LOCUS       NM_002291               5650 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens laminin subunit beta 1 (LAMB1), mRNA.
ACCESSION   NM_002291
VERSION     NM_002291.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5650)
  AUTHORS   Li,M., Fu,H., Li,J., Meng,D., Zhang,Q. and Fei,D.
  TITLE     Compound variants of FKTN, POMGNT1, and LAMB1 gene identified by
            prenatal whole-exome sequencing in three fetuses with congenital
            hydrocephalus
  JOURNAL   J Obstet Gynaecol Res 48 (10), 2624-2629 (2022)
   PUBMED   35843586
  REMARK    GeneRIF: Compound variants of FKTN, POMGNT1, and LAMB1 gene
            identified by prenatal whole-exome sequencing in three fetuses with
            congenital hydrocephalus.
REFERENCE   2  (bases 1 to 5650)
  AUTHORS   Liu,T., Gan,H., He,S., Deng,J., Hu,X., Li,L., Cai,L., He,J.,
            Long,H., Cai,J., Li,H., Zhang,Q., Wang,L., Chen,F., Chen,Y.,
            Zhang,H., Li,J., Yang,L., Liu,Y., Yang,J.H., Kuang,D.M., Pang,P.,
            He,H. and Shan,H.
  TITLE     RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular
            Carcinoma Progression
  JOURNAL   Cancer Res 82 (17), 3074-3087 (2022)
   PUBMED   35763670
  REMARK    GeneRIF: RNA Helicase DDX24 Stabilizes LAMB1 to Promote
            Hepatocellular Carcinoma Progression.
REFERENCE   3  (bases 1 to 5650)
  AUTHORS   Wu,X., Dong,S., Xu,Y., Zhu,G. and Yan,M.
  TITLE     Evaluation of JUN, FN1 and LAMB1 polymorphisms in pterygium in a
            Chinese Han population
  JOURNAL   Ophthalmic Genet 43 (4), 488-495 (2022)
   PUBMED   35445627
  REMARK    GeneRIF: Evaluation of JUN, FN1 and LAMB1 polymorphisms in
            pterygium in a Chinese Han population.
REFERENCE   4  (bases 1 to 5650)
  AUTHORS   Yang,Y., Gao,L., Chen,J., Xiao,W., Liu,R. and Kan,H.
  TITLE     Lamin B1 is a potential therapeutic target and prognostic biomarker
            for hepatocellular carcinoma
  JOURNAL   Bioengineered 13 (4), 9211-9231 (2022)
   PUBMED   35436411
  REMARK    GeneRIF: Lamin B1 is a potential therapeutic target and prognostic
            biomarker for hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 5650)
  AUTHORS   Aloui,C., Herve,D., Marenne,G., Savenier,F., Le Guennec,K.,
            Bergametti,F., Verdura,E., Ludwig,T.E., Lebenberg,J., Jabeur,W.,
            Morel,H., Coste,T., Demarquay,G., Bachoumas,P., Cogez,J.,
            Mathey,G., Bernard,E., Chabriat,H., Genin,E. and
            Tournier-Lasserve,E.
  CONSRTM   FREX consortium
  TITLE     End-Truncated LAMB1 Causes a Hippocampal Memory Defect and a
            Leukoencephalopathy
  JOURNAL   Ann Neurol 90 (6), 962-975 (2021)
   PUBMED   34606115
  REMARK    GeneRIF: End-Truncated LAMB1 Causes a Hippocampal Memory Defect and
            a Leukoencephalopathy.
REFERENCE   6  (bases 1 to 5650)
  AUTHORS   Aeschlimann,D. and Paulsson,M.
  TITLE     Cross-linking of laminin-nidogen complexes by tissue
            transglutaminase. A novel mechanism for basement membrane
            stabilization
  JOURNAL   J Biol Chem 266 (23), 15308-15317 (1991)
   PUBMED   1678389
REFERENCE   7  (bases 1 to 5650)
  AUTHORS   Bonneau,D., Huret,J.L., Godeau,G., Couet,D., Putterman,M.,
            Tanzer,J., Babin,P. and Larregue,M.
  TITLE     Recurrent ctb(7)(q31.3) and possible laminin involvement in a
            neonatal cutis laxa with a Marfan phenotype
  JOURNAL   Hum Genet 87 (3), 317-319 (1991)
   PUBMED   1864606
REFERENCE   8  (bases 1 to 5650)
  AUTHORS   Chung,A.E. and Durkin,M.E.
