LOCUS       NM_002288                665 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens leukocyte associated immunoglobulin like receptor 2
            (LAIR2), transcript variant 1, mRNA.
ACCESSION   NM_002288
VERSION     NM_002288.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 665)
  AUTHORS   Wang,P., Zhuang,W., Zheng,Z., Zhang,L., Zhang,X. and Chen,Q.
  TITLE     Dissecting T-cell heterogeneity in esophageal squamous cell
            carcinoma reveals the potential role of LAIR2 in antitumor immunity
  JOURNAL   Clin Exp Immunol 214 (1), 36-49 (2023)
   PUBMED   37422711
  REMARK    GeneRIF: Dissecting T-cell heterogeneity in esophageal squamous
            cell carcinoma reveals the potential role of LAIR2 in antitumor
            immunity.
REFERENCE   2  (bases 1 to 665)
  AUTHORS   Elsayed,O.M., Abdelazim,S.A., Darwish,H.A., Shaker,O.G. and
            Senousy,M.A.
  TITLE     Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with
            their expression with clinical and subclinical hypothyroidism
  JOURNAL   Sci Rep 13 (1), 6 (2023)
   PUBMED   36593237
  REMARK    GeneRIF: Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms
            along with their expression with clinical and subclinical
            hypothyroidism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 665)
  AUTHORS   Chen,Z., Yu,M., Yan,J., Guo,L., Zhang,B., Liu,S., Lei,J., Zhang,W.,
            Zhou,B., Gao,J., Yang,Z., Li,X., Zhou,J., Fan,J., Ye,Q., Li,H.,
            Xu,Y. and Xiao,Y.
  TITLE     PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival
            Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor
            Microenvironment: Characterization of Immune Microenvironment
            Combining Single-Cell and Bulk Sequencing Technology
  JOURNAL   Front Immunol 12, 647209 (2021)
   PUBMED   33841428
  REMARK    GeneRIF: PNOC Expressed by B Cells in Cholangiocarcinoma Was
            Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker
            in Tumor Microenvironment: Characterization of Immune
            Microenvironment Combining Single-Cell and Bulk Sequencing
            Technology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 665)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 665)
  AUTHORS   Liu,J., Zhao,H., Zhou,F., Huang,Y., Chen,X., Wang,S., Hao,J.,
            Xu,X., He,B. and Wang,J.
  TITLE     Human-specific LAIR2 contributes to the high invasiveness of human
            extravillous trophoblast cells
  JOURNAL   Reprod Biol 19 (3), 287-292 (2019)
   PUBMED   31548102
  REMARK    GeneRIF: These data suggest that species-specific genes are pivotal
            to the evolution of a more aggressive human placenta to match the
            physiological demands of human development.
REFERENCE   6  (bases 1 to 665)
  AUTHORS   Lebbink,R.J., van den Berg,M.C., de Ruiter,T., Raynal,N., van
            Roon,J.A., Lenting,P.J., Jin,B. and Meyaard,L.
  TITLE     The soluble leukocyte-associated Ig-like receptor (LAIR)-2
            antagonizes the collagen/LAIR-1 inhibitory immune interaction
  JOURNAL   J Immunol 180 (3), 1662-1669 (2008)
   PUBMED   18209062
  REMARK    GeneRIF: LAIR-2 prevents binding of human LAIR-1 to collagens and
            LAIR-1 cross-linking in vitro, suggesting that the protein has an
            immunoregulatory function in vivo.
REFERENCE   7  (bases 1 to 665)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   8  (bases 1 to 665)
  AUTHORS   Wende,H., Volz,A. and Ziegler,A.
  TITLE     Extensive gene duplications and a large inversion characterize the
            human leukocyte receptor cluster
  JOURNAL   Immunogenetics 51 (8-9), 703-713 (2000)
   PUBMED   10941842
  REMARK    Erratum:[Immunogenetics 2001;52(3-4):308]
REFERENCE   9  (bases 1 to 665)
  AUTHORS   Meyaard,L., Hurenkamp,J., Clevers,H., Lanier,L.L. and Phillips,J.H.
