LOCUS       NM_005560              11426 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens laminin subunit alpha 5 (LAMA5), mRNA.
ACCESSION   NM_005560
VERSION     NM_005560.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11426)
  AUTHORS   Parte,S., Kaur,A.B., Nimmakayala,R.K., Ogunleye,A.O.,
            Chirravuri,R., Vengoji,R., Leon,F., Nallasamy,P., Rauth,S.,
            Alsafwani,Z.W., Lele,S., Cox,J.L., Bhat,I., Singh,S., Batra,S.K.
            and Ponnusamy,M.P.
  TITLE     Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell
            Transdifferentiation and Pancreatic Cancer Initiation Via
            LAMA5/ITGA4 Axis
  JOURNAL   Gastroenterology 166 (5), 842-858 (2024)
   PUBMED   38154529
  REMARK    GeneRIF: Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell
            Transdifferentiation and Pancreatic Cancer Initiation Via
            LAMA5/ITGA4 Axis.
REFERENCE   2  (bases 1 to 11426)
  AUTHORS   Kaimori,J.Y., Kikkawa,Y., Motooka,D., Namba-Hamano,T., Takuwa,A.,
            Okazaki,A., Kobayashi,K., Tanigawa,A., Kotani,Y., Uno,Y.,
            Yoshimi,K., Hattori,K., Asahina,Y., Kajimoto,S., Doi,Y., Oka,T.,
            Sakaguchi,Y., Mashimo,T., Sekiguchi,K., Nakaya,A., Nomizu,M. and
            Isaka,Y.
  TITLE     A heterozygous LAMA5 variant may contribute to slowly progressive,
            vinculin-enhanced familial FSGS and pulmonary defects
  JOURNAL   JCI Insight 7 (23), e158378 (2022)
   PUBMED   36173685
  REMARK    GeneRIF: A heterozygous LAMA5 variant may contribute to slowly
            progressive, vinculin-enhanced familial FSGS and pulmonary defects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11426)
  AUTHORS   Dunville,K., Tonelli,F., Novelli,E., Codino,A., Massa,V.,
            Frontino,A.M., Galfre,S., Biondi,F., Gustincich,S., Caleo,M.,
            Pandolfini,L., Alia,C. and Cremisi,F.
  TITLE     Laminin 511 and WNT signalling sustain prolonged expansion of
            hiPSC-derived hippocampal progenitors
  JOURNAL   Development 149 (20) (2022)
   PUBMED   35993299
  REMARK    GeneRIF: Laminin 511 and WNT signalling sustain prolonged expansion
            of hiPSC-derived hippocampal progenitors.
REFERENCE   4  (bases 1 to 11426)
  AUTHORS   Yang,Z.S., Pan,H.Y., Shi,W.W., Chen,S.T., Wang,Y., Li,M.Y.,
            Zhang,H.Y., Yang,C., Liu,A.X. and Yang,Z.M.
  TITLE     Regulation and Function of Laminin A5 during Mouse and Human
            Decidualization
  JOURNAL   Int J Mol Sci 23 (1), 199 (2021)
   PUBMED   35008625
  REMARK    GeneRIF: Regulation and Function of Laminin A5 during Mouse and
            Human Decidualization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11426)
  AUTHORS   Taniguchi,Y., Nagano,C., Sekiguchi,K., Tashiro,A., Sugawara,N.,
            Sakaguchi,H., Umeda,C., Aoto,Y., Ishiko,S., Rossanti,R.,
            Sakakibara,N., Horinouchi,T., Yamamura,T., Kondo,A., Nagai,S.,
            Nagase,H., Iijima,K., Miner,J.H. and Nozu,K.
  TITLE     Clear Evidence of LAMA5 Gene Biallelic Truncating Variants Causing
            Infantile Nephrotic Syndrome
  JOURNAL   Kidney360 2 (12), 1968-1978 (2021)
   PUBMED   35419533
  REMARK    GeneRIF: Clear Evidence of LAMA5 Gene Biallelic Truncating Variants
            Causing Infantile Nephrotic Syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11426)
  AUTHORS   Shimizu,H., Hosokawa,H., Ninomiya,H., Miner,J.H. and Masaki,T.
  TITLE     Adhesion of cultured bovine aortic endothelial cells to laminin-1
            mediated by dystroglycan
  JOURNAL   J Biol Chem 274 (17), 11995-12000 (1999)
   PUBMED   10207021
REFERENCE   7  (bases 1 to 11426)
  AUTHORS   Tiger,C.F., Champliaud,M.F., Pedrosa-Domellof,F., Thornell,L.E.,
            Ekblom,P. and Gullberg,D.
