LOCUS       NM_006014                967 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens L antigen family member 3 (LAGE3), mRNA.
ACCESSION   NM_006014
VERSION     NM_006014.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 967)
  AUTHORS   Zhang,H., Jian,J., Chen,H., Zhu,X., Xie,J. and Xu,X.
  TITLE     LAGE3 promotes cell metastasis and stemness in non-small cell lung
            cancer companied with AKT/PI3K signaling pathway activation
  JOURNAL   Pathol Res Pract 248, 154700 (2023)
   PUBMED   37473499
  REMARK    GeneRIF: LAGE3 promotes cell metastasis and stemness in non-small
            cell lung cancer companied with AKT/PI3K signaling pathway
            activation.
REFERENCE   2  (bases 1 to 967)
  AUTHORS   Xing,Y., Liu,Y., Qi,Z., Liu,Z., Wang,X. and Zhang,H.
  TITLE     LAGE3 promoted cell proliferation, migration, and invasion and
            inhibited cell apoptosis of hepatocellular carcinoma by
            facilitating the JNK and ERK signaling pathway
  JOURNAL   Cell Mol Biol Lett 26 (1), 49 (2021)
   PUBMED   34837962
  REMARK    GeneRIF: LAGE3 promoted cell proliferation, migration, and invasion
            and inhibited cell apoptosis of hepatocellular carcinoma by
            facilitating the JNK and ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 967)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 967)
  AUTHORS   Dong,X., Yang,Q., Gu,J., Lv,S., Song,D., Chen,D., Song,J., Zhang,X.
            and Huang,D.
  TITLE     Identification and validation of L Antigen Family Member 3 as an
            immune-related biomarker associated with the progression of
            papillary thyroid cancer
  JOURNAL   Int Immunopharmacol 90, 107267 (2021)
   PUBMED   33310661
  REMARK    GeneRIF: Identification and validation of L Antigen Family Member 3
            as an immune-related biomarker associated with the progression of
            papillary thyroid cancer.
REFERENCE   5  (bases 1 to 967)
  AUTHORS   Zhang,Y., Huang,C., Zhu,Z., Hou,Y., Huang,S., Sun,C., Tang,Y.,
            Zhang,Z., Wang,L., Chen,H., Ju,W., Qiao,X. and Chen,M.
  TITLE     lncRNA NEAT1 regulates the proliferation and migration of
            hepatocellular carcinoma cells by acting as a miR-320a molecular
            sponge and targeting L antigen family member 3
  JOURNAL   Int J Oncol 57 (4), 1001-1012 (2020)
   PUBMED   32945386
  REMARK    GeneRIF: lncRNA NEAT1 regulates the proliferation and migration of
            hepatocellular carcinoma cells by acting as a miR320a molecular
            sponge and targeting L antigen family member 3.
REFERENCE   6  (bases 1 to 967)
  AUTHORS   Costessi,A., Mahrour,N., Sharma,V., Stunnenberg,R., Stoel,M.A.,
            Tijchon,E., Conaway,J.W., Conaway,R.C. and Stunnenberg,H.G.
  TITLE     The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin
            ligases by the human tumour antigen PRAME
  JOURNAL   PLoS One 7 (8), e42822 (2012)
   PUBMED   22912744
REFERENCE   7  (bases 1 to 967)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 967)
  AUTHORS   Alpen,B., Gure,A.O., Scanlan,M.J., Old,L.J. and Chen,Y.T.
  TITLE     A new member of the NY-ESO-1 gene family is ubiquitously expressed
            in somatic tissues and evolutionarily conserved
  JOURNAL   Gene 297 (1-2), 141-149 (2002)
   PUBMED   12384295
REFERENCE   9  (bases 1 to 967)
  AUTHORS   Faranda,S., Frattini,A., Zucchi,I., Patrosso,C., Milanesi,L.,
            Montagna,C. and Vezzoni,P.
  TITLE     Characterization and fine localization of two new genes in Xq28
            using the genomic sequence/EST database screening approach
  JOURNAL   Genomics 34 (3), 323-327 (1996)
   PUBMED   8786131
REFERENCE   10 (bases 1 to 967)
  AUTHORS   Chen,E.Y., Zollo,M., Mazzarella,R., Ciccodicola,A., Chen,C.N.,
            Zuo,L., Heiner,C., Burough,F., Repetto,M., Schlessinger,D. and
            D'Urso,M.
  TITLE     Long-range sequence analysis in Xq28: thirteen known and six
            candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and
            G6PD loci
  JOURNAL   Hum Mol Genet 5 (5), 659-668 (1996)
   PUBMED   8733135
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244090.3.
            
            On Apr 27, 2021 this sequence version replaced NM_006014.4.
