LOCUS       NM_005561               2701 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens lysosomal associated membrane protein 1 (LAMP1), mRNA.
ACCESSION   NM_005561
VERSION     NM_005561.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Liu,W., Wang,Y., Liu,S., Zhang,X., Cao,X. and Jiang,M.
  TITLE     E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by
            Promoting LAMP-1 Proteasomal Degradation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2309560 (2024)
   PUBMED   39031743
  REMARK    GeneRIF: E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal
            Degradation by Promoting LAMP-1 Proteasomal Degradation.
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Ohashi,S., Takakura,D., Kobayashi,N., Tokuhisa,M., Ichikawa,Y. and
            Kawasaki,N.
  TITLE     Comparative Analysis of Site-Specific N-glycosylation of LAMP1 from
            Breast Cancer Tissues
  JOURNAL   J Biochem 175 (5), 561-572 (2024)
   PUBMED   38215735
  REMARK    GeneRIF: Comparative Analysis of Site-Specific N-glycosylation of
            LAMP1 from Breast Cancer Tissues.
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Ecard,J., Lian,Y.L., Divoux,S., Gouveia,Z., Vigne,E., Perez,F. and
            Boncompain,G.
  TITLE     Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the
            Golgi apparatus independently of their clathrin adaptor binding
            motif
  JOURNAL   Mol Biol Cell 35 (3), ar42 (2024)
   PUBMED   38231876
  REMARK    GeneRIF: Lysosomal membrane proteins LAMP1 and LIMP2 are segregated
            in the Golgi apparatus independently of their clathrin adaptor
            binding motif.
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Basbous,S., Dif,L., Dantzer,C., Di-Tommaso,S., Dupuy,J.W.,
            Bioulac-Sage,P., Raymond,A.A., Desdouets,C., Saltel,F. and
            Moreau,V.
  TITLE     Loss of RND3/RHOE controls entosis through LAMP1 expression in
            hepatocellular carcinoma
  JOURNAL   Cell Death Dis 15 (1), 46 (2024)
   PUBMED   38218945
  REMARK    GeneRIF: Loss of RND3/RHOE controls entosis through LAMP1
            expression in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Zhang,J., Zeng,W., Han,Y., Lee,W.R., Liou,J. and Jiang,Y.
  TITLE     Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition
            of the TMEM175 channel
  JOURNAL   Mol Cell 83 (14), 2524-2539 (2023)
   PUBMED   37390818
  REMARK    GeneRIF: Lysosomal LAMP proteins regulate lysosomal pH by direct
            inhibition of the TMEM175 channel.
REFERENCE   6  (bases 1 to 2701)
  AUTHORS   Schleutker,J., Haataja,L., Renlund,M., Puhakka,L., Viitala,J.,
            Peltonen,L. and Aula,P.
  TITLE     Confirmation of the chromosomal localization of human lamp genes
            and their exclusion as candidate genes for Salla disease
  JOURNAL   Hum Genet 88 (1), 95-97 (1991)
   PUBMED   1959930
REFERENCE   7  (bases 1 to 2701)
  AUTHORS   Carlsson,S.R. and Fukuda,M.
  TITLE     The polylactosaminoglycans of human lysosomal membrane
            glycoproteins lamp-1 and lamp-2. Localization on the peptide
            backbones
  JOURNAL   J Biol Chem 265 (33), 20488-20495 (1990)
   PUBMED   2243102
REFERENCE   8  (bases 1 to 2701)
  AUTHORS   Mattei,M.G., Matterson,J., Chen,J.W., Williams,M.A. and Fukuda,M.
  TITLE     Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2,
            are encoded by genes localized to chromosome 13q34 and chromosome
            Xq24-25, respectively
  JOURNAL   J Biol Chem 265 (13), 7548-7551 (1990)
   PUBMED   2332441
REFERENCE   9  (bases 1 to 2701)
  AUTHORS   Carlsson,S.R. and Fukuda,M.
