LOCUS       NM_005559               9642 bp    mRNA    linear   PRI 23-OCT-2022
DEFINITION  Homo sapiens laminin subunit alpha 1 (LAMA1), mRNA.
ACCESSION   NM_005559 XM_939267
VERSION     NM_005559.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9642)
  AUTHORS   Schiff ER, Aychoua N, Nutan S, Davagnanam I, Moore AT, Robson AG,
            Patel CK, Webster AR and Arno G.
  TITLE     Variability of retinopathy consequent upon novel mutations in LAMA1
  JOURNAL   Ophthalmic Genet 43 (5), 671-678 (2022)
   PUBMED   35616092
  REMARK    GeneRIF: Variability of retinopathy consequent upon novel mutations
            in LAMA1.
REFERENCE   2  (bases 1 to 9642)
  AUTHORS   Zhou PL, Wu Z, Zhang W, Xu M, Ren J, Zhang Q, Sun Z and Han X.
  TITLE     Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate
            LAMA1 and promote esophageal carcinoma progression
  JOURNAL   Cell Death Dis 12 (7), 676 (2021)
   PUBMED   34226522
  REMARK    GeneRIF: Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to
            upregulate LAMA1 and promote esophageal carcinoma progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9642)
  AUTHORS   Kurek M, Akesson E, Yoshihara M, Oliver E, Cui Y, Becker M,
            Alves-Lopes JP, Bjarnason R, Romerius P, Sundin M, Noren Nystrom U,
            Langenskiold C, Vogt H, Henningsohn L, Petersen C, Soder O, Guo J,
            Mitchell RT, Jahnukainen K and Stukenborg JB.
  TITLE     Spermatogonia Loss Correlates with LAMA 1 Expression in Human
            Prepubertal Testes Stored for Fertility Preservation
  JOURNAL   Cells 10 (2), 241 (2021)
   PUBMED   33513766
  REMARK    GeneRIF: Spermatogonia Loss Correlates with LAMA 1 Expression in
            Human Prepubertal Testes Stored for Fertility Preservation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9642)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean
            LJH, Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301317
REFERENCE   5  (bases 1 to 9642)
  AUTHORS   Aeschlimann D and Paulsson M.
  TITLE     Cross-linking of laminin-nidogen complexes by tissue
            transglutaminase. A novel mechanism for basement membrane
            stabilization
  JOURNAL   J Biol Chem 266 (23), 15308-15317 (1991)
   PUBMED   1678389
REFERENCE   6  (bases 1 to 9642)
  AUTHORS   Nissinen M, Vuolteenaho R, Boot-Handford R, Kallunki P and
            Tryggvason K.
  TITLE     Primary structure of the human laminin A chain. Limited expression
            in human tissues
  JOURNAL   Biochem J 276 (Pt 2), 369-379 (1991)
   PUBMED   2049067
REFERENCE   7  (bases 1 to 9642)
  AUTHORS   Haaparanta T, Uitto J, Ruoslahti E and Engvall E.
  TITLE     Molecular cloning of the cDNA encoding human laminin A chain
  JOURNAL   Matrix 11 (3), 151-160 (1991)
   PUBMED   1714537
REFERENCE   8  (bases 1 to 9642)
  AUTHORS   Chung AE and Durkin ME.
  TITLE     Entactin: structure and function
  JOURNAL   Am J Respir Cell Mol Biol 3 (4), 275-282 (1990)
   PUBMED   2119632
  REMARK    Review article
REFERENCE   9  (bases 1 to 9642)
  AUTHORS   Engvall E, Earwicker D, Haaparanta T, Ruoslahti E and Sanes JR.
  TITLE     Distribution and isolation of four laminin variants; tissue
            restricted distribution of heterotrimers assembled from five
            different subunits
  JOURNAL   Cell Regul 1 (10), 731-740 (1990)
   PUBMED   2099832
REFERENCE   10 (bases 1 to 9642)
  AUTHORS   Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML and Uitto J.
  TITLE     Human laminin A chain (LAMA) gene: chromosomal mapping to locus
            18p11.3
  JOURNAL   Genomics 5 (4), 932-935 (1989)
   PUBMED   2591971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP005062.2, AP002409.3 and
            AP005210.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005559.3.
