LOCUS       NM_000426               9696 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens laminin subunit alpha 2 (LAMA2), transcript variant 1,
            mRNA.
ACCESSION   NM_000426
VERSION     NM_000426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9696)
  AUTHORS   Camelo,C.G., Moreno,C.A.M., Artilheiro,M.D.C., Fonseca,A.T.Q.M.,
            Gurgel Gianetti,J., Barbosa,A.V., Donis,K.C., Saute,J.A.M.,
            Pessoa,A., Van der Linden,H. Jr., Goncalves,A.R.A.,
            Kulikowski,L.D., Kok,F. and Zanoteli,E.
  TITLE     Genetic profile of Brazilian patients with LAMA2-related
            dystrophies
  JOURNAL   Clin Genet 106 (3), 305-314 (2024)
   PUBMED   38747280
  REMARK    GeneRIF: Genetic profile of Brazilian patients with LAMA2-related
            dystrophies.
REFERENCE   2  (bases 1 to 9696)
  AUTHORS   Bouman,K., van den Heuvel,F.M.A., Evertz,R., Boesaard,E.,
            Groothuis,J.T., van Engelen,B.G.M., Nijveldt,R., Erasmus,C.E.,
            Udink Ten Cate,F.E.A. and Voermans,N.C.
  TITLE     Cardiac Involvement in LAMA2-Related Muscular Dystrophy and
            SELENON-Related Congenital Myopathy: A Case Series
  JOURNAL   J Neuromuscul Dis 11 (5), 919-934 (2024)
   PUBMED   39177608
  REMARK    GeneRIF: Cardiac Involvement in LAMA2-Related Muscular Dystrophy
            and SELENON-Related Congenital Myopathy: A Case Series.
REFERENCE   3  (bases 1 to 9696)
  AUTHORS   Sabry,S., Issa,M.Y., Abdel-Hamid,M.S., Eissa,N.R.,
            Abdel-Ghafar,S.F., Ibrahim,M.M. and Zaki,M.S.
  TITLE     An atypical expression of core alpha-Dystroglycan and
            Laminin-alpha2 in skin fibroblasts of patients with congenital
            muscular dystrophies
  JOURNAL   Mol Biol Rep 50 (8), 6373-6379 (2023)
   PUBMED   37318662
  REMARK    GeneRIF: An atypical expression of core alpha-Dystroglycan and
            Laminin-alpha2 in skin fibroblasts of patients with congenital
            muscular dystrophies.
REFERENCE   4  (bases 1 to 9696)
  AUTHORS   Huang,X., Tan,D., Zhang,Z., Ge,L., Liu,J., Ding,J., Yang,H.,
            Wei,C., Chang,X., Yuan,Y., Yan,C. and Xiong,H.
  TITLE     Unique genotype-phenotype correlations within LAMA2-related limb
            girdle muscular dystrophy in Chinese patients
  JOURNAL   Front Neurol 14, 1158094 (2023)
   PUBMED   37206914
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9696)
  AUTHORS   Oliveira,J., Parente Freixo,J., Santos,M. and Coelho,T.
  TITLE     LAMA2 Muscular Dystrophy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22675738
REFERENCE   6  (bases 1 to 9696)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
REFERENCE   7  (bases 1 to 9696)
  AUTHORS   Aeschlimann,D. and Paulsson,M.
  TITLE     Cross-linking of laminin-nidogen complexes by tissue
            transglutaminase. A novel mechanism for basement membrane
            stabilization
  JOURNAL   J Biol Chem 266 (23), 15308-15317 (1991)
   PUBMED   1678389
REFERENCE   8  (bases 1 to 9696)
  AUTHORS   Chung,A.E. and Durkin,M.E.
  TITLE     Entactin: structure and function
  JOURNAL   Am J Respir Cell Mol Biol 3 (4), 275-282 (1990)
   PUBMED   2119632
  REMARK    Review article
REFERENCE   9  (bases 1 to 9696)
  AUTHORS   Engvall,E., Earwicker,D., Haaparanta,T., Ruoslahti,E. and
            Sanes,J.R.
