LOCUS       NM_001318237             513 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 4 (LAMTOR4), transcript variant 3, mRNA.
ACCESSION   NM_001318237
VERSION     NM_001318237.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Gamallat,Y., Alwazan,H., Turko,R., Dang,V., Seyedi,S., Ghosh,S. and
            Bismar,T.A.
  TITLE     Elevated LAMTOR4 Expression Is Associated with Lethal Prostate
            Cancer and Its Knockdown Decreases Cell Proliferation, Invasion,
            and Migration In Vitro
  JOURNAL   Int J Mol Sci 25 (15), 8100 (2024)
   PUBMED   39125671
  REMARK    GeneRIF: Elevated LAMTOR4 Expression Is Associated with Lethal
            Prostate Cancer and Its Knockdown Decreases Cell Proliferation,
            Invasion, and Migration In Vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 513)
  AUTHORS   Zhang,S., Lee,S.H., Nie,L., Huang,Y., Zou,G., Jung,Y.S., Jun,S.,
            Zhang,J., Lien,E.M., Chen,J. and Park,J.I.
  TITLE     Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is
            required for mammary tumorigenesis
  JOURNAL   Cancer Commun (Lond) 43 (1), 159-163 (2023)
   PUBMED   36336962
  REMARK    GeneRIF: Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling
            integrity is required for mammary tumorigenesis.
REFERENCE   4  (bases 1 to 513)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   5  (bases 1 to 513)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 513)
  AUTHORS   Rebsamen,M., Pochini,L., Stasyk,T., de Araujo,M.E., Galluccio,M.,
            Kandasamy,R.K., Snijder,B., Fauster,A., Rudashevskaya,E.L.,
            Bruckner,M., Scorzoni,S., Filipek,P.A., Huber,K.V., Bigenzahn,J.W.,
            Heinz,L.X., Kraft,C., Bennett,K.L., Indiveri,C., Huber,L.A. and
            Superti-Furga,G.
  TITLE     SLC38A9 is a component of the lysosomal amino acid sensing
            machinery that controls mTORC1
  JOURNAL   Nature 519 (7544), 477-481 (2015)
   PUBMED   25561175
REFERENCE   7  (bases 1 to 513)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 513)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
  REMARK    GeneRIF: Study identified HBXIP and C7orf59 as two additional
            Ragulator components that are required for mTORC1 activation by
            amino acids.
REFERENCE   9  (bases 1 to 513)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   10 (bases 1 to 513)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU450474.1 and BI771662.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001318237.1.
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            5' coding region compared to variant 1. The encoded isoform (3) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI771662.1, BY796807.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CU450474.1         73-130
            59-513              BI771662.1         64-518
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..513
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 4"
                     /db_xref="GeneID:389541"
                     /db_xref="HGNC:HGNC:33772"
                     /db_xref="MIM:618834"
     exon            1..58
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..274
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="isoform 3 is encoded by transcript variant 3;
                     UPF0539 protein C7orf59; late endosomal/lysosomal adaptor
                     and MAPK and MTOR activator 4; ragulator complex protein
                     LAMTOR4"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR4 isoform 3"
                     /protein_id="NP_001305166.1"
                     /db_xref="CCDS:CCDS83211.1"
                     /db_xref="GeneID:389541"
                     /db_xref="HGNC:HGNC:33772"
                     /db_xref="MIM:618834"
                     /translation="MSSGDLENDEQAASAISELVSTACGFRLHRGMNVPFKRLSVVFG
                     EHTLLVTVSGQRVFVVKRQNRGREPIDV"
     exon            59..176
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            177..513
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      488..493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="hexamer: AATAAA"
     polyA_site      513
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="major polyA site"
ORIGIN      
        1 ctgaagccgg aagctaccta tctggtaggg agctccccca gcaccgaaga ctgcgatgtc
       61 atctggggac ctggagaatg atgagcaggc agccagtgcc atctctgagc tggtcagcac
      121 agcctgcggt ttccggctgc accgcggcat gaatgtgccc ttcaagcgcc tgtctgtggt
      181 ctttggagaa cacacactgc tggtgacggt gtcaggacag agggtgtttg tggtgaagag
      241 gcagaaccga ggtcgggagc ccattgatgt ctgagcctgc cggagggcga gggtcggaga
      301 agcggattgg gtcctgggcc tctgtgatga ggcaggcaca cctgtcggtc ttggcttgct
      361 gctagaacta gggccttctg ctcgcccacc tcccacccct acctggacgg gcccaggctt
      421 ggggactctg agctgtgtta aggagaacaa gggcaaggag acctcccttt gtgctccctc
      481 actccctaat aaacatgagt ctgatgttct cca
//
