LOCUS       NM_012261               1810 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens lysosomal associated membrane protein family member 5
            (LAMP5), transcript variant 1, mRNA.
ACCESSION   NM_012261
VERSION     NM_012261.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1810)
  AUTHORS   Umeda,S., Kanda,M., Shimizu,D., Nakamura,S., Sawaki,K., Inokawa,Y.,
            Hattori,N., Hayashi,M., Tanaka,C., Nakayama,G. and Kodera,Y.
  TITLE     Lysosomal-associated membrane protein family member 5 promotes the
            metastatic potential of gastric cancer cells
  JOURNAL   Gastric Cancer 25 (3), 558-572 (2022)
   PUBMED   35226222
  REMARK    GeneRIF: Lysosomal-associated membrane protein family member 5
            promotes the metastatic potential of gastric cancer cells.
REFERENCE   2  (bases 1 to 1810)
  AUTHORS   Wang,W.T., Han,C., Sun,Y.M., Chen,Z.H., Fang,K., Huang,W.,
            Sun,L.Y., Zeng,Z.C., Luo,X.Q. and Chen,Y.Q.
  TITLE     Activation of the Lysosome-Associated Membrane Protein LAMP5 by
            DOT1L Serves as a Bodyguard for MLL Fusion Oncoproteins to Evade
            Degradation in Leukemia
  JOURNAL   Clin Cancer Res 25 (9), 2795-2808 (2019)
   PUBMED   30651276
  REMARK    GeneRIF: High LAMP5 expression is associated with Leukemia.
REFERENCE   3  (bases 1 to 1810)
  AUTHORS   Combes,A., Camosseto,V., N'Guessan,P., Arguello,R.J., Mussard,J.,
            Caux,C., Bendriss-Vermare,N., Pierre,P. and Gatti,E.
  TITLE     BAD-LAMP controls TLR9 trafficking and signalling in human
            plasmacytoid dendritic cells
  JOURNAL   Nat Commun 8 (1), 913 (2017)
   PUBMED   29030552
  REMARK    GeneRIF: BAD-LAMP (LAMP5)-silencing enhances TLR9 retention in
            endolysosome compartment and consequent downstream signalling
            events.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1810)
  AUTHORS   Defays,A., David,A., de Gassart,A., De Angelis Rigotti,F.,
            Wenger,T., Camossetto,V., Brousset,P., Petrella,T., Dalod,M.,
            Gatti,E. and Pierre,P.
  TITLE     BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid
            dendritic cells
  JOURNAL   Blood 118 (3), 609-617 (2011)
   PUBMED   21642595
REFERENCE   5  (bases 1 to 1810)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031652.4 and BC050727.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012261.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.229926.1,
                                           SRR3476690.80562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246070.3/ ENSP00000246070.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AL031652.4         107858-107922
            66-1810             BC050727.1         1-1745
FEATURES             Location/Qualifiers
     source          1..1810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.2"
     gene            1..1810
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /note="lysosomal associated membrane protein family member
                     5"
                     /db_xref="GeneID:24141"
                     /db_xref="HGNC:HGNC:16097"
                     /db_xref="MIM:614641"
     exon            1..327
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1106
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LAMP family protein C20orf103; brain-associated
                     LAMP-like protein; lysosome-associated membrane protein 5;
                     brain and dendritic cell-associated LAMP;
                     lysosome-associated membrane glycoprotein 5"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 5
                     isoform 1 precursor"
                     /protein_id="NP_036393.1"
