LOCUS       NM_032857               1911 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lactamase beta (LACTB), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_032857
VERSION     NM_032857.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   Zeng,K., Huang,N., Liu,N., Deng,X., Mu,Y., Zhang,X., Zhang,J.,
            Zhang,C., Li,Y. and Li,Z.
  TITLE     LACTB suppresses liver cancer progression through regulation of
            ferroptosis
  JOURNAL   Redox Biol 75, 103270 (2024)
   PUBMED   39047638
  REMARK    GeneRIF: LACTB suppresses liver cancer progression through
            regulation of ferroptosis.
REFERENCE   2  (bases 1 to 1911)
  AUTHORS   Ma,W., Sun,Y., Yan,R., Zhang,P., Shen,S., Lu,H., Zhou,Z., Jiang,Z.,
            Ye,L., Mao,Q., Xiong,N., Jia,W., Sun,L., Gao,P. and Zhang,H.
  TITLE     OXCT1 functions as a succinyltransferase, contributing to
            hepatocellular carcinoma via succinylating LACTB
  JOURNAL   Mol Cell 84 (3), 538-551 (2024)
   PUBMED   38176415
  REMARK    GeneRIF: OXCT1 functions as a succinyltransferase, contributing to
            hepatocellular carcinoma via succinylating LACTB.
REFERENCE   3  (bases 1 to 1911)
  AUTHORS   Luo,Y., Zhang,Y., Pang,S., Min,J., Wang,T., Wu,D., Lin,C., Xiao,Z.,
            Xiang,Q., Li,Q. and Ma,L.
  TITLE     PCBP1 protects bladder cancer cells from mitochondria injury and
            ferroptosis by inducing LACTB mRNA degradation
  JOURNAL   Mol Carcinog 62 (7), 907-919 (2023)
   PUBMED   37157950
  REMARK    GeneRIF: PCBP1 protects bladder cancer cells from mitochondria
            injury and ferroptosis by inducing LACTB mRNA degradation.
REFERENCE   4  (bases 1 to 1911)
  AUTHORS   Bennett,J.A., Steward,L.R., Rudolph,J., Voss,A.P. and Aydin,H.
  TITLE     The structure of the human LACTB filament reveals the mechanisms of
            assembly and membrane binding
  JOURNAL   PLoS Biol 20 (12), e3001899 (2022)
   PUBMED   36534696
  REMARK    GeneRIF: The structure of the human LACTB filament reveals the
            mechanisms of assembly and membrane binding.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1911)
  AUTHORS   Cutano,V., Ferreira Mendes,J.M., Escudeiro-Lopes,S., Machado,S.,
            Vinaixa Forner,J., Gonzales-Morena,J.M., Prevorovsky,M.,
            Zemlianski,V., Feng,Y., Kralova Viziova,P., Hartmanova,A.,
            Malcekova,B., Jakoube,P., Iyer,S. and Keckesova,Z.
  TITLE     LACTB exerts tumor suppressor properties in epithelial ovarian
            cancer through regulation of Slug
  JOURNAL   Life Sci Alliance 6 (1), e202201510 (2022)
   PUBMED   36375842
  REMARK    GeneRIF: LACTB exerts tumor suppressor properties in epithelial
            ovarian cancer through regulation of Slug.
            Erratum:[Life Sci Alliance. 2023 Dec 6;7(2):e202302497. doi:
            10.26508/lsa.202302497.. PMID: 38056910]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1911)
  AUTHORS   Chen,Y., Zhu,J., Lum,P.Y., Yang,X., Pinto,S., MacNeil,D.J.,
            Zhang,C., Lamb,J., Edwards,S., Sieberts,S.K., Leonardson,A.,
            Castellini,L.W., Wang,S., Champy,M.F., Zhang,B., Emilsson,V.,
            Doss,S., Ghazalpour,A., Horvath,S., Drake,T.A., Lusis,A.J. and
            Schadt,E.E.
  TITLE     Variations in DNA elucidate molecular networks that cause disease
  JOURNAL   Nature 452 (7186), 429-435 (2008)
   PUBMED   18344982
REFERENCE   7  (bases 1 to 1911)
  AUTHORS   Peitsaro,N., Polianskyte,Z., Tuimala,J., Porn-Ares,I., Liobikas,J.,
            Speer,O., Lindholm,D., Thompson,J. and Eriksson,O.
  TITLE     Evolution of a family of metazoan active-site-serine enzymes from
            penicillin-binding proteins: a novel facet of the bacterial legacy
  JOURNAL   BMC Evol Biol 8, 26 (2008)
   PUBMED   18226203
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1911)
  AUTHORS   Hell-Pourmojib,M., Neuner,P., Fischer,H., Rezaie,S.,
            Kindas-Mugge,I., Knobler,R. and Trautinger,F.
  TITLE     Differential expression of a novel gene in response to hsp27 and
            cell differentiation in human keratinocytes
  JOURNAL   J Invest Dermatol 119 (1), 154-159 (2002)
   PUBMED   12164938
  REMARK    GeneRIF: Differential expression of a novel gene, G24, in response
            to hsp27 and cell differentiation in human keratinocytes.(G24
            PROTEIN)
REFERENCE   9  (bases 1 to 1911)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   10 (bases 1 to 1911)
  AUTHORS   Smith,T.S., Southan,C., Ellington,K., Campbell,D., Tew,D.G. and
            Debouck,C.