  TITLE     Distribution and isolation of four laminin variants; tissue
            restricted distribution of heterotrimers assembled from five
            different subunits
  JOURNAL   Cell Regul 1 (10), 731-740 (1990)
   PUBMED   2099832
REFERENCE   10 (bases 1 to 9696)
  AUTHORS   Ehrig,K., Leivo,I., Argraves,W.S., Ruoslahti,E. and Engvall,E.
  TITLE     Merosin, a tissue-specific basement membrane protein, is a
            laminin-like protein
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3264-3268 (1990)
   PUBMED   2185464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445439.9, DA864571.1,
            AL041786.1, Z26653.1, CN414799.1, DB106101.1, AB208922.1,
            AL356124.17 and BM984634.1.
            
            On Dec 30, 2019 this sequence version replaced NM_000426.3.
            
            Summary: Laminin, an extracellular protein, is a major component of
            the basement membrane. It is thought to mediate the attachment,
            migration, and organization of cells into tissues during embryonic
            development by interacting with other extracellular matrix
            components. It is composed of three subunits, alpha, beta, and
            gamma, which are bound to each other by disulfide bonds into a
            cross-shaped molecule. This gene encodes the alpha 2 chain, which
            constitutes one of the subunits of laminin 2 (merosin) and laminin
            4 (s-merosin). Mutations in this gene have been identified as the
            cause of congenital merosin-deficient muscular dystrophy. Two
            transcript variants encoding different proteins have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z26653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421865.3/ ENSP00000400365.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL445439.9         118901-118903
            4-488               DA864571.1         1-485
            489-627             AL041786.1         244-382
            628-1289            Z26653.1           569-1230
            1290-1415           CN414799.1         524-649
            1416-3206           Z26653.1           1357-3147
            3207-3708           DB106101.1         62-563
            3709-5573           Z26653.1           3650-5514
            5574-6344           AB208922.1         1673-2443
            6345-7867           Z26653.1           6286-7808
            7868-7868           AL356124.17        45931-45931
            7869-7937           Z26653.1           7810-7878
            7938-7952           AB208922.1         4025-4039
            7953-8526           Z26653.1           7894-8467
            8527-9594           AB208922.1         4614-5681
            9595-9696           BM984634.1         16-117              c
FEATURES             Location/Qualifiers
     source          1..9696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.33"
     gene            1..9696
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /note="laminin subunit alpha 2"
                     /db_xref="GeneID:3908"
                     /db_xref="HGNC:HGNC:6482"
                     /db_xref="MIM:156225"
     exon            1..220
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..9477
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; merosin heavy chain; laminin M chain; laminin-2
                     subunit alpha; laminin-4 subunit alpha; laminin-12 subunit
                     alpha; laminin, alpha 2; mutant laminin subunit alpha 2"
                     /codon_start=1
                     /product="laminin subunit alpha-2 isoform a precursor"
                     /protein_id="NP_000417.3"
                     /db_xref="CCDS:CCDS5138.1"
                     /db_xref="GeneID:3908"
                     /db_xref="HGNC:HGNC:6482"
                     /db_xref="MIM:156225"
                     /translation="MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVL
                     NLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNA
                     IDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDD
                     VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISL
                     INGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYY
                     SVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGT
                     FLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCET
                     CTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGG
                     VSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQ
                     EDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMSGWYLTDLPGRIRVAPQQDDLDSPQQ
                     ISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLM
                     IILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLK
                     RVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWP
                     RHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTK
                     GTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPS
                     VPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKN
                     CQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSF
                     GSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRC
                     ICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGA
                     KCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCD
                     RCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQH
                     TTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAR
                     EETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRV
                     HRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIE
                     KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSIC
                     QNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC
                     TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGA
                     TGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLY
                     GLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDA
                     ERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIK
                     ELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVD
                     DAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEA
                     NRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQL
                     NDSSAVLDGILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATG
                     PRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTL
                     NDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLAD
                     SVAKTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKE
                     LINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAK
                     FIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRAL
                     DGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKADAVRVITFTGCMGET
                     YFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTV
                     MFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKW
                     KSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLS
                     MKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVE
                     LSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLE
                     VHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQP
                     IEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAH
                     QKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSR
                     NSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYD
                     LGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLY
                     VGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYF
                     DGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVD
                     NGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADT
                     NDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVS
                     CPAN"
     exon            221..391
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            392..504
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            505..747
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            748..927
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1017
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1135
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1314
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1414
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1575
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1716
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1890
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1992
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2204
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2316
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2430
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2558
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2645
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2857
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2964
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3145
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3282
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3519
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3663
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3843
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..4032
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4166
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4284
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4419
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4544
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4631
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4825
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4826..4968
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4969..5067
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5068..5179
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5342
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5343..5553
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5554..5670
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5671..5834
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5835..5973
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5974..6076
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6077..6193
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6194..6376
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6377..6382
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6383..6537
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6538..6681
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6682..6815
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6816..6975
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            6976..7100
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            7101..7263
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            7264..7408
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            7409..7547
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            7548..7559
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            7560..7680
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            7681..7857
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            7858..8006
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8007..8183
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8184..8352
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8353..8465
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8466..8655
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8656..8811
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8812..8965
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8966..9096
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            9097..9319
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            9320..9696
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9672..9677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /note="hexamer: ATTAAA"