            
            Summary: This gene encodes one of the alpha 1 subunits of laminin.
            The laminins are a family of extracellular matrix glycoproteins
            that have a heterotrimeric structure consisting of an alpha, beta
            and gamma chain. These proteins make up a major component of the
            basement membrane and have been implicated in a wide variety of
            biological processes including cell adhesion, differentiation,
            migration, signaling, neurite outgrowth and metastasis. Mutations
            in this gene may be associated with Poretti-Boltshauser syndrome.
            [provided by RefSeq, Sep 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3063225.1,
                                           SRR14038197.492460.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389658.4/ ENSP00000374309.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AP005062.2         68469-68606         c
            139-309             AP005062.2         31096-31266         c
            310-422             AP005062.2         30784-30896         c
            423-665             AP002409.3         174085-174327       c
            666-845             AP002409.3         172469-172648       c
            846-935             AP002409.3         169669-169758       c
            936-1053            AP002409.3         168113-168230       c
            1054-1232           AP002409.3         166618-166796       c
            1233-1338           AP002409.3         165536-165641       c
            1339-1499           AP002409.3         163467-163627       c
            1500-1640           AP002409.3         162201-162341       c
            1641-1814           AP002409.3         160969-161142       c
            1815-1916           AP002409.3         159378-159479       c
            1917-2128           AP002409.3         157870-158081       c
            2129-2240           AP002409.3         156375-156486       c
            2241-2351           AP002409.3         155457-155567       c
            2352-2479           AP002409.3         149370-149497       c
            2480-2566           AP002409.3         147771-147857       c
            2567-2778           AP002409.3         146555-146766       c
            2779-2885           AP002409.3         140669-140775       c
            2886-3066           AP002409.3         139882-140062       c
            3067-3203           AP002409.3         139113-139249       c
            3204-3440           AP002409.3         137206-137442       c
            3441-3584           AP002409.3         135386-135529       c
            3585-3764           AP002409.3         134691-134870       c
            3765-3950           AP002409.3         133591-133776       c
            3951-4078           AP002409.3         132630-132757       c
            4079-4199           AP002409.3         131879-131999       c
            4200-4337           AP002409.3         130530-130667       c
            4338-4459           AP002409.3         125655-125776       c
            4460-4546           AP002409.3         123302-123388       c
            4547-4740           AP002409.3         122836-123029       c
            4741-4883           AP002409.3         121133-121275       c
            4884-4973           AP002409.3         118748-118837       c
            4974-5085           AP002409.3         117032-117143       c
            5086-5245           AP002409.3         115952-116111       c
            5246-5456           AP002409.3         109528-109738       c
            5457-5573           AP002409.3         108918-109034       c
            5574-5737           AP002409.3         108628-108791       c
            5738-5873           AP002409.3         106490-106625       c
            5874-5967           AP002409.3         105888-105981       c
            5968-6084           AP002409.3         103912-104028       c
