LOCUS       NM_001008395             594 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 4 (LAMTOR4), transcript variant 1, mRNA.
ACCESSION   NM_001008395 XM_371939
VERSION     NM_001008395.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 594)
  AUTHORS   Gamallat,Y., Alwazan,H., Turko,R., Dang,V., Seyedi,S., Ghosh,S. and
            Bismar,T.A.
  TITLE     Elevated LAMTOR4 Expression Is Associated with Lethal Prostate
            Cancer and Its Knockdown Decreases Cell Proliferation, Invasion,
            and Migration In Vitro
  JOURNAL   Int J Mol Sci 25 (15), 8100 (2024)
   PUBMED   39125671
  REMARK    GeneRIF: Elevated LAMTOR4 Expression Is Associated with Lethal
            Prostate Cancer and Its Knockdown Decreases Cell Proliferation,
            Invasion, and Migration In Vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 594)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 594)
  AUTHORS   Zhang,S., Lee,S.H., Nie,L., Huang,Y., Zou,G., Jung,Y.S., Jun,S.,
            Zhang,J., Lien,E.M., Chen,J. and Park,J.I.
  TITLE     Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is
            required for mammary tumorigenesis
  JOURNAL   Cancer Commun (Lond) 43 (1), 159-163 (2023)
   PUBMED   36336962
  REMARK    GeneRIF: Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling
            integrity is required for mammary tumorigenesis.
REFERENCE   4  (bases 1 to 594)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   5  (bases 1 to 594)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 594)
  AUTHORS   Rebsamen,M., Pochini,L., Stasyk,T., de Araujo,M.E., Galluccio,M.,
            Kandasamy,R.K., Snijder,B., Fauster,A., Rudashevskaya,E.L.,
            Bruckner,M., Scorzoni,S., Filipek,P.A., Huber,K.V., Bigenzahn,J.W.,
            Heinz,L.X., Kraft,C., Bennett,K.L., Indiveri,C., Huber,L.A. and
            Superti-Furga,G.
  TITLE     SLC38A9 is a component of the lysosomal amino acid sensing
            machinery that controls mTORC1
  JOURNAL   Nature 519 (7544), 477-481 (2015)
   PUBMED   25561175
REFERENCE   7  (bases 1 to 594)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 594)
  AUTHORS   Bar-Peled,L., Schweitzer,L.D., Zoncu,R. and Sabatini,D.M.
  TITLE     Ragulator is a GEF for the rag GTPases that signal amino acid
            levels to mTORC1
  JOURNAL   Cell 150 (6), 1196-1208 (2012)
   PUBMED   22980980
  REMARK    GeneRIF: Study identified HBXIP and C7orf59 as two additional
            Ragulator components that are required for mTORC1 activation by
            amino acids.
REFERENCE   9  (bases 1 to 594)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   10 (bases 1 to 594)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU450474.1 and BI598677.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001008395.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063401.1, BI754529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341942.10/ ENSP00000343118.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                CU450474.1         73-138
            67-594              BI598677.1         89-616
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..594
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 4"
                     /db_xref="GeneID:389541"
                     /db_xref="HGNC:HGNC:33772"
                     /db_xref="MIM:618834"
     exon            1..58
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..355
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0539 protein C7orf59; late endosomal/lysosomal adaptor
                     and MAPK and MTOR activator 4; ragulator complex protein
                     LAMTOR4"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR4 isoform 1"
                     /protein_id="NP_001008396.1"
                     /db_xref="CCDS:CCDS34702.1"
                     /db_xref="GeneID:389541"
                     /db_xref="HGNC:HGNC:33772"
                     /db_xref="MIM:618834"
                     /translation="MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAIS
                     ELVSTACGFRLHRGMNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV"
     exon            59..139
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            140..257
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            258..594
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      569..574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="hexamer: AATAAA"
     polyA_site      594
                     /gene="LAMTOR4"
                     /gene_synonym="C7orf59"
                     /note="major polyA site"
ORIGIN      
        1 ctgaagccgg aagctaccta tctggtaggg agctccccca gcaccgaaga ctgcgatgac
       61 ttctgcgctg acccaggggc tggagcgaat cccagaccag ctcggctacc tggtactgag
      121 tgaaggtgca gtgctggcgt catctgggga cctggagaat gatgagcagg cagccagtgc
      181 catctctgag ctggtcagca cagcctgcgg tttccggctg caccgcggca tgaatgtgcc
      241 cttcaagcgc ctgtctgtgg tctttggaga acacacactg ctggtgacgg tgtcaggaca
      301 gagggtgttt gtggtgaaga ggcagaaccg aggtcgggag cccattgatg tctgagcctg
      361 ccggagggcg agggtcggag aagcggattg ggtcctgggc ctctgtgatg aggcaggcac
      421 acctgtcggt cttggcttgc tgctagaact agggccttct gctcgcccac ctcccacccc
      481 tacctggacg ggcccaggct tggggactct gagctgtgtt aaggagaaca agggcaagga
      541 gacctccctt tgtgctccct cactccctaa taaacatgag tctgatgttc tcca
//