  TITLE     Structure of human lysosomal membrane glycoprotein 1. Assignment of
            disulfide bonds and visualization of its domain arrangement
  JOURNAL   J Biol Chem 264 (34), 20526-20531 (1989)
   PUBMED   2584229
REFERENCE   10 (bases 1 to 2701)
  AUTHORS   Mane,S.M., Marzella,L., Bainton,D.F., Holt,V.K., Cha,Y.,
            Hildreth,J.E. and August,J.T.
  TITLE     Purification and characterization of human lysosomal membrane
            glycoproteins
  JOURNAL   Arch Biochem Biophys 268 (1), 360-378 (1989)
   PUBMED   2912382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136221.38.
            
            On Nov 23, 2018 this sequence version replaced NM_005561.3.
            
            Summary: The protein encoded by this gene is a member of a family
            of membrane glycoproteins.  This glycoprotein provides selectins
            with carbohydrate ligands.  It may also play a role in tumor cell
            metastasis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025335.1, J04182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332556.5/ ENSP00000333298.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL136221.38        89050-89306
            258-379             AL136221.38        98296-98417
            380-599             AL136221.38        101454-101673
            600-758             AL136221.38        102520-102678
            759-946             AL136221.38        111280-111467
            947-1072            AL136221.38        112156-112281
            1073-1139           AL136221.38        113215-113281
            1140-1310           AL136221.38        113368-113538
            1311-2701           AL136221.38        114093-115483
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..2701
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /note="lysosomal associated membrane protein 1"
                     /db_xref="GeneID:3916"
                     /db_xref="HGNC:HGNC:6499"
                     /db_xref="MIM:153330"
     exon            1..257
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1450
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /note="lysosome-associated membrane glycoprotein 1; CD107
                     antigen-like family member A; lysosome-associated membrane
                     protein 1"
                     /codon_start=1
                     /product="lysosome-associated membrane glycoprotein 1
                     precursor"
                     /protein_id="NP_005552.3"
                     /db_xref="CCDS:CCDS41909.1"
                     /db_xref="GeneID:3916"
                     /db_xref="HGNC:HGNC:6499"
                     /db_xref="MIM:153330"
                     /translation="MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMA
                     NFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTL
                     NFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQ
                     VHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPS
                     VDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTL
                     ELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGN
                     SYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMLIPIAVGGAL
                     AGLVLIVLIAYLVGRKRSHAGYQTI"
     exon            258..379
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            380..599
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            600..758
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            759..946
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1072
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1139
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1310
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..2701
