LOCUS       NM_021970               4163 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 3 (LAMTOR3), transcript variant 1, mRNA.
ACCESSION   NM_021970 XM_001723301 XM_001723365 XM_001724550
VERSION     NM_021970.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Gong,Y., Lv,Y., Xu,F., Xiu,Y., Lu,Y., Liu,Z. and Deng,L.
  TITLE     LAMTOR3 is a prognostic biomarker in kidney renal clear cell
            carcinoma
  JOURNAL   J Clin Lab Anal 36 (9), e24648 (2022)
   PUBMED   36082464
  REMARK    GeneRIF: LAMTOR3 is a prognostic biomarker in kidney renal clear
            cell carcinoma.
REFERENCE   4  (bases 1 to 4163)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4163)
  AUTHORS   Lunin,V.V., Munger,C., Wagner,J., Ye,Z., Cygler,M. and Sacher,M.
  TITLE     The structure of the MAPK scaffold, MP1, bound to its partner, p14.
            A complex with a critical role in endosomal map kinase signaling
  JOURNAL   J Biol Chem 279 (22), 23422-23430 (2004)
   PUBMED   15016825
REFERENCE   7  (bases 1 to 4163)
  AUTHORS   Paces-Fessy,M., Boucher,D., Petit,E., Paute-Briand,S. and
            Blanchet-Tournier,M.F.
  TITLE     The negative regulator of Gli, Suppressor of fused (Sufu),
            interacts with SAP18, Galectin3 and other nuclear proteins
  JOURNAL   Biochem J 378 (Pt 2), 353-362 (2004)
   PUBMED   14611647
REFERENCE   8  (bases 1 to 4163)
  AUTHORS   Teis,D., Wunderlich,W. and Huber,L.A.
  TITLE     Localization of the MP1-MAPK scaffold complex to endosomes is
            mediated by p14 and required for signal transduction
  JOURNAL   Dev Cell 3 (6), 803-814 (2002)
   PUBMED   12479806
REFERENCE   9  (bases 1 to 4163)
  AUTHORS   Wunderlich,W., Fialka,I., Teis,D., Alpi,A., Pfeifer,A.,
            Parton,R.G., Lottspeich,F. and Huber,L.A.
  TITLE     A novel 14-kilodalton protein interacts with the mitogen-activated
            protein kinase scaffold mp1 on a late endosomal/lysosomal
            compartment
  JOURNAL   J Cell Biol 152 (4), 765-776 (2001)
   PUBMED   11266467
REFERENCE   10 (bases 1 to 4163)
  AUTHORS   Schaeffer,H.J., Catling,A.D., Eblen,S.T., Collier,L.S., Krauss,A.
            and Weber,M.J.
  TITLE     MP1: a MEK binding partner that enhances enzymatic activation of
            the MAP kinase cascade
  JOURNAL   Science 281 (5383), 1668-1671 (1998)
   PUBMED   9733512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC026245.1, AF201947.1,
            AK022313.1, DA300823.1 and AP001962.2.
            
            On Nov 22, 2018 this sequence version replaced NM_021970.3.
            
            Summary: This gene encodes a scaffold protein that functions in the
            extracellular signal-regulated kinase (ERK) cascade. The protein is
            localized to late endosomes by the mitogen-activated
            protein-binding protein-interacting protein, and binds specifically
            to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP
            kinase MAPK1/ERK2. Studies of the orthologous gene in mouse
            indicate that it regulates late endosomal traffic and cell
            proliferation. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. A pseudogene of
            this gene is located on the long arm of chromosome 13. [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.47431.1,
                                           SRR1660807.249589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000499666.7/ ENSP00000424183.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               BC026245.1         13-276
            265-1292            AF201947.1         294-1321
            1293-1900           AK022313.1         83-690
            1901-1909           DA300823.1         225-233
            1910-4161           AK022313.1         699-2950
            4162-4163           AP001962.2         19481-19482
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..4163
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 3"
                     /db_xref="GeneID:8649"