  TITLE     Entactin: structure and function
  JOURNAL   Am J Respir Cell Mol Biol 3 (4), 275-282 (1990)
   PUBMED   2119632
  REMARK    Review article
REFERENCE   9  (bases 1 to 5650)
  AUTHORS   Vuolteenaho,R., Chow,L.T. and Tryggvason,K.
  TITLE     Structure of the human laminin B1 chain gene
  JOURNAL   J Biol Chem 265 (26), 15611-15616 (1990)
   PUBMED   1975589
REFERENCE   10 (bases 1 to 5650)
  AUTHORS   Engvall,E., Earwicker,D., Haaparanta,T., Ruoslahti,E. and
            Sanes,J.R.
  TITLE     Distribution and isolation of four laminin variants; tissue
            restricted distribution of heterotrimers assembled from five
            different subunits
  JOURNAL   Cell Regul 1 (10), 731-740 (1990)
   PUBMED   2099832
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA861108.1, BC113455.1,
            BC026018.2 and AC005046.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002291.2.
            
            Summary: Laminins, a family of extracellular matrix glycoproteins,
            are the major noncollagenous constituent of basement membranes.
            They have been implicated in a wide variety of biological processes
            including cell adhesion, differentiation, migration, signaling,
            neurite outgrowth and metastasis. Laminins are composed of 3 non
            identical chains: laminin alpha, beta and gamma (formerly A, B1,
            and B2, respectively) and they form a cruciform structure
            consisting of 3 short arms, each formed by a different chain, and a
            long arm composed of all 3 chains. Each laminin chain is a
            multidomain protein encoded by a distinct gene. Several isoforms of
            each chain have been described. Different alpha, beta and gamma
            chain isomers combine to give rise to different heterotrimeric
            laminin isoforms which are designated by Arabic numerals in the
            order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is
            laminin 1. The biological functions of the different chains and
            trimer molecules are largely unknown, but some of the chains have
            been shown to differ with respect to their tissue distribution,
            presumably reflecting diverse functions in vivo. This gene encodes
            the beta chain isoform laminin, beta 1. The beta 1 chain has 7
            structurally distinct domains which it shares with other beta chain
            isomers. The C-terminal helical region containing domains I and II
            are separated by domain alpha, domains III and V contain several
            EGF-like repeats, and domains IV and VI have a globular
            conformation. Laminin, beta 1 is expressed in most tissues that
            produce basement membranes, and is one of the 3 chains constituting
            laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm
            (EHS) tumor. A sequence in the beta 1 chain that is involved in
            cell attachment, chemotaxis, and binding to the laminin receptor
            was identified and shown to have the capacity to inhibit
            metastasis. [provided by RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by published experimental evidence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M61916.1, SRR14038197.771538.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222399.11/ ENSP00000222399.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                DA861108.1         33-126
            95-5538             BC113455.1         1-5444
            5539-5648           BC026018.2         3295-3404
            5649-5650           AC005046.3         141609-141610       c
FEATURES             Location/Qualifiers
     source          1..5650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..5650
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /note="laminin subunit beta 1"
                     /db_xref="GeneID:3912"
                     /db_xref="HGNC:HGNC:6486"
                     /db_xref="MIM:150240"
     exon            1..51
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            52..174
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..5498