  TITLE     Presence of laminin alpha5 chain and lack of laminin alpha1 chain
            during human muscle development and in muscular dystrophies
  JOURNAL   J Biol Chem 272 (45), 28590-28595 (1997)
   PUBMED   9353324
REFERENCE   8  (bases 1 to 11426)
  AUTHORS   Durkin,M.E., Loechel,F., Mattei,M.G., Gilpin,B.J., Albrechtsen,R.
            and Wewer,U.M.
  TITLE     Tissue-specific expression of the human laminin alpha5-chain, and
            mapping of the gene to human chromosome 20q13.2-13.3 and to distal
            mouse chromosome 2 near the locus for the ragged (Ra) mutation
  JOURNAL   FEBS Lett 411 (2-3), 296-300 (1997)
   PUBMED   9271224
REFERENCE   9  (bases 1 to 11426)
  AUTHORS   Utani,A., Nomizu,M. and Yamada,Y.
  TITLE     Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via
            conserved amino acid sequences
  JOURNAL   J Biol Chem 272 (5), 2814-2820 (1997)
   PUBMED   9006922
REFERENCE   10 (bases 1 to 11426)
  AUTHORS   Miner,J.H., Lewis,R.M. and Sanes,J.R.
  TITLE     Molecular cloning of a novel laminin chain, alpha 5, and widespread
            expression in adult mouse tissues
  JOURNAL   J Biol Chem 270 (48), 28523-28526 (1995)
   PUBMED   7499364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354836.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_005560.5.
            
            Summary: This gene encodes one of the vertebrate laminin alpha
            chains. Laminins, a family of extracellular matrix glycoproteins,
            are the major noncollagenous constituent of basement membranes.
            They have been implicated in a wide variety of biological processes
            including cell adhesion, differentiation, migration, signaling,
            neurite outgrowth and metastasis. Laminins are composed of 3 non
            identical chains: laminin alpha, beta and gamma (formerly A, B1,
            and B2, respectively) and they form a cruciform structure
            consisting of 3 short arms, each formed by a different chain, and a
            long arm composed of all 3 chains. Each laminin chain is a
            multidomain protein encoded by a distinct gene. The protein encoded
            by this gene is the alpha-5 subunit of of laminin-10 (laminin-511),
            laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by
            RefSeq, Jun 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF443072.1, SRR14038193.2769185.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252999.7/ ENSP00000252999.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AL354836.13        131374-131737       c
            365-517             AL354836.13        126825-126977       c
            518-635             AL354836.13        117559-117676       c
            636-754             AL354836.13        116667-116785       c
            755-925             AL354836.13        116334-116504       c
            926-1023            AL354836.13        116129-116226       c
            1024-1139           AL354836.13        111338-111453       c
            1140-1258           AL354836.13        111107-111225       c
            1259-1349           AL354836.13        110931-111021       c
            1350-1484           AL354836.13        110506-110640       c
            1485-1544           AL354836.13        110243-110302       c
            1545-1685           AL354836.13        102893-103033       c
            1686-1823           AL354836.13        102657-102794       c
            1824-1958           AL354836.13        102441-102575       c
            1959-2093           AL354836.13        102229-102363       c
            2094-2231           AL354836.13        102015-102152       c
            2232-2284           AL354836.13        101159-101211       c
            2285-2390           AL354836.13        100765-100870       c
            2391-2443           AL354836.13        99642-99694         c
            2444-2549           AL354836.13        99446-99551         c
            2550-2649           AL354836.13        98947-99046         c
            2650-2806           AL354836.13        98611-98767         c