                     /db_xref="HGNC:HGNC:15606"
                     /db_xref="MIM:603296"
     exon            1..93
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /inference="alignment:Splign:2.1.0"
     exon            94..139
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..505
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="isoform 1 is encoded by transcript variant 1; MAPK
                     scaffold protein 1; mitogen-activated protein kinase
                     kinase 1 interacting protein 1; MEK binding partner 1;
                     mitogen-activated protein kinase scaffold protein 1;
                     ragulator complex protein LAMTOR3; late
                     endosomal/lysosomal adaptor and MAPK and MTOR activator 3"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR3 isoform 1"
                     /protein_id="NP_068805.1"
                     /db_xref="CCDS:CCDS3652.1"
                     /db_xref="GeneID:8649"
                     /db_xref="HGNC:HGNC:15606"
                     /db_xref="MIM:603296"
                     /translation="MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHA
                     LRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGL
                     IVSLEKELAPLFEELRQVVEVS"
     exon            140..174
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /inference="alignment:Splign:2.1.0"
     exon            175..233
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /inference="alignment:Splign:2.1.0"
     exon            234..367
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /inference="alignment:Splign:2.1.0"
     exon            368..431
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..4163
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1269..1274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="hexamer: AATAAA"
     polyA_site      1292
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="major polyA site"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="hexamer: AATAAT"
     polyA_site      1401
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
     regulatory      4087..4092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="hexamer: AATAAA"
     regulatory      4107..4112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="hexamer: AATAAA"
     polyA_site      4108
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
     regulatory      4128..4133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
                     /note="hexamer: AAGAAA"
     polyA_site      4129
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
     polyA_site      4163
                     /gene="LAMTOR3"
                     /gene_synonym="MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633;
                     Ragulator3"
ORIGIN      
        1 atgaatcatg tgacggtggc ttgaggagga acctgtcttt aaagctgtcc ctgaagtgac
       61 agcggagaga accaggcagc ccagaaaccc caggcgtgga gattgatcct gcgagagaag
      121 ggggttcatc atggcggatg acctaaagcg attcttgtat aaaaagttac caagtgttga
      181 agggctccat gccattgttg tgtcagatag agatggagta cctgttatta aagtggcaaa
      241 tgacaatgct ccagagcatg ctttgcgacc tggtttctta tccacttttg cccttgcaac
      301 agaccaagga agcaaacttg gactttccaa aaataaaagt atcatctgtt actataacac
      361 ctaccaggtg gttcaattta atcgtttacc tttggtggtg agtttcatag ccagcagcag
      421 tgccaataca ggactaattg tcagcctaga aaaggaactt gctccattgt ttgaagaact
      481 gagacaagtt gtggaagttt cttaatctga cagtggtttc agtgtgtacc ttatcttcat
      541 tataacaaca caatatcaat ccagcaatct ttagactaca ataatacttt tatccatgtg
      601 ctcaagaaag ggcccctttt tccaacttat actaaagagc tagcatatag atgtaattta
      661 tagatagatc agttgctata ttttctggtg tagggtcttt cttatttagt gagatctagg
      721 gataccacag aaatggttca gtctatcaca gctcccatgg agttagtctg gtcaccagat
      781 atggatgaga gattctattc agtggatcag aatcaaactg gtacattgat ccacttgagc
      841 cgttaagtgc tgccaattgt acaatatgcc caggcttgca gaataaagcc aactttttat
      901 tgtgaataat aataaggaca tatttttctt cagattatgt tttatttctt tgcattgagt
