LOCUS       NM_007356               5861 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens laminin subunit beta 4 (LAMB4), transcript variant 1,
            mRNA.
ACCESSION   NM_007356 XM_209857
VERSION     NM_007356.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5861)
  AUTHORS   Goletz,S., Pigors,M., Lari,T.R., Hammers,C.M., Wang,Y.,
            Emtenani,S., Aumailley,M., Holtsche,M.M., Stang,F.H., Weyers,I.,
            Konig,I.R., Has,C., Radzimski,C., Komorowski,L., Zillikens,D. and
            Schmidt,E.
  TITLE     Laminin beta4 is a constituent of the cutaneous basement membrane
            zone and additional autoantigen of anti-p200 pemphigoid
  JOURNAL   J Am Acad Dermatol 90 (4), 790-797 (2024)
   PUBMED   37992812
  REMARK    GeneRIF: Laminin beta4 is a constituent of the cutaneous basement
            membrane zone and additional autoantigen of anti-p200 pemphigoid.
REFERENCE   2  (bases 1 to 5861)
  AUTHORS   Coble,J.L., Sheldon,K.E., Yue,F., Salameh,T.J., Harris,L.R. III,
            Deiling,S., Ruggiero,F.M., Eshelman,M.A., Yochum,G.S., Koltun,W.A.,
            Gerhard,G.S. and Broach,J.R.
  TITLE     Identification of a rare LAMB4 variant associated with familial
            diverticulitis through exome sequencing
  JOURNAL   Hum Mol Genet 26 (16), 3212-3220 (2017)
   PUBMED   28595269
  REMARK    GeneRIF: We identified a rare single nucleotide variant in the
            laminin beta 4 gene (LAMB4) that segregated with familial
            diverticulitis in a dominant pattern and causes a damaging missense
            substitution (D435N). Targeted sequencing of LAMB4 in 148
            non-familial and unrelated sporadic diverticulitis patients
            identified two additional rare variants in the gene.
REFERENCE   3  (bases 1 to 5861)
  AUTHORS   Choi,M.R., An,C.H., Yoo,N.J. and Lee,S.H.
  TITLE     Laminin gene LAMB4 is somatically mutated and expressionally
            altered in gastric and colorectal cancers
  JOURNAL   APMIS 123 (1), 65-71 (2015)
   PUBMED   25257191
  REMARK    GeneRIF: Loss of LAMB4 expression was identified in 17-32% of the
            GC and CRC. Of note, the loss expression was more common in the
            cancers with LAMB4 mutation or those with MSI-H.
REFERENCE   4  (bases 1 to 5861)
  AUTHORS   Amin,N., Byrne,E., Johnson,J., Chenevix-Trench,G., Walter,S.,
            Nolte,I.M., Vink,J.M., Rawal,R., Mangino,M., Teumer,A., Keers,J.C.,
            Verwoert,G., Baumeister,S., Biffar,R., Petersmann,A., Dahmen,N.,
            Doering,A., Isaacs,A., Broer,L., Wray,N.R., Montgomery,G.W.,
            Levy,D., Psaty,B.M., Gudnason,V., Chakravarti,A., Sulem,P.,
            Gudbjartsson,D.F., Kiemeney,L.A., Thorsteinsdottir,U.,
            Stefansson,K., van Rooij,F.J., Aulchenko,Y.S., Hottenga,J.J.,
            Rivadeneira,F.R., Hofman,A., Uitterlinden,A.G., Hammond,C.J.,
            Shin,S.Y., Ikram,A., Witteman,J.C., Janssens,A.C., Snieder,H.,
            Tiemeier,H., Wolfenbuttel,B.H., Oostra,B.A., Heath,A.C.,
            Wichmann,E., Spector,T.D., Grabe,H.J., Boomsma,D.I., Martin,N.G.
            and van Duijn,C.M.
