LOCUS       NM_002289                728 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens lactalbumin alpha (LALBA), transcript variant 1, mRNA.
ACCESSION   NM_002289
VERSION     NM_002289.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 728)
  AUTHORS   Lebedev,D.V., Zabrodskaya,Y.A., Pipich,V., Kuklin,A.I., Ramsay,E.,
            Sokolov,A.V., Elizarova,A.Y., Shaldzhyan,A.A., Grudinina,N.A.,
            Pantina,R.A., Wu,B., Shtam,T.A., Volnitskiy,A.V., Schmidt,A.E.,
            Shvetsov,A.V., Vasilyev,V.B., Isaev-Ivanov,V.V. and Egorov,V.V.
  TITLE     Effect of alpha-lactalbumin and lactoferrin oleic acid complexes on
            chromatin structural organization
  JOURNAL   Biochem Biophys Res Commun 520 (1), 136-139 (2019)
   PUBMED   31582209
  REMARK    GeneRIF: human alpha-lactalbumin and human lactoferrin complexes
            appeared to interact with the chromatin of isolated nuclei
            affecting chromatin structural organization
REFERENCE   2  (bases 1 to 728)
  AUTHORS   Permyakov,E.A., Permyakov,S.E., Breydo,L., Redwan,E.M.,
            Almehdar,H.A. and Uversky,V.N.
  TITLE     Disorder in Milk Proteins: alpha-Lactalbumin. Part C. Peculiarities
            of Metal Binding
  JOURNAL   Curr Protein Pept Sci 17 (8), 735-745 (2016)
   PUBMED   27238572
  REMARK    GeneRIF: Studies indicate that alpha-lactalbumin has two domains, a
            large alpha-helical domain and a small beta-sheet domain connected
            by a calcium binding loop.
            Review article
REFERENCE   3  (bases 1 to 728)
  AUTHORS   Wu,Y., Gao,H., Li,H., Tabara,Y., Nakatochi,M., Chiu,Y.F.,
            Park,E.J., Wen,W., Adair,L.S., Borja,J.B., Cai,Q., Chang,Y.C.,
            Chen,P., Croteau-Chonka,D.C., Fogarty,M.P., Gan,W., He,C.T.,
            Hsiung,C.A., Hwu,C.M., Ichihara,S., Igase,M., Jo,J., Kato,N.,
            Kawamoto,R., Kuzawa,C.W., Lee,J.J., Liu,J., Lu,L., McDade,T.W.,
            Osawa,H., Sheu,W.H., Teo,Y., Vadlamudi,S., Van Dam,R.M., Wang,Y.,
            Xiang,Y.B., Yamamoto,K., Ye,X., Young,T.L., Zheng,W., Zhu,J.,
            Shu,X.O., Shin,C., Jee,S.H., Chuang,L.M., Miki,T., Yokota,M.,
            Lin,X., Mohlke,K.L. and Tai,E.S.
  TITLE     A meta-analysis of genome-wide association studies for adiponectin
            levels in East Asians identifies a novel locus near WDR11-FGFR2
  JOURNAL   Hum Mol Genet 23 (4), 1108-1119 (2014)
   PUBMED   24105470
REFERENCE   4  (bases 1 to 728)
  AUTHORS   Kulig,M. and Ecroyd,H.
  TITLE     The small heat-shock protein alphaB-crystallin uses different
            mechanisms of chaperone action to prevent the amorphous versus
            fibrillar aggregation of alpha-lactalbumin
  JOURNAL   Biochem J 448 (3), 343-352 (2012)
   PUBMED   23005341
  REMARK    GeneRIF: High molecular mass complexes are formed with
            alpha-lactalbumin and alphaB-crystallin, preventing the amorphous
            aggregation of alpha-lactalbumin.
REFERENCE   5  (bases 1 to 728)
  AUTHORS   Zhang,D.L., Wu,L.J., Chen,J. and Liang,Y.
  TITLE     Effects of macromolecular crowding on the structural stability of
            human alpha-lactalbumin
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 44 (8), 703-711 (2012)
   PUBMED   22735492
  REMARK    GeneRIF: analysis of macromolecular crowding on the structural
            stability of human alpha-lactalbumin
REFERENCE   6  (bases 1 to 728)
  AUTHORS   Heine,W.E., Klein,P.D. and Reeds,P.J.
  TITLE     The importance of alpha-lactalbumin in infant nutrition
  JOURNAL   J Nutr 121 (3), 277-283 (1991)
   PUBMED   2002399
  REMARK    Review article
REFERENCE   7  (bases 1 to 728)
  AUTHORS   Davies,M.S., West,L.F., Davis,M.B., Povey,S. and Craig,R.K.