            
            Summary: This gene belongs to the ESO/LAGE gene family, members of
            which are clustered together on chromosome Xq28, and have similar
            exon-intron structures. Unlike the other family members which are
            normally expressed only in testis and activated in a wide range of
            human tumors, this gene is ubiquitously expressed in somatic
            tissues. The latter, combined with the finding that it is highly
            conserved in mouse and rat, suggests that the encoded protein is
            functionally important. An intronless pseudogene with high sequence
            similarity to this gene is located on chromosome 9. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015744.1, BM973372.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2145743,
                                           SAMEA2148093 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357360.5/ ENSP00000349923.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               AC244090.3         105507-106060       c
            555-683             AC244090.3         105062-105190       c
            684-967             AC244090.3         104554-104837       c
FEATURES             Location/Qualifiers
     source          1..967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..967
                     /gene="LAGE3"
                     /gene_synonym="CVG5; DXS9879E; DXS9951E; ESO3; GAMOS2;
                     ITBA2; Pcc1"
                     /note="L antigen family member 3"
                     /db_xref="GeneID:8270"
                     /db_xref="HGNC:HGNC:26058"
                     /db_xref="MIM:300060"
     exon            1..554
                     /gene="LAGE3"
                     /gene_synonym="CVG5; DXS9879E; DXS9951E; ESO3; GAMOS2;
                     ITBA2; Pcc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..798
                     /gene="LAGE3"
                     /gene_synonym="CVG5; DXS9879E; DXS9951E; ESO3; GAMOS2;
                     ITBA2; Pcc1"
                     /note="protein ESO-3"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit LAGE3"
                     /protein_id="NP_006005.2"
                     /db_xref="CCDS:CCDS14753.1"
                     /db_xref="GeneID:8270"
                     /db_xref="HGNC:HGNC:26058"
                     /db_xref="MIM:300060"
                     /translation="MRDADADAGGGADGGDGRGGHSCRGGVDTAAAPAGGAPPAHAPG
                     PGRDAASAARGSRMRPHIFTLSVPFPTPLEAEIAHGSLAPDAEPHQRVVGKDLTVSGR
                     ILVVRWKAEDCRLLRISVINFLDQLSLVVRTMQRFGPPVSR"
     exon            555..683
                     /gene="LAGE3"
                     /gene_synonym="CVG5; DXS9879E; DXS9951E; ESO3; GAMOS2;
                     ITBA2; Pcc1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..967
                     /gene="LAGE3"
                     /gene_synonym="CVG5; DXS9879E; DXS9951E; ESO3; GAMOS2;
                     ITBA2; Pcc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      950..955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAGE3"
                     /gene_synonym="CVG5; DXS9879E; DXS9951E; ESO3; GAMOS2;
                     ITBA2; Pcc1"
                     /note="hexamer: AATAAA"
     polyA_site      967
                     /gene="LAGE3"
                     /gene_synonym="CVG5; DXS9879E; DXS9951E; ESO3; GAMOS2;
                     ITBA2; Pcc1"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcggggt gcgcctctgg gataggcgac cacggtgtct tcaaaagccc cgtcagggtt
       61 ggcttcctgg ggccggaccg actgtgggtc agtttgcacc agcgctctgg aatcgagtta
      121 cgcgcgaaag ggcagagttt ctggaggaaa ccgcagcctc tcaaccgctg accgggtctc
      181 agaaggcccc cggcagggcc gcttggcggg aactgaccac gcgccagtca ggctctccag
      241 ggacctgcgc aggcgcgtgt gggcggagtc gtgcgcaggg ggcggggctt cgggaaggag
      301 ccacagagag ggcggggcgt aggacctgcg cttcgggggt ggagtcggag cggcgcggcg
      361 gcggtcatgc gggacgcgga tgcagacgca ggcggaggcg ctgacggcgg ggatggccgg
      421 ggtggccaca gctgccgcgg gggcgtggac acagccgcag ctccggccgg tggagctccc
      481 ccagcgcacg cgccaggtcc gggcagagac gccgcgtctg cggccagggg gtcacgaatg
      541 cggccgcaca tattcaccct cagcgtgcct ttcccgaccc ccttggaggc ggaaatcgcc
      601 catgggtccc tggcaccaga tgccgagccc caccaaaggg tggttgggaa ggatctcaca
      661 gtgagtggca ggatcctggt cgtccgctgg aaagctgaag actgtcgcct gctccgaatt
      721 tccgtcatca actttcttga ccagctttcc ctggtggtgc ggaccatgca gcgctttggg
      781 ccccccgttt cccgctaagc ctggcctggg caaatggagc gaggtcccac tttgcgtctc
      841 cttgtaggca gtgcgtccat ccttccctag ggcaggaatt cccacagttg ctactttcct
      901 gggagggcct catgttttat ctggttctta aatgtttgtt actacagaaa ataaaactgc
      961 gctacta
//