      961 gaggaacata aaatggcttg gtaaaagtaa taaaatcagt acaatcacta actttccttt
     1021 gtacatatta ttttgcagta tagatgaata ttactaatca gtttgattat tctcagaggg
     1081 tgctgctctt taatgaaaat gaaaattata gctaatgttt tttcctcaaa ctctgctttc
     1141 tgtaaccaat cagtgtttta atgtttgtgt gttcttcata aaatttaaat acaattcgtt
     1201 attctgtttc caatgttagt atgtatgtaa acatgatagt acagccattt ttttcatatg
     1261 tgagtaaaaa taaaatagta tttttaaaaa tatagtttga gcactgtata ggtccttttt
     1321 ttgttcagac tttttccaaa aatctaaaca taattaatat actctttcag ccacatgaat
     1381 aaataatgag tgtttcttgt aggtattggt ttggagattg ttttacggta gtatgaactg
     1441 ttaactggaa aagaaacctg agattgcagt cagccaagat tgtgccactg caccccagcc
     1501 tgggcaacag agactccgtc tcaaaaacaa aaaagaaaag aaaccaagaa acctcaggca
     1561 tgaacctaat ttaatctcca tgaaagaggt actacagttc tagaatatac cctttatgtt
     1621 caggaatgca gtctatcatt cagagttaat ttctttctag gctctttgac aatcagtttt
     1681 tccctggatc agttcagtac atatgcattg agcacctgtg tgccagtcag ccgagctatc
     1741 acattgcaca attctaagaa gcaccattca tgtctcatca tatttctatg ctctgggagt
     1801 tgcctttcac atagaatatg tgtgattgtt atccctagaa ttgtgcagtg aggcaattgg
     1861 ctaggtgctg tgctgctttt tctttctttc tttttttttt taagagacag agtcttgctg
     1921 tgttgcccag tctggagtgc agtggtggca tgatcttgcc tcactgtaac ctctgcctcc
     1981 tgggttcaag ctgttctcat gccccattct cccttgtagc tgggattaca ggcttacacc
     2041 atcgcacttg gcaaatttgt gtatttttag tagagacagg aattcaccat gttggccagg
     2101 ctggtcttga actcctgact taaagtgatc cacctgcttt ggcctcccaa aatgctagga
     2161 ttataggtgt gagccactgc accgggccat gtgctacttt ttcttccttc catccttcct
     2221 cccttcttca gtgtaaatat gagattaatt tgtgatacct tactttaaag aacttagagt
     2281 tcagtaaagg aagcaggtat agaaagtgct atgataaagc tatacatagg atggtataga
     2341 accacagact aggggcactt aaaatgggca agaaaatagc ctttgtaaat aaaatagagg
     2401 caagagatat aatgctttac ctgcaaagag ctataaatac agccatgtac catataatga
     2461 tgtttcagtt agtgaaggac cacatacgag ggtggtcaga acagcaggct ataccatata
     2521 gcctaggtgt gtagtaggct ataccatata gcctaggtgt gtagtagtag gctataccat
     2581 atagcctagg tgtgtagtag taggcgatac catatagcct aggtgtgtag tagtaggcta
     2641 taccatatag cctaggtgta tagtagtagg ctataccata tagcctaggt gtgtagtagg
     2701 ctataccata tagcctaggt atgtagtagt aggctatacc atatagccta ggtgtgtagt
     2761 agtaggctat accatctggg gttcctgtca gtacagtatg atgttcacat aatgatgaaa
     2821 tcacctaaca aagcatgtct cgaaatgtat ccacattgtt acgtaacaca tgactgtagt
     2881 taattgttac aattgaaata ctagatgtac tcattgaaat ccagaattcc cattatctgg
     2941 attatttaat atcgttcagg aaatttttgc cagtgcaatg gtgcatgaaa caatgtcttt
     3001 tagaaatgag gtggccagat ttctatttgc agataataat tgtatatcta aaaatcctag
     3061 aaaaagaaat gataacaaat ggagctactt aacctttaca tgttgaatgc tgccactgtt
     3121 aaaatttctg agggggtata atagataaac tatcccatag ttcatctgga aaaataaggt
     3181 ggtgaaaatt gctaagaaat ttttgaaagg gtaatgtaaa cctagattaa ctgtttttga
     3241 aaggtagtac agaactgaat gcacaactag atatcaatgg tatgtactca cccagaaaaa
     3301 agacttcagt acatacatgt gagggcttaa aacattgtta taaagacggg atcacaatgg
     3361 gaaaaggatt attcaataag tagggcaggc attctctatg cctgctaggg aagtgtgact
     3421 tgttatactc tttatgtaca gcaattggca gtctgtgaaa cttttaaatt catatacata
     3481 accttttgcc ctgcaattcc acttctagaa atttatccta ccaaacaaag cacatagatg
     3541 tgcaaaagta tgtatttaca agtatattct ttgcaacttg gtaatgtcaa agaattggaa
     3601 gcaacctaaa tatctgccat aggtaggata accatatgct ttggcttttt gaacactacc
     3661 agtttatacc tgctgttctt ggataattat taatagtgct ttcattctca atgtctcact
     3721 ttagataata aattacagag gattggtgaa actaatttgc ccaatggaaa aaggaatgaa
     3781 gaagtgcttt aggtactgag atgaaaagat ctctaaggca taataatgtt tattgagaaa
     3841 agcatggtgt caaactgtat ggcatgctac aattgatgta taagaagaaa aaatgtgtat
     3901 gtattcctat ttgtttgtat atggtagact gtctctgaag acatatatgg aagaacctga
     3961 tcacattggt agtctccaag gagcagaact agatacctgg gggataagga tcccaggagt
     4021 gagccttttc attgtaaact tcattgtact ttgagttttt aactgttcaa aaataataaa
     4081 attagaaata aaatatttca acaaacaata aaatgggata tttggggaag aaagttgtct
     4141 cagggctctc caaagaagca gaa
//