  TITLE     Leukocyte-associated Ig-like receptor-1 functions as an inhibitory
            receptor on cytotoxic T cells
  JOURNAL   J Immunol 162 (10), 5800-5804 (1999)
   PUBMED   10229813
REFERENCE   10 (bases 1 to 665)
  AUTHORS   Meyaard,L., Adema,G.J., Chang,C., Woollatt,E., Sutherland,G.R.,
            Lanier,L.L. and Phillips,J.H.
  TITLE     LAIR-1, a novel inhibitory receptor expressed on human mononuclear
            leukocytes
  JOURNAL   Immunity 7 (2), 283-290 (1997)
   PUBMED   9285412
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX106365.1, AC245036.3,
            BC069366.1 and AI262718.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002288.5.
            
            Summary: The protein encoded by this gene is a member of the
            immunoglobulin superfamily. It was identified by its similarity to
            leukocyte-associated immunoglobulin-like receptor 1, a
            membrane-bound receptor that modulates innate immune response. The
            protein encoded by this locus is a soluble receptor that may play
            roles in both inhibition of collagen-induced platelet aggregation
            and vessel formation during placental implantation. This gene maps
            to a region of 19q13.4, termed the leukocyte receptor cluster,
            which contains 29 genes in the immunoglobulin superfamily.
            Alternatively spliced transcript variants have been described for
            this gene. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057790.1, BC069366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301202.7/ ENSP00000301202.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BX106365.1         35-47
            14-14               AC245036.3         52848-52848
            15-76               BX106365.1         49-110
            77-594              BC069366.1         12-529
            595-665             AI262718.1         4-74                c
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..665
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /note="leukocyte associated immunoglobulin like receptor
                     2"
                     /db_xref="GeneID:3904"
                     /db_xref="HGNC:HGNC:6478"
                     /db_xref="MIM:602993"
     exon            1..122
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..547
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; leukocyte-associated Ig-like receptor-2;
                     LAIR-2"
                     /codon_start=1
                     /product="leukocyte-associated immunoglobulin-like
                     receptor 2 isoform a precursor"
                     /protein_id="NP_002279.2"
                     /db_xref="CCDS:CCDS12897.1"
                     /db_xref="GeneID:3904"
                     /db_xref="HGNC:HGNC:6478"
                     /db_xref="MIM:602993"
                     /translation="MSPHLTALLGLVLCLAQTIHTQEGALPRPSISAEPGTVISPGSH
                     VTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCL
                     YYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAP"
     exon            123..158
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /inference="alignment:Splign:2.1.0"
     exon            159..452
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /inference="alignment:Splign:2.1.0"
     exon            453..503
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /inference="alignment:Splign:2.1.0"
     exon            504..665
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /inference="alignment:Splign:2.1.0"
     regulatory      644..649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /note="hexamer: AATAAA"
     polyA_site      665
                     /gene="LAIR2"
                     /gene_synonym="CD306"
                     /note="major polyA site"
ORIGIN      
        1 agttgctgtg gaagccccac gggcaggagg cccccggcca gcacatcctg tctgcttgtg
       61 tctgctgcag agttctggga ccggggccat gtctccacac ctcactgctc tcctgggcct
      121 agtgctctgc ctggcccaga ccatccacac gcaggagggg gcccttccca gaccctccat
      181 ctcggctgag ccaggcactg tgatctcccc ggggagccat gtgactttca tgtgccgggg
      241 cccggttggg gttcaaacat tccgcctgga gagggaggat agagccaagt acaaagatag
      301 ttataatgtg tttcgacttg gtccatctga gtcagaggcc agattccaca ttgactcagt
      361 aagtgaagga aatgccgggc tttatcgctg cctctattat aagccccctg gatggtctga
      421 gcacagtgac ttcctggagc tgctggtgaa agaaagctct ggaggcccgg actccccgga
      481 cacagagccc ggctcctcag ctgggactgt gccaggcact gaagcctccg gatttgatgc
      541 accatgaatg aggagaaatg gcctcccgtc ttgtgaactt caatggggag aaataattag
      601 aatgagcaat agaaatgcac agatgcctat acatacatat acaaataaaa agatacgatt
      661 cgcaa
//