            6085-6267           AP002409.3         101587-101769       c
            6268-6422           AP002409.3         101118-101272       c
            6423-6566           AP002409.3         99328-99471         c
            6567-6700           AP002409.3         98294-98427         c
            6701-6851           AP002409.3         96448-96598         c
            6852-6976           AP002409.3         95248-95372         c
            6977-7127           AP002409.3         89538-89688         c
            7128-7272           AP002409.3         88679-88823         c
            7273-7414           AP002409.3         88053-88194         c
            7415-7529           AP002409.3         85336-85450         c
            7530-7703           AP002409.3         84977-85150         c
            7704-7855           AP002409.3         82732-82883         c
            7856-8041           AP002409.3         81868-82053         c
            8042-8171           AP002409.3         80027-80156         c
            8172-8284           AP002409.3         78744-78856         c
            8285-8474           AP002409.3         74173-74362         c
            8475-8633           AP002409.3         72492-72650         c
            8634-8787           AP002409.3         71794-71947         c
            8788-8921           AP002409.3         70554-70687         c
            8922-9144           AP005210.2         180271-180493       c
            9145-9642           AP005210.2         178833-179330       c
FEATURES             Location/Qualifiers
     source          1..9642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..9642
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /note="laminin subunit alpha 1"
                     /db_xref="GeneID:284217"
                     /db_xref="HGNC:HGNC:6481"
                     /db_xref="MIM:150320"
     exon            1..138
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..9305
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /note="laminin A chain; S-laminin subunit alpha; laminin-3
                     subunit alpha; S-LAM alpha; laminin, alpha 1"
                     /codon_start=1
                     /product="laminin subunit alpha-1 precursor"
                     /protein_id="NP_005550.2"
                     /db_xref="CCDS:CCDS32787.1"
                     /db_xref="GeneID:284217"
                     /db_xref="HGNC:HGNC:6481"
                     /db_xref="MIM:150320"
                     /translation="MRGGVLLVLLLCVAAQCRQRGLFPAILNLASNAHISTNATCGEK
                     GPEMFCKLVEHVPGRPVRNPQCRICDGNSANPRERHPISHAIDGTNNWWQSPSIQNGR
                     EYHWVTITLDLRQVFQVAYVIIKAANAPRPGNWILERSLDGTTFSPWQYYAVSDSECL
                     SRYNITPRRGPPTYRADDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDLSPKLLEF
                     TSARYIRLRLQRIRTLNADLMTLSHREPKELDPIVTRRYYYSIKDISVGGMCICYGHA
                     SSCPWDETTKKLQCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAK
                     DCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDE
                     PCRPCNCDPVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKDYPT
                     CVSCGCNPVGSASDEPCTGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCFGV
                     SDVCSSLSWPVGQVNSMSGWLVTDLISPRKIPSQQDALGGRHQVSINNTAVMQRLAPK
                     YYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSNLMSHADVIIKGNGLTLSTQAE
                     GLSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANVTHLLIRANYNSAKMAL
                     YRLESVSLDIASSNAIDLVVAADVEHCECPQGYTGTSCESCLSGYYRVDGILFGGICQ
                     PCECHGHAAECNVHGVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIA
                     SNNFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPTVPGESCVPCDCSGNVD
                     PSEAGHCDSVTGECLKCLGNTDGAHCERCADGFYGDAVTAKNCRACECHVKGSHSAVC
                     HLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCV
                     PGVAGKRCDRCAHGFYAYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKCEECED
                     GHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGYRDFPDCV
                     PCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTFALRADNPLG
                     CSPCFCSGLSHLCSELEDYVRTPVTLGSDQPLLRVVSQSNLRGTTEGVYYQAPDFLLD
                     AATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKLKYSVAFYSLDGVGTSNFEPQVLIKG
                     GRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSVSEKPVTREDFMSVLSDIEYI
                     LIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVASLLENCVCPPGTVGFSCQDCAP
                     GYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCLNCGDNTAGDHCDVCTS
                     GYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDACLLGYEGKHCERCSSS
                     YYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDECEPRHILMETD
                     CVSCDDECVGVLLNDLDEIGDAVLSLNLTGIIPVPYGILSNLENTTKYLQESLLKENM
                     QKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSI
                     TEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEIMQIRDFTQLHQNATLELKAAE
                     DLLSQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLM
                     VNANLREFSDKKLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLL
                     LWSAKIRHHIDDLVMHMSQRNAVDLVYRAEDHAAEFQRLADVLYSGLENIRNVSLNAT
                     SAAYVHYNIQSLIEESEELARDAHRTVTETSLLSESLVSNGKAAVQRSSRFLKEGNNL
                     SRKLPGIALELSELRNKTNRFQENAVEITRQTNESLLILRAIPKGIRDKGAKTKELAT
                     SASQSAVSTLRDVAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLLAGRKVKDV
                     EIQANLLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKVAVSADRDCIRAYQP
                     QISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLE
                     FPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLM
                     FVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGCFGSSQNEDP
                     SFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVK
                     VMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGA
                     SSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTFDLLRNSYGVRKG
                     CLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAALGGDVEKRGDRE
                     EAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRIIT
                     VQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGCIKNLIFNL
                     ELLDFNSAVGHEQVDLDTCWLSERPKLAPDAEDSKLLPEPRAFPEQCVVDAALEYVPG
                     AHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAHQNQADYAVLQLHG
                     GRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGT
                     MLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQLDKDSPVSAFTVNRCY
                     AVAQEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLEL
                     VDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAES
                     PHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIKSPQVQSFDFSRAF
                     ELHGVFLHSCPGTES"
     exon            139..309
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            310..422
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            423..665
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            666..845
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            846..935
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1053
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1232
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1338
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1499
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1640
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1814
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1916
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2128
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2240