  TITLE     The gene for human alpha-lactalbumin is assigned to chromosome
            12q13
  JOURNAL   Ann Hum Genet 51 (3), 183-188 (1987)
   PUBMED   3479943
REFERENCE   8  (bases 1 to 728)
  AUTHORS   Hall,L., Emery,D.C., Davies,M.S., Parker,D. and Craig,R.K.
  TITLE     Organization and sequence of the human alpha-lactalbumin gene
  JOURNAL   Biochem J 242 (3), 735-742 (1987)
   PUBMED   2954544
REFERENCE   9  (bases 1 to 728)
  AUTHORS   Hall,L., Craig,R.K., Edbrooke,M.R. and Campbell,P.N.
  TITLE     Comparison of the nucleotide sequence of cloned human and
            guinea-pig pre-alpha-lactalbumin cDNA with that of chick
            pre-lysozyme cDNA suggests evolution from a common ancestral gene
  JOURNAL   Nucleic Acids Res 10 (11), 3503-3515 (1982)
   PUBMED   6285305
REFERENCE   10 (bases 1 to 728)
  AUTHORS   Findlay,J.B. and Brew,K.
  TITLE     The complete amino-acid sequence of human -lactalbumin
  JOURNAL   Eur J Biochem 27 (1), 65-86 (1972)
   PUBMED   5049057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC089987.26.
            
            On Jun 16, 2020 this sequence version replaced NM_002289.2.
            
            Summary: This gene encodes alpha-lactalbumin, a principal protein
            of milk. Alpha-lactalbumin forms the regulatory subunit of the
            lactose synthase (LS) heterodimer and beta
            1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic
            component. Together, these proteins enable LS to produce lactose by
            transfering galactose moieties to glucose. As a monomer,
            alpha-lactalbumin strongly binds calcium and zinc ions and may
            possess bactericidal or antitumor activity. A folding variant of
            alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor
            and immature cells. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069103.1, J00270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301046.6/ ENSP00000301046.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC089987.26        41539-41697
            160-318             AC089987.26        42345-42503
            319-394             AC089987.26        42993-43068
            395-728             AC089987.26        43568-43901
FEATURES             Location/Qualifiers
     source          1..728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..728
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /note="lactalbumin alpha"
                     /db_xref="GeneID:3906"
                     /db_xref="HGNC:HGNC:6480"
                     /db_xref="MIM:149750"
     exon            1..159
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..455
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /EC_number="2.4.1.22"
                     /note="lactose synthase B protein; alpha-lactalbumin;
                     lysozyme-like protein 7; lysozyme G"
                     /codon_start=1
                     /product="alpha-lactalbumin precursor"
                     /protein_id="NP_002280.1"
                     /db_xref="CCDS:CCDS8765.1"
                     /db_xref="GeneID:3906"
                     /db_xref="HGNC:HGNC:6480"
                     /db_xref="MIM:149750"
                     /translation="MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPE
                     LICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDD
                     DITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWLCEKL"
     exon            160..318
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /inference="alignment:Splign:2.1.0"
     exon            319..394
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /inference="alignment:Splign:2.1.0"
     exon            395..728
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      705..710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /note="hexamer: AATAAA"
     polyA_site      728
                     /gene="LALBA"
                     /gene_synonym="HAMLET; LYZG"
                     /note="major polyA site"
ORIGIN      
        1 atttcaggtt cttgggggta gccaaaatga ggttctttgt ccctctgttc ctggtgggca
       61 tcctgttccc tgccatcctg gccaagcaat tcacaaaatg tgagctgtcc cagctgctga
      121 aagacataga tggttatgga ggcatcgctt tgcctgaatt gatctgtacc atgtttcaca
      181 ccagtggtta tgacacacaa gccatagttg aaaacaatga aagcacggaa tatggactct
      241 tccagatcag taataagctt tggtgcaaga gcagccaggt ccctcagtca aggaacatct
      301 gtgacatctc ctgtgacaag ttcctggatg atgacattac tgatgacata atgtgtgcca
      361 agaagatcct ggatattaaa ggaattgact actggttggc ccataaagcc ctctgcactg
      421 agaagctgga acagtggctt tgtgagaagt tgtgagtgtc tgctgtcctt ggcacccctg
      481 cccactccac actcctggaa tacctcttcc ctaatgccac ctcagtttgt ttctttctgt
      541 tcccccaaag cttatctgtc tctgagcctt gggccctgta gtgacatcac cgaattcttg
      601 aagactattt tccagggatg cctgagtggt gcactgagct ctagaccctt actcagtgcc
      661 ttcgatggca ctttcactac agcacagatt tcacctctgt cttgaataaa ggtcccactt
      721 tgaagtca
//
