LOCUS       NM_014398               3196 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens lysosomal associated membrane protein 3 (LAMP3), mRNA.
ACCESSION   NM_014398
VERSION     NM_014398.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3196)
  AUTHORS   Dicenta,V., Pelzer,A., Laspa,Z., Castor,T., Gawaz,M.P. and
            Rohlfing,A.K.
  TITLE     The subtilisin-like protease furin regulates hemin-induced CD63
            surface expression on platelets
  JOURNAL   Biochem Biophys Res Commun 701, 149629 (2024)
   PUBMED   38330730
  REMARK    GeneRIF: The subtilisin-like protease furin regulates hemin-induced
            CD63 surface expression on platelets.
REFERENCE   2  (bases 1 to 3196)
  AUTHORS   Fu,B., Zhou,M., Geng,X., Jiang,Y., Zeng,H., Zhou,X., Yu,Z., Pan,J.,
            Zhu,Y., Zheng,H., Huang,S., Gong,Y., Huang,D. and Zhong,Y.
  TITLE     LAMP3 is a potent uterine corpus endometrial carcinoma prognostic
            biomarker associated with immune behavior
  JOURNAL   Aging (Albany NY) 16 (1), 714-745 (2024)
   PUBMED   38217544
  REMARK    GeneRIF: LAMP3 is a potent uterine corpus endometrial carcinoma
            prognostic biomarker associated with immune behavior.
REFERENCE   3  (bases 1 to 3196)
  AUTHORS   Lu,H., Zhou,J., Li,X., Han,X., Ma,S. and Feng,C.
  TITLE     MiR-526b-3p enhances sensitivity of head and neck squamous cell
            carcinoma cells to radiotherapy via suppressing exosomal
            LAMP3-mediated autophagy
  JOURNAL   Autoimmunity 56 (1), 2259125 (2023)
   PUBMED   37740656
  REMARK    GeneRIF: MiR-526b-3p enhances sensitivity of head and neck squamous
            cell carcinoma cells to radiotherapy via suppressing exosomal
            LAMP3-mediated autophagy.
REFERENCE   4  (bases 1 to 3196)
  AUTHORS   Tian,X., Zheng,L., Ma,J., Xu,Y., Zhang,Y. and Pi,Y.
  TITLE     Inhibition of LAMP3 mediates the protective effect of vitamin D
            against hypoxia/reoxygenation in trophoblast cells
  JOURNAL   Braz J Med Biol Res 56, e12816 (2023)
   PUBMED   37878884
  REMARK    GeneRIF: Inhibition of LAMP3 mediates the protective effect of
            vitamin D against hypoxia/reoxygenation in trophoblast cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3196)
  AUTHORS   Nakamura,H., Tanaka,T., Zheng,C., Afione,S.A., Warner,B.M.,
            Noguchi,M., Atsumi,T. and Chiorini,J.A.
  TITLE     Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent
            Cell Death by Impairing Autophagic Caspase 8 Degradation in the
            Salivary Glands of Individuals With Sjogren's Disease
  JOURNAL   Arthritis Rheumatol 75 (9), 1586-1598 (2023)
   PUBMED   37096570
  REMARK    GeneRIF: Lysosome-Associated Membrane Protein 3 Induces
            Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8
            Degradation in the Salivary Glands of Individuals With Sjogren's
            Disease.
REFERENCE   6  (bases 1 to 3196)
  AUTHORS   Arruda,L.B., Sim,D., Chikhlikar,P.R., Maciel,M. Jr., Akasaki,K.,
            August,J.T. and Marques,E.T.
  TITLE     Dendritic cell-lysosomal-associated membrane protein (LAMP) and
            LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking
            pathways and prime T and B cell responses to a diverse repertoire
            of epitopes
  JOURNAL   J Immunol 177 (4), 2265-2275 (2006)
   PUBMED   16887987
  REMARK    GeneRIF: LAMP-1 and DC-LAMP antigen chimeras follow different
            trafficking pathways, induce distinct modulatory immune responses,
            and are able to present cryptic epitopes.
REFERENCE   7  (bases 1 to 3196)
  AUTHORS   Kanao,H., Enomoto,T., Kimura,T., Fujita,M., Nakashima,R., Ueda,Y.,
            Ueno,Y., Miyatake,T., Yoshizaki,T., Buzard,G.S., Tanigami,A.,
            Yoshino,K. and Murata,Y.
  TITLE     Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in
            uterine cervical cancer
  JOURNAL   Cancer Res 65 (19), 8640-8645 (2005)
   PUBMED   16204031
  REMARK    GeneRIF: Findings indicate that LAMP3 overexpression is associated
            with an enhanced metastatic potential and may be a prognostic
            factor for cervical cancer.