                     /db_xref="CCDS:CCDS13106.1"
                     /db_xref="GeneID:24141"
                     /db_xref="HGNC:HGNC:16097"
                     /db_xref="MIM:614641"
                     /translation="MDLQGRGVPSIDRLRVLLMLFHTMAQIMAEQEVENLSGLSTNPE
                     KDIFVVRENGTTCLMAEFAAKFIVPYDVWASNYVDLITEQADIALTRGAEVKGRCGHS
                     QSELQVFWVDRAYALKMLFVKESHNMSKGPEATWRLSKVQFVYDSSEKTHFKDAVSAG
                     KHTANSHHLSALVTPAGKSYECQAQQTISLASSDPQKTVTMILSAVHIQPFDIISDFV
                     FSEEHKCPVDEREQLEETLPLILGLILGLVIMVTLAIYHVHHKMTANQVQIPRDRSQY
                     KHMG"
     exon            328..500
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /inference="alignment:Splign:2.1.0"
     exon            501..632
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /inference="alignment:Splign:2.1.0"
     exon            633..738
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /inference="alignment:Splign:2.1.0"
     exon            739..927
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1810
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1788..1793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /note="hexamer: AATAAA"
     polyA_site      1810
                     /gene="LAMP5"
                     /gene_synonym="BAD-LAMP; BADLAMP; C20orf103; LAMP-5;
                     UNC-46"
                     /note="major polyA site"
ORIGIN      
        1 ggattgcttt cagcactcgc agccgtggac cgccgtgcgg tcctttcctc cgcagtgagc
       61 cgatttgctc tgccagcagc tgtcggtgcc gcgctcgaca ccgagtccta gctaggcgct
      121 cacagaatac gcgctccctc cctccccctt ctctgtcccc cgcctctcgc tcaccccggc
      181 ccactccagc ggcgactttg agggattccc tctctggcgg cctctgcagc agcacagccg
      241 gcctcattcg gggcactgcg agtatggatc tccaaggaag aggggtcccc agcatcgaca
      301 gacttcgagt tctcctgatg ttgttccata caatggctca aatcatggca gaacaagaag
      361 tggaaaatct ctcaggcctt tccactaacc ctgaaaaaga tatatttgtg gtgcgggaaa
      421 atgggacgac gtgtctcatg gcagagtttg cagccaaatt tattgtacct tatgatgtgt
      481 gggccagcaa ctacgtagat ctgatcacag aacaggccga tatcgcattg acccggggag
      541 ctgaggtgaa gggccgctgt ggccacagcc agtcggagct gcaagtgttc tgggtggatc
      601 gcgcatatgc actcaaaatg ctctttgtaa aggaaagcca caacatgtcc aagggacctg
      661 aggcgacttg gaggctgagc aaagtgcagt ttgtctacga ctcctcggag aaaacccact
      721 tcaaagacgc agtcagtgct gggaagcaca cagccaactc gcaccacctc tctgccttgg
      781 tcacccccgc tgggaagtcc tatgagtgtc aagctcaaca aaccatttca ctggcctcta
      841 gtgatccgca gaagacggtc accatgatcc tgtctgcggt ccacatccaa ccttttgaca
      901 ttatctcaga ttttgtcttc agtgaagagc ataaatgccc agtggatgag cgggagcaac
      961 tggaagaaac cttgcccctg attttggggc tcatcttggg cctcgtcatc atggtaacac
     1021 tcgcgattta ccacgtccac cacaaaatga ctgccaacca ggtgcagatc cctcgggaca
     1081 gatcccagta taagcacatg ggctagaggc cgttaggcag gcacccccta ttcctgctcc
     1141 cccaactgga tcaggtagaa caacaaaagc acttttccat cttgtacacg agatacacca
     1201 acatagctac aatcaaacag gcctgggtat ctgaggcttg cttggcttgt gtccatgctt
     1261 aaacccacgg aagggggaga ctctttcgga tttgtagggt gaaatggcaa ttattctctc
     1321 catgctgggg aggaggggag gagggtctca gacagctttc gtgctcatgg tggcttggct
     1381 ttgactctcc aaagagcaat aaatgccact tggagctgta tctggcccca aagtttaggg
     1441 attgaaaaca tgcttctttg aggaggaaac ccctttaggt tcagaagaat atggggtgct
     1501 ttgctccctt ggacacagct ggcttatcct atacagttgt caatgcacac agaatacaac
     1561 ctcatgctcc ctgcagcaag acccctgaaa gtgattcatg cttctggctg gcattctgca
     1621 tgtttagtga ttgtcttggg aatgtttcac tgctacccgc atccagcgac tgcagcacca
     1681 gaaaacgact aatgtaacta tgcagagttg tttggacttc ttcctgtgcc aggtccaagt
     1741 cgggggacct gaagaatcaa tctgtgtgag tctgtttttc aaaatgaaat aaaacacact
     1801 attctctggc
//
