtgttcat ttatcctgtc acatgtttct gtttctatag taatttagaa attgcaaata
     3961 gttaactttt catcatgtaa aaagttaaca ttatcctatt tccatagata ccatggacgg
     4021 cggtgtggcc tgagttgtca gtctttaatc ctgagtcatg tggctctctt ttcatctttg
     4081 atgtcagttc caattatttg gcatcaaaaa ccttcatggt aggtagagtt ttaggtaaaa
     4141 gtggatctag ggttactttc tttattaaca tttcctaaat aactgaattg agagacatac
     4201 tctgctacta tgtcctcagg ttaatttttg tctgatctta cgatgccctg ccttttacta
     4261 gctactttag aaatagaaaa tgtgaagagt gactatttac atgtatactc ctttggctgc
     4321 tagaactcat ctgtagtcct ttattattta cactgaattc caatttcatt tctgcttccg
     4381 ctaagtaaga gcacctcatt cctgtgtttt ctctactatt gagctgtaga cgaactgttt
     4441 ctctaattat aaagcaaact gtttgggata ttcagggaaa ctaccccaat gttatgttgt
     4501 catttaatgg gaaaggctgg gatcatatgt atttctatgt tctgtaaagt atttgactta
     4561 ctagttctca ataaaatttt attaggacta ta
//