            2807-2945           AL354836.13        98326-98464         c
            2946-3088           AL354836.13        97989-98131         c
            3089-3195           AL354836.13        97800-97906         c
            3196-3349           AL354836.13        97515-97668         c
            3350-3510           AL354836.13        96982-97142         c
            3511-3619           AL354836.13        96797-96905         c
            3620-3717           AL354836.13        95457-95554         c
            3718-3919           AL354836.13        95168-95369         c
            3920-4046           AL354836.13        94913-95039         c
            4047-4186           AL354836.13        94202-94341         c
            4187-4302           AL354836.13        93563-93678         c
            4303-4514           AL354836.13        93269-93480         c
            4515-4719           AL354836.13        92666-92870         c
            4720-4864           AL354836.13        92291-92435         c
            4865-5005           AL354836.13        91954-92094         c
            5006-5179           AL354836.13        91658-91831         c
            5180-5281           AL354836.13        91290-91391         c
            5282-5365           AL354836.13        91102-91185         c
            5366-5596           AL354836.13        89741-89971         c
            5597-5710           AL354836.13        88866-88979         c
            5711-5835           AL354836.13        88505-88629         c
            5836-5916           AL354836.13        88201-88281         c
            5917-6131           AL354836.13        87881-88095         c
            6132-6232           AL354836.13        87083-87183         c
            6233-6413           AL354836.13        86694-86874         c
            6414-6563           AL354836.13        86444-86593         c
            6564-6715           AL354836.13        85164-85315         c
            6716-6826           AL354836.13        84984-85094         c
            6827-6938           AL354836.13        84109-84220         c
            6939-7109           AL354836.13        83268-83438         c
            7110-7306           AL354836.13        82879-83075         c
            7307-7423           AL354836.13        82087-82203         c
            7424-7578           AL354836.13        81770-81924         c
            7579-7720           AL354836.13        81307-81448         c
            7721-7823           AL354836.13        81096-81198         c
            7824-7934           AL354836.13        80373-80483         c
            7935-8114           AL354836.13        79453-79632         c
            8115-8263           AL354836.13        79224-79372         c
            8264-8434           AL354836.13        78980-79150         c
            8435-8571           AL354836.13        78729-78865         c
            8572-8725           AL354836.13        78074-78227         c
            8726-8859           AL354836.13        77752-77885         c
            8860-9022           AL354836.13        77513-77675         c
            9023-9145           AL354836.13        77313-77435         c
            9146-9294           AL354836.13        77057-77205         c
            9295-9427           AL354836.13        76825-76957         c
            9428-9571           AL354836.13        76598-76741         c
            9572-9702           AL354836.13        76345-76475         c
            9703-9873           AL354836.13        76039-76209         c
            9874-10009          AL354836.13        75826-75961         c
            10010-10155         AL354836.13        75587-75732         c
            10156-10348         AL354836.13        75327-75519         c
            10349-10513         AL354836.13        75090-75254         c
            10514-10667         AL354836.13        74844-74997         c
            10668-10801         AL354836.13        74603-74736         c
            10802-10895         AL354836.13        74413-74506         c
            10896-11015         AL354836.13        74141-74260         c