REFERENCE   8  (bases 1 to 3196)
  AUTHORS   Akasaki,K., Nakamura,N., Tsukui,N., Yokota,S., Murata,S., Katoh,R.,
            Michihara,A., Tsuji,H., Marques,E.T. Jr. and August,J.T.
  TITLE     Human dendritic cell lysosome-associated membrane protein expressed
            in lung type II pneumocytes
  JOURNAL   Arch Biochem Biophys 425 (2), 147-157 (2004)
   PUBMED   15111122
REFERENCE   9  (bases 1 to 3196)
  AUTHORS   de Saint-Vis,B., Vincent,J., Vandenabeele,S., Vanbervliet,B.,
            Pin,J.J., Ait-Yahia,S., Patel,S., Mattei,M.G., Banchereau,J.,
            Zurawski,S., Davoust,J., Caux,C. and Lebecque,S.
  TITLE     A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced
            upon DC maturation, is transiently expressed in MHC class II
            compartment
  JOURNAL   Immunity 9 (3), 325-336 (1998)
   PUBMED   9768752
REFERENCE   10 (bases 1 to 3196)
  AUTHORS   Ozaki,K., Nagata,M., Suzuki,M., Fujiwara,T., Ueda,K., Miyoshi,Y.,
            Takahashi,E. and Nakamura,Y.
  TITLE     Isolation and characterization of a novel human lung-specific gene
            homologous to lysosomal membrane glycoproteins 1 and 2:
            significantly increased expression in cancers of various tissues
  JOURNAL   Cancer Res 58 (16), 3499-3503 (1998)
   PUBMED   9721848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC399447.1, DA994656.1, AJ005766.1 and AC104641.11.
            
            On Nov 22, 2018 this sequence version replaced NM_014398.3.
            
            Summary: Dendritic cells (DCs) are the most potent
            antigen-presenting cells. Immature DCs efficiently capture antigens
            and differentiate into interdigitating dendritic cells (IDCs) in
            lymphoid tissues that induce primary T-cell responses (summary by
            de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec
            2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032940.2, AB013924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265598.8/ ENSP00000265598.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               DC399447.1         178-505
            329-559             DA994656.1         311-541
            560-1381            AJ005766.1         523-1344
            1382-3196           AC104641.11        108920-110734       c
FEATURES             Location/Qualifiers
     source          1..3196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..3196
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /note="lysosomal associated membrane protein 3"
                     /db_xref="GeneID:27074"
                     /db_xref="HGNC:HGNC:14582"
                     /db_xref="MIM:605883"
     exon            1..128
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1330
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /note="lysosome-associated membrane glycoprotein 3;
                     DC-lysosome-associated membrane glycoprotein"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 3
                     precursor"
                     /protein_id="NP_055213.2"
                     /db_xref="CCDS:CCDS3242.1"
                     /db_xref="GeneID:27074"
                     /db_xref="HGNC:HGNC:14582"
                     /db_xref="MIM:605883"
                     /translation="MPRQLSAAAALFASLAVILHDGSQMRAKAFPETRDYSQPTAAAT
                     VQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITY
                     TLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTT
                     QPSNQTTLPATLSIALHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTVPGPTLAP
                     QPSSVKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGT
                     RKSNLLLNFQGGFVNLTFTKDEESYYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVG
                     HSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHFGNVDECSSDYTIVLPVIGAIVV
                     GLCLMGMGVYKIRLRCQSSGYQRI"
     exon            129..838
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            839..967
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1025
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1196
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..3196
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3178..3183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /note="hexamer: AATAAA"
