LOCUS       NM_016027               1526 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lactamase beta 2 (LACTB2), mRNA.
ACCESSION   NM_016027
VERSION     NM_016027.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1526)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1526)
  AUTHORS   Chen,Q., Zheng,W., Zhu,L., Liu,H., Song,Y., Hu,S., Bai,Y., Pan,Y.,
            Zhang,J., Guan,J. and Shao,C.
  TITLE     LACTB2 renders radioresistance by activating PINK1/Parkin-dependent
            mitophagy in nasopharyngeal carcinoma
  JOURNAL   Cancer Lett 518, 127-139 (2021)
   PUBMED   34271102
  REMARK    GeneRIF: LACTB2 renders radioresistance by activating
            PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma.
REFERENCE   3  (bases 1 to 1526)
  AUTHORS   Borne,Y., Soderholm,M., Barregard,L., Fagerberg,B., Persson,M.,
            Melander,O., Thevenod,F., Hedblad,B. and Engstrom,G.
  TITLE     Genome wide association study identifies two loci associated with
            cadmium in erythrocytes among never-smokers
  JOURNAL   Hum Mol Genet 25 (11), 2342-2348 (2016)
   PUBMED   27005419
  REMARK    GeneRIF: This genome-wide study of never smokers from the general
            population identified two independent regions related to
            erythrocyte cadmium. The strongest locus covers the XKR9 and LACTB2
            genes, which both could have related functions in cadmium
            absorption and metabolism
REFERENCE   4  (bases 1 to 1526)
  AUTHORS   Levy,S., Allerston,C.K., Liveanu,V., Habib,M.R., Gileadi,O. and
            Schuster,G.
  TITLE     Identification of LACTB2, a metallo-beta-lactamase protein, as a
            human mitochondrial endoribonuclease
  JOURNAL   Nucleic Acids Res 44 (4), 1813-1832 (2016)
   PUBMED   26826708
  REMARK    GeneRIF: this study discovered that LACTB2 is an endoribonuclease
            that is involved in the turnover of mitochondrial RNA, and is
            essential for mitochondrial function in human cells.
REFERENCE   5  (bases 1 to 1526)
  AUTHORS   Yu,J., Wu,W.K., Liang,Q., Zhang,N., He,J., Li,X., Zhang,X., Xu,L.,
            Chan,M.T., Ng,S.S. and Sung,J.J.
  TITLE     Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal
            cancer
  JOURNAL   Oncogene 35 (2), 187-195 (2016)
   PUBMED   25823027
  REMARK    GeneRIF: Disruption of NCOA2 by recurrent fusion with LACTB2 in
            colorectal cancer
REFERENCE   6  (bases 1 to 1526)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB445101.1, AF151841.1 and AC022731.4.
            
            On Nov 23, 2018 this sequence version replaced NM_016027.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005563.1, SRR3476690.399725.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276590.5/ ENSP00000276590.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DB445101.1         28-81
            55-968              AF151841.1         25-938
            969-969             AC022731.4         98106-98106         c
            970-1526            AF151841.1         940-1496
FEATURES             Location/Qualifiers
     source          1..1526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.3"
     gene            1..1526
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /note="lactamase beta 2"
                     /db_xref="GeneID:51110"
                     /db_xref="HGNC:HGNC:18512"
                     /db_xref="MIM:618921"
     exon            1..187
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..932
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /note="beta-lactamase-like protein 2; testicular secretory
                     protein Li 23"
                     /codon_start=1
                     /product="endoribonuclease LACTB2"
                     /protein_id="NP_057111.1"
                     /db_xref="CCDS:CCDS6208.1"
                     /db_xref="GeneID:51110"
                     /db_xref="HGNC:HGNC:18512"
                     /db_xref="MIM:618921"
                     /translation="MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRIL
                     IDTGEPAIPEYISCLKQALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIK
                     KLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAI
                     FSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRN
                     IREQQILTLFRENFEKSFTVMELVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFS
                     NTDPDKKWKAHL"
     exon            188..351
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /inference="alignment:Splign:2.1.0"
     exon            352..478
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /inference="alignment:Splign:2.1.0"
     exon            479..657
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /inference="alignment:Splign:2.1.0"
     exon            658..806
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /inference="alignment:Splign:2.1.0"
     exon            807..888
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1526
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /note="hexamer: AATAAA"
     polyA_site      1240
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /note="major polyA site"
     polyA_site      1427
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /note="major polyA site"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /note="hexamer: ATTAAA"
     polyA_site      1526
                     /gene="LACTB2"
                     /gene_synonym="CGI-83"
                     /note="major polyA site"
ORIGIN      
        1 ctgttggctt cttccgcgct ggagtatcca gataggcgac acgccggcgg gcggctgagg
       61 cgggaatggc tgctgtactg cagcgcgtcg agcggctgtc caatcgagtc gtgcgtgtgt
      121 tgggctgtaa cccgggtccc atgaccctcc aaggcaccaa cacctaccta gtggggaccg
      181 gccccaggag aatcctcatt gacactggag aaccagcaat tccagaatac atcagctgtt
      241 taaagcaggc tctaactgaa tttaacacag caatccagga aattgtagtg actcactggc
      301 accgagatca ttctggaggc ataggagata tttgtaaaag catcaataat gacactacct
      361 attgcattaa aaaactccca cggaatcctc agagagaaga aattatagga aatggagagc
      421 aacaatatgt ttatctgaaa gatggagatg tgattaagac tgagggagcc actctaagag
      481 ttctatatac ccctggccac actgatgatc acatggctct actcttagaa gaggaaaatg
      541 ctatcttttc tggagattgc atcctagggg aaggaacaac ggtatttgaa gacctctatg
      601 attatatgaa ctctttaaaa gagttattga aaatcaaagc tgatattata tatccaggac
      661 atggcccagt aattcataat gctgaagcta aaattcaaca atacatttct cacagaaata
      721 ttcgagagca gcaaattctt acattatttc gtgagaactt tgagaaatca tttacagtaa
      781 tggagcttgt aaaaattatt tacaagaata ctcctgagaa tttacatgaa atggctaaac
      841 ataatctctt acttcatttg aaaaaactag aaaaagaagg aaaaatattt agcaacacag
      901 atcctgacaa gaaatggaaa gctcatcttt agtttcagat taaagaaagc tttgttttat
      961 tttgctttca gagaatggta tgttttctta actataggtt attttataga gaatataaaa
     1021 gtataaaaca ttaaaaataa ccctagatat actttaaaat aatgttatat ttatgctaaa
     1081 atatgtaaat tacactatac aaccatatga taggttattt ctctaacctt gtcttctaac
     1141 gttttaccaa aaattcataa tctaatagtt tatcagtttt caatagatta aataaaatga
     1201 ttactttaaa aataataaaa tttatctaat ttaaagttga tattattttt ggccgttagt
     1261 tatctattac tagtgatcag ttatactgtt ttctatagct actttattta acagcacaga
     1321 tttctatgca cctttactct ttcctcaacc cttgtctcta tctgtacata attgctttgt
     1381 cttgatgttt ctatcaacta tatcatgact atctattggt tccataactc tgtatcatgt
     1441 gtattttctt attctggtat accacaaatg attcatgcaa atgaattttt ggtgattgaa
     1501 aaatattaaa ttcccaattt aaagta
//