            11016-11426         AL354836.13        73490-73900         c
FEATURES             Location/Qualifiers
     source          1..11426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..11426
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /note="laminin subunit alpha 5"
                     /db_xref="GeneID:3911"
                     /db_xref="HGNC:HGNC:6485"
                     /db_xref="MIM:601033"
     exon            1..364
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            365..517
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            518..635
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            636..754
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            755..925
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1023
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1139
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1258
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1349
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1484
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1544
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1685
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1823
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1958
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2093
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2231
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2284
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2390
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2443
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2549
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2649
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2806
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2945
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3088
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3195
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3349
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3510
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3619
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3717
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3919
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4046
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4186
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4302
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4514
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            4515..4719
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4864
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5005
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5006..5179
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5281
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5282..5365
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5596
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5597..5710
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5711..5835
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..5916
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            5917..6131
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            6132..6232
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            6233..6413
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            6414..6563
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            6564..6715
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            6716..6826
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            6827..6938
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            6939..7109
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            7110..7306
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            7307..7423
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            7424..7578
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            7579..7720
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            7721..7823
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            7824..7934
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            7935..8114
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            8115..8263
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            8264..8434
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            8435..8571
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            8572..8725
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            8726..8859
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            8860..9022
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            9023..9145
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            9146..9294
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            9295..9427
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            9428..9571
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            9572..9702
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            9703..9873
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            9874..10009
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            10010..10155
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            10156..10348
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            10349..10513
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            10514..10667
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            10668..10801
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            10802..10895
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            10896..11015
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     exon            11016..11426
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11309..11314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /note="hexamer: AATAAA"
     polyA_site      11333
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /note="major polyA site"
     regulatory      11404..11409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /note="hexamer: ATTAAA"
     polyA_site      11426
                     /gene="LAMA5"
                     /gene_synonym="BBDS2; NPHS26"
                     /note="major polyA site"
ORIGIN      
        1 agacccgccg ggctcccgcc gcgcgcgctg tccctggagc tcggggacgc ggcccggagc
       61 cgggaagatg gcgaagcggc tctgcgcggg gagcgcactg tgtgttcgcg gcccccgggg
      121 ccccgcgccg ctgctgctgg tcgggctggc gctgctgggc gcggcgcggg cgcgggagga
      181 ggcgggcggc ggcttcagcc tgcacccgcc ctacttcaac ctggccgagg gcgcccgcat
      241 cgccgcctcc gcgacctgcg gagaggaggc cccggcgcgc ggctccccgc gccccaccga
      301 ggacctttac tgcaagctgg tagggggccc cgtggccggc ggcgacccca accagaccat
      361 ccggggccag tactgtgaca tctgcacggc tgccaacagc aacaaggcac accccgcgag
      421 caatgccatc gatggcacgg agcgctggtg gcagagtcca ccgctgtccc gcggcctgga
      481 gtacaacgag gtcaacgtca ccctggacct gggccaggtc ttccacgtgg cctacgtcct
      541 catcaagttt gccaactcac cccggccgga cctctgggtg ctggagcggt ccatggactt
      601 cggccgcacc taccagccct ggcagttctt tgcctcctcc aagagggact gtctggagcg
      661 gttcgggcca cagacgctgg agcgcatcac acgggacgac gcggccatct gcaccaccga
      721 gtactcacgc atcgtgcccc tggagaacgg agagatcgtg gtgtccctgg tgaacggacg
      781 tccgggcgcc atgaatttct cctactcgcc gctgctacgt gagttcacca aggccaccaa
      841 cgtccgcctg cgcttcctgc gtaccaacac gctgctgggc catctcatgg ggaaggcgct
      901 gcgggacccc acggtcaccc gccggtatta ttacagcatc aaggatatca gcatcggagg
      961 ccgctgtgtc tgccacggcc acgcggatgc ctgcgatgcc aaagacccca cggacccgtt
     1021 caggctgcag tgcacctgcc agcacaacac ctgcgggggc acctgcgacc gctgctgccc
     1081 cggcttcaat cagcagccgt ggaagcctgc gactgccaac agtgccaacg agtgccagtc
     1141 ctgtaactgc tacggccatg ccaccgactg ttactacgac cctgaggtgg accggcgccg
     1201 cgccagccag agcctggatg gcacctatca gggtgggggt gtctgtatcg actgccagca
     1261 ccacaccacc ggcgtcaact gtgagcgctg cctgcccggc ttctaccgct ctcccaacca
     1321 ccctctcgac tcgccccacg tctgccgccg ctgcaactgc gagtccgact tcacggatgg
     1381 cacctgcgag gacctgacgg gtcgatgcta ctgccggccc aacttctctg gggagcggtg
     1441 tgacgtgtgt gccgagggct tcacgggctt cccaagctgc tacccgacgc cctcgtcctc
     1501 caatgacacc agggagcagg tgctgccagc cggccagatt gtgaattgtg actgcagcgc
