LOCUS       NM_005558               2627 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens ladinin 1 (LAD1), mRNA.
ACCESSION   NM_005558 XM_942663 XM_946199 XM_946200 XM_946202
VERSION     NM_005558.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2627)
  AUTHORS   Abe,T., Yamazaki,M., Nozumi,M., Maruyama,S., Takamura,K.,
            Ohashi,R., Ajioka,Y. and Tanuma,J.I.
  TITLE     Ladinin-1 in actin arcs of oral squamous cell carcinoma is involved
            in cell migration and epithelial phenotype
  JOURNAL   Sci Rep 14 (1), 22778 (2024)
   PUBMED   39354061
  REMARK    GeneRIF: Ladinin-1 in actin arcs of oral squamous cell carcinoma is
            involved in cell migration and epithelial phenotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2627)
  AUTHORS   Hu,L., Liu,Y., Fu,C., Zhao,J., Cui,Q., Sun,Q., Wang,H., Lu,L.,
            Dai,H., Xu,X. and Yang,W.
  TITLE     The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung
            Adenocarcinoma and Its Potential as a Therapeutic Target
  JOURNAL   Molecules 28 (3), 1103 (2023)
   PUBMED   36770773
  REMARK    GeneRIF: The Tumorigenic Effect of the High Expression of Ladinin-1
            in Lung Adenocarcinoma and Its Potential as a Therapeutic Target.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2627)
  AUTHORS   Chang,C.Y., Huang,Y.C., Chiang,H.H., Wu,Y.Y., Wu,K.L., Chang,Y.Y.,
            Liu,L.X., Tsai,Y.M. and Hsu,Y.L.
  TITLE     Ladinin 1 Shortens Survival via Promoting Proliferation and
            Enhancing Invasiveness in Lung Adenocarcinoma
  JOURNAL   Int J Mol Sci 24 (1), 431 (2022)
   PUBMED   36613882
  REMARK    GeneRIF: Ladinin 1 Shortens Survival via Promoting Proliferation
            and Enhancing Invasiveness in Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2627)
  AUTHORS   Li,J., Wang,Z. and Tie,C.
  TITLE     High expression of ladinin-1 (LAD1) predicts adverse outcomes: a
            new candidate docetaxel resistance gene for prostatic cancer (PCa)
  JOURNAL   Bioengineered 12 (1), 5749-5759 (2021)
   PUBMED   34516317
  REMARK    GeneRIF: High expression of ladinin-1 (LAD1) predicts adverse
            outcomes: a new candidate docetaxel resistance gene for prostatic
            cancer (PCa).
REFERENCE   5  (bases 1 to 2627)
  AUTHORS   Roth,L., Srivastava,S., Lindzen,M., Sas-Chen,A., Sheffer,M.,
            Lauriola,M., Enuka,Y., Noronha,A., Mancini,M., Lavi,S., Tarcic,G.,
            Pines,G., Nevo,N., Heyman,O., Ziv,T., Rueda,O.M., Gnocchi,D.,
            Pikarsky,E., Admon,A., Caldas,C. and Yarden,Y.
  TITLE     SILAC identifies LAD1 as a filamin-binding regulator of actin
            dynamics in response to EGF and a marker of aggressive breast
            tumors
  JOURNAL   Sci Signal 11 (515) (2018)
   PUBMED   29382783
  REMARK    GeneRIF: High abundance of LAD1 is associated with breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2627)
  AUTHORS   Ishiko,A., Shimizu,H., Masunaga,T., Yancey,K.B., Giudice,G.J.,
            Zone,J.J. and Nishikawa,T.
  TITLE     97 kDa linear IgA bullous dermatosis antigen localizes in the
            lamina lucida between the NC16A and carboxyl terminal domains of
            the 180 kDa bullous pemphigoid antigen
  JOURNAL   J Invest Dermatol 111 (1), 93-96 (1998)
   PUBMED   9665393
REFERENCE   7  (bases 1 to 2627)
  AUTHORS   Motoki,K., Megahed,M., LaForgia,S. and Uitto,J.
  TITLE     Cloning and chromosomal mapping of mouse ladinin, a novel basement
            membrane zone component
  JOURNAL   Genomics 39 (3), 323-330 (1997)
   PUBMED   9119369
REFERENCE   8  (bases 1 to 2627)
  AUTHORS   Ishiko,A., Shimizu,H., Masunaga,T., Hashimoto,T., Dmochowski,M.,
            Wojnarowska,F., Bhogal,B.S., Black,M.M. and Nishikawa,T.