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2351
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2479
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2566
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2778
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2885
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3066
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3203
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3440
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3584
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3764
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3950
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4078
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4199
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4200..4337
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4338..4459
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4546
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4547..4740
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..4883
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..4973
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            4974..5085
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5086..5245
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5246..5456
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5457..5573
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5574..5737
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5738..5873
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5874..5967
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            5968..6084
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6085..6267
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6268..6422
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6423..6566
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6567..6700
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6701..6851
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6852..6976
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            6977..7127
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            7128..7272
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            7273..7414
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            7415..7529
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            7530..7703
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            7704..7855
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            7856..8041
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            8042..8171
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            8172..8284
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            8285..8474
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            8475..8633
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            8634..8787
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            8788..8921
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            8922..9144
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            9145..9642
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9477..9482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /note="hexamer: ATTAAA"
     polyA_site      9498
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /note="major polyA site"
     regulatory      9620..9625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
                     /note="hexamer: AATACA"
     polyA_site      9642
                     /gene="LAMA1"
                     /gene_synonym="LAMA; PTBHS; S-LAM-alpha"
ORIGIN      
        1 ggactcgcgt cccgtggagc gttccaggcg ggcgcgcggc tttctcccca gacccaccga
       61 gtggcggcgg aggcgagatg cgcgggggcg tgctcctggt cttgctgctg tgtgtcgccg
      121 cgcagtgccg gcagagaggc ctgtttcctg ccattctcaa tcttgccagc aatgctcaca
      181 tcagcaccaa tgccacctgt ggcgagaagg ggccggagat gttctgcaaa cttgtggagc
