LOCUS       NM_006059               7455 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens laminin subunit gamma 3 (LAMC3), mRNA.
ACCESSION   NM_006059
VERSION     NM_006059.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7455)
  AUTHORS   Saarela,A., Timonen,O., Kirjavainen,J., Liu,Y., Silvennoinen,K.,
            Mervaala,E. and Kalviainen,R.
  TITLE     Novel LAMC3 pathogenic variant enriched in Finnish population
            causes malformations of cortical development and severe epilepsy
  JOURNAL   Epileptic Disord 26 (4), 498-509 (2024)
   PUBMED   38758065
  REMARK    GeneRIF: Novel LAMC3 pathogenic variant enriched in Finnish
            population causes malformations of cortical development and severe
            epilepsy.
REFERENCE   2  (bases 1 to 7455)
  AUTHORS   Lei,S.M., Liu,X., Xia,L.P., Ke,Y., Wei,L.W., Li,L. and Yin,F.J.
  TITLE     [Relationships between decreased LAMC3 and poor prognosis in
            ovarian cancer]
  JOURNAL   Zhonghua Fu Chan Ke Za Zhi 56 (7), 489-497 (2021)
   PUBMED   34304441
  REMARK    GeneRIF: [Relationships between decreased LAMC3 and poor prognosis
            in ovarian cancer].
REFERENCE   3  (bases 1 to 7455)
  AUTHORS   Urgen,B.M., Topac,Y., Ustun,F.S., Demirayak,P., Oguz,K.K.,
            Kansu,T., Saygi,S., Ozcelik,T., Boyaci,H. and Doerschner,K.
  TITLE     Homozygous LAMC3 mutation links to structural and functional
            changes in visual attention networks
  JOURNAL   Neuroimage 190, 242-253 (2019)
   PUBMED   29626609
  REMARK    GeneRIF: LAMC3 mutation causes structural and functional
            impairments in visual attention networks.
REFERENCE   4  (bases 1 to 7455)
  AUTHORS   Dorgau,B., Felemban,M., Sharpe,A., Bauer,R., Hallam,D., Steel,D.H.,
            Lindsay,S., Mellough,C. and Lako,M.
  TITLE     Laminin gamma3 plays an important role in retinal lamination,
            photoreceptor organisation and ganglion cell differentiation
  JOURNAL   Cell Death Dis 9 (6), 615 (2018)
   PUBMED   29795281
  REMARK    GeneRIF: These data demonstrate a unique temporal and spatial
            expression for laminins and reveal a novel role for laminin gamma3
            during human retinogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7455)
  AUTHORS   Zambonin,J.L., Dyment,D.A., Xi,Y., Lamont,R.E., Hartley,T.,
            Miller,E., Kerr,M., Boycott,K.M., Parboosingh,J.S. and
            Venkateswaran,S.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     A novel mutation in LAMC3 associated with generalized
            polymicrogyria of the cortex and epilepsy
  JOURNAL   Neurogenetics 19 (1), 61-65 (2018)
   PUBMED   29247375
  REMARK    GeneRIF: Study reports a novel mutation in LAMC3 associated with
            generalized polymicrogyria of the cortex and epilepsy.  Study
            identified a homozygous nonsense mutation in LAMC3: c.3190C>T
            (p.Gln1064*).
REFERENCE   6  (bases 1 to 7455)
  AUTHORS   McArthur,C.P., Wang,Y., Heruth,D. and Gustafson,S.
  TITLE     Amplification of extracellular matrix and oncogenes in
            tat-transfected human salivary gland cell lines with expression of
            laminin, fibronectin, collagens I, III, IV, c-myc and p53
  JOURNAL   Arch Oral Biol 46 (6), 545-555 (2001)
   PUBMED   11311202
REFERENCE   7  (bases 1 to 7455)
  AUTHORS   Cserhalmi-Friedman,P.B., Olson,P.F., Koch,M., Champliaud,M.F.,
            Brunken,W.J., Burgeson,R.E. and Christiano,A.M.