  CONSRTM   kConFab Investigators
  TITLE     Genome-wide association analysis of coffee drinking suggests
            association with CYP1A1/CYP1A2 and NRCAM
  JOURNAL   Mol Psychiatry 17 (11), 1116-1129 (2012)
   PUBMED   21876539
REFERENCE   5  (bases 1 to 5861)
  AUTHORS   Maestrini,E., Pagnamenta,A.T., Lamb,J.A., Bacchelli,E., Sykes,N.H.,
            Sousa,I., Toma,C., Barnby,G., Butler,H., Winchester,L.,
            Scerri,T.S., Minopoli,F., Reichert,J., Cai,G., Buxbaum,J.D.,
            Korvatska,O., Schellenberg,G.D., Dawson,G., de Bildt,A.,
            Minderaa,R.B., Mulder,E.J., Morris,A.P., Bailey,A.J. and
            Monaco,A.P.
  CONSRTM   IMGSAC
  TITLE     High-density SNP association study and copy number variation
            analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4
            gene region in autism susceptibility
  JOURNAL   Mol Psychiatry 15 (9), 954-968 (2010)
   PUBMED   19401682
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5861)
  AUTHORS   Schonberger,J., Kuhler,L., Martins,E., Lindner,T.H.,
            Silva-Cardoso,J. and Zimmer,M.
  TITLE     A novel locus for autosomal-dominant dilated cardiomyopathy maps to
            chromosome 7q22.3-31.1
  JOURNAL   Hum Genet 118 (3-4), 451-457 (2005)
   PUBMED   16228230
REFERENCE   7  (bases 1 to 5861)
  AUTHORS   Dry,K., Kenwrick,S., Rosenthal,A. and Platzer,M.
  TITLE     The complete sequence of the human locus for NgCAM-related cell
            adhesion molecule reveals a novel alternative exon in chick and man
            and conserved genomic organization for the L1 subfamily
  JOURNAL   Gene 273 (1), 115-122 (2001)
   PUBMED   11483367
REFERENCE   8  (bases 1 to 5861)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005048.2, DA859196.1, AF028816.1 and BC045172.2.
            
            On Nov 23, 2018 this sequence version replaced NM_007356.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Both variants 1 and
            2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388781.8/ ENSP00000373433.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC005048.2         124404-124408       c
            6-570               DA859196.1         2-566
            571-3631            AF028816.1         562-3622
            3632-5235           BC045172.2         621-2224
            5236-5861           AF028816.1         5227-5852
FEATURES             Location/Qualifiers
     source          1..5861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..5861
                     /gene="LAMB4"
                     /note="laminin subunit beta 4"
                     /db_xref="GeneID:22798"
                     /db_xref="HGNC:HGNC:6491"
                     /db_xref="MIM:616380"
     exon            1..56
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            57..123
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..5375
                     /gene="LAMB4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; laminin beta-1-related protein"
                     /codon_start=1
                     /product="laminin subunit beta-4 isoform 1 precursor"
                     /protein_id="NP_031382.2"
                     /db_xref="CCDS:CCDS34732.1"
                     /db_xref="GeneID:22798"
                     /db_xref="HGNC:HGNC:6491"
                     /db_xref="MIM:616380"
                     /translation="MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLM
                     ASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREK
                     KWWQSENGLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFA
                     KDCATSFPNITSGQAQGVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIENPYSPYIQ
                     DLVTLTNLRINFTKLHTLGDALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRP
                     MQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSC
                     NSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYAC
                     IPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPL
                     GCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPCDC
                     DIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLNFYLYEAEEATTLQGLAP
                     LGSETFGQSPAVHVVLGEPVPGNPVTWTGPGFARVLPGAGLRFAVNNIPFPVDFTIAI
                     HYETQSAADWTVQIVVNPPGGSEHCIPKTLQSKPQSFALPAATRIMLLPTPICLEPDV
                     QYSIDVYFSQPLQGESHAHSHVLVDSLGLIPQINSLENFCSKQDLDEYQLHNCVEIAS
                     AMGPQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRC
                     CDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFG
                     FPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCP
                     DDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCAC
                     NNNIDVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVS
                     PMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQ
                     SSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGM
                     CRCREGVSGQRCDRCARGHSQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANME
                     DKRETLPVCEADFKDLRGNVSEIERILKHPVFPSGKFLKVKDYHDSVRRQIMQLNEQL
                     KAVYEFQDLKDTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHISSS
                     AEKKINETSSTINTSANTRNDLLTILDTLTSKGNLSLERLKQIKIPDIQILNEKVCGD
                     PGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTLSTNALQKAQEAKSIIRNLDKQV
                     RGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVKNFLLEENV
                     PPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEEADGAQKL
                     LVKAKAAEKAANILLNLDKTLNQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQ
                     TREMKSELELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVE
                     LKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRITDLERKIQDLNL
                     SRQAKADQLRILEDQVVAIKNEIVEQEKKYARCYS"
     exon            124..281
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            282..417
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            418..491
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            492..680
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            681..744
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            745..959
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1080
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1269
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1449
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1559
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1639
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1790
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1976
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2092
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2213
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2391
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2535
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2767
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2925
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3150
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3371
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3468
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3844
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4005
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..4211
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4415
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            4416..4560
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4768
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..4907
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            4908..5081
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5235