      241 atgtgccagg tcggcccgtc cgaaacccac agtgccggat ctgtgatggc aacagcgcaa
      301 accccagaga acgccatcca atatcacatg ccatagatgg caccaataac tggtggcaaa
      361 gtcccagcat tcagaatggg agagaatatc actgggtcac aatcactctg gacttaagac
      421 aggtctttca agttgcatat gtcatcatta aagctgccaa tgcccctcga cctggaaact
      481 ggattttgga gcgttctctg gatggcacca cgttcagccc ctggcagtat tatgcagtca
      541 gcgactcaga gtgtttgtct cgttacaata taactccaag acgagggcca cccacctaca
      601 gggctgatga tgaagtgatc tgcacctcct attattccag attggtgcca cttgagcatg
      661 gagagattca tacatcactc atcaatggca gaccaagcgc tgacgatctt tcacccaagt
      721 tgttggaatt cacttctgca cgatatattc gccttcgctt gcaacgcatt agaacgctca
      781 atgcagatct catgaccctt agccaccggg aacctaaaga actggatcct attgttacca
      841 gacgctatta ttattcaata aaggacattt ctgttggagg catgtgtatc tgctatggcc
      901 atgctagtag ctgcccatgg gatgaaacta caaagaaact gcagtgtcaa tgtgagcata
      961 atacttgcgg ggagagctgt aacaggtgct gtcctgggta ccatcagcag ccctggaggc
     1021 cgggaaccgt gtcctccggc aatacatgtg aagcatgtaa ttgtcacaat aaagccaaag
     1081 actgttacta tgatgaaagt gttgcaaagc agaagaaaag tttgaatact gctggacagt
     1141 tcagaggagg aggggtttgc ataaattgct tgcagaacac catgggaatc aactgtgaaa
     1201 cctgtattga tggatattat agaccacaca aagtgtctcc ttatgaggat gagccttgcc
     1261 gcccctgtaa ttgtgaccct gtggggtccc tcagttctgt ctgtattaag gatgacctcc
     1321 attctgactt acacaatggg aagcagccag gtcagtgccc atgtaaggaa ggttatacag
     1381 gagaaaaatg tgatcgctgc caacttggct ataaggatta cccgacctgt gtctcctgtg
     1441 ggtgcaaccc agtgggcagt gccagtgatg agccctgcac agggccctgt gtttgtaagg
     1501 aaaacgttga ggggaaggcc tgtgatcgct gcaagccagg attctataac ttgaaggaaa
     1561 aaaacccccg gggctgctcc gagtgcttct gctttggcgt ttctgatgtc tgcagcagcc
     1621 tctcttggcc tgttggtcag gtaaacagta tgtccgggtg gctggtcacc gacttgatca
     1681 gtcccaggaa gatcccgtct cagcaagatg cactaggcgg gcgccatcag gtcagcatca
     1741 acaacaccgc ggtcatgcag agactggctc ccaagtacta ctgggcagcc cccgaggcct
     1801 accttggaaa taagctgact gcgtttggcg gattcctgaa atacacggtg tcctacgata
     1861 ttccggtaga gacggtagac agtaacctca tgtcgcatgc tgacgtcatc attaagggaa
     1921 acggactcac tttaagcaca caggctgagg gtctgtcatt gcagccttat gaagagtacc
     1981 taaacgtggt tagacttgtg cctgaaaact tccaagattt tcacagcaaa aggcagattg
     2041 atcgtgacca gctgatgact gtccttgcca atgtgacaca tcttttgatc agagccaact
     2101 acaattctgc aaaaatggct ctttacaggt tggagtccgt ctctctggac atagccagct
     2161 ctaatgccat cgacctggtg gtggccgctg atgtggagca ctgtgaatgt ccgcaaggct
     2221 acacagggac ctcctgtgag tcgtgcctct ctggctatta ccgcgtggat ggaatactct
     2281 ttggaggaat ttgtcaaccc tgtgaatgcc acggccatgc agctgagtgt aatgttcacg
     2341 gcgtttgcat tgcgtgtgcg cacaacacca ccggcgtcca ctgtgagcag tgcttgcccg
     2401 gcttctacgg ggagccttcc cgagggacac ctggggactg ccagccctgc gcctgccctc
     2461 tcaccatagc ctccaacaat ttcagcccca cctgccacct caatgatgga gatgaagtgg
     2521 tctgtgactg gtgtgccccg ggctactcag gagcttggtg tgagagatgt gcagatggtt
     2581 actatggaaa cccaacagtg cctggcgaat cttgtgttcc ctgtgactgc agcggcaacg
     2641 tggacccctc ggaggctggt cactgtgact cagtcaccgg ggagtgcctg aagtgcctgg
     2701 ggaacacaga tggcgcccac tgtgaaaggt gtgctgacgg gttctatggg gacgctgtga
     2761 cagccaagaa ctgccgcgcc tgtgaatgcc atgtgaaagg ctcccattct gccgtgtgcc
     2821 atcttgagac cgggctctgt gactgcaaac caaacgtgac tggacagcag tgtgaccagt
     2881 gcttgcatgg ctattatggg ctggactcag gccatggctg ccggccctgc aactgcagcg
     2941 tggcaggctc cgtgtcagat ggctgcacgg atgaaggcca gtgtcactgt gtcccaggtg
     3001 tggcagggaa aaggtgtgac aggtgtgccc atggcttcta cgcctaccag gatggtagct
     3061 gtacaccctg tgactgccca cacactcaga atacctgcga cccagaaact ggagagtgtg
     3121 tctgcccccc tcacacacag ggtgtgaagt gtgaagaatg tgaggatggg cactggggct
     3181 acgatgcgga ggtggggtgc caggcctgca attgcagtct cgtggggtcg actcatcatc
     3241 ggtgcgatgt ggtcaccggc cattgccagt gcaagtcaaa atttggtggc cgggcctgcg
     3301 atcagtgttc cttgggttac agagactttc ccgactgtgt tccctgtgac tgtgacctga
