LOCUS       NM_001382293             620 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 5 (LAMTOR5), transcript variant 2, mRNA.
ACCESSION   NM_001382293
VERSION     NM_001382293.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Zhang,W., Sha,Z., Tang,Y., Jin,C., Gao,W., Chen,C., Yu,L., Lv,N.,
            Liu,S., Xu,F., Wang,D. and Shi,L.
  TITLE     Defective Lamtor5 Leads to Autoimmunity by Deregulating v-ATPase
            and Lysosomal Acidification
  JOURNAL   Adv Sci (Weinh) 11 (22), e2400446 (2024)
   PUBMED   38639386
  REMARK    GeneRIF: Defective Lamtor5 Leads to Autoimmunity by Deregulating
            v-ATPase and Lysosomal Acidification.
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Cheng,L., Guo,L., Zou,T., Yang,Y., Tao,R. and Liu,S.
  TITLE     Research progress on oncoprotein hepatitis B X-interacting protein
            (Review)
  JOURNAL   Mol Med Rep 29 (6) (2024)
   PUBMED   38577934
  REMARK    GeneRIF: Research progress on oncoprotein hepatitis B X-interacting
            protein (Review).
            Review article
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Zhang,S., Wang,R., Wang,X., Guo,X., Du,Y., Guo,X., Zong,X., Zhu,C.
            and Zhou,X.
  TITLE     HBXIP is a novel regulator of the unfolded protein response that
            sustains tamoxifen resistance in ER+ breast cancer
  JOURNAL   J Biol Chem 298 (3), 101644 (2022)
   PUBMED   35093383
  REMARK    GeneRIF: HBXIP is a novel regulator of the unfolded protein
            response that sustains tamoxifen resistance in ER+ breast cancer.
REFERENCE   5  (bases 1 to 620)
  AUTHORS   Guo,Z.Y., Jiang,L.P. and Zhu,Z.T.
  TITLE     High HBXIP expression is related to poor prognosis in HCC by
            extensive database interrogation
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (20), 6196-6207 (2021)
   PUBMED   34730200
  REMARK    GeneRIF: High HBXIP expression is related to poor prognosis in HCC
            by extensive database interrogation.
REFERENCE   6  (bases 1 to 620)
  AUTHORS   Lee,S.H., Park,S.G., Lim,S.O. and Jung,G.
  TITLE     The hepatitis B virus X protein up-regulates lymphotoxin alpha
            expression in hepatocytes
  JOURNAL   Biochim Biophys Acta 1741 (1-2), 75-84 (2005)
   PUBMED   15955450
  REMARK    GeneRIF: HBXIP up-regulates LTA expression in hepatocytes.
REFERENCE   7  (bases 1 to 620)
  AUTHORS   Marusawa,H., Matsuzawa,S., Welsh,K., Zou,H., Armstrong,R., Tamm,I.
            and Reed,J.C.
  TITLE     HBXIP functions as a cofactor of survivin in apoptosis suppression
  JOURNAL   EMBO J 22 (11), 2729-2740 (2003)
   PUBMED   12773388
  REMARK    GeneRIF: Survivin-HBXIP complexes, but neither survivin nor HBXIP
            individually, bind pro-caspase-9, preventing its recruitment to
            Apaf1, and thereby selectively suppressing apoptosis.
REFERENCE   8  (bases 1 to 620)
  AUTHORS   Li,Y. and Lu,Y.Y.
  TITLE     Applying a highly specific and reproducible cDNA RDA method to
            clone garlic up-regulated genes in human gastric cancer cells
  JOURNAL   World J Gastroenterol 8 (2), 213-216 (2002)
   PUBMED   11925594
  REMARK    GeneRIF: Elevated levels of GDN/PN1 and XIP mRNAs induced by
            Allitridi provide valuable molecular evidence for elucidating
            garlic's efficacies against neurodegenerative and inflammatory
            diseases.
REFERENCE   9  (bases 1 to 620)
  AUTHORS   Shamay,M., Barak,O., Doitsh,G., Ben-Dor,I. and Shaul,Y.
  TITLE     Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to
            coactivate transcription
  JOURNAL   J Biol Chem 277 (12), 9982-9988 (2002)
   PUBMED   11788598
  REMARK    GeneRIF: Hepatitis B virus pX interacts with HBXAP
REFERENCE   10 (bases 1 to 620)
  AUTHORS   Melegari,M., Scaglioni,P.P. and Wands,J.R.
  TITLE     Cloning and characterization of a novel hepatitis B virus x binding
            protein that inhibits viral replication
  JOURNAL   J Virol 72 (3), 1737-1743 (1998)
   PUBMED   9499022
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390797.16.
            
            Summary: This gene encodes a protein that specifically complexes
            with the C-terminus of hepatitis B virus X protein (HBx). The
            function of this protein is to negatively regulate HBx activity and
            thus to alter the replication life cycle of the virus. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses a downstream
            transcription start site and a downstream in-frame translation
            start site, compared to variant 1. The encoded isoform (2) has a
            shorter N-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062619.1, BF791527.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602318.6/ ENSP00000473439.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AL390797.16        14256-14364         c
            110-171             AL390797.16        12988-13049         c
            172-289             AL390797.16        10589-10706         c
            290-620             AL390797.16        7923-8253           c
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..620
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 5"
                     /db_xref="GeneID:10542"
                     /db_xref="HGNC:HGNC:17955"
                     /db_xref="MIM:608521"
     exon            1..109
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..350
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     HBx-interacting protein; hepatitis B virus x-interacting
                     protein (9.6kD); HBV X-interacting protein; hepatitis B
                     virus x interacting protein; late endosomal/lysosomal
                     adaptor and MAPK and MTOR activator 5; ragulator complex
                     protein LAMTOR5"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR5 isoform 2"
                     /protein_id="NP_001369222.1"
                     /db_xref="CCDS:CCDS91022.1"
                     /db_xref="GeneID:10542"
                     /db_xref="HGNC:HGNC:17955"
                     /db_xref="MIM:608521"
                     /translation="MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGV
                     ISVLAQQAAKLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS"
     exon            110..171
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /inference="alignment:Splign:2.1.0"
     exon            172..289
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /inference="alignment:Splign:2.1.0"
     exon            290..620
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      599..604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /note="hexamer: AATAAA"
     polyA_site      620
                     /gene="LAMTOR5"
                     /gene_synonym="HBXIP; XIP"
                     /note="major polyA site"
ORIGIN      
        1 aagtgactga ggcctgtggt ggagaaggac gtgccgtgcc gctgggttct gagccggagt
       61 ggtcggtggg tgggatggag gcgaccttgg agcagcactt ggaagacaca atgaagaatc
      121 cctccattgt tggagtcctg tgcacagatt cacaaggact taatctgggt tgccgcggga
      181 ccctgtcaga tgagcatgct ggagtgatat ctgttctagc ccagcaagca gctaagctaa
      241 cctctgaccc cactgatatt cctgtggtgt gtctagaatc agataatggg aacattatga
      301 tccagaaaca cgatggcatc acggtggcag tgcacaaaat ggcctcttga tgctcatatc
      361 tgttcttcag cagcctgtca taggaactgg atcctaccta tgttaattac cttatagaac
      421 tactaaagtt ccagtagtta ggccattcat ttaatgtgca ttaggcactt ttctgtttat
      481 ttaagagtca attgctttct aatgctctat ggaccgacta tcaagatatt agtaagaaag
      541 gatcatgttt tgaagcagca ggtccaggtc actttgtata tagaattttg ctgtattcaa
      601 taaatctgtt tggaggaaaa
//