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /note="laminin B1 chain; laminin, beta 1"
                     /codon_start=1
                     /product="laminin subunit beta-1 precursor"
                     /protein_id="NP_002282.2"
                     /db_xref="CCDS:CCDS5750.1"
                     /db_xref="GeneID:3912"
                     /db_xref="HGNC:HGNC:6486"
                     /db_xref="MIM:150240"
                     /translation="MGLLQLLAFSFLALCRARVRAQEPEFSYGCAEGSCYPATGDLLI
                     GRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTT
                     FAPNRLKIWWQSENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTW
                     GVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEGEVIFRALDPAFKIED
                     PYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGH
                     ASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKK
                     CNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDP
                     NFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSE
                     DPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCR
                     PCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYYFATLDHYLYEAEEANLGP
                     GVSIVERQYIQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPDHW
                     EKAVITVQRPGRIPTSSRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCFEKGTNYTVRL
                     ELPQYTSSDSDVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWETFQRYRCL
                     ENSRSVVKTPMTDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCRPNV
                     VGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCLP
                     GHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHC
                     RPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGS
                     CQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDALQQDCRKCVC
                     NYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNA
                     AHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQCDQ
                     STGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIAELTNRTHRFLEKA
                     KALKISGVIGPYRETVDSVERKVSEIKDILAQSPAAEPLKNIGNLFEEAEKLIKDVTE
                     MMAQVEVKLSDTTSQSNSTAKELDSLQTEAESLDNTVKELAEQLEFIKNSDIRGALDS
                     ITKYFQMSLEAEERVNASTTEPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLL
                     DELAGKLQSLDLSAAAEMTCGTPPGASCSETECGGPNCRTDEGERKCGGPGCGGLVTV
                     AHNAWQKAMDLDQDVLSALAEVEQLSKMVSEAKLRADEAKQSAEDILLKTNATKEKMD
                     KSNEELRNLIKQIRNFLTQDSADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVE
                     SLSQVEVILQHSAADIARAEMLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAE
                     KAIKQADEDIQGTQNLLTSIESETAASEETLFNASQRISELERNVEELKRKAAQNSGE
                     AEYIEKVVYTVKQSAEDVKKTLDGELDEKYKKVENLIAKKTEESADARRKAEMLQNEA
                     KTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLEGEVRSLLKDISQKVAVYST
                     CL"
     exon            175..350
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            351..486
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            487..560
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            561..749
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            750..813
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1016
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1137
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1326
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1506
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1619
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1699
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1835
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1994
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2122
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2246
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2451
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2595
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2827