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     exon            5236..5861
                     /gene="LAMB4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5839..5844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMB4"
                     /note="hexamer: AATAAA"
     polyA_site      5861
                     /gene="LAMB4"
                     /note="major polyA site"
ORIGIN      
        1 gtcttcacat gccccgtttg ctgcctgaac ctctccacaa agactcccag atcctgtaga
       61 attgaattta atcatctcct gacaaaagaa tgcaatttca actgaccctt tttttgcacc
      121 ttgggtggct cagttactca aaagctcaag atgactgcaa caggggtgcc tgtcatccca
      181 ccactggtga tctcctggtg ggcaggaaca cgcagcttat ggcttcttct acctgtgggc
      241 tgagcagagc ccagaaatac tgcatcctca gttacctgga gggggaacaa aaatgcttca
      301 tctgtgactc tagatttcca tatgatccgt atgaccaacc caacagccac accattgaga
      361 atgtcattgt aagttttgaa ccagacagag aaaagaaatg gtggcaatct gaaaatggtc
      421 ttgatcatgt cagcatcaga ctggacttag aggcattatt tcggttcagc caccttatcc
      481 tgacctttaa gacttttcgg cctgctgcaa tgttagttga acgttccaca gactatggac
      541 acaactggaa agtgttcaaa tattttgcaa aagactgtgc cacttccttt cctaacatca
      601 catctggcca ggcccaggga gtgggagaca ttgtttgtga ctccaaatac tcggatattg
      661 aaccctcaac aggtggagag gttgttttaa aagttttgga tcccagtttt gaaattgaaa
      721 acccttatag cccctacatc caagaccttg tgacattgac aaacctgagg ataaacttta
      781 ccaagctcca cacccttggg gatgctttgc ttggaaggag gcaaaatgat tcccttgata
      841 aatactacta tgctctgtac gagatgattg ttcggggaag ctgcttttgc aatggccatg
      901 ctagcgaatg tcgccctatg cagaagatgc ggggagatgt tttcagccct cctggaatgg
      961 ttcacggtca gtgtgtgtgt cagcacaata cagatggtcc gaactgtgag agatgcaagg
     1021 acttcttcca ggatgctcct tggaggccag ctgcagacct ccaggacaac gcttgcagat
     1081 cgtgcagctg taatagccac tccagccgct gtcactttga catgactacg tacctggcaa
     1141 gcggtggcct cagcgggggc gtgtgtgaag actgccagca caacactgag gggcagcact
     1201 gcgaccgctg cagacccctc ttctacaggg acccgctcaa gaccatctca gatccctacg
     1261 cgtgcattcc ttgtgaatgt gaccccgatg ggaccatatc tggtggcatt tgtgtgagcc
     1321 actctgatcc tgccttaggg tctgtggccg gccagtgcct ttgtaaagag aacgtggaag
     1381 gagccaaatg cgaccagtgc aaacccaacc actacggact aagcgccacc gaccccctgg
     1441 gctgccagcc ctgcgactgt aacccccttg ggagtctgcc attcttgacc tgtgatgtgg
     1501 atacaggcca atgcttgtgc ctgtcatatg tcaccggagc acactgcgaa gaatgcactg
     1561 ttggatactg gggcctggga aatcatctcc atgggtgttc tccctgtgac tgtgatattg
     1621 gaggtgctta ttctaacgtg tgctcaccca agaatgggca gtgtgaatgc cgcccacatg
     1681 tcactggccg tagctgctct gaaccagccc ctggctactt ctttgctcct ttgaatttct
     1741 atctctacga ggcagaggaa gccacaacac tccaaggact ggcgcctttg ggctcggaga
     1801 cgtttggcca gagtcctgct gttcacgttg ttttaggaga gccagttcct gggaaccctg
     1861 ttacatggac tggacctgga tttgccaggg ttctccctgg ggctggcttg agatttgctg
     1921 tcaacaacat tccctttcct gtggacttca ccattgccat tcactatgaa acccagtctg
     1981 cagctgactg gactgtccag attgtggtga acccccctgg agggagtgag cactgcatac
     2041 ccaagactct acagtcaaag cctcagtctt ttgccttacc agcggctacg agaatcatgc
     2101 tgcttcccac acccatctgt ttagaaccag atgtacaata ttccatagat gtctattttt
     2161 ctcagccttt gcaaggagag tcccacgctc attcacatgt cctggtggac tctcttggcc
     2221 ttattcccca aatcaattca ttggagaatt tctgcagcaa gcaggactta gatgagtatc
     2281 agcttcacaa ctgtgttgaa attgcctcag caatgggacc tcaagtgctc ccgggtgcct
     2341 gtgaaaggct gatcatcagc atgtctgcca agctgcatga tggggctgtg gcctgcaagt
     2401 gtcaccccca gggctcagtc ggatccagct gcagccgact tggaggccag tgccagtgta
     2461 aacctcttgt ggtcgggcgc tgctgtgaca ggtgctcaac tggaagctat gatttggggc
     2521 atcacggctg tcacccatgt cactgccatc ctcaaggatc aaaggacact gtatgtgacc
     2581 aagtaacagg acagtgcccc tgccatggag aggtgtctgg ccgccgctgt gatcgctgcc
     2641 tggcaggcta ctttggattt cccagctgcc acccttgccc ttgtaatagg tttgctgaac
     2701 tttgtgatcc tgagacaggg tcatgcttca attgtggagg ctttacaact ggcagaaact
