LOCUS       NM_000228               4014 bp    mRNA    linear   PRI 06-MAR-2025
DEFINITION  Homo sapiens laminin subunit beta 3 (LAMB3), transcript variant 1,
            mRNA.
ACCESSION   NM_000228
VERSION     NM_000228.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4014)
  AUTHORS   Ma,D., Liu,S., Liu,K., Kong,L., Xiao,L., Xin,Q., Jiang,C. and Wu,J.
  TITLE     MDFI promotes the proliferation and tolerance to chemotherapy of
            colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT
            signaling pathway
  JOURNAL   Cancer Biol Ther 25 (1), 2314324 (2024)
   PUBMED   38375821
  REMARK    GeneRIF: MDFI promotes the proliferation and tolerance to
            chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to
            activate the AKT signaling pathway.
REFERENCE   2  (bases 1 to 4014)
  AUTHORS   Wu,J., Wu,Y., Chen,S., Guo,Q., Shao,Y., Liu,C., Lin,K., Wang,S.,
            Zhu,J., Chen,X., Ju,X., Xia,L. and Wu,X.
  TITLE     PARP1-stabilised FOXQ1 promotes ovarian cancer progression by
            activating the LAMB3/WNT/beta-catenin signalling pathway
  JOURNAL   Oncogene 43 (12), 866-883 (2024)
   PUBMED   38297082
  REMARK    GeneRIF: PARP1-stabilised FOXQ1 promotes ovarian cancer progression
            by activating the LAMB3/WNT/beta-catenin signalling pathway.
REFERENCE   3  (bases 1 to 4014)
  AUTHORS   Qin,X., Zeng,B., Sooranna,S.R. and Li,M.
  TITLE     LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in
            Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway
  JOURNAL   Cell Biochem Biophys 82 (1), 127-137 (2024)
   PUBMED   37801199
  REMARK    GeneRIF: LAMB3 Promotes Myofibrogenesis and Cytoskeletal
            Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9
            Pathway.
REFERENCE   4  (bases 1 to 4014)
  AUTHORS   Wattanathavorn,W., Seki,M., Suzuki,Y., Buranapraditkun,S.,
            Kitkumthorn,N., Sasivimolrattana,T., Bhattarakosol,P. and
            Chaiwongkot,A.
  TITLE     Downregulation of LAMB3 Altered the Carcinogenic Properties of
            Human Papillomavirus 16-Positive Cervical Cancer Cells
  JOURNAL   Int J Mol Sci 25 (5), 2535 (2024)
   PUBMED   38473784
  REMARK    GeneRIF: Downregulation of LAMB3 Altered the Carcinogenic
            Properties of Human Papillomavirus 16-Positive Cervical Cancer
            Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4014)
  AUTHORS   Liu,F., Xu,W., Wang,Y., Huang,Z., Zhu,Z., Ou,W., Tang,W., Fu,J.,
            Liu,C., Gu,Y., Liu,Y. and Du,P.
  TITLE     LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is
            Directly Transcriptionally Regulated by P65 in Inflammatory Bowel
            Disease
  JOURNAL   Inflamm Bowel Dis 30 (2), 257-272 (2024)
   PUBMED   37454278
  REMARK    GeneRIF: LAMB3 Promotes Intestinal Inflammation Through SERPINA3
            and Is Directly Transcriptionally Regulated by P65 in Inflammatory
            Bowel Disease.
REFERENCE   6  (bases 1 to 4014)
  AUTHORS   McGrath,J.A., Pulkkinen,L., Christiano,A.M., Leigh,I.M., Eady,R.A.
            and Uitto,J.
  TITLE     Altered laminin 5 expression due to mutations in the gene encoding
            the beta 3 chain (LAMB3) in generalized atrophic benign
            epidermolysis bullosa
  JOURNAL   J Invest Dermatol 104 (4), 467-474 (1995)
   PUBMED   7706760
REFERENCE   7  (bases 1 to 4014)
  AUTHORS   Pulkkinen,L., McGrath,J.A., Christiano,A.M. and Uitto,J.