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2435..2440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /note="hexamer: AATAAA"
     polyA_site      2456
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /note="major polyA site"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /note="hexamer: ATTAAA"
     polyA_site      2701
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
ORIGIN      
        1 acgtgacaag cgctgccggc cgcggtgtct tcttcgtgcc ggcgtcgcag tggccgggcc
       61 tcttgcgtct ggtaacgccg ctgtctctaa cgccagccct tggcgcccgc gccccgccac
      121 cgcagcgccc ggcagtccgc ggcccaaccg ccgcccgcgc ccccgctccc cgcaccgtac
      181 ccggccgcct cgcgccatgg cggcccccgg cagcgcccgg cgacccctgc tgctgctact
      241 gctgttgctg ctgctcggcc tcatgcattg tgcgtcagca gcaatgttta tggtgaaaaa
      301 tggcaacggg accgcgtgca taatggccaa cttctctgct gccttctcag tgaactacga
      361 caccaagagt ggccctaaga acatgacctt tgacctgcca tcagatgcca cagtggtgct
      421 caaccgcagc tcctgtggaa aagagaacac ttctgacccc agtctcgtga ttgcttttgg
      481 aagaggacat acactcactc tcaatttcac gagaaatgca acacgttaca gcgtccagct
      541 catgagtttt gtttataact tgtcagacac acaccttttc cccaatgcga gctccaaaga
      601 aatcaagact gtggaatcta taactgacat cagggcagat atagataaaa aatacagatg
      661 tgttagtggc acccaggtcc acatgaacaa cgtgaccgta acgctccatg atgccaccat
      721 ccaggcgtac ctttccaaca gcagcttcag ccggggagag acacgctgtg aacaagacag
      781 gccttcccca accacagcgc cccctgcgcc acccagcccc tcgccctcac ccgtgcccaa
      841 gagcccctct gtggacaagt acaacgtgag cggcaccaac gggacctgcc tgctggccag
      901 catggggctg cagctgaacc tcacctatga gaggaaggac aacacgacgg tgacaaggct
      961 tctcaacatc aaccccaaca agacctcggc cagcgggagc tgcggcgccc acctggtgac
     1021 tctggagctg cacagcgagg gcaccaccgt cctgctcttc cagttcggga tgaatgcaag
     1081 ttctagccgg tttttcctac aaggaatcca gttgaataca attcttcctg acgccagaga
     1141 ccctgccttt aaagctgcca acggctccct gcgagcgctg caggccacag tcggcaattc
     1201 ctacaagtgc aacgcggagg agcacgtccg tgtcacgaag gcgttttcag tcaatatatt
     1261 caaagtgtgg gtccaggctt tcaaggtgga aggtggccag tttggctctg tggaggagtg
     1321 tctgctggac gagaacagca tgctgatccc catcgctgtg ggtggtgccc tggcggggct
     1381 ggtcctcatc gtcctcatcg cctacctcgt cggcaggaag aggagtcacg caggctacca
     1441 gactatctag cctggtgcac gcaggcacag cagctgcagg ggcctctgtt cctttctctg
     1501 ggcttagggt cctgtcgaag gggaggcaca ctttctggca aacgtttctc aaatctgctt
     1561 catccaatgt gaagttcatc ttgcagcatt tactatgcac aacagagtaa ctatcgaaat
     1621 gacggtgtta attttgctaa ctgggttaaa tattttgcta actggttaaa cattaatatt
     1681 taccaaagta ggattttgag ggtgggggtg ctctctctga gggggtgggg gtgccgctgt
     1741 ctctgagggg tgggggtgcc gctgtctctg aggggtgggg gtgccgctct ctctgagggg
     1801 gtgggggtgc cgctttctct gagggggtgg gggtgccgct ctctctgagg gggtgggggt
     1861 gctgctctct ccgaggggtg gaatgccgct gtctctgagg ggtgggggtg ccgctctaaa
     1921 ttggctccat atcatttgag tttagggttc tggtgtttgg tttcttcatt ctttactgca
     1981 ctcagattta agccttacaa agggaaagcc tctggccgtc acacgtagga cgcatgaagg
     2041 tcactcgtgg tgaggctgac atgctcacac attacaacag tagagaggga acatcctaag
     2101 acagaggaac tccagagatg agtgtctgga gcgcttcagt tcagctttaa aggccaggac
     2161 gggccacacg tggctggcgg cctcgttcca gtggcggcac gtccttgggc gtctctaatg
     2221 tctgcagctc aagggctggc acttttttaa atataaaaat gggtgttatt tttattttta
     2281 tttgtaaagt gatttttggt cttctgttga cattcggggt gatcctgttc tgcgctgtgt
     2341 acaatgtgag atcggtgcgt tctcctgatg ttttgccgtg gcttggggat tgtacacggg
     2401 accagctcac gtaatgcatt gcctgtaaca atgtaataaa aagcctcttt ctttttgggg
     2461 tgggccttgt ccttctgtca gctaaaatgg gagctcatga gagaaggacg tcagggaaac
     2521 ggggttgagg gtggtctcgg tgcagagaga agggtgtcag ggaaacgggg ggtgagggtg
     2581 gtcttggtgc cagacgtagg gaatggtgtt gggagtggcc cgagtgcctg gcacagttgt
     2641 ctggttcatt catgtaacat gataattttt aaatcattaa aaaaattacc tttcatacag
     2701 a
//