     2761 gtgaaaggtg tattgatggt tactatggaa atccttcttc aggacagccc tgtcgtcctt
     2821 gcctgtgtcc agatgatccc tcaagcaatc agtattttgc ccattcctgt tatcagaatc
     2881 tgtggagctc agatgtaatc tgcaattgtc ttcaaggtta tacgggtact cagtgtggag
     2941 aatgctctac tggtttctat ggaaatccaa gaatttcagg agcaccttgc caaccatgtg
     3001 cctgcaacaa caacatagat gtaaccgatc cagagtcctg cagccgggta acaggggagt
     3061 gccttcgatg tttgcacaac actcagggcg caaactgcca gctctgcaaa ccaggtcact
     3121 atggatcagc cctcaatcag acctgcagaa gatgctcctg ccatgcttcc ggcgtgagtc
     3181 ccatggagtg tccccctggt gggggagctt gcctctgtga ccctgtcact ggtgcatgtc
     3241 cttgtctgcc gaatgtcaca ggcctggcct gtgaccgttg tgctgatgga tactggaatc
     3301 tggtccctgg cagaggatgt cagtcatgtg actgtgaccc taggacctct caaagtagcc
     3361 actgtgacca gcttacaggc cagtgtccgt gtaaattagg ttacggcggg aaacgttgca
     3421 gtgagtgcca ggaaaattat tatggtgatc cacctgggcg atgcattcca tgtgattgta
     3481 acagggcagg tacccagaag cccatctgtg atccagacac aggcatgtgc cgctgccggg
     3541 agggtgtcag cggccagaga tgtgatcgct gtgcccgggg acacagccag gaattcccta
     3601 cttgtcttca atgtcacttg tgctttgatc agtgggacca caccatttct tccctctcca
     3661 aagcggtgca agggttaatg agactggctg ctaacatgga agataaaaga gagaccctgc
     3721 ctgtctgtga ggcagacttc aaagacctca gagggaacgt gtctgaaata gaaaggattt
     3781 tgaaacatcc tgttttccca tctgggaaat tcttaaaagt caaggattat catgactctg
     3841 ttagaagaca aatcatgcag ctaaatgaac aactgaaagc agtgtatgaa tttcaagatc
     3901 tgaaagatac aatagaaaga gcaaagaatg aagcagacct cttacttgaa gaccttcagg
     3961 aagaaattga tttgcaatcc agtgtcctta atgcaagcat tgcggactcc tcagaaaaca
     4021 tcaagaaata ttatcacata tcatcatctg ctgaaaagaa aattaatgaa actagttcca
     4081 ccattaatac ctctgcaaat acaaggaatg acttacttac catcttagat acactaacct
     4141 caaaaggaaa cttgtcattg gaaagattaa agcagattaa gataccagat atccaaatat
     4201 tgaatgaaaa ggtgtgcgga gatccaggaa atgtgccatg tgtgcccttg ccctgtggcg
     4261 gtgctctctg cacgggccgg aaggggcaca ggaagtgtag gggtcccggc tgtcacggct
     4321 ccctgaccct ctcaacgaat gccctccaaa aagcccagga agcaaaatcc attattcgta
     4381 atttggacaa acaggttcgt gggttgaaaa atcagatcga aagtataagt gaacaggcag
     4441 aagtctccaa aaacaatgcc ttacagctga gggaaaaact gggaaatata agaaaccaaa
     4501 gtgactctga agaagaaaac atcaatcttt tcatcaaaaa agtgaaaaac tttttgttag
     4561 aggaaaacgt gcctccagaa gacatcgaga aggttgcgaa tggtgtgctt gacattcacc
     4621 taccaattcc atcccaaaat ctaaccgatg aacttgtcaa aatacagaaa catatgcaac
     4681 tctgtgagga ttacaggaca gatgaaaaca ggttaaatga agaagcagat ggagcccaaa
     4741 agcttttggt gaaggccaaa gcagctgaga aagcagcaaa tattctatta aatcttgaca
     4801 aaacattgaa ccagttacaa caagctcaaa tcactcaagg acgggcaaac tctaccatta
     4861 cacagctgac tgccaatata acaaaaataa aaaagaatgt gctgcaggct gaaaatcaaa
     4921 ccagggaaat gaagagtgag ctggagttag caaagcagcg atcagggctg gaggatggac
     4981 tttccctgct gcagaccaag ttgcaaaggc atcaagacca cgctgtcaat gcgaaagttc
     5041 aggctgaatc tgcccaacac caggctggga gtcttgagaa ggaatttgtt gagctgaaaa
     5101 aacaatatgc tattctccaa cgtaagacaa gcactacagg actaacaaag gagacattag
     5161 gaaaagttaa acagctaaaa gatgcggcag aaaaattggc tggagataca gaggccaaga
     5221 taagaagaat aacagattta gaaaggaaaa tccaagattt gaatctaagt agacaagcaa
     5281 aagctgatca actgagaata ttggaagatc aagttgttgc cattaaaaat gaaattgttg
     5341 aacaagaaaa aaaatatgct aggtgctata gctaggcaga gttaaagagc aaaagcttgt
     5401 gcctttgttt ctggtttctg atgtacaagc ccctggggct ctgttgaacc tgtgaaatac
     5461 tgacaatgtc ttctaccttc cttccccaca ccctgtcctt attagacacc tgctcagtgt
     5521 ggctggaggt tgaaatgcca ccaggaaaat gccacttcat aattgaaagg ggaaagtaat
     5581 gaaattgtct ctggtttcag aaacttttcc tcttaccttc ctttctcttt cctaacttaa
     5641 aaataacagt ttccatataa caagtagaaa tttaagtaag tactctacta actaataatc
     5701 atttcagtca gataaaccta aacattaaat aaatatctcc aatattagga tggaatacat
     5761 atgtatggca tgtactagat tgtcctatat tttatgttta tttggatttg cttttatttg
     5821 taaaattatt cttttctgaa taaactgcat acaattcaaa a
//