     polyA_site      9696
                     /gene="LAMA2"
                     /gene_synonym="LAMM; MDC1A"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcccca gcagctgctg ctcgctcagc tcacaagcca aggccagggg acagggcggc
       61 agcgactcct ctggctcccg agaagtggat ccggtcgcgg ccactacgat gccgggagcc
      121 gccggggtcc tcctccttct gctgctctcc ggaggcctcg ggggcgtaca ggcgcagcgg
      181 ccgcagcagc agcggcagtc acaggcacat cagcaaagag gtttattccc tgctgtcctg
      241 aatcttgctt ctaatgctct tatcacgacc aatgcaacat gtggagaaaa aggacctgaa
      301 atgtactgca aattggtaga acatgtccct gggcagcctg tgaggaaccc gcagtgtcga
      361 atctgcaatc aaaacagcag caatccaaac cagagacacc cgattacaaa tgctattgat
      421 ggaaagaaca cttggtggca gagtcccagt attaagaatg gaatcgaata ccattatgtg
      481 acaattaccc tggatttaca gcaggtgttc cagatcgcgt atgtgattgt gaaggcagct
      541 aactcccccc ggcctggaaa ctggattttg gaacgctctc ttgatgatgt tgaatacaag
      601 ccctggcagt atcatgctgt gacagacacg gagtgcctaa cgctttacaa tatttatccc
      661 cgcactgggc caccgtcata tgccaaagat gatgaggtca tctgcacttc attttactcc
      721 aagatacacc ccttagaaaa tggagagatt cacatctctt taatcaatgg gagaccaagt
      781 gccgatgatc cttctccaga actgctagaa tttacctccg ctcgctatat tcgcctgaga
      841 tttcagagga tccgcacact gaatgctgac ttgatgatgt ttgctcacaa agacccaaga
      901 gaaattgacc ccattgtcac cagaagatat tactactcgg tcaaggatat ttcagttgga
      961 gggatgtgca tctgctatgg tcatgccagg gcttgtccac ttgatccagc gacaaataaa
     1021 tctcgctgtg agtgtgagca taacacatgt ggcgatagct gtgatcagtg ctgtccagga
     1081 ttccatcaga aaccctggag agctggaact tttctaacta aaactgaatg tgaagcatgc
     1141 aattgtcatg gaaaagctga agaatgctat tatgatgaaa atgttgccag aagaaatctg
     1201 agtttgaata tacgtggaaa gtacattgga gggggtgtct gcattaattg tacccaaaac
     1261 actgctggta taaactgcga gacatgtact gatggcttct tcagacccaa aggggtatct
     1321 ccaaattatc caaggccatg ccagccatgt cattgcgatc caattggttc cttaaatgaa
     1381 gtctgtgtca aggatgagaa acatgctcga cgaggtttgg cacctggatc ctgtcattgc
     1441 aaaactggtt ttggaggtgt gagctgtgat cggtgtgcca ggggctacac tggctacccg
     1501 gactgcaaag cctgtaactg cagtgggtta gggagcaaaa atgaggatcc ttgttttggc
     1561 ccctgtatct gcaaggaaaa tgttgaagga ggagactgta gtcgttgcaa atccggcttc
     1621 ttcaatttgc aagaggataa ttggaaaggc tgcgatgagt gtttctgttc aggggtttca
     1681 aacagatgtc agagttccta ctggacctat ggcaaaatac aagatatgag tggctggtat
     1741 ctgactgacc ttcctggccg cattcgagtg gctccccagc aggacgactt ggactcacct
     1801 cagcagatca gcatcagtaa cgcggaggcc cggcaagccc tgccgcacag ctactactgg
     1861 agcgcgccgg ctccctatct gggaaacaaa ctcccagcag taggaggaca gttgacattt
     1921 accatatcat atgaccttga agaagaggaa gaagatacag aacgtgttct ccagcttatg
     1981 attatcttag agggtaatga cttgagcatc agcacagccc aagatgaggt gtacctgcac
     2041 ccatctgaag aacatactaa tgtattgtta cttaaagaag aatcatttac catacatggc
     2101 acacattttc cagtccgtag aaaggaattt atgacagtgc ttgcgaattt gaagagagtc
     2161 ctcctacaaa tcacatacag ctttgggatg gatgccatct tcaggttgag ctctgttaac
     2221 cttgaatccg ctgtctccta tcctactgat ggaagcattg cagcagctgt agaagtgtgt
     2281 cagtgcccac cagggtatac tggctcctct tgtgaatctt gttggcctag gcacaggcga
     2341 gttaacggca ctatttttgg tggcatctgt gagccatgtc agtgctttgg tcatgcggag
     2401 tcctgtgatg acgtcactgg agaatgcctg aactgtaagg atcacacagg tggcccatat
     2461 tgtgataaat gtcttcctgg tttctatggc gagcctacta aaggaacctc tgaagactgt
     2521 caaccctgtg cctgtccact caatatccca tccaataact ttagcccaac gtgccattta
     2581 gaccggagtc ttggattgat ctgtgatgga tgccctgtcg ggtacacagg accacgctgt
     2641 gagaggtgtg cagaaggcta ttttggacaa ccctctgtac ctggaggatc atgtcagcca
     2701 tgccaatgca atgacaacct tgacttctcc atccctggca gctgtgacag cttgtctggc
     2761 tcctgtctga tatgtaaacc aggtacaaca ggccggtact gtgagctctg tgctgatgga
     2821 tattttggag atgcagttga tgcgaagaac tgtcagccct gtcgctgtaa tgccggtggc
     2881 tctttctctg aggtttgcca cagtcaaact ggacagtgtg agtgcagagc caacgttcag
     2941 ggtcagagat gtgacaaatg caaggctggg acctttggcc tacaatcagc aaggggctgt
     3001 gttccctgca actgcaattc ttttgggtct aagtcattcg actgtgaaga gagtggacaa
     3061 tgttggtgcc aacctggagt cacagggaag aaatgtgacc gctgtgccca cggctatttc
     3121 aacttccaag aaggaggctg cacagcttgt gaatgttctc atctgggtaa taattgtgac