  TITLE     97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the
            lamina lucida of the epidermal basement membrane
  JOURNAL   J Invest Dermatol 106 (4), 739-743 (1996)
   PUBMED   8618014
REFERENCE   9  (bases 1 to 2627)
  AUTHORS   Marinkovich,M.P., Taylor,T.B., Keene,D.R., Burgeson,R.E. and
            Zone,J.J.
  TITLE     LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel
            120-kDa anchoring filament protein synthesized by epidermal cells
  JOURNAL   J Invest Dermatol 106 (4), 734-738 (1996)
   PUBMED   8618013
  REMARK    Erratum:[J Invest Dermatol 1996 Jun;106(6):1343]
REFERENCE   10 (bases 1 to 2627)
  AUTHORS   Uitto,J. and Pulkkinen,L.
  TITLE     Molecular complexity of the cutaneous basement membrane zone
  JOURNAL   Mol Biol Rep 23 (1), 35-46 (1996)
   PUBMED   8983017
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC119427.3.
            
            On May 17, 2019 this sequence version replaced NM_005558.3.
            
            Summary: The protein encoded by this gene may be an anchoring
            filament that is a component of basement membranes. It may
            contribute to the stability of the association of the epithelial
            layers with the underlying mesenchyme. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.967085.1,
                                           SRR7346977.981631.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391967.7/ ENSP00000375829.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC119427.3         152287-152342       c
            57-200              AC119427.3         142178-142321       c
            201-1044            AC119427.3         139353-140196       c
            1045-1149           AC119427.3         138719-138823       c
            1150-1193           AC119427.3         137810-137853       c
            1194-1266           AC119427.3         136335-136407       c
            1267-1404           AC119427.3         136092-136229       c
            1405-1491           AC119427.3         135671-135757       c
            1492-1566           AC119427.3         135270-135344       c
            1567-2627           AC119427.3         133851-134911       c
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2627
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /note="ladinin 1"
                     /db_xref="GeneID:3898"
                     /db_xref="HGNC:HGNC:6472"
                     /db_xref="MIM:602314"
     exon            1..56
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1572
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /note="linear IgA bullous dermatosis antigen; linear IgA
                     disease antigen homolog; lad-1"
                     /codon_start=1
                     /product="ladinin-1"
                     /protein_id="NP_005549.2"
                     /db_xref="CCDS:CCDS1410.1"
                     /db_xref="GeneID:3898"
                     /db_xref="HGNC:HGNC:6472"
                     /db_xref="MIM:602314"
                     /translation="MAVSRKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDE
                     APRLSQNGDRQASASERLPSVEEAEVPKPLPPASKDEDEDIQSILRTRQERRQRRQVV
                     EAAQAPIQERLEAEEGRNSLSPVQATQKPLVSKKELEIPPRRRLSREQRGPWALEEES
                     LVGREPEERKKGVPEKSPVLEKSSMPKKTAPEKSLVSDKTSISEKVLASEKTSLSEKI
                     AVSEKRNSSEKKSVLEKTSVSEKSLAPGMALGSGRRLVSEKASIFEKALASEKSPTAD
                     AKPAPKRATASEQPLAQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVAS
                     RLPPVTLQVKIPSKEEEADMSSPTQRTYSSSLKRSSPRTISFRMKPKKENSETTLTRS
                     ASMKLPDNTVKLGEKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKELA
                     GQSRAEPASSRKENLRLSGVVTSRLNLWISRTQESGDQDPQEAQKASSATERTQWGQK
                     SDSSLDAEV"
     exon            57..200
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            201..1044
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1149
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1193
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1266