     polyA_site      3196
                     /gene="LAMP3"
                     /gene_synonym="CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP;
                     LAMP-3; TSC403"
                     /note="major polyA site"
ORIGIN      
        1 acaggtaggt ttctctggca ccgattcggg gcctgcccgg acttcgccgc acgctgcaga
       61 acctcgccca gcgcccacca tgccccggca gctcagcgcg gcggccgcgc tcttcgcgtc
      121 cctggccgta attttgcacg atggcagtca aatgagagca aaagcatttc cagaaaccag
      181 agattattct caacctactg cagcagcaac agtacaggac ataaaaaaac ctgtccagca
      241 accagctaag caagcacctc accaaacttt agcagcaaga ttcatggatg gtcatatcac
      301 ctttcaaaca gcggccacag taaaaattcc aacaactacc ccagcgacta caaaaaacac
      361 tgcaaccacc agcccaatta cctacaccct ggtcacaacc caggccacac ccaacaactc
      421 acacacagct cctccagtta ctgaagttac agtcggccct agcttagccc cttattcact
      481 gccacccacc atcaccccac cagctcatac aactggaacc agttcatcaa ccgtcagcca
      541 cacaactggg aacaccactc aacccagtaa ccagaccacc cttccagcaa ctttatcgat
      601 agcactgcac aaaagcacaa ccggtcagaa gcctgttcaa cccacccatg ccccaggaac
      661 aacggcagct gcccacaata ccacccgcac agctgcacct gcctccacgg ttcctgggcc
      721 cacccttgca cctcagccat cgtcagtcaa gactggaatt tatcaggttc taaacggaag
      781 cagactctgt ataaaagcag agatggggat acagctgatt gttcaagaca aggagtcggt
      841 tttttcacct cggagatact tcaacatcga ccccaacgca acgcaagcct ctgggaactg
      901 tggcacccga aaatccaacc ttctgttgaa ttttcagggc ggatttgtga atctcacatt
      961 taccaaggat gaagaatcat attatatcag tgaagtggga gcctatttga ccgtctcaga
     1021 tccagagaca atttaccaag gaatcaaaca tgcggtggtg atgttccaga cagcagtcgg
     1081 gcattccttc aagtgcgtga gtgaacagag cctccagttg tcagcccacc tgcaggtgaa
     1141 aacaaccgat gtccaacttc aagcctttga ttttgaagat gaccactttg gaaatgtgga
     1201 tgagtgctcg tctgactaca caattgtgct tcctgtgatt ggggccatcg tggttggtct
     1261 ctgccttatg ggtatgggtg tctataaaat ccgcctaagg tgtcaatcat ctggatacca
     1321 gagaatctaa ttgttgcccg gggggaatga aaataatgga atttagagaa ctctttcatc
     1381 ccttccagga tggatgttgg gaaattccct cagagtgtgg gtccttcaaa caatgtaaac
     1441 caccatcttc tattcaaatg aagtgagtca tgtgtgattt aagttcaggc agcacatcaa
     1501 tttctaaata ctttttgttt attttatgaa agatatagtg agctgtttat tttctagttt
     1561 cctttagaat attttagcca ctcaaagtca acatttgaga tatgttgaat taacataata
     1621 tatgtaaagt agaataagcc ttcaaattat aaaccaaggg tcaattgtaa ctaatactac
     1681 tgtgtgtgca ttgaagattt tattttaccc ttgatcttaa caaagccttt gctttgttat
     1741 caaatggact ttcagtgctt ttactatctg tgttttatgg tttcatgtaa catacatatt
     1801 cctggtgtag cacttaactc cttttccact ttaaatttgt ttttgttttt tgagacggag
     1861 tttcactctt gtcacccagg ctggagtaca gtggcacgat ctcggcttat ggcaacctcc
     1921 gcctcccggg ttcaagtgat tctcctgctt cagcttcccg agtagctggg attacaggca
     1981 cacactacca cgcctggcta atttttgtat ttttattata gacggggttt caccatgttg
     2041 gccagactgg tcttgaactc ttgacctcag gtgatccacc cacctcagcc tcccaaagtg
     2101 ctgggattac aggcatgagc cattgcgccc ggccttaaat gtttttttta atcatcaaaa
     2161 agaacaacat atctcaggtt gtctaagtgt ttttatgtaa aaccaacaaa aagaacaaat
     2221 cagcttatat tttttatctt gatgactcct gctccagaat cgctagacta agaattaggt
     2281 ggctacagat ggtagaacta aacaataagc aagagacaat aataatggcc cttaattatt
     2341 aacaaagtgc cagagtctag gctaagcact ttatctatat ctcatttcat tctcacaact
     2401 tataggtgaa tgagtaaact gagacttaag ggaactgaat cacttaaatg tcacctggct
     2461 aactgatggc agagccagag cttgaattca tgttggtctg acatcaaggt ctttggtctt
     2521 ctccctacac caagttacct acaagaacaa tgacaccaca ctctgcctga aggctcacac
     2581 ctcataccag catacgctca ccttacaggg aaatgggttt atccaggatc atgagacatt
     2641 agggtagatg aaaggagagc tttgcagata acaaaatagc ctatccttaa taaatcctcc
     2701 actctctgga aggagactga ggggctttgt aaaacattag tcagttgctc atttttatgg
     2761 gattgcttag ctgggctgta aagatgaagg catcaaataa actcaaagta tttttaaatt
     2821 tttttgataa tagagaaact tcgctaacca actgttcttt cttgagtgta tagccccatc
     2881 ttgtggtaac ttgctgcttc tgcacttcat atccatattt cctattgttc actttattct
     2941 gtagagcagc ctgccaagaa ttttatttct gctgtttttt ttgctgctaa agaaaggaac
     3001 taagtcagga tgttaacaga aaagtccaca taaccctaga attcttagtc aaggaataat
     3061 tcaagtcagc ctagagacca tgttgacttt cctcatgtgt ttccttatga ctcagtaagt
     3121 tggcaaggtc ctgactttag tcttaataaa acattgaatt gtagtaaagg tttttgtaat
     3181 aaaaacttac tttgga
//