     3361 gggggacgtc gggggacgcc tgcaacctgg agcagggtct ctgcggctgt gtggaggaaa
     3421 ccggggcctg cccttgcaag gaaaatgtct ttggtcctca gtgcaacgaa tgtcgagagg
     3481 gcaccttcgc tctccgcgca gacaaccccc tgggctgcag cccgtgcttc tgctccgggc
     3541 tgtcccacct ctgctcagag ctggaggact acgtgaggac cccagtaacg ctgggctccg
     3601 atcagcctct tctgcgtgtg gtttctcaga gtaacttgag gggcacgacc gagggggttt
     3661 actaccaggc ccccgacttc ctgctggatg ccgccaccgt ccggcagcac atccgtgcag
     3721 agccgtttta ctggcggctg ccgcagcagt tccaaggaga ccagctcatg gcctatggtg
     3781 gcaaactgaa gtacagcgtg gccttctatt ctttggatgg cgtcggcacc tccaattttg
     3841 agcctcaagt tctcatcaaa ggtggtcgga tcagaaagca agtcatttac atggatgcac
     3901 cagccccaga gaatggagtg agacaggaac aagaagtagc aatgagagag aatttttgga
     3961 aatattttaa ctctgtttct gaaaaacctg tcacgcgaga ggattttatg tctgtcctca
     4021 gcgatattga gtacatcctc atcaaggcat cgtatggtca aggattacag cagagcagaa
     4081 tctcagacat ttcaatggag gttggcagaa aggctgaaaa gctgcaccca gaagaagagg
     4141 ttgcatctct tttagagaat tgtgtctgtc ctcctggcac tgtgggattc tcatgtcagg
     4201 actgcgcccc tgggtaccac agagggaagc tcccagcagg gagtgacagg ggaccacgcc
     4261 ctctggttgc tccttgtgtt ccctgcagtt gcaacaacca cagtgacacc tgtgacccca
     4321 acaccgggaa gtgtctgaac tgtggcgata acacagcagg tgaccattgt gatgtgtgta
     4381 cttctggcta ctacgggaag gtgactggct cagcaagtga ctgtgctctg tgtgcctgtc
     4441 ctcacagccc tcctgccagt tttagtccca cttgtgtctt ggaaggggac cacgatttcc
     4501 gttgtgacgc ctgtctcctg ggctatgaag gaaaacactg tgaaaggtgc tcctcaagct
     4561 attatgggaa ccctcaaaca ccaggtggca gttgccagaa gtgtgactgc aacccgcacg
     4621 gctctgtcca cggtgactgt gaccgcacat ctgggcagtg cgtttgcagg ctgggggcct
     4681 cggggctccg gtgcgatgag tgtgaaccga ggcacattct gatggaaaca gattgtgttt
     4741 cctgtgatga tgagtgtgta ggtgtgctgc tgaatgactt ggatgagatt ggtgatgccg
     4801 ttctttctct gaacctcact ggcattatcc ctgtcccata tggaattttg tcaaacctgg
     4861 aaaatacaac taaatatctc caggaatctt tattaaaaga aaatatgcaa aaggacctgg
     4921 gaaaaattaa gcttgaaggt gttgcagaag aaacggacaa cctgcaaaag aagctcacta
     4981 ggatgttagc gagtacccaa aaggtgaata gggcaactga gagaatcttc aaggagagtc
     5041 aagacctggc catagccatt gagaggctgc agatgagcat cacagaaatt atggaaaaga
     5101 caactttaaa tcagactttg gatgaagatt tcctactacc caattctact cttcagaaca
     5161 tgcaacagaa tggtacatct ttgctagaaa tcatgcagat aagagacttc acacagttgc
     5221 accaaaatgc cacccttgaa ctcaaggctg ctgaagattt attgtcacaa attcaggaaa
     5281 attaccagaa gccgctggaa gaattggagg tattgaaaga agcagcaagc cacgtccttt
     5341 caaagcacaa caatgaacta aaggcggctg aggcgctcgt gagggaagct gaggcaaaga
     5401 tgcaggaaag caaccacctg ctgctcatgg tcaatgctaa tctgagagaa ttcagtgata
     5461 aaaagctgca tgttcaagaa gaacaaaatc tgacctcaga gctcattgtc caaggaagag
     5521 gattgataga tgctgctgct gcacaaacag atgctgtaca agatgctcta gagcacttag
     5581 aggatcacca ggataagcta cttttatggt ctgccaaaat caggcaccac atagatgacc
     5641 tggtcatgca catgtcccaa aggaacgcag tcgacctggt ctacagagct gaggaccatg
     5701 ccgctgagtt ccagagacta gcagatgttc tgtacagtgg ccttgaaaac atcagaaatg
     5761 tgtccctgaa tgccaccagt gcagcctatg tccattacaa catccagagc ctgattgaag
     5821 aatcggagga actggccaga gatgctcaca ggactgtgac tgagacgagc ctgctctcag
     5881 aatcccttgt ttctaacggg aaagcggccg tgcagcgcag ctccagattt ctaaaagaag
     5941 gcaacaacct cagcaggaag cttccaggta ttgcattgga actgagtgaa ttgagaaata
     6001 agacaaacag atttcaagag aatgctgttg aaattaccag gcaaaccaat gaatcactct
     6061 tgatacttag agcaattcct aaaggtataa gagacaaggg agccaaaacc aaagagctgg
     6121 ccacgtctgc aagccagagc gcggtgagca cgctgaggga cgtggcgggg ctgagccagg
     6181 agctgctgaa cacatctgcc agcctgtcca gggtcaacac cacattacga gagacacacc
     6241 agcttctgca ggactccacc atggccactc tgttggctgg aagaaaagtc aaagacgtgg
     6301 aaattcaagc caaccttttg tttgatcggt tgaagccttt gaagatgtta gaggagaatc
     6361 tgagcagaaa cctatcagaa attaaactgt tgatcagcca ggcccgcaaa caagcagctt
     6421 ctattaaagt cgccgtgtct gcagacagag attgcatccg ggcctaccag cctcagattt