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2991
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3216
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3431
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3528
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3898
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..4083
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4325
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            4326..4529
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            4530..4674
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4882
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..5024
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..5201
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            5202..5361
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     exon            5362..5650
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5625..5630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /note="hexamer: AATAAA"
     polyA_site      5650
                     /gene="LAMB1"
                     /gene_synonym="CLM; LIS5"
                     /note="major polyA site"
ORIGIN      
        1 cttctttggg ctcgggggct cccggagcag ggcgagagct cgcgtcgccg gaaaggaaga
       61 cgggaagaaa gggcaggcgg ctcggcgggc gtcttctcca ctcctctgcc gcgtccccgt
      121 ggctgcaggg agccggcatg gggcttctcc agttgctagc tttcagtttc ttagccctgt
      181 gcagagcccg agtgcgcgct caggaacccg agttcagcta cggctgcgca gaaggcagct
      241 gctatcccgc cacgggcgac cttctcatcg gccgagcaca gaagctttcg gtgacctcga
      301 cgtgcgggct gcacaagccc gaaccctact gtatcgtcag ccacttgcag gaggacaaaa
      361 aatgcttcat atgcaattcc caagatcctt atcatgagac cctgaatcct gacagccatc
      421 tcattgaaaa tgtggtcact acatttgctc caaaccgcct taagatttgg tggcaatctg
      481 aaaatggtgt ggaaaatgta actatccaac tggatttgga agcagaattc cattttactc
      541 atctcataat gactttcaag acattccgtc cagctgctat gctgatagaa cgatcgtccg
      601 actttgggaa aacctggggt gtgtatagat acttcgccta tgactgtgag gcctcgtttc
      661 caggcatttc aactggcccc atgaaaaaag tcgatgacat aatttgtgat tctcgatatt
      721 ctgacattga accctcaact gaaggagagg tgatatttcg tgctttagat cctgctttca
      781 aaatagaaga tccttatagc ccaaggatac agaatttatt aaaaattacc aacttgagaa
      841 tcaagtttgt gaaactgcat actttgggag ataaccttct ggattccagg atggaaatca
      901 gagaaaagta ttattatgca gtttatgata tggtggttcg aggaaattgc ttctgctatg
      961 gtcatgccag cgaatgtgcc cctgtggatg gattcaatga agaagtggaa ggaatggttc
     1021 acggacactg catgtgcagg cataacacca agggcttaaa ctgtgaactc tgcatggatt
     1081 tctaccatga tttaccttgg agacctgctg aaggccgaaa cagcaacgcc tgtaaaaaat
     1141 gtaactgcaa tgaacattcc atctcttgtc actttgacat ggctgtttac ctggccacgg
     1201 ggaacgtcag cggaggcgtg tgtgatgact gtcagcacaa caccatgggg cgcaactgtg
     1261 agcagtgcaa gccgttttac taccagcacc cagagaggga catccgagat cctaatttct
     1321 gtgaacgatg tacgtgtgac ccagctggct ctcaaaatga gggaatttgt gacagctata
     1381 ctgatttttc tactggtctc attgctggcc agtgtcggtg taaattaaat gtggaaggag
     1441 aacattgtga tgtttgcaaa gaaggcttct atgatttaag cagtgaagat ccatttggtt
     1501 gtaaatcttg tgcttgcaat cctctgggaa caattcctgg agggaatcct tgtgattccg
     1561 agacaggtca ctgctactgc aagcgtctgg tgacaggaca gcattgtgac cagtgcctgc
     1621 cagagcactg gggcttaagc aatgatttgg atggatgtcg accatgtgac tgtgaccttg
     1681 ggggagcctt aaacaacagt tgctttgcgg agtcaggcca gtgctcatgc cggcctcaca
     1741 tgattggacg tcagtgcaac gaagtggaac ctggttacta ctttgccacc ctggatcact
     1801 acctctatga agcggaggaa gccaacttgg ggcctggggt tagcatagtg gagcggcaat
     1861 atatccagga ccggattccc tcctggactg gagccggctt cgtccgagtg cctgaagggg
     1921 cttatttgga gtttttcatt gacaacatac catattccat ggagtacgac atcctaattc
     1981 gctacgagcc acagctaccc gaccactggg aaaaagctgt catcacagtg cagcgacctg
     2041 gaaggattcc aaccagcagc cgatgtggta ataccatccc cgatgatgac aaccaggtgg
     2101 tgtcattatc accaggctca agatatgtcg tccttcctcg gccggtgtgc tttgagaagg
     2161 gaacaaacta cacggtgagg ttggagctgc ctcagtacac ctcctctgat agcgacgtgg
     2221 agagccccta cacgctgatc gattctcttg ttctcatgcc atactgtaaa tcactggaca
     2281 tcttcaccgt gggaggttca ggagatgggg tggtcaccaa cagtgcctgg gaaacctttc