     3181 ccaaagactg ggcgatgcat ttgccctccc aataccattg gagagaaatg ttctaaatgt
     3241 gcacccaata cctggggcca cagcattacc actggttgta aggcttgtaa ctgcagcaca
     3301 gtgggatcct tggatttcca atgcaatgta aatacaggcc aatgcaactg tcatccaaaa
     3361 ttctctggtg caaaatgtac agagtgcagt cgaggtcact ggaactaccc tcgctgcaat
     3421 ctctgtgact gcttcctccc tgggacagat gccacaacct gtgattcaga gactaaaaaa
     3481 tgctcctgta gtgatcaaac tgggcagtgc acttgtaagg tgaatgtgga aggcatccac
     3541 tgtgacagat gccggcctgg caaattcgga ctcgatgcca agaatccact tggctgcagc
     3601 agctgctatt gcttcggcac tactacccag tgctctgaag caaaaggact gatccggacg
     3661 tgggtgactc tgaaggctga gcagaccatt ctacccctgg tagatgaggc tctgcagcac
     3721 acgaccacca agggcattgt ttttcaacat ccagagattg ttgcccacat ggacctgatg
     3781 agagaagatc tccatttgga acctttttat tggaaacttc cagaacaatt tgaaggaaag
     3841 aagttgatgg cctatggggg caaactcaag tatgcaatct atttcgaggc tcgggaagaa
     3901 acaggtttct ctacatataa tcctcaagtg atcattcgag gtgggacacc tactcatgct
     3961 agaattatcg tcaggcatat ggctgctcct ctgattggcc aattgacaag gcatgaaatt
     4021 gaaatgacag agaaagaatg gaaatattat ggggatgatc ctcgagtcca tagaactgtg
     4081 acccgagaag acttcttgga tatactatat gatattcatt acattcttat caaagctact
     4141 tatggaaatt tcatgcgaca aagcaggatt tctgaaatct caatggaggt agctgaacaa
     4201 ggacgtggaa caacaatgac tcctccagct gacttgattg aaaaatgtga ttgtcccctg
     4261 ggctattctg gcctgtcctg tgaggcatgc ttgccgggat tttatcgact gcgttctcaa
     4321 ccaggtggcc gcacccctgg accaaccctg ggcacctgtg ttccatgtca atgtaatgga
     4381 cacagcagcc tgtgtgaccc tgaaacatcg atatgccaga attgtcaaca tcacactgct
     4441 ggtgacttct gtgaacgatg tgctcttgga tactatggaa ttgtcaaggg attgccaaat
     4501 gactgtcagc aatgtgcctg ccctctgatt tcttccagta acaatttcag cccctcttgt
     4561 gtcgcagaag gacttgacga ctaccgctgc acggcttgtc cacggggata tgaaggccag
     4621 tactgtgaaa ggtgtgcccc tggctatact ggcagtccag gcaaccctgg aggctcctgc
     4681 caagaatgtg agtgtgatcc ctatggctca ctgcctgtgc cctgtgaccc tgtcacagga
     4741 ttctgcacgt gccgacctgg agccacggga aggaagtgtg acggctgcaa gcactggcat
     4801 gcacgcgagg gctgggagtg tgttttttgt ggagatgagt gcactggcct tcttctcggt
     4861 gacttggctc gcctggagca gatggtcatg agcatcaacc tcactggtcc gctgcctgcg
     4921 ccatataaaa tgctgtatgg tcttgaaaat atgactcagg agctaaagca cttgctgtca
     4981 cctcagcggg ccccagagag gcttattcag ctggcagagg gcaatctgaa tacactcgtg
     5041 accgaaatga acgagctgct gaccagggct accaaagtga cagcagatgg cgagcagacc
     5101 ggacaggatg ctgagaggac caacacaaga gcaaagtccc tgggagaatt cattaaggag
     5161 cttgcccggg atgcagaagc tgtaaatgaa aaagctataa aactaaatga aactctagga
     5221 actcgagacg aggcctttga gagaaatttg gaagggcttc agaaagagat tgaccagatg
     5281 attaaagaac tgaggaggaa aaatctagag acacaaaagg aaattgctga agatgagttg
     5341 gtagctgcag aagcccttct gaaaaaagtg aagaagctgt ttggagagtc ccggggggaa
     5401 aatgaagaaa tggagaagga tctccgggaa aaactggctg actacaaaaa caaagttgat
     5461 gatgcttggg accttttgag agaagccaca gataaaatca gagaagctaa tcgcctattt
     5521 gcagtaaatc agaaaaacat gactgcattg gagaaaaaga aggaggctgt tgaaagcggc
     5581 aaacgacaaa ttgagaacac tttaaaagag ggcaatgaca tactcgatga agccaaccgt
     5641 cttgcagatg aaatcaactc catcatagac tatgttgaag acatccaaac taaattgcca
     5701 cctatgtctg aggagcttaa tgataaaata gatgacctct cccaagaaat aaaggacagg
     5761 aagcttgctg agaaggtgtc ccaggctgag agccacgcag ctcagttgaa tgactcatct
     5821 gctgtccttg atggaatcct tgatgaggct aaaaacatct ccttcaatgc cactgcagcc
     5881 ttcaaagctt acagcaatat taaggactat attgatgaag ctgagaaagt tgccaaagaa
     5941 gccaaagatc ttgcacatga agctacaaaa ctggcaacag gtcctcgggg tttattaaag
     6001 gaagatgcca aaggctgtct tcagaaaagc ttcaggattc ttaacgaagc caagaagtta
     6061 gcaaatgatg taaaagaaaa tgaagaccat ctaaatggct taaaaaccag gatagaaaat
     6121 gctgatgcta gaaatgggga tctcttgaga actttgaatg acactttggg aaagttatca
     6181 gctattccaa atgatacagc tgctaaactg caagctgtta aggacaaagc cagacaagcc
     6241 aacgacacag ctaaagatgt actggcacag attacagagc tccaccagaa cctcgatggc
     6301 ctgaagaaga attacaataa actagcagac agcgtcgcca aaacgaatgc tgtggttaaa
     6361 gatccttcca agaacaaaat cattgccgat gcagatgcca ctgtcaaaaa tttagaacag