     1561 ggcagggacc cagggcaacg cctgccggaa ggacccaagg gtgggacgct gtctgtgcaa
     1621 acccaacttc caaggcaccc attgtgagct ctgcgcgcca gggttctacg gccccggctg
     1681 ccagccctgc cagtgttcca gccctggagt ggccgatgac cgctgtgacc ctgacacagg
     1741 ccagtgcagg tgccgagtgg gcttcgaggg ggccacatgt gatcgctgtg cccccggcta
     1801 ctttcacttc cctctctgcc agttgtgtgg ctgcagccct gcaggaacct tgcccgaggg
     1861 ctgcgatgag gccggccgct gcctatgcca gcctgagttt gctggacctc attgtgaccg
     1921 gtgccgccct ggctaccatg gtttccccaa ctgccaagca tgcacctgcg accctcgggg
     1981 agccctggac cagctctgtg gggcgggagg tttgtgccgc tgccgccccg gctacacagg
     2041 cactgcctgc caggaatgca gccccggctt tcacggcttc cccagctgtg tcccctgcca
     2101 ctgctctgct gaaggctccc tgcacgcagc ctgtgacccc cggagtgggc agtgcagctg
     2161 ccggccccgt gtgacggggc tgcggtgtga cacatgtgtg cccggtgcct acaacttccc
     2221 ctactgcgaa gctggctctt gccaccctgc cggtctggcc ccagtggatc ctgcccttcc
     2281 tgaggcacag gttccctgta tgtgccgggc tcacgtggag gggccgagct gtgaccgctg
     2341 caaacctggg ttctggggac tgagccccag caaccccgag ggctgtaccc gctgcagctg
     2401 cgacctcagg ggcacactgg gtggagttgc tgagtgccag ccgggcaccg gccagtgctt
     2461 ctgcaagccc cacgtgtgcg gccaggcctg cgcgtcctgc aaggatggct tctttggact
     2521 ggatcaggct gactattttg gctgccgcag ctgccggtgt gacattggcg gtgcactggg
     2581 ccagagctgt gaaccgagga cgggcgtctg ccggtgccgc cccaacaccc agggccccac
     2641 ctgcagcgag cctgcgaggg accactacct cccggacctg caccacctgc gcctggagct
     2701 ggaggaggct gccacacctg agggtcacgc cgtgcgcttt ggcttcaacc ccctcgagtt
     2761 cgagaacttc agctggaggg gctacgcgca gatggcacct gtccagccca ggatcgtggc
     2821 caggctgaac ctgacctccc ctgacctttt ctggctcgtc ttccgatacg tcaaccgggg
     2881 ggccatgagt gtgagcgggc gggtctctgt gcgagaggag ggcaggtcgg ccacctgcgc
     2941 caactgcaca gcacagagtc agcccgtggc cttcccaccc agcacggagc ctgccttcat
     3001 caccgtgccc cagaggggct tcggagagcc ctttgtgctg aaccctggca cctgggccct
     3061 gcgtgtggag gccgaagggg tgctcctgga ctacgtggtt ctgctgccta gcgcatacta
     3121 cgaggcggcg ctcctgcagc tgcgggtgac tgaggcctgc acataccgtc cctctgccca
     3181 gcagtctggc gacaactgcc tcctctacac acacctcccc ctggatggct tcccctcggc
     3241 cgccgggctg gaggccctgt gtcgccagga caacagcctg ccccggccct gccccacgga
     3301 gcagctcagc ccgtcgcacc cgccactgat cacctgcacg ggcagtgatg tggacgtcca
     3361 gcttcaagtg gcagtgccac agccaggccg ctatgcccta gtggtggagt acgccaatga
     3421 ggatgcccgc caggaggtgg gcgtggccgt gcacacccca cagcgggccc cccagcaggg
     3481 gctgctctcc ctgcacccct gcctgtacag caccctgtgc cggggcactg cccgggatac
     3541 ccaggaccac ctggctgtct tccacctgga ctcggaggcc agcgtgaggc tcacagccga
     3601 acaggcacgc ttcttcctgc acggggtcac tctggtgccc attgaggagt tcagcccgga
     3661 gttcgtggag ccccgggtca gctgcatcag cagccacggc gcctttggcc ccaacagtgc
     3721 cgcctgtctg ccctcgcgct tcccaaagcc gccccagccc atcatcctca gggactgcca
     3781 ggtgatcccg ctgccgcccg gcctcccgct gacccacgcg caggatctca ctccagccat
     3841 gtccccagct ggaccccgac ctcggccccc caccgctgtg gaccctgatg cagagcccac
     3901 cctgctgcgt gagccccagg ccaccgtggt cttcaccacc catgtgccca cgctgggccg
     3961 ctatgccttc ctgctgcacg gctaccagcc agcccacccc accttccccg tggaagtcct
     4021 catcaacgcc ggccgcgtgt ggcagggcca cgccaacgcc agcttctgtc cacatggcta
     4081 cggctgccgc accctggtgg tgtgtgaggg ccaggccctg ctggacgtga cccacagcga
     4141 gctcactgtg accgtgcgtg tgcccaaggg ccggtggctc tggctggatt atgtactcgt
     4201 ggtccctgag aacgtctaca gctttggcta cctccgggag gagcccctgg ataaatccta
     4261 tgacttcatc agccactgcg cagcccaggg ctaccacatc agccccagca gctcatccct
     4321 gttctgccga aacgctgctg cttccctctc cctcttctat aacaacggag cccgtccatg
     4381 tggctgccac gaagtaggtg ctacaggccc cacgtgtgag cccttcgggg gccagtgtcc
     4441 ctgccatgcc catgtcattg gccgtgactg ctcccgctgt gccaccggat actggggctt
     4501 ccccaactgc aggccctgtg actgcggtgc ccgcctctgt gacgagctca cgggccagtg
     4561 catctgcccg ccacgcacca tcccgcccga ctgcctgctg tgccagcccc agacctttgg
     4621 ctgccacccc ctggtcggct gtgaggagtg taactgctca gggcccggca tccaggagct
     4681 cacagaccct acctgtgaca cagacagcgg ccagtgcaag tgcagaccca acgtgactgg
     4741 gcgccgctgt gatacctgct ctccgggctt ccatggctac ccccgctgcc gcccctgtga
     4801 ctgtcacgag gcgggcactg cgcctggcgt gtgtgacccc ctcacagggc agtgctactg