  TITLE     Detection of sequence variants in the gene encoding the beta 3
            chain of laminin 5 (LAMB3)
  JOURNAL   Hum Mutat 6 (1), 77-84 (1995)
   PUBMED   7550237
REFERENCE   8  (bases 1 to 4014)
  AUTHORS   Pulkkinen,L., Christiano,A.M., Gerecke,D., Wagman,D.W.,
            Burgeson,R.E., Pittelkow,M.R. and Uitto,J.
  TITLE     A homozygous nonsense mutation in the beta 3 chain gene of laminin
            5 (LAMB3) in Herlitz junctional epidermolysis bullosa
  JOURNAL   Genomics 24 (2), 357-360 (1994)
   PUBMED   7698759
REFERENCE   9  (bases 1 to 4014)
  AUTHORS   Gerecke,D.R., Wagman,D.W., Champliaud,M.F. and Burgeson,R.E.
  TITLE     The complete primary structure for a novel laminin chain, the
            laminin B1k chain
  JOURNAL   J Biol Chem 269 (15), 11073-11080 (1994)
   PUBMED   7512558
REFERENCE   10 (bases 1 to 4014)
  AUTHORS   Pfendner,E.G. and Lucky,A.W.
  TITLE     Junctional Epidermolysis Bullosa
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL555685.3, BC058922.1,
            AY035783.1 and BC075838.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000228.2.
            
            Summary: The product encoded by this gene is a laminin that belongs
            to a family of basement membrane proteins. This protein is a beta
            subunit laminin, which together with an alpha and a gamma subunit,
            forms laminin-5. Mutations in this gene cause epidermolysis bullosa
            junctional Herlitz type, and generalized atrophic benign
            epidermolysis bullosa, diseases that are characterized by
            blistering of the skin. Multiple alternatively spliced transcript
            variants that encode the same protein have been found for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1, also known as B3A) encodes the
            same protein as variants 2 and 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058922.1, D37766.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356082.9/ ENSP00000348384.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AL555685.3         51-705
            656-1672            BC058922.1         697-1713
            1673-2407           AY035783.1         1579-2313
            2408-3525           BC075838.1         2489-3606
            3526-3992           BC058922.1         3566-4032
            3993-4014           BC075838.1         4074-4095
FEATURES             Location/Qualifiers
     source          1..4014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..4014
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /note="laminin subunit beta 3"
                     /db_xref="GeneID:3914"
                     /db_xref="HGNC:HGNC:6490"
                     /db_xref="MIM:150310"
     exon            1..57
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..122
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3613
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /note="nicein-125kDa; kalinin-140kDa; laminin, beta 3
                     (nicein (125kD), kalinin (140kD), BM600 (125kD)); kalinin
                     B1 chain; laminin S B3 chain; laminin B1k chain; nicein
                     subunit beta; kalinin subunit beta; epiligrin subunit
                     bata; laminin-5 subunit beta; laminin beta 3"
                     /codon_start=1
                     /product="laminin subunit beta-3 precursor"
                     /protein_id="NP_000219.2"
                     /db_xref="CCDS:CCDS1487.1"
                     /db_xref="GeneID:3914"
                     /db_xref="HGNC:HGNC:6490"
                     /db_xref="MIM:150310"
                     /translation="MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRAS
                     STCGLTKPETYCTQYGEWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVN
                     PVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRV
                     RQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLR
                     VNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVH
                     DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAA
                     SQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPC
                     DPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGR
                     CLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGG
                     LMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQ
                     CQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRI
                     LDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDL
                     ESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLD
                     QLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTFNKLCGNSRQMACTP
                     ISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAA
                     EESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVSE
                     AVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSR
                     AHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVT
                     SMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAEL
                     KDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIMLRSAD
                     LTGLEKRVEQIRDHINGRVLYYATCK"
     exon            123..277
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..392
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..466
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..658
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..722
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..916
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1037
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1226
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1382
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1579
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1691
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2070
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2231
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2452
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2650
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2795
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..3003
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3145
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3322
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3476
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..4014
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3970..3975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /note="hexamer: AATAAA"
     polyA_site      4014
                     /gene="LAMB3"
                     /gene_synonym="AI1A; BM600-125KDA; JEB1A; JEB1B; LAM5;
                     LAMNB1"
                     /note="major polyA site"
ORIGIN      
        1 acattcaaga ggagctttca ggcgatctgg agaaagaacg gcagaacaca cagcaaggaa
       61 aggtcctttc tggggatcac cccattggct gaagatgaga ccattcttcc tcttgtgttt
      121 tgccctgcct ggcctcctgc atgcccaaca agcctgctcc cgtggggcct gctatccacc
      181 tgttggggac ctgcttgttg ggaggacccg gtttctccga gcttcatcta cctgtggact
      241 gaccaagcct gagacctact gcacccagta tggcgagtgg cagatgaaat gctgcaagtg
      301 tgactccagg cagcctcaca actactacag tcaccgagta gagaatgtgg cttcatcctc
      361 cggccccatg cgctggtggc agtcacagaa tgatgtgaac cctgtctctc tgcagctgga
      421 cctggacagg agattccagc ttcaagaagt catgatggag ttccaggggc ccatgcccgc
      481 cggcatgctg attgagcgct cctcagactt cggtaagacc tggcgagtgt accagtacct
      541 ggctgccgac tgcacctcca ccttccctcg ggtccgccag ggtcggcctc agagctggca
      601 ggatgttcgg tgccagtccc tgcctcagag gcctaatgca cgcctaaatg gggggaaggt
      661 ccaacttaac cttatggatt tagtgtctgg gattccagca actcaaagtc aaaaaattca
      721 agaggtgggg gagatcacaa acttgagagt caatttcacc aggctggccc ctgtgcccca
      781 aaggggctac caccctccca gcgcctacta tgctgtgtcc cagctccgtc tgcaggggag
      841 ctgcttctgt cacggccatg ctgatcgctg cgcacccaag cctggggcct ctgcaggccc
