LOCUS       NM_002287               4875 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens leukocyte associated immunoglobulin like receptor 1
            (LAIR1), transcript variant a, mRNA.
ACCESSION   NM_002287
VERSION     NM_002287.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Bartho,L.A., Walker,S.P., Cannon,P., Nguyen,T.V., Nguyen,A.,
            Botha,S.M., Hannan,N.J., Tong,S. and Kaitu'u-Lino,T.J.
  TITLE     Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is
            reduced with preeclampsia and small for gestational aged fetuses
  JOURNAL   Placenta 156, 10-13 (2024)
   PUBMED   39216164
  REMARK    GeneRIF: Leukocyte-associated immunoglobulin-like receptor 1
            (LAIR1) is reduced with preeclampsia and small for gestational aged
            fetuses.
REFERENCE   2  (bases 1 to 4875)
  AUTHORS   Fan,C., Zhang,Y., Yang,R., Wu,X., Zhou,J. and Xue,J.
  TITLE     [leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1)
            inhibits proliferation and promotes apoptosis of human HEL cells
            with JAK2 V617F mutation by blocking the JAK/STAT and PI3K/AKT
            signaling pathways]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 40 (3), 207-214 (2024)
   PUBMED   38512030
  REMARK    GeneRIF: [leukocyte-associated immunoglobulin-like receptor 1
            (LAIR-1) inhibits proliferation and promotes apoptosis of human HEL
            cells with JAK2 V617F mutation by blocking the JAK/STAT and
            PI3K/AKT signaling pathways].
REFERENCE   3  (bases 1 to 4875)
  AUTHORS   Helou,D.G., Quach,C., Hurrell,B.P., Li,X., Li,M., Akbari,A.,
            Shen,S., Shafiei-Jahani,P. and Akbari,O.
  TITLE     LAIR-1 limits macrophage activation in acute inflammatory lung
            injury
  JOURNAL   Mucosal Immunol 16 (6), 788-800 (2023)
   PUBMED   37634572
  REMARK    GeneRIF: LAIR-1 limits macrophage activation in acute inflammatory
            lung injury.
REFERENCE   4  (bases 1 to 4875)
  AUTHORS   Wei,X., Pan,S., Wang,Z., Chen,J., Lu,L., Cao,Q., Song,S., Zhang,H.,
            Liu,X., Qu,X., Lin,X. and Xu,H.
  TITLE     LAIR1 drives glioma progression by nuclear focal adhesion kinase
            dependent expressions of cyclin D1 and immunosuppressive
            chemokines/cytokines
  JOURNAL   Cell Death Dis 14 (10), 684 (2023)
   PUBMED   37845206
  REMARK    GeneRIF: LAIR1 drives glioma progression by nuclear focal adhesion
            kinase dependent expressions of cyclin D1 and immunosuppressive
            chemokines/cytokines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4875)
  AUTHORS   Hammad,R., Aglan,R.B., Mohammed,S.A., Awad,E.A., Elsaid,M.A.,
            Bedair,H.M., Khirala,S.K., Selim,M.A., Abo Elqasem,A.A., Rushdi,A.,
            Ali,M., Abo-Elkheir,O.I., Sanad,E.F. and Hamdy,N.M.
  TITLE     Cytotoxic T Cell Expression of Leukocyte-Associated
            Immunoglobulin-Like Receptor-1 (LAIR-1) in Viral Hepatitis
            C-Mediated Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 23 (20), 12541 (2022)
   PUBMED   36293412
  REMARK    GeneRIF: Cytotoxic T Cell Expression of Leukocyte-Associated
            Immunoglobulin-Like Receptor-1 (LAIR-1) in Viral Hepatitis
            C-Mediated Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4875)
  AUTHORS   Sinclair,N.R.
  TITLE     Why so many coinhibitory receptors?
  JOURNAL   Scand J Immunol 50 (1), 10-13 (1999)
   PUBMED   10404045
  REMARK    Review article
REFERENCE   7  (bases 1 to 4875)
  AUTHORS   Meyaard,L., Hurenkamp,J., Clevers,H., Lanier,L.L. and Phillips,J.H.
  TITLE     Leukocyte-associated Ig-like receptor-1 functions as an inhibitory
            receptor on cytotoxic T cells
  JOURNAL   J Immunol 162 (10), 5800-5804 (1999)
   PUBMED   10229813
REFERENCE   8  (bases 1 to 4875)
  AUTHORS   Meyaard,L.