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1404
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1491
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1566
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..2627
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2223..2228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /note="hexamer: GATAAA"
     polyA_site      2242
                     /gene="LAD1"
                     /gene_synonym="LadA"
                     /note="major polyA site"
     polyA_site      2275
                     /gene="LAD1"
                     /gene_synonym="LadA"
     polyA_site      2627
                     /gene="LAD1"
                     /gene_synonym="LadA"
ORIGIN      
        1 acgcggggct cctgcagcat ggctgtcagc aggaaggact ggtccgcgct gtccagcctt
       61 gcccggcaga ggactctgga ggatgaggag gaacaggagc gcgagcgcag gcggcggcac
      121 cgcaacctga gctccaccac ggacgatgag gctcccaggc tcagccagaa tggagaccgg
      181 caggcctctg cttctgagag actaccgagc gtggaagaag cagaggtgcc caagccactg
      241 cccccagcct ccaaagatga ggacgaggac atccagagca tcctcagaac acggcaggag
      301 cggaggcaga ggcggcaggt ggtggaggct gcacaggccc ccatccagga gaggctggag
      361 gcagaggagg ggaggaacag cttgagccct gtgcaggcca cacagaaacc cctagtctcc
      421 aagaaggaac tggaaatccc acctcgccgg agactgagtc gggaacagcg gggcccctgg
      481 gccctggagg aggagagctt ggtgggcagg gagccagaag agaggaagaa aggggttcca
      541 gaaaagtccc cagtcttgga gaagtcctcc atgccaaaga agacggcacc tgaaaagagc
      601 ctggtctccg ataaaacctc catctctgag aaggtgctgg cctcagagaa gacatctcta
      661 tcagagaaga tagcagtgtc agagaaaaga aacagctcag agaagaagtc tgttctagaa
      721 aaaaccagtg tctctgagaa gtcgctggcc ccagggatgg cactgggctc aggaaggagg
      781 ctggtgtctg agaaagcttc catctttgag aaggcactgg cctcagagaa gagcccaact
      841 gcagatgcta agccggcccc aaagagggcc acagcctcag agcagcccct ggcgcaggag
      901 ccgccagcct ctgggggaag cccagccacc accaaggagc agagaggaag ggccctccct
      961 gggaagaacc tgccctcttt ggcaaagcag ggggcttcag accctccgac tgtggcctcc
     1021 cgcctcccac ccgtcacact ccaggtgaaa atccccagca aggaggaaga ggcagatatg
     1081 tcctcaccca cacagcgaac ctacagcagc tccctcaaac gctccagccc caggaccatc
     1141 tcctttcgga tgaaacccaa gaaagaaaac tcggaaacaa ccctaactcg cagtgccagc
     1201 atgaagctcc cagacaacac agtgaagttg ggagagaagc tggagagata ccacacggcc
     1261 atacggagat cagaatctgt caagtctcgg ggtctgcctt gcactgagtt attcgtggct
     1321 cctgtgggtg tagccagcaa gcgccacctc tttgagaagg aactggcggg ccagagccga
     1381 gcagaaccag cctccagccg gaaggagaac ttgaggctct caggggttgt gacatcaagg
     1441 ctcaacctgt ggatcagcag gacccaggaa tctggagatc aggaccccca ggaggcacag
     1501 aaagcatcat ctgcaaccga gaggactcag tggggacaga aatctgactc ctcgctggac
     1561 gctgaggtgt gacaagcccc gccaagacag acctgcaagt cttcgtctca agggacctcc
     1621 ctcatgccag gcccctgcct ctcacagcag caccctttcc tctcattgtc cctgttccct
     1681 ttttgcctgt ggatctgttt ggccagggtc cctggggtca ggaatatttg caagactcag
     1741 ccagctcctt cccagcccag cctcttgggg ctgggacttt ctcaccctgc ggcaggcaca
     1801 acagatgctg ggacccagtc tctgcccagg tcacagcaca agtgcacatc agcactatgg
     1861 ggcctatgtc ctgcccagag acctctgctc cttcctgctc acatccacag tcagggcacg
     1921 gcgcccctca agaactccag agtcacctgt ctcatcggct cccagcaagt gcctctttgt
     1981 ctatgatgtc ccccttctct gaggcctgga cccacccatc tttgtccctg gggcctgctc
     2041 ccagccactg aggcccgctc tggccagggg agaaggagct gccgtgcgtc ttccctgtgc
     2101 cccgtctccc tgcttggttc tcccctccct tccctggccg gctgccatgg ccaggagcta
     2161 agtgcctttt tgtgtgcaac cacttaccct ttctctgaaa aacctgttct caggaaggat
     2221 ctgataaact catttactct caggtgtaag agactgatga gaccttagaa gcgaattcct
     2281 ctctggaggc cttgctttct agcagaggtc acctgaagtg tgtgaggagg atcatcattt
     2341 tcctcatccc ccctcttctc acattaaggt ggtggcttgc cactcagcag tcctagcttg
     2401 gtgactggga actgccacat acagggccag gcctaccctc cttccccaca agccccctcc
     2461 aacccccacc cccatgctct ggacctcatg gctcctatga gcttggagca tggtgaacca
     2521 tcagagaatc tagaaccaac caagctagga acatcagcct ggtgccctgt taacccctta
     2581 aagctgtggt ttacaacttt tcaaaaattt aaatcattag aactctc
//