  TITLE     Structural analysis and mutation detection strategy for the human
            LAMC3 gene
  JOURNAL   Biochem Biophys Res Commun 280 (1), 39-44 (2001)
   PUBMED   11162474
REFERENCE   8  (bases 1 to 7455)
  AUTHORS   Koch,M., Olson,P.F., Albus,A., Jin,W., Hunter,D.D., Brunken,W.J.,
            Burgeson,R.E. and Champliaud,M.F.
  TITLE     Characterization and expression of the laminin gamma3 chain: a
            novel, non-basement membrane-associated, laminin chain
  JOURNAL   J Cell Biol 145 (3), 605-618 (1999)
   PUBMED   10225960
REFERENCE   9  (bases 1 to 7455)
  AUTHORS   Orian-Rousseau,V., Aberdam,D., Rousselle,P., Messent,A.,
            Gavrilovic,J., Meneguzzi,G., Kedinger,M. and Simon-Assmann,P.
  TITLE     Human colonic cancer cells synthesize and adhere to laminin-5.
            Their adhesion to laminin-5 involves multiple receptors among which
            is integrin alpha2beta1
  JOURNAL   J Cell Sci 111 (Pt 14), 1993-2004 (1998)
   PUBMED   9645947
REFERENCE   10 (bases 1 to 7455)
  AUTHORS   Burgeson,R.E., Chiquet,M., Deutzmann,R., Ekblom,P., Engel,J.,
            Kleinman,H., Martin,G.R., Meneguzzi,G., Paulsson,M., Sanes,J. et
            al.
  TITLE     A new nomenclature for the laminins
  JOURNAL   Matrix Biol 14 (3), 209-211 (1994)
   PUBMED   7921537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF041835.1, AK075536.1,
            AB208887.1, AL355872.15, AL551493.3, BX327938.1, AL157938.22 and
            R45355.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006059.3.
            
            Summary: Laminins, a family of extracellular matrix glycoproteins,
            are the major noncollagenous constituent of basement membranes.
            They have been implicated in a wide variety of biological processes
            including cell adhesion, differentiation, migration, signaling,
            neurite outgrowth and metastasis. Laminins are composed of 3 non
            identical chains: laminin alpha, beta and gamma (formerly A, B1,
            and B2, respectively) and they form a cruciform structure
            consisting of 3 short arms, each formed by a different chain, and a
            long arm composed of all 3 chains. Each laminin chain is a
            multidomain protein encoded by a distinct gene. Several isoforms of
            each chain have been described. Different alpha, beta and gamma
            chain isomers combine to give rise to different heterotrimeric
            laminin isoforms which are designated by Arabic numerals in the
            order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is
            laminin 1. The biological functions of the different chains and
            trimer molecules are largely unknown, but some of the chains have
            been shown to differ with respect to their tissue distribution,
            presumably reflecting diverse functions in vivo. This gene encodes
            the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most
            similar to the gamma 1 chain, and contains all the 6 domains
            expected of the gamma chain. It is a component of laminin 12. The
            gamma 3 chain is broadly expressed in skin, heart, lung, and the
            reproductive tracts. In skin, it is seen within the basement
            membrane of the dermal-epidermal junction at points of nerve
            penetration. Gamma 3 is also a prominent element of the apical
            surface of ciliated epithelial cells of lung, oviduct, epididymis,
            ductus deferens, and seminiferous tubules. The distribution of
            gamma 3-containing laminins along ciliated epithelial surfaces
            suggests that the apical laminins are important in the
            morphogenesis and structural stability of the ciliated processes of
            these cells. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361069.9/ ENSP00000354360.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AF041835.1         58-59