     6481 cctctaccaa ctacaatacc ttaacactaa atgttaagac acaggaaccc gataatcttc
     6541 tcttctacct cggtagcagc accgcttctg atttccttgc agtggagatg cggcgaggga
     6601 gagtggcctt cctgtgggac ctgggctccg ggtccacacg cttggagttt ccagactttc
     6661 ccattgatga caacagatgg cacagtatcc atgtagccag atttggaaac attggttcac
     6721 tgagtgtaaa ggaaatgagc tcaaatcaaa agtcaccaac aaaaacaagt aaatcccctg
     6781 ggacagctaa tgttctggat gtaaacaatt caacactcat gtttgttgga ggtcttggag
     6841 gacaaatcaa gaaatctcct gctgtgaagg ttactcattt taaaggctgc ttgggggagg
     6901 ccttcctgaa tggaaaatcc ataggcctat ggaactatat tgaaagggaa ggcaagtgcc
     6961 gtgggtgctt cggaagctcc cagaatgaag acccttcctt ccattttgac gggagtgggt
     7021 actctgtcgt ggagaagtca cttccggcta ccgtgaccca gataatcatg ctttttaata
     7081 ccttttcacc taatggactt cttctctacc tgggttcata cggcacaaaa gactttttat
     7141 ccatcgagct gtttcgtggc agagtgaagg ttatgactga cctgggttca ggacccatta
     7201 cccttttgac agacagacgt tataacaatg gaacctggta caaaattgcc ttccagcgaa
     7261 accggaagca aggagtgcta gcagttatcg atgcctataa caccagtaat aaagaaacca
     7321 agcagggcga gactccggga gcatcttctg acctcaaccg cctagacaag gacccgattt
     7381 atgtgggtgg attaccaagg tcaagagttg taaggagagg tgtcaccacc aaaagctttg
     7441 tgggctgcat caagaacctg gaaatatcca gatcaacctt tgacttactc agaaattcct
     7501 atggagtgag aaaaggctgt ttactggagc ccatccggag tgttagcttc ctgaaaggcg
     7561 gctacattga attgccaccc aaatctttgt caccagaatc agaatggctg gtaacatttg
     7621 ccaccacgaa cagcagtggc atcatcctgg ctgccctcgg cggggatgtg gagaagcggg
     7681 gtgatcgtga ggaagcacac gtgcccttct tttccgtcat gctgatcgga ggcaacattg
     7741 aggtacatgt caatcctggg gatgggacag gcctgagaaa agctctcctg cacgctccca
     7801 cgggtacctg cagtgatgga caagcgcatt ccatctcctt ggtcaggaat cggagaatta
     7861 tcactgtcca attggatgag aacaatcctg tggaaatgaa gttgggcaca ttagtagaaa
     7921 gcaggacgat aaatgtgtcc aatctgtacg tcgggggaat tccagaggga gaggggacgt
     7981 cactgctcac aatgagaaga tcgttccatg gctgtatcaa aaacctgatc ttcaatttgg
     8041 aacttttgga tttcaacagt gcagttggcc atgagcaagt cgacctggac acctgctggc
     8101 tgtcagaaag gcctaagctg gctcccgatg cagaggacag caagctcttg ccagagcccc
     8161 gggcttttcc agaacagtgt gtggtggatg cagctctgga gtacgttccc ggcgctcacc
     8221 agtttggtct cacacaaaac agccatttca tcttgccttt taatcagtcg gctgtcagaa
     8281 agaagctctc ggttgagcta agcatccgca cgttcgcctc cagcggcctg atttactaca
     8341 tggctcatca gaaccaagca gactacgctg tgctccagct gcacgggggc cgcctccact
     8401 tcatgtttga ccttggcaaa ggcagaacaa aggtctctca ccctgcactg ctcagtgatg
     8461 gcaagtggca cacggtcaag acagactatg ttaaaagaaa aggcttcata actgtcgacg
     8521 gccgagagtc tcccatggtg actgtggtgg gagatggaac catgctggat gtggagggtt
     8581 tgttctacct aggaggcctg ccctcccagt accaggccag gaaaattgga aatatcaccc
     8641 acagcatccc tgcctgcatt ggggatgtga cggttaacag caaacagctg gacaaggaca
     8701 gcccggtgtc tgccttcacg gtgaacaggt gctacgcagt ggcccaggaa ggaacatact
     8761 ttgacggaag cggatatgca gctcttgtca aagagggcta caaagtccag tcagatgtga
     8821 acatcacact ggagtttcga acctcctcgc agaatggcgt cctcctgggg atcagcactg
     8881 ccaaagtgga tgccattgga ctagagcttg tggacggcaa ggtcttgttc catgtcaaca
     8941 atggtgctgg caggataaca gctgcatatg agcccaaaac cgccactgtg ctctgtgatg
     9001 gaaaatggca cactcttcaa gctaacaaaa gcaaacaccg tatcactctg attgttgacg
     9061 ggaacgcagt tggcgctgaa agtccacaca cccagtctac ctcagtggac accaacaatc
     9121 ccatttatgt tggtggctat cctgctggtg tgaagcaaaa atgcctgcgc agccagacct
     9181 cgttccgcgg gtgtttgagg aagctagctc tgattaagag cccgcaggtg cagtcctttg
     9241 acttcagcag agcgttcgaa ctgcacggag ttttccttca ttcctgtcct gggaccgagt
     9301 cctgaacttc aagcagaatc ctcagttgga atcattgcta atattttgag gagaagtgta
     9361 tgtgtgaatt aagaatctct tcagttcata tttcatttcc aactcaggtt aagtgtttct
     9421 ggggagagat gttgtgttta cgttacacta aaaccacatg tgcaacaaat acctccatta
     9481 aatggtctaa aatgtaaatt gaattccctg gctctctttt taaacgtatt tttaaaaaaa
     9541 tctttataca cattgaatgt tctgttgatt acttgatagt attttatgtt tttcattttg
     9601 agctttttaa aaaagtatca atacagatga taacagatca ga
//
