LOCUS       NM_017907               1089 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR
            activator 1 (LAMTOR1), mRNA.
ACCESSION   NM_017907
VERSION     NM_017907.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1089)
  AUTHORS   Zhao,L., Gao,N., Peng,X., Chen,L., Meng,T., Jiang,C., Jin,J.,
            Zhang,J., Duan,Q., Tian,H., Weng,L., Wang,X., Tan,X., Li,Y.,
            Qin,H., Yuan,J., Ge,X., Deng,L. and Wang,P.
  TITLE     TRAF4-Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation
            and Inhibits the Inflammation-Induced Colorectal Cancer Progression
  JOURNAL   Adv Sci (Weinh) 11 (12), e2301164 (2024)
   PUBMED   38229144
  REMARK    GeneRIF: TRAF4-Mediated LAMTOR1 Ubiquitination Promotes mTORC1
            Activation and Inhibits the Inflammation-Induced Colorectal Cancer
            Progression.
REFERENCE   2  (bases 1 to 1089)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1089)
  AUTHORS   Wu,B., Wang,Q., Li,B. and Jiang,M.
  TITLE     LAMTOR1 degrades MHC-II via the endocytic in hepatocellular
            carcinoma
  JOURNAL   Carcinogenesis 43 (11), 1059-1070 (2022)
   PUBMED   36070764
  REMARK    GeneRIF: LAMTOR1 degrades MHC-II via the endocytic in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 1089)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   5  (bases 1 to 1089)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1089)
  AUTHORS   Nada,S., Hondo,A., Kasai,A., Koike,M., Saito,K., Uchiyama,Y. and
            Okada,M.
  TITLE     The novel lipid raft adaptor p18 controls endosome dynamics by
            anchoring the MEK-ERK pathway to late endosomes
  JOURNAL   EMBO J 28 (5), 477-489 (2009)
   PUBMED   19177150
  REMARK    GeneRIF: Studies in rat and mice, identified the rat p18 protein as
            an endosomal membrane anchoring protein which interacts with MEK1
            scaffold p14/MP1 and mobilizes them to late endosome.
REFERENCE   7  (bases 1 to 1089)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1089)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 1089)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 1089)
  AUTHORS   Jiang,L.Q., Wen,S.J., Wang,H.Y. and Chen,L.Y.
  TITLE     Screening the proteins that interact with calpain in a human heart
            cDNA library using a yeast two-hybrid system
  JOURNAL   Hypertens Res 25 (4), 647-652 (2002)
   PUBMED   12358155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX381569.2, AK000632.1 and BC001706.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017907.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.21511.1,
                                           SRR5189655.16392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278671.10/ ENSP00000278671.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BX381569.2         91-111
            22-892              AK000632.1         1-871
            893-1089            BC001706.1         845-1041
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1089
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /note="late endosomal/lysosomal adaptor, MAPK and MTOR
                     activator 1"
                     /db_xref="GeneID:55004"
                     /db_xref="HGNC:HGNC:26068"
                     /db_xref="MIM:613510"
     exon            1..115
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..559
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /note="p27kip1 releasing factor from RhoA; ragulator
                     complex protein PDRO; protein associated with DRMs and
                     endosomes; RhoA activator C11orf59; p27Kip1-releasing
                     factor from RhoA; lipid raft adaptor protein p18; late
                     endosomal/lysosomal adaptor and MAPK and MTOR activator 1"
                     /codon_start=1
                     /product="ragulator complex protein LAMTOR1"
                     /protein_id="NP_060377.1"
                     /db_xref="CCDS:CCDS8209.1"
                     /db_xref="GeneID:55004"
                     /db_xref="HGNC:HGNC:26068"
                     /db_xref="MIM:613510"
                     /translation="MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLP
                     SARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHW
                     KKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGI
                     P"
     exon            116..261
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..339
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..466
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1089
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1067..1072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /note="hexamer: GATAAA"
     polyA_site      1089
                     /gene="LAMTOR1"
                     /gene_synonym="C11orf59; p18; p27RF-Rho; PDRO; Ragulator1"
                     /note="major polyA site"
ORIGIN      
        1 atgtgaccgg aagggctcct cacggacgcc gtccctcctc ggcgcggcct gagcgcccgg
       61 cccgaccccg gccatggggt gctgctacag cagcgagaac gaggactcgg accaggaccg
      121 agaggagcgg aagctgctgc tggaccctag cagcccccct accaaagctc tcaatggagc
      181 cgagcccaac taccacagcc tgccttccgc tcgcactgat gagcaggccc tgctctcttc
      241 catccttgcc aagacagcca gcaacatcat tgatgtgtct gctgcagact cacagggcat
      301 ggagcagcat gagtacatgg accgtgccag gcagtacagc acccgcttgg ctgtgctgag
      361 cagcagcctg acccattgga agaagctgcc accgctgccg tctcttacca gccagcccca
      421 ccaagtgctg gccagtgagc ccatcccgtt ctctgatttg cagcaggtct ccaggatagc
      481 tgcttatgcc tacagtgcac tttctcagat ccgtgtggac gcaaaagagg agctggttgt
      541 acagtttggg atcccatgaa gagaggggtc cttggacagc tcttctcctc tcttcatccc
      601 atctctaccc cacccccttg gcccccagcc tcactgcggc ttatacagta ccctaacctg
      661 ctactaatca cagagaaaaa tgtgaagaag gaggagaaga ggaaggctag aagcctgagc
      721 aagtgagggt agaacctttt gggactggcc tttgaagctc tggccaggga tggggtgggg
      781 gccaaaagga cagagcctgg tatgtcttca tagtcattga gaatgtggag ataccagttt
      841 gggtgggggg tgatcaccag gggacctagg gagatcccct tcccaccctc tctgttggcc
      901 tcagagtcac tcctgccccc tctccctgac ttggtgctca catgcacctc actagggttt
      961 gtgaccaggg tctggatgag cttgaatttg aatgaattga gtttgtattt ctagaaccct
     1021 gggtttttac atgtttggtc tttttttgtt ttggtttgtc accctcgata aaggaagtat
     1081 attcatcca
//