            3-573               AK075536.1         3-573
            574-1258            AF041835.1         630-1314
            1259-1671           AB208887.1         632-1044
            1672-1672           AL355872.15        10798-10798
            1673-1972           AB208887.1         1046-1345
            1973-2348           AF041835.1         2029-2404
            2349-2373           AL551493.3         75-99
            2374-3284           AB208887.1         1747-2657
            3285-3734           BX327938.1         254-703
            3735-4338           AB208887.1         3108-3711
            4339-4889           AF041835.1         4431-4981
            4890-5964           AL157938.22        2042-3116
            5965-6041           R45355.1           10-86               c
            6042-7455           AL157938.22        3194-4607
FEATURES             Location/Qualifiers
     source          1..7455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.12"
     gene            1..7455
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /note="laminin subunit gamma 3"
                     /db_xref="GeneID:10319"
                     /db_xref="HGNC:HGNC:6494"
                     /db_xref="MIM:604349"
     exon            1..414
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..4769
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /note="laminin-12 subunit gamma; laminin-14 subunit gamma;
                     laminin-15 subunit gamma; laminin, gamma 3"
                     /codon_start=1
                     /product="laminin subunit gamma-3 precursor"
                     /protein_id="NP_006050.3"
                     /db_xref="CCDS:CCDS6938.1"
                     /db_xref="GeneID:10319"
                     /db_xref="HGNC:HGNC:6494"
                     /db_xref="MIM:604349"
                     /translation="MAAAALLLGLALLAPRAAGAGMGACYDGAGRPQRCLPVFENAAF
                     GRLAQASHTCGSPPEDFCPHVGAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTW
                     WQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPY
                     QFYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYN
                     FEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGH
                     ASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSE
                     ECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLH
                     LQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDTCDPRSGRCPC
                     KENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGA
                     EGWWARSVGGSEHPPQWSPNGVLLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPP
                     GDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFH
                     FQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQ
                     FCESCAPGYKREMPQGGPYASCVPCTCNQHGTCDPNTGICVCSHHTEGPSCERCLPGF
                     YGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPL
                     GLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALA
                     PRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGC
                     RSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGA
                     ASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKAR
                     LTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLPGAREAFLEQMMSLEGAVK
                     AAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGP
                     SQPTKWSHLATEARALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQ
                     RDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYLALLASPGALPQK
                     SRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQ
                     ASSSVQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTK
                     QAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLTSQTQAT
                     LQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGS
                     LDTHQAPAQALNETQWALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQGFESDLAE
                     IRADKQNLEAILHSLPENCASWQ"
     exon            415..719
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            720..850
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1017
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1206
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1324
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1423
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1560
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1671
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1864
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1980
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2199
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2388
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2634
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2788
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2931
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3110
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3252
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3458
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3535
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3670
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3818
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..3968
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4071
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4271
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4418
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4518
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..7455
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5009..5014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /note="hexamer: CATAAA"
     polyA_site      5043
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /note="major polyA site"
     regulatory      6020..6025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /note="hexamer: AATAAA"
     polyA_site      6041
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /note="major polyA site"
     regulatory      7435..7440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
                     /note="hexamer: ATTAAA"
     polyA_site      7455
                     /gene="LAMC3"
                     /gene_synonym="OCCM"
ORIGIN      
        1 gagcggggcc ggcagagcgc gcggcgtcgg tgcccttgac catggcggcg gctgcgcttc
       61 tgctggggct ggcgctgctg gcaccgcggg cggccggcgc gggcatgggc gcgtgctatg
      121 acggcgcagg gcgcccgcag cgctgcctgc cggtgttcga gaacgcggcg tttgggcggc
      181 tcgcccaggc ctcgcacacg tgcggcagcc cgcccgagga cttctgtccc cacgtgggcg
      241 ccgcgggcgc gggggctcat tgccagcgct gcgacgccgc cgacccccag cgccaccaca
      301 acgcctccta cctcaccgac ttccacagcc aggacgagag cacctggtgg cagagcccgt
      361 ccatggcctt cggcgtgcag taccccacct cggtcaacat caccctccgc ctagggaagg
      421 cttatgagat cacgtatgtg aggctgaagt tccacaccag tcgccctgag agctttgcca
      481 tctacaagcg cagccgcgcc gacggcccat gggagcccta ccagttctac agcgcctcct
      541 gccagaagac ctacggccgg cccgagggcc agtacctgcg ccccggcgag gacgagcgcg
      601 tggccttctg cacctctgag ttcagcgaca tctccccgct gagtggcggc aacgtggcct
      661 tctccaccct ggagggccgg cccagcgcct acaacttcga ggagagccct gggctgcagg
      721 agtgggtcac cagcaccgaa ctcctcatct ctctagaccg gctcaacacg tttggggacg
      781 acatcttcaa ggaccccaag gtgctccagt cctactatta tgccgtgtcc gacttctctg
      841 tgggcggcag gtgcaagtgc aacgggcatg ccagcgagtg cggccccgac gtggcaggcc
      901 agttggcctg ccggtgccag cacaacacca ccggcacaga ctgtgagcgc tgcctgccct
      961 tcttccagga ccgcccgtgg gcccggggca ccgccgaggc tgcccacgag tgtctgccct
     1021 gcaactgcag tggccgctcc gaggaatgca cgtttgatcg ggagctcttc cgcagcacag
     1081 gccacggcgg gcgctgtcac cactgccgtg accacacagc tgggccacac tgtgagcgct
     1141 gtcaggagaa tttctatcac tgggacccgc ggatgccatg ccagccctgt gactgccagt