     4861 taaggagaac gtgcagggcc ccaaatgtga ccagtgcagc cttgggacct tctcactgga
     4921 tgctgccaac cccaaaggtt gcacccgctg cttctgcttt ggggccacgg agcgctgccg
     4981 gagctcgtcc tacacccgcc aggagttcgt ggatatggag ggatgggtgc tgctgagcac
     5041 tgaccggcag gtggtgcccc acgagcggca gccagggacg gagatgctcc gtgcagacct
     5101 gcggcacgtg cctgaggctg tgcccgaggc tttccccgag ctgtactggc aggccccacc
     5161 ctcctacctg ggggaccggg tgtcatccta cggtgggacc ctccgttatg aactgcactc
     5221 agagacccag cggggagatg tctttgtccc catggagagc aggccggatg tggtgctgca
     5281 gggcaaccag atgagcatca cattcctgga gccggcatac cccacgcctg gccacgttca
     5341 ccgtgggcag ctgcagctgg tggaggggaa cttccggcat acggagacgc gcaacactgt
     5401 gtcccgcgag gagctcatga tggtgctggc cagcctggag cagctgcaga tccgtgccct
     5461 cttctcacag atctcctcgg ctgtcttcct gcgcagggtg gcactggagg tggccagccc
     5521 agcaggccag ggggccctgg ccagcaatgt ggagctgtgc ctgtgccccg ccagctaccg
     5581 gggggactca tgccaggaat gtgcccccgg cttctatcgg gacgtcaaag gtctcttcct
     5641 gggccgatgt gtcccttgtc agtgccatgg acactcagac cgctgcctcc ctggctctgg
     5701 cgtctgtgtg gactgccagc acaacaccga aggggcccac tgtgagcgct gccaggctgg
     5761 cttcgtgagc agcagggacg accccagcgc cccctgtgtc agctgcccct gccccctctc
     5821 agtgccttcc aacaacttcg ccgagggctg tgtcctgcga ggcggccgca cccagtgcct
     5881 ctgcaaacct ggttatgcag gtgcctcctg cgagcggtgt gcgcccggat tctttgggaa
     5941 cccactggtg ctgggcagct cctgccagcc atgcgactgc agcggcaacg gtgaccccaa
     6001 cttgctcttc agcgactgcg accccctgac gggcgcctgc cgtggctgcc tgcgccacac
     6061 cactgggccc cgctgcgaga tctgtgcccc cggcttctac ggcaacgccc tgctgcccgg
     6121 caactgcacc cggtgcgact gtaccccatg tgggacagag gcctgcgacc cccacagcgg
     6181 gcactgcctg tgcaaggcgg gcgtgactgg gcggcgctgt gaccgctgcc aggagggaca
     6241 ttttggtttc gatggctgcg ggggctgccg cccgtgtgct tgtggaccgg ccgccgaggg
     6301 ctccgagtgc cacccccaga gcggacagtg ccactgccga ccagggacca tgggacccca
     6361 gtgccgcgag tgtgcccctg gctactgggg gctccctgag cagggctgca ggcgctgcca
     6421 gtgccctggg ggccgctgtg accctcacac gggccgctgc aactgccccc cggggctcag
     6481 cggggagcgc tgcgacacct gcagccagca gcatcaggtg cctgttccag gcgggcctgt
     6541 gggccacagc atccactgtg aagtgtgtga ccactgtgtg gtcctgctcc tggatgacct
     6601 ggaacgggcc ggcgccctcc tccccgccat tcacgagcaa ctgcgtggca tcaatgccag
     6661 ctccatggcc tgggcccgtc tgcacaggct gaacgcctcc atcgctgacc tgcagagcca
     6721 gctccggagc cccctgggcc cccgccatga gacggcacag cagctggagg tgctggagca
     6781 gcagagcaca agcctcgggc aggacgcacg gcggctaggc ggccaggccg tggggacccg
     6841 agaccaggcg agccaattgc tggccggcac cgaggccaca ctgggccatg cgaagacgct
     6901 gttggcggcc atccgggctg tggaccgcac cctgagcgag ctcatgtccc agacgggcca
     6961 cctggggctg gccaatgcct cggctccatc aggtgagcag ctgctccgga cactggccga
     7021 ggtggagcgg ctgctctggg agatgcgggc ccgggacctg ggggccccgc aggcagcagc
     7081 tgaggctgag ttggctgcag cacagagatt gctggcccgg gtgcaggagc agctgagcag
     7141 cctctgggag gagaaccagg cactggccac acaaacccgc gaccggctgg cccagcacga
     7201 ggccggcctc atggacctgc gagaggcttt gaaccgggca gtggacgcca cacgggaggc
     7261 ccaggagctc aacagccgca accaggagcg cctggaggaa gccctgcaaa ggaagcagga
     7321 gctgtcccgg gacaatgcca ccctgcaggc cactctgcat gcggctaggg acaccctggc
     7381 cagcgtcttc agattgctgc acagcctgga ccaggctaag gaggagctgg agcgcctcgc
     7441 cgccagcctg gatggggctc ggaccccact gctgcagagg atgcagacct tctccccggc
     7501 gggcagcaag ctgcgtctag tggaggccgc cgaggcccac gcacagcagc tgggccagct
     7561 ggcactcaat ctgtccagca tcatcctgga cgtcaaccag gaccgcctca cccagagggc
     7621 catcgaggcc tccaacgcct acagccgcat cctgcaggcc gtgcaggctg ccgaggatgc
     7681 tgctggccag gccctgcagc aggcggacca cacgtgggcg acggtggtgc ggcagggcct
     7741 ggtggaccga gcccagcagc tcctggccaa cagcactgca ctagaagagg ccatgctcca
     7801 ggaacagcag aggctgggcc ttgtgtgggc tgccctccag ggtgccagga cccagctccg
     7861 agatgtccgg gccaagaagg accagctgga ggcgcacatc caggcggcgc aggccatgct
     7921 tgccatggac acagacgaga caagcaagaa gatcgcacat gccaaggctg tggctgctga
     7981 agcccaggac accgccaccc gtgtgcagtc ccagctgcag gccatgcagg agaatgtgga
     8041 gcggtggcag ggccagtacg agggcctgcg gggccaggac ctgggccagg cagtgcttga
     8101 cgcaggccac tcagtgtcca ccctggagaa gacgctgccc cagctgctgg ccaagctgag