     2341 agagataccg atgtctagag aacagcagaa gcgttgtgaa aacaccgatg acagatgttt
     2401 gcagaaacat catctttagc atttctgccc tgttacacca gacaggcctg gcttgtgaat
     2461 gcgaccctca gggttcgtta agttccgtgt gtgatcccaa cggaggccag tgccagtgcc
     2521 ggcccaacgt ggttggaaga acctgcaaca gatgtgcacc tggaactttt ggctttggcc
     2581 ccagtggatg caaaccttgt gagtgccatc tgcaaggatc tgtcaatgcc ttctgcaatc
     2641 ccgtcactgg ccagtgccac tgtttccagg gagtgtatgc tcggcagtgt gatcggtgct
     2701 tacctgggca ctggggcttt ccaagttgcc agccctgcca gtgcaatggc cacgccgatg
     2761 actgcgaccc agtgactggg gagtgcttga actgccagga ctacaccatg ggtcataact
     2821 gtgaaaggtg cttggctggt tactatggcg accccatcat tgggtcagga gatcactgcc
     2881 gcccttgccc ttgcccagat ggtcccgaca gtggacgcca gtttgccagg agctgctacc
     2941 aagatcctgt tactttacag cttgcctgtg tttgtgatcc tggatacatt ggttccagat
     3001 gtgacgactg tgcctcagga tactttggca atccatcaga agttgggggg tcgtgtcagc
     3061 cttgccagtg tcacaacaac attgacacga cagacccaga agcctgtgac aaggagactg
     3121 ggaggtgtct caagtgcctg taccacacgg aaggggaaca ctgtcagttc tgccggtttg
     3181 gatactatgg tgatgccctc cagcaggact gtcgaaagtg tgtctgtaat tacctgggca
     3241 ccgtgcaaga gcactgtaac ggctctgact gccagtgcga caaagccact ggtcagtgct
     3301 tgtgtcttcc taatgtgatc gggcagaact gtgaccgctg tgcgcccaat acctggcagc
     3361 tggccagtgg cactggctgt gacccatgca actgcaatgc tgctcattcc ttcgggccat
     3421 cttgcaatga gttcacgggg cagtgccagt gcatgcctgg gtttggaggc cgcacctgca
     3481 gcgagtgcca ggaactcttc tggggagacc ccgacgtgga gtgccgagcc tgtgactgtg
     3541 accccagggg cattgagacg ccacagtgtg accagtccac gggccagtgt gtctgcgttg
     3601 agggtgttga gggtccacgc tgtgacaagt gcacgcgagg gtactcgggg gtcttccctg
     3661 actgcacacc ctgccaccag tgctttgctc tctgggatgt gatcattgcc gagctgacca
     3721 acaggacaca cagattcctg gagaaagcca aggccttgaa gatcagtggt gtgatcgggc
     3781 cttaccgtga gactgtggac tcggtggaga ggaaagtcag cgagataaaa gacatcctgg
     3841 cgcagagccc cgcagcagag ccactgaaaa acattgggaa tctctttgag gaagcagaga
     3901 aactgattaa agatgttaca gaaatgatgg ctcaagtaga agtgaaatta tctgacacaa
     3961 cttcccaaag caacagcaca gccaaagaac tggattctct acagacagaa gccgaaagcc
     4021 tagacaacac tgtgaaagaa cttgctgaac aactggaatt tatcaaaaac tcagatattc
     4081 ggggtgcctt ggatagcatt accaagtatt tccagatgtc tcttgaggca gaggagaggg
     4141 tgaatgcctc caccacagaa cccaacagca ctgtggagca gtcagccctc atgagagaca
     4201 gagtagaaga cgtgatgatg gagcgagaat cccagttcaa ggaaaaacaa gaggagcagg
     4261 ctcgcctcct tgatgaactg gcaggcaagc tacaaagcct agacctttca gccgctgccg
     4321 aaatgacctg tggaacaccc ccaggggcct cctgttccga gactgaatgt ggcgggccaa
     4381 actgcagaac tgacgaagga gagaggaagt gtggggggcc tggctgtggt ggtctggtta
     4441 ctgttgcaca caacgcctgg cagaaagcca tggacttgga ccaagatgtc ctgagtgccc
     4501 tggctgaagt ggaacagctc tccaagatgg tctctgaagc aaaactgagg gcagatgagg
     4561 caaaacaaag tgctgaagac attctgttga agacaaatgc taccaaagaa aaaatggaca
     4621 agagcaatga ggagctgaga aatctaatca agcaaatcag aaactttttg acccaggata
     4681 gtgctgattt ggacagcatt gaagcagttg ctaatgaagt attgaaaatg gagatgccta
     4741 gcaccccaca gcagttacag aacttgacag aagatatacg tgaacgagtt gaaagccttt
     4801 ctcaagtaga ggttattctt cagcatagtg ctgctgacat tgccagagct gagatgttgt
     4861 tagaagaagc taaaagagca agcaaaagtg caacagatgt taaagtcact gcagatatgg
     4921 taaaggaagc tctggaagaa gcagaaaagg cccaggtcgc agcagagaag gcaattaaac
     4981 aagcagatga agacattcaa ggaacccaga acctgttaac ttcgattgag tctgaaacag
     5041 cagcttctga ggaaaccttg ttcaacgcgt cccagcgcat cagcgagtta gagaggaatg
     5101 tggaagaact taagcggaaa gctgcccaaa actccgggga ggcagaatat attgaaaaag
     5161 tagtatatac tgtgaagcaa agtgcagaag atgttaagaa gactttagat ggtgaacttg
     5221 atgaaaagta taaaaaagta gaaaatttaa ttgccaaaaa aactgaagag tcagctgatg
     5281 ccagaaggaa agccgaaatg ctacaaaatg aagcaaaaac tcttttagct caagcaaata
     5341 gcaagctgca actgctcaaa gatttagaaa gaaaatatga agacaatcaa agatacttag
     5401 aagataaagc tcaagaatta gcaagactgg aaggagaagt ccgttcactc ctaaaggata
     5461 taagccagaa agttgctgtg tatagcacat gcttgtaaca gaggagaata aaaaatggct
     5521 gaggtgaaca aggtaaaaca actacatttt aaaaactgac ttaatgctct tcaaaataaa
     5581 acatcaccta tttaatgttt ttaatcacat tttgtatgga gttaaataaa gtacagtgct
     5641 tttgtatata
//