     1201 cggcaggctc cctacacctc cagtgcgatg acacaggcac ctgcgcctgc aagcccacgg
     1261 tgactggctg gaagtgtgac cgctgtctgc ccgggttcca ctcgctcagt gagggaggct
     1321 gcagaccctg cacttgcaat cccgctggca gcctggacac ctgtgacccc cgcagtgggc
     1381 gctgcccctg caaagagaat gtggaaggca acctatgtga cagatgtcgc ccggggacct
     1441 ttaacctgca gccccacaat ccagctggct gcagcagctg tttctgctat ggccactcca
     1501 aggtgtgcgc gtccactgcc cagttccagg tgcatcacat cctcagcgat ttccaccagg
     1561 gagccgaagg ctggtgggcc agaagtgtgg ggggctctga gcacccccca caatggagcc
     1621 caaatggggt cctcctgagc ccagaagacg aggaggagct cacagcacca gagaagttcc
     1681 tgggagacca gcggttcagc tatgggcagc ccctcatact gaccttccgg gtgccccccg
     1741 gggactcccc actccctgta cagctgaggc tggaagggac aggcttggcc ctgtccctga
     1801 ggcactctag cctgtctggc ccccaggatg ccgggcatcc cagggaggta gagctcaggt
     1861 tccacctgca ggagacctcc gaggacgtgg cccctccact gccccccttc cacttccagc
     1921 ggctcctcgc caacctgacc agcctccgcc tccgcgtcag tcccggcccc agccctgccg
     1981 gtccagtgtt cctgactgag gtccggctca catccgcccg gccagggctt tccccgccag
     2041 cctcctgggt ggagatttgt tcatgtccca ctggctacac gggccagttc tgtgaatcct
     2101 gtgctccggg atacaagagg gagatgccac aggggggtcc ctatgccagc tgtgtcccct
     2161 gcacctgtaa ccagcatggc acctgtgacc ccaacacagg gatctgtgtc tgcagccacc
     2221 ataccgaggg cccatcctgt gaacgctgtt tgccaggttt ctatggcaac cctttcgcgg
     2281 gccaagccga cgactgccag ccctgtccct gccctggcca gtcggcctgt acgaccatcc
     2341 cagagagccg ggaggtggtg tgtacccact gccccccggg ccagagaggg cggcgctgtg
     2401 aggtctgtga tgatggcttt tttggggacc cgctggggct ctttgggcac ccccagccct
     2461 gccaccagtg ccagtgtagc gggaacgtgg accccaatgc cgtgggcaac tgtgaccccc
     2521 tgtctggcca ctgcctgcgc tgcctgcaca acaccacggg tgaccactgt gagcactgtc
     2581 aggaaggctt ctacgggagc gccctggccc ctcgacccgc agacaaatgc atgccttgca
     2641 gctgtcaccc acagggctcg gtcagtgagc agatgccctg cgacccagtg acaggccaat
     2701 gctcctgcct gcctcatgtg actgcacggg actgcagccg ctgctaccct ggcttcttcg
     2761 acctccagcc tgggaggggc tgccggagct gcaagtgtca cccactgggc tcccaggagg
     2821 accagtgcca tcccaagact ggacagtgca cctgccgccc aggtgtcaca ggccaggcct
     2881 gtgacaggtg ccagctgggt ttcttcggct tctccatcaa gggctgccgg gcctgcaggt
     2941 gctccccact gggcgctgcc tcggcccagt gccacgagaa cggcacatgc gtgtgcaggc
     3001 ctggcttcga gggctacaaa tgtgaccgct gccacgacaa cttcttcctc acggcagacg
     3061 gcacacactg ccagcaatgt ccgtcctgct acgccctggt gaaggaggag gcagccaagc
     3121 tgaaggccag actgactttg acggaggggt ggctccaagg gtccgactgt ggcagtccct
     3181 ggggaccact agacattctg ctgggagagg ccccaagggg ggacgtctac cagggccatc
     3241 acctgcttcc aggggctcgg gaagccttcc tggagcagat gatgagcctc gagggtgctg
     3301 tcaaggccgc ccgggagcag ctgcagaggc tgaacaaggg tgcccgctgt gcccaggccg
     3361 gatcccagaa gacctgcacc cagctggcag acctggaggc agtgctggag tcctcggaag
     3421 aggagattct gcatgcagct gccattctcg cgtctctgga gattcctcag gaaggtccca
     3481 gtcagccgac caaatggagc cacctggcca cagaggcccg tgccctcgcc aggagccaca
     3541 gagacaccgc caccaagatc gcagccactg cttggagggc cctgctcgcc tccaacacca
     3601 gctacgcgct tctctggaat ctgctggagg gaagggtggc cctagagacc cagcgggacc
     3661 tggaggacag gtaccaggag gtccaggcgg cccagaaagc actgaggacg gctgtggcag
     3721 aggtgctgcc tgaagcggaa agcgtgttgg ccaccgtgca gcaagttggc gcagatacag
     3781 ccccgtacct ggccttgctg gcttccccgg gagctctgcc tcagaagtcc cgggctgaag
     3841 acctgggcct gaaggcgaag gccctggaga agacagttgc atcatggcag cacatggcca
     3901 ctgaggctgc ccgaaccctc cagactgctg cccaggcgac gctacggcaa acagaacccc
     3961 tcacaaagct gcaccaggag gccagagccg ccctgaccca ggcttcctca tctgtccagg
     4021 ctgcgacagt gactgtcatg ggagccagga ctctgctggc tgatctggaa ggaatgaagc
     4081 tgcagtttcc ccggcccaag gaccaggcgg cattgcagag gaaggcagac tccgtcagtg
     4141 acagactcct tgcagacacg agaaagaaga ccaagcaggc ggagaggatg ctgggaaacg
     4201 cggcccctct ttcctccagt gccaagaaga agggcagaga agcagaggtg ttggccaagg
     4261 acagtgccaa gcttgccaag gccttgctga gggagcggaa acaggcgcac cgccgtgcca