  TITLE     LAIR-1, a widely distributed human ITIM-bearing receptor on
            hematopoietic cells
  JOURNAL   Curr Top Microbiol Immunol 244, 151-157 (1999)
   PUBMED   10453657
  REMARK    Review article
REFERENCE   9  (bases 1 to 4875)
  AUTHORS   Poggi,A., Tomasello,E., Ferrero,E., Zocchi,M.R. and Moretta,L.
  TITLE     p40/LAIR-1 regulates the differentiation of peripheral blood
            precursors to dendritic cells induced by granulocyte-monocyte
            colony-stimulating factor
  JOURNAL   Eur J Immunol 28 (7), 2086-2091 (1998)
   PUBMED   9692876
REFERENCE   10 (bases 1 to 4875)
  AUTHORS   Meyaard,L., Adema,G.J., Chang,C., Woollatt,E., Sutherland,G.R.,
            Lanier,L.L. and Phillips,J.H.
  TITLE     LAIR-1, a novel inhibitory receptor expressed on human mononuclear
            leukocytes
  JOURNAL   Immunity 7 (2), 283-290 (1997)
   PUBMED   9285412
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315419.1, DC389365.1,
            AC245884.3 and AF013249.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002287.5.
            
            Summary: The protein encoded by this gene is an inhibitory receptor
            found on peripheral mononuclear cells, including natural killer
            cells, T cells, and B cells. Inhibitory receptors regulate the
            immune response to prevent lysis of cells recognized as self. The
            gene is a member of both the immunoglobulin superfamily and the
            leukocyte-associated inhibitory receptor family. The gene maps to a
            region of 19q13.4 called the leukocyte receptor cluster, which
            contains at least 29 genes encoding leukocyte-expressed receptors
            of the immunoglobulin superfamily. The encoded protein has been
            identified as an anchor for tyrosine phosphatase SHP-1, and may
            induce cell death in myeloid leukemias. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013249.1, BC027899.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391742.7/ ENSP00000375622.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AK315419.1         30-344
            316-494             DC389365.1         341-519
            495-495             AC245884.3         77605-77605         c
            496-991             AK315419.1         525-1020
            992-1735            AF013249.1         933-1676
            1736-4875           AC245884.3         68920-72059         c
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..4875
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /note="leukocyte associated immunoglobulin like receptor
                     1"
                     /db_xref="GeneID:3903"
                     /db_xref="HGNC:HGNC:6477"
                     /db_xref="MIM:602992"
     exon            1..161
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..991
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /note="isoform a precursor is encoded by transcript
                     variant a; leukocyte-associated Ig-like receptor 1;
                     immunoglobulin heavy chain variable region"
                     /codon_start=1
                     /product="leukocyte-associated immunoglobulin-like
                     receptor 1 isoform a precursor"
                     /protein_id="NP_002278.2"
                     /db_xref="CCDS:CCDS12891.1"
                     /db_xref="GeneID:3903"
                     /db_xref="HGNC:HGNC:6477"
                     /db_xref="MIM:602992"
                     /translation="MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSH
                     VTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCI
                     YYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLK
                     AEHLYILIGVSVVFLFCLLLLVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLE
                     RTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMA
                     ESITYAAVARH"
     exon            162..197
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..491
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..542
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..581
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..710
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..753
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..791
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..844
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..4875
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1560..1565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /note="hexamer: AATAAA"
     polyA_site      1582
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /note="major polyA site"
     regulatory      2613..2618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2637
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /note="major polyA site"
     regulatory      4853..4858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
                     /note="hexamer: AATAAA"
     polyA_site      4875
                     /gene="LAIR1"
                     /gene_synonym="CD305; LAIR-1"
ORIGIN      
        1 agttgctgtg gaagccccat aggcaggagg cccccgggca gcacatcctg tctgcttgtg
       61 tctgctgcag agttctgtcc ttgcattggt gcgcctcagg ccaggctgca ctgctgggac
      121 ctgggccatg tctccccacc ccaccgccct cctgggccta gtgctctgcc tggcccagac
      181 catccacacg caggaggaag atctgcccag accctccatc tcggctgagc caggcaccgt
      241 gatccccctg gggagccatg tgactttcgt gtgccggggc ccggttgggg ttcaaacatt
      301 ccgcctggag agggacagta gatccacata caatgatact gaagatgtgt ctcaagctag
      361 tccatctgag tcagaggcca gattccgcat tgactcagta agagaaggaa atgccgggct
      421 ttatcgctgc atctattata agccccctaa atggtctgag cagagtgact acctggagct
      481 gctggtgaaa gaaagctctg gaggcccgga ctccccggac acagagcccg gctcctcagc
      541 tggacccacg cagaggccgt cggacaacag tcacaatgag catgcacctg cttcccaagg
      601 cctgaaagct gagcatctgt atattctcat cggggtctca gtggtcttcc tcttctgtct
      661 cctcctcctg gtcctcttct gcctccatcg ccagaatcag ataaagcagg ggccccccag
      721 aagcaaggac gaggagcaga agccacagca gaggcctgac ctggctgttg atgttctaga
      781 gaggacagca gacaaggcca cagtcaatgg acttcctgag aaggacagag agacggacac
      841 ctcggccctg gctgcaggga gttcccagga ggtgacgtat gctcagctgg accactgggc
      901 cctcacacag aggacagccc gggctgtgtc cccacagtcc acaaagccca tggccgagtc
      961 catcacgtat gcagccgttg ccagacactg accccatacc cacctggcct ctgcacctga
     1021 gggtagaaag tcactctagg aaaagcctga agcagccatt tggaaggctt cctgttggat
     1081 tcctcttcat ctagaaagcc agccaggcag ctgtcctgga gacaagagct ggagactgga
     1141 ggtttctaac cagcatccag aaggttcgtt agccaggtgg tcccttctac aatcgagcag
     1201 ctccttggac agactgtttc tcagttattt ccagagaccc agctacagtt ccctggctgt
     1261 ttctagagac ccagctttat tcacctgact gtttccagag acccagctaa agtcacctgc
     1321 ctgttctaaa ggcccagcta cagccaatca gccgatttcc tgagcagtga tgccacctcc
     1381 aagcttgtcc taggtgtctg ctgtgaacct ccagtgaccc cagagacttt gctgtaatta
     1441 tctgccctgc tgaccctaaa gaccttccta gaagtcaaga gctagccttg agactgtgct
     1501 atacacacac agctgagagc caagcccagt tctctgggtt gtgctttact ccacgcatca
     1561 ataaataatt ttgaaggcct cacatctggc agccccaggc ctggtcctgg gtgcataggt
     1621 ctctcggacc cactctctgc cttcacagtt gttcaaagct gagtgaggga aacaggactt
     1681 acgaaaacgt gtcagcgttt tctttttaaa atttaattga tcaggattgt acgtattcaa
     1741 ggtgtaaaat gtgataattt gtcgtacacg tacattgtgc aatgacagtc acaatcaatt
     1801 cctcagcgca cccatcgcca cagatacgat acattagata ttctgaactt gctcatctta
     1861 ggacttcaca ttggtgtcag tgttttctga caaatcacgt gtatcaggaa tgaatgaggg