     8161 catcctggag aaccgtgggg tgcacaacgc cagcctggcc ctgtccgcca gcattggccg
     8221 cgtgcgagag ctcattgccc aggcccgggg ggctgccagt aaggtcaagg tgcccatgaa
     8281 gttcaacggg cgctcagggg tgcagctgcg caccccacgg gatcttgccg accttgctgc
     8341 ctacactgcc ctcaagttct acctgcaggg cccagagcct gagcctgggc agggtaccga
     8401 ggatcgcttt gtgatgtaca tgggcagccg ccaggccact ggggactaca tgggtgtgtc
     8461 tctgcgtgac aagaaggtgc actgggtgta tcagctgggt gaggcgggcc ctgcagtcct
     8521 aagcatcgat gaggacattg gggagcagtt cgcagctgtc agcctggaca ggactctcca
     8581 gtttggccac atgtccgtca cagtggagag acagatgatc caggaaacca agggtgacac
     8641 ggtggcccct ggggcagagg ggctgctcaa cctgcggcca gacgacttcg tcttctacgt
     8701 cggggggtac cccagtacct tcacgccccc tcccctgctt cgcttccccg gctaccgggg
     8761 ctgcatcgag atggacacgc tgaatgagga ggtggtcagc ctctacaact tcgagaggac
     8821 cttccagctg gacacggctg tggacaggcc ttgtgcccgc tccaagtcga ccggggaccc
     8881 gtggctcacg gacggctcct acctggacgg caccggcttc gcccgcatca gcttcgacag
     8941 tcagatcagc accaccaagc gcttcgagca ggagctgcgg ctcgtgtcct acagcggggt
     9001 gctcttcttc ctgaagcagc agagccagtt cctgtgcttg gccgtgcaag aaggcagcct
     9061 cgtgctgttg tatgactttg gggctggcct gaaaaaggcc gtcccactgc agcccccacc
     9121 gcccctgacc tcggccagca aggcgatcca ggtgttcctg ctggggggca gccgcaagcg
     9181 tgtgctggtg cgtgtggagc gggccacggt gtacagcgtg gagcaggaca atgatctgga
     9241 gctggccgac gcctactacc tggggggcgt gccgcccgac cagctgcccc cgagcctgcg
     9301 acggctcttc cccaccggag gctcagtccg tggctgcgtc aaaggcatca aggccctggg
     9361 caagtatgtg gacctcaagc ggctgaacac gacaggcgtg agcgccggct gcaccgccga
     9421 cctgctggtg gggcgcgcca tgactttcca tggccacggc ttccttcgcc tggcgctctc
     9481 gaacgtggca ccgctcactg gcaacgtcta ctccggcttc ggcttccaca gcgcccagga
     9541 cagtgccctg ctctactacc gggcgtcccc ggatgggcta tgccaggtgt ccctgcagca
     9601 gggccgtgtg agcctacagc tcctgaggac tgaagtgaaa actcaagcgg gcttcgccga
     9661 tggtgccccc cattacgtcg ccttctacag caatgccacg ggagtctggc tgtatgtcga
     9721 tgaccagctc cagcagatga agccccaccg gggaccaccc cccgagctcc agccgcagcc
     9781 tgaggggccc ccgaggctcc tcctgggagg cctgcctgag tctggcacca tttacaactt
     9841 cagtggctgc atcagcaacg tcttcgtgca gcggctcctg ggcccacagc gcgtatttga
     9901 tctgcagcag aacctgggca gcgtcaatgt gagcacgggc tgtgcacccg ccctgcaagc
     9961 ccagaccccg ggcctggggc ctagaggact gcaggccacc gcccggaagg cctcccgccg
    10021 cagccgtcag cccgcccggc atcctgcctg catgctgccc ccacacctca ggaccacccg
    10081 agactcctac cagtttgggg gttccctgtc cagtcacctg gagtttgtgg gcatcctggc
    10141 ccgacatagg aactggccca gtctctccat gcacgtcctc ccgcgaagct cccgaggcct
    10201 cctcctcttc actgcccgtc tgaggcccgg cagcccctcc ctggcgctct tcctgagcaa
    10261 tggccacttc gttgcacaga tggaaggcct cgggactcgg ctccgcgccc agagccgcca
    10321 gcgctcccgg cctggccgct ggcacaaggt ctccgtgcgc tgggagaaga accggatcct
    10381 gctggtgacg gacggggccc gggcctggag ccaggagggg ccgcaccggc agcaccaggg
    10441 ggcagagcac ccccagcccc acaccctctt tgtgggcggc ctcccggcca gcagccacag
    10501 ctccaaactt ccggtgaccg tcgggttcag cggctgtgtg aagagactga ggctgcacgg
    10561 gaggcccctg ggggccccca cacggatggc aggggtcaca ccctgcatct tgggccccct
    10621 ggaggcgggc ctgttcttcc caggcagcgg gggagttatc actttagacc tcccaggagc
    10681 tacactgcct gatgtgggcc tggaactgga ggtgcggccc ctggcagtca ccggactgat
    10741 cttccacttg ggccaggccc ggacgccccc ctacttgcag ttgcaggtga ccgagaagca
    10801 agtcctgctg cgggcggatg acggagcagg ggagttctcc acgtcagtga cccgcccctc
    10861 agtgctgtgt gatggccagt ggcaccggct agcggtgatg aaaagcggga atgtgctccg
    10921 gctggaggtg gacgcgcaga gcaaccacac cgtgggcccc ttgctggcgg ctgcagctgg
    10981 tgccccagcc cctctgtacc tcgggggcct gcctgagccc atggccgtgc agccctggcc
    11041 ccccgcctac tgcggctgca tgaggaggct ggcggtgaac cggtcccccg tcgccatgac
    11101 tcgctctgtg gaggtccacg gggcagtggg ggccagtggc tgcccagccg cctaggacac
    11161 agccaacccc ggcccctggt caggcccctg cagctgcctc acaccgcccc ttgtgctcgc
    11221 ctcataggtg tctatttgga ctctaagctc tacgggtgac agatcttgtt tctgaagatg
    11281 gtttaagtta tagcttctta aacgaaagaa taaaatactg caaaatgttt ttatatttgg
    11341 cccttccacc catttttaat tgtgagagat ttgtcaccaa tcatcactgg ttcctcctta
    11401 aaaattaaaa agtaacttct gtgtaa
//