     6421 gaagctgacc ggctaataga taaactcaaa cccatcaagg aacttgagga taacctaaag
     6481 aaaaacatct ctgagataaa ggaattgata aaccaagctc ggaaacaagc caattctatc
     6541 aaagtatctg tgtcttcagg aggtgactgc attcgaacat acaaaccaga aatcaagaaa
     6601 ggaagttaca ataatattgt tgtcaacgta aagacagctg ttgctgataa cctcctcttt
     6661 tatcttggaa gtgccaaatt tattgacttt ctggctatag aaatgcgtaa aggcaaagtc
     6721 agcttcctct gggatgttgg atctggagtt ggacgtgtag agtacccaga tttgactatt
     6781 gatgactcat attggtaccg tatcgtagca tcaagaactg ggagaaatgg aactatttct
     6841 gtgagagccc tggatggacc caaagccagc attgtgccca gcacacacca ttcgacgtct
     6901 cctccagggt acacgattct agatgtggat gcaaatgcaa tgctgtttgt tggtggcctg
     6961 actgggaaat taaagaaggc tgatgctgta cgtgtgatta cattcactgg ctgcatggga
     7021 gaaacatact ttgacaacaa acctataggt ttgtggaatt tccgagaaaa agaaggtgac
     7081 tgcaaaggat gcactgtcag tcctcaggtg gaagatagtg aggggactat tcaatttgat
     7141 ggagaaggtt atgcattggt cagccgtccc attcgctggt accccaacat ctccactgtc
     7201 atgttcaagt tcagaacatt ttcttcgagt gctcttctga tgtatcttgc cacacgagac
     7261 ctgagagatt tcatgagtgt ggagctcact gatgggcaca taaaagtcag ttacgatctg
     7321 ggctcaggaa tggcttccgt tgtcagcaat caaaaccata atgatgggaa atggaaatca
     7381 ttcactctgt caagaattca aaaacaagcc aatatatcaa ttgtagatat agatactaat
     7441 caggaggaga atatagcaac ttcgtcttct ggaaacaact ttggtcttga cttgaaagca
     7501 gatgacaaaa tatattttgg tggcctgcca acgctgagaa acttgagtat gaaagcaagg
     7561 ccagaagtaa atctgaagaa atattccggc tgcctcaaag atattgaaat ttcaagaact
     7621 ccgtacaata tactcagtag tcccgattat gttggtgtta ccaaaggatg ttccctggag
     7681 aatgtttaca cagttagctt tcctaagcct ggttttgtgg agctctcccc tgtgccaatt
     7741 gatgtaggaa cagaaatcaa cctgtcattc agcaccaaga atgagtccgg catcattctt
     7801 ttgggaagtg gagggacacc agcaccacct aggagaaaac gaaggcagac tggacaggcc
     7861 tattatgcaa tactcctcaa caggggccgt ctggaagtgc atctctccac aggggcacga
     7921 acaatgagga aaattgtgat cagaccagag ccgaatctgt ttcatgatgg aagagaacat
     7981 tccgttcatg tagagcgaac tagaggcatc tttacagttc aagtggatga aaacagaaga
     8041 tacatgcaaa acctgacagt tgaacagcct atcgaagtta aaaagctttt cgttgggggt
     8101 gctccacctg aatttcaacc ttccccactc agaaatattc ctccttttga aggctgcata
     8161 tggaatcttg ttattaactc tgtccccatg gactttgcaa ggcctgtgtc cttcaaaaat
     8221 gctgacattg gtcgctgtgc ccatcagaaa ctccgtgaag atgaagatgg agcagctcca
     8281 gctgaaatag ttatccagcc tgagccagtt cccaccccag cctttcctac gcccacccca
     8341 gttctgacac atggtccttg tgctgcagaa tcagaaccag ctcttttgat agggagcaag
     8401 cagttcgggc tttcaagaaa cagtcacatt gcaattgcat ttgatgacac caaagttaaa
     8461 aaccgtctca caattgagtt ggaagtaaga accgaagctg aatccggctt gcttttttac
     8521 atggctcgca tcaatcatgc tgattttgca acagttcagc tgagaaatgg attgccctac
     8581 ttcagctatg acttggggag tggggacacc cacaccatga tccccaccaa aatcaatgat
     8641 ggccagtggc acaagattaa gataatgaga agtaagcaag aaggaattct ttatgtagat
     8701 ggggcttcca acagaaccat cagtcccaaa aaagccgaca tcctggatgt cgtgggaatg
     8761 ctgtatgttg gtgggttacc catcaactac actacccgaa gaattggtcc agtgacctat
     8821 agcattgatg gctgcgtcag gaatctccac atggcagagg cccctgccga tctggaacaa
     8881 cccacctcca gcttccatgt tgggacatgt tttgcaaatg ctcagagggg aacatatttt
     8941 gacggaaccg gttttgccaa agcagttggt ggattcaaag tgggattgga ccttcttgta
     9001 gaatttgaat tccgcacaac tacaacgact ggagttcttc tggggatcag tagtcaaaaa
     9061 atggatggaa tgggtattga aatgattgat gaaaagttga tgtttcatgt ggacaatggt
     9121 gcgggcagat tcactgctgt ctatgatgct ggggttccag ggcatttgtg tgatggacaa
     9181 tggcataaag tcactgccaa caagatcaaa caccgcattg agctcacagt cgatgggaac
     9241 caggtggaag cccaaagccc aaacccagca tctacatcag ctgacacaaa tgaccctgtg
     9301 tttgttggag gcttcccaga tgacctcaag cagtttggcc taacaaccag tattccgttc
     9361 cgaggttgca tcagatccct gaagctcacc aaaggcacag gcaagccact ggaggttaat
     9421 tttgccaagg ccctggaact gaggggcgtt caacctgtat catgcccagc caactaataa
     9481 aaataagtgt aaccccagga agagtctgtc aaaacaagta tatcaagtaa aacaaacaaa
     9541 tatattttac ctatatatgt taattaaact aatttgtgca tgtacataga attctttctg
     9601 tattcagatg gtgctaattc agactccaga ctgaatttta attcaagttc tttctcaagt
     9661 ctataaataa tattaaactg attatttcat tctaaa
//