     4321 gcaggctcac cagccagacg caagccacgc tccaacaggc gtcccagcag gtgctggcgt
     4381 ctgaagcacg cagacaggag ctggaggaag ctgagcgggt gggtgctggg ctgagcgaga
     4441 tggagcagca gatccgggaa tcgcgtatct cactggagaa ggacatcgag accttgtcag
     4501 agctgcttgc caggctgggg tcgctggaca cccatcaagc cccagcccag gccctgaacg
     4561 agactcagtg ggcactagaa cgcctgaggc tgcagctggg ctccccgggg tccttgcaga
     4621 ggaaactcag tctgctggag caggaatccc agcagcagga gctgcagatc cagggcttcg
     4681 agagtgacct cgccgagatc cgcgccgaca aacagaacct ggaggccatt ctgcacagcc
     4741 tgcccgagaa ctgtgccagc tggcagtgag ggctgcccag atccccggca cacactcccc
     4801 cacctgctgt ttacatgacc cagggggtgc acactacccc acaggtgtgc ccatacagac
     4861 attccccgga gccggctgct gtgaactcgc ccccgtgtgg atagtcactc cctgccgatt
     4921 ctgtctgtgg cttcttccct gccagcagga ctgagtgtgc gtacccagtt cacctggaca
     4981 tgagtgcaca ctctcacccc tgcacatgca taaacgggca caccccagtg tcaataacat
     5041 acacacgtga gggtgcatgt ctgtgtgtat gacccacacg tgttcaagtc taatccatcc
     5101 agtcagcagc ttacggtcca cacacattac agtccacagc tgttgtgaga gccacctgtg
     5161 tgctggacac cctctggatg ttgggcaagt tgttacatga gatgccctgg ggtgctacat
     5221 ccactcactc cagatagcag ggaggtctca gcagatctgc agagatcaag ggggtcagca
     5281 acagccaaag cccctagtcc cagagctggc tgccctctgt ttcacagcag ctccctgacc
     5341 tgtgttgctg cgtgcactcc ctacagctcg acacagccag gggaccaaca ggccaagaaa
     5401 tgcaagatcc cgggagggtt cttagcagca gaatctgagg cccagagacc ctgaggccgt
     5461 ggccaggcct gctagtctgg ctagagcaag gcccattcct ggcgggggtg tcattgcctt
     5521 caccggacgc ttccctctca gggtcctggg actgcaccag atgccctgag ggaatggccc
     5581 accctggcct gtacccactt cagcctgtga tctatccaaa gagccaggcc caaaagcgcc
     5641 taggtcaggg tgctcaggct accaggagca cgcctctgtg cccccggcaa cccagttgac
     5701 ctttaattga cgctttccag accagccctg cggcaccact tgccatgcgg gaggccacca
     5761 gggtgtgcaa gcctggctgc cattccagtc tgtcctgtct gggaatcgcc ctgtggccag
     5821 gcccgcatgc tggcctctgc ccaggactcc tcagcatttc ctcttggcat ccctcccctc
     5881 tcccagaccc tcttccagca gatggcaagg cctcggcatt gggaagtcag gcacctctgc
     5941 gggcccagcc ccctcccgtg gctcccctga caggggcagg ggtagggcag cagcacagac
     6001 caattccgtt gaacgtggaa ataaaggacc ctttcactgg gcagggtggt gtgcctcacc
     6061 ctccccggct ggtgggcagc cagggccctg gctgtgggtg tgcatatgac acacctagta
     6121 ggtggccagc atgtggaccg gacgttggta ggaaggtggc aaaagccgag ctcgtggctg
     6181 ggccagtacc tcccattaga gggctttgct ggggttgtgt gatcacaggt acctaccctg
     6241 tcctctcagg cacttaccac gtaaagccta ggagctggtg agttggaggg gtggggtgcg
     6301 gagaggccct cagctgacct ctggttcagg ctcgagacga actcacagcc aagtgtccga
     6361 ggatggtgag gagcagggag gggcgccatc caggaggggg atggtgtggg tggggccttg
     6421 aagggtgggg aggcagagaa ggaagcattc caggcaagag ggtggacaac agtccggggc
     6481 ccgcagggtt ggggctcggc cagcttgcat cactccagga ccccaggttg aatggggtgg
     6541 gatgttggag ctgctcagtc agggctcttg gccgcaggcc tcaaacccct cctgaggtgg
     6601 tttcagcaga aaaggggtgt tgggagggtc gcttggaacc ctggagtaaa aacggctgcc
     6661 acgtgttgga gatagcctag ggaggggagc ctgaggcttc cgggataggt tggcttccct
     6721 cttcccccct cccgcctctc ttcttggtct gtgtctctgc tctcctctcc tgtatctgct
     6781 tcgttctttt ctctttattt attgattttt tttgagatgg agtctcgctc tgttgcccag
     6841 gctggagtgc agtggcatga tctctgccca ctgcatcctc cacctcccag gtttaagcaa
     6901 ttctcctgcc tcagcctccc gagtagctag gactacaggt gcttgccacc atgcccagct
     6961 aattttggta tttttagtag agacagggtt tcaccacgtt ggtcaggctg gtctcaaact
     7021 cctgacctca gatgatatac ctgcattggc ctcttaaagt tctgggattt caggcatgag
     7081 ccactgcaac cggcccattc ttttctcttt gcagagtggc tttctttgtt tttcttgtgc
     7141 ctgataggag aggacaccca cccctaccgc catcccccat aatggcccca ggtgtacatg
     7201 tcatcaggtc cagtgcttgc aagagacaag ctggtgactc tgtcctgatt ccagcttctc
     7261 agcttaggtg aagtcccacc aacccccgtt caggataatg aggatctctg gatctaaggc
     7321 caataatgga tgaccggtgc caccccccaa cctaatggga gatggtgttc agagaagagg
     7381 tgtgctcctc cacagaaaac tgtaaaatca aggctacggt gggggattga catgattaaa
     7441 ctgagctagg agtga
//