     1921 aggtgtggct gggtgaaggc agagagccga ccctacaggt ccacatctgc acatacatgc
     1981 acaggaatgc atgctctcac acacatgcat acacacacgc acacacacag acatgcacat
     2041 acactcacac gccccaggaa atccaaggaa tcactgagcc tgctgttggt tgaggcattt
     2101 ctgagtatcc accctacctg tagggtcaga tgtactgatt gacacagaaa attaccctat
     2161 gtaccactag gaggcggcag aatctcattt gggttaatct gtgtttgtct ttaaaaaaca
     2221 aaaacaggcc gggcatggag gctcacgcct gtaatcccag cactttggga ggctgaggtg
     2281 ggcggatcac gaggtcagga gatcgagacc atcctggcta acacggtgaa accccatctc
     2341 tactaaaaat acaaaaaaat tagccgggtg tggtggtggg tgcctgtagt cccagctact
     2401 cgggaggctg agggaggaga atggcgtgaa cccgggaggc ggagtttgca gtgagccgag
     2461 gtggtgccac tgcactccag cctgggcgac agagcgagac tccgtcaaaa aagaaaagaa
     2521 aagaaaagaa agatttttaa gaattcagca aaaactcagc cagctctttc tatggggcag
     2581 ttgctaattt agttctaggc aaacgtggac acattaaatt ctcctacaaa ccctccacag
     2641 cgtgctctat tattttcctc atttataaaa acagaaacta tggaccgaga catgaagtaa
     2701 cctgtccaag gtcggccaag tctcagagac aggggcttca gacccacctg aggctcctga
     2761 ctccacatta tgaaccccgg gatgggctgc agctcggtct gctgggaggt ttctgtgctg
     2821 gttcaaagag ggtggtacct gactggccta cccaatttta atttgtactg agctttaatt
     2881 ttctatttgt gctcaggttt aatttcctcc tgggatctgc ttcccagtgc tgtactctgt
     2941 atctttgctt tcttgtgtga acattgtgac cgattttccc tgttcttcac gtgggacaca
     3001 ttctccctgc tctgtctgtc tctgtccctg tctctctttc tgtctttctc tctcactgtg
     3061 tgtctctctg tctctctctc tctttttttt tttttttgag atggagtttc gctcttgttg
     3121 cccaggctgg agtgcaatgg cacaatcttg gctcactgca acctctgcct cccgggttca
     3181 agcgattctc ctgcctcagc ctcctgagca gctgggatta caggcatgca ccaccacaca
     3241 cggctaattt tttgtatttt tgttagagac ggggggctct ccatgttgct caggctggtc
     3301 ttgaactccc gacctcaggt gatctgccca cctcagcctc ccaaagtcct gggattacag
     3361 gcatgagcca ctgcgtccag ccgtctttgt ctctttttct acatctctgt ctttcttctc
     3421 tggttgtttt tcaaccatca gctgggtgtt ttctcccata acgtcttgtt tgtttgacta
     3481 tgaggttgac aggtgggtac atgaactcta tagcagaagg tggacagtct gcacatagca
     3541 gaggatgggt gaatttttct accccttgca gagcacagga gagctgagca gatgccagtg
     3601 tctgctccag tgtaaggaag tccaggaagt tcaggtggtg aggtcacagt ggaaagcagg
     3661 acagatagag tttaggggaa attaagcaaa aataccacac tgttatttct tgacatatta
     3721 gtggaaagag gaagggccca gagagaagac agaaaattag atgcaggggc ttgttttttc
     3781 tcttgacttg ccaacccgcc caacgcaggg gccagaactc agggtggtga gatctgggaa
     3841 cattgctgtg cggagaagat gtccctcctg ctgcacgggc ccccaagcac cacctggggg
     3901 aagagccatg tttaattcac ctggcagtgc agtgtggcca ggcagagagg gagggcctac
     3961 cctgtgctta tgatcccacc ccagttcccc tggggtgtgc cctggcggtg aacaccagga
     4021 ggctgcagtg gggcccaacg tgaaagggag gagcagcctc accggggcca gatggggcag
     4081 cagcagatat tcacagatgt ccctgtgagt aaccagggca gaggccaggg gtctggcctt
     4141 ccctttcttg gagccctggg ccagctgggc aaggcgttga gagaaagatt acccggtgac
     4201 ctttatcaaa gcagagtaag gagggcttta ttcagaacca tcactgtagg taccaggacc
     4261 ccagcggtgg gattttgtag taggggaaag aaaatgggct cgacgttgaa tacagcatga
     4321 acaagtgaga atgtttgtta tacaaactat agggtggact ttttttttct tttttttaac
     4381 ttttttttac cttttagtgt aaaactgaac atagaaaata aattcatgaa gaagggatat
     4441 tttctgaggg tgtccagggc tgcccaacac ctcgtctacc ttctctgtca tagccccatt
     4501 taaaacactc tctctggatg aatacaccaa acctcacagt ctttgctctc ttgctaggaa
     4561 gaggagcaag agcgtgtttc actcttggct cctgcttaca cacctgctgt ccaatggaaa
     4621 ctactactta agacatttaa aaatagttgt ggtgatagca tgttgtgttt tggttggtga
     4681 tgccagttag tctctgaaaa ctttctgtga tgagtgtaaa attctacacc ttaatctcct
     4741 ttcttgtagg atctgggaag cagtatgcac ttgattgcac caaagatttt acgttcatag
     4801 aaaatttctg gcatctgtgt gaagaaagta aactatatct tccatttaga caaataaaat
     4861 atctttttga taaaa
//