      901 ctccaccgct gtgcaggtcc acgatgtctg tgtctgccag cacaacactg ccggcccaaa
      961 ttgtgagcgc tgtgcaccct tctacaacaa ccggccctgg agaccggcgg agggccagga
     1021 cgcccatgaa tgccaaaggt gcgactgcaa tgggcactca gagacatgtc actttgaccc
     1081 cgctgtgttt gccgccagcc agggggcata tggaggtgtg tgtgacaatt gccgggacca
     1141 caccgaaggc aagaactgtg agcggtgtca gctgcactat ttccggaacc ggcgcccggg
     1201 agcttccatt caggagacct gcatctcctg cgagtgtgat ccggatgggg cagtgccagg
     1261 ggctccctgt gacccagtga ccgggcagtg tgtgtgcaag gagcatgtgc agggagagcg
     1321 ctgtgaccta tgcaagccgg gcttcactgg actcacctac gccaacccgc agggctgcca
     1381 ccgctgtgac tgcaacatcc tggggtcccg gagggacatg ccgtgtgacg aggagagtgg
     1441 gcgctgcctt tgtctgccca acgtggtggg tcccaaatgt gaccagtgtg ctccctacca
     1501 ctggaagctg gccagtggcc agggctgtga accgtgtgcc tgcgacccgc acaactccct
     1561 cagcccacag tgcaaccagt tcacagggca gtgcccctgt cgggaaggct ttggtggcct
     1621 gatgtgcagc gctgcagcca tccgccagtg tccagaccgg acctatggag acgtggccac
     1681 aggatgccga gcctgtgact gtgatttccg gggaacagag ggcccgggct gcgacaaggc
     1741 atcaggccgc tgcctctgcc gccctggctt gaccgggccc cgctgtgacc agtgccagcg
     1801 aggctactgt aatcgctacc cggtgtgcgt ggcctgccac ccttgcttcc agacctatga
     1861 tgcggacctc cgggagcagg ccctgcgctt tggtagactc cgcaatgcca ccgccagcct
     1921 gtggtcaggg cctgggctgg aggaccgtgg cctggcctcc cggatcctag atgcaaagag
     1981 taagattgag cagatccgag cagttctcag cagccccgca gtcacagagc aggaggtggc
     2041 tcaggtggcc agtgccatcc tctccctcag gcgaactctc cagggcctgc agctggatct
     2101 gcccctggag gaggagacgt tgtcccttcc gagagacctg gagagtcttg acagaagctt
     2161 caatggtctc cttactatgt atcagaggaa gagggagcag tttgaaaaaa taagcagtgc
     2221 tgatccttca ggagccttcc ggatgctgag cacagcctac gagcagtcag cccaggctgc
     2281 tcagcaggtc tccgacagct cgcgcctttt ggaccagctc agggacagcc ggagagaggc
     2341 agagaggctg gtgcggcagg cgggaggagg aggaggcacc ggcagcccca agcttgtggc
     2401 cctgaggctg gagatgtctt cgttgcctga cctgacaccc accttcaaca agctctgtgg
     2461 caactccagg cagatggctt gcaccccaat atcatgccct ggtgagctat gtccccaaga
     2521 caatggcaca gcctgtggct cccgctgcag gggtgtcctt cccagggccg gtggggcctt
     2581 cttgatggcg gggcaggtgg ctgagcagct gcggggcttc aatgcccagc tccagcggac
     2641 caggcagatg attagggcag ccgaggaatc tgcctcacag attcaatcca gtgcccagcg
     2701 cttggagacc caggtgagcg ccagccgctc ccagatggag gaagatgtca gacgcacacg
     2761 gctcctaatc cagcaggtcc gggacttcct aacagacccc gacactgatg cagccactat
     2821 ccaggaggtc agcgaggccg tgctggccct gtggctgccc acagactcag ctactgttct
     2881 gcagaagatg aatgagatcc aggccattgc agccaggctc cccaacgtgg acttggtgct
     2941 gtcccagacc aagcaggaca ttgcgcgtgc ccgccggttg caggctgagg ctgaggaagc
     3001 caggagccga gcccatgcag tggagggcca ggtggaagat gtggttggga acctgcggca
     3061 ggggacagtg gcactgcagg aagctcagga caccatgcaa ggcaccagcc gctcccttcg
     3121 gcttatccag gacagggttg ctgaggttca gcaggtactg cggccagcag aaaagctggt
     3181 gacaagcatg accaagcagc tgggtgactt ctggacacgg atggaggagc tccgccacca
     3241 agcccggcag cagggggcag aggcagtcca ggcccagcag cttgcggaag gtgccagcga
     3301 gcaggcattg agtgcccaag agggatttga gagaataaaa caaaagtatg ctgagttgaa
     3361 ggaccggttg ggtcagagtt ccatgctggg tgagcagggt gcccggatcc agagtgtgaa
     3421 gacagaggca gaggagctgt ttggggagac catggagatg atggacagga tgaaagacat
     3481 ggagttggag ctgctgcggg gcagccaggc catcatgctg cgctcagcgg acctgacagg
     3541 actggagaag cgtgtggagc agatccgtga ccacatcaat gggcgcgtgc tctactatgc
     3601 cacctgcaag tgatgctaca gcttccagcc cgttgcccca ctcatctgcc gcctttgctt
     3661 ttggttgggg gcagattggg ttggaatgct ttccatctcc aggagacttt catgcagcct
     3721 aaagtacagc ctggaccacc cctggtgtgt agctagtaag attaccctga gctgcagctg
     3781 agcctgagcc aatgggacag ttacacttga cagacaaaga tggtggagat tggcatgcca
     3841 ttgaaactaa gagctctcaa gtcaaggaag ctgggctggg cagtatcccc cgcctttagt
     3901 tctccactgg ggaggaatcc tggaccaagc acaaaaactt aacaaaagtg atgtaaaaat
     3961 gaaaagccaa ataaaaatct ttggaaaaga gcctggaggt tcaacgagga aaaa
//