  TITLE     Identification, genomic organization, and mRNA expression of LACTB,
            encoding a serine beta-lactamase-like protein with an
            amino-terminal transmembrane domain
  JOURNAL   Genomics 78 (1-2), 12-14 (2001)
   PUBMED   11707067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC067288.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_032857.4.
            
            Summary: This gene encodes a mitochondrially-localized protein that
            has sequence similarity to prokaryotic beta-lactamases. Many of the
            residues responsible for beta-lactamase activity are not conserved
            in this protein, suggesting it may have a different enzymatic
            function. Increased expression of the related mouse gene was found
            to be associated with obesity. Alternative splicing results in
            multiple transcript variants encoding different protein isoforms.
            [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067288.1, SRR1163655.712254.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000261893.9/
                                                  ENSP00000261893.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1911              BC067288.1         42-1952
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..1911
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /note="lactamase beta"
                     /db_xref="GeneID:114294"
                     /db_xref="HGNC:HGNC:16468"
                     /db_xref="MIM:608440"
     exon            1..368
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1655
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; mitochondrial 39S ribosomal protein L56; serine
                     beta-lactamase-like protein LACTB, mitochondrial; serine
                     beta-lactamase-like protein, mitochondrial"
                     /codon_start=1
                     /product="serine beta-lactamase-like protein LACTB,
                     mitochondrial isoform a precursor"
                     /protein_id="NP_116246.2"
                     /db_xref="CCDS:CCDS10182.1"
                     /db_xref="GeneID:114294"
                     /db_xref="HGNC:HGNC:16468"
                     /db_xref="MIM:608440"
                     /translation="MYRLMSAVTARAAAPGGLASSCGRRGVHQRAGLPPLGHGWVGGL
                     GLGLGLALGVKLAGGLRGAAPAQSPAAPDPEASPLAEPPQEQSLAPWSPQTPAPPCSR
                     CFARAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVM
                     RIASISKSLTMVALAKLWEAGKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLS
                     GIRHYEKDIKKVKEEKAYKALKMMKENVAFEQEKEGKSNEKNDFTKFKTEQENEAKCR
                     NSKPGKKKNDFEQGELYLREKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAI
                     VERASGCKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNS
                     YKWAGGGFLSTVGDLLKFGNAMLYGYQVGLFKNSNENLLPGYLKPETMVMMWTPVPNT
                     EMSWDKEGKYAMAWGVVERKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDTETI
                     NNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRSD"
     exon            369..435
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /inference="alignment:Splign:2.1.0"
     exon            436..626
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /inference="alignment:Splign:2.1.0"
     exon            627..963
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1129
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1911
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /note="hexamer: AATAAA"
     polyA_site      1911
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /note="major polyA site"
ORIGIN      
        1 gcagagacgc catgtaccgg ctcatgtcag cagtgactgc ccgggctgcc gcccccgggg
       61 gcttggcctc aagctgcgga cgacgcgggg tccatcagcg cgccgggctg ccgcctctcg
      121 gccacggctg ggtcgggggc ctcgggctgg ggctggggct ggcgctcggg gtgaagctgg
      181 caggtgggct gaggggcgcg gccccggcgc agtcccccgc ggcccccgac cctgaggcgt
      241 cgcctctggc cgagccgcca caggagcagt ccctcgcccc gtggtctccg cagaccccgg
      301 cgccgccctg ctccaggtgc ttcgccagag ccatcgagag cagccgcgac ctgctgcaca
      361 ggatcaagga tgaggtgggc gcaccgggca tagtggttgg agtttctgta gatggaaaag
      421 aagtctggtc agaaggttta ggttatgctg atgttgagaa ccgtgtacca tgtaaaccag
      481 agacagttat gcgaattgct agcatcagca aaagtctcac catggttgct cttgccaaat
      541 tgtgggaagc agggaaactg gatcttgata ttccagtaca acattatgtt cccgaattcc
      601 cagaaaaaga atatgaaggt gaaaaggttt ctgtcacaac aagattactg atttcccatt
      661 taagtggaat tcgtcattat gaaaaggaca taaaaaaggt gaaagaagag aaagcttata
      721 aagccttgaa gatgatgaaa gagaatgttg catttgagca agaaaaagaa ggcaaaagta
      781 atgaaaagaa tgattttact aaatttaaaa cagagcagga gaatgaagcc aaatgccgga
      841 attcaaaacc tggcaagaaa aagaatgatt ttgaacaagg cgaattatat ttgagagaaa
      901 agtttgaaaa ttcaattgaa tccctaagat tatttaaaaa tgatcctttg ttcttcaaac
      961 ctggtagtca gtttttgtat tcaacttttg gctataccct actggcagcc atagtagaga
     1021 gagcttcagg atgtaaatat ttggactata tgcagaaaat attccatgac ttggatatgc
     1081 tgacgactgt gcaggaagaa aacgagccag tgatttacaa tagagcaaga ttttatgttt
     1141 acaataaaaa gaaacgtctt gtcaacacac cttacgtgga taactcctat aaatgggctg
     1201 gtggtggatt tctgtctaca gtgggtgacc ttctgaaatt tgggaatgca atgctttatg
     1261 gttaccaagt tgggctgttt aagaactcaa atgaaaatct tttacctgga tacctcaaac
     1321 cagaaacaat ggttatgatg tggaccccag tccctaacac agagatgtct tgggataaag
     1381 agggtaaata tgcaatggcg tggggtgttg tggaaaggaa acaaacgtat ggttcgtgta
     1441 gaaagcaacg gcattatgct tcacatactg gaggggcagt gggtgccagt agtgtcctgc
     1501 tggtccttcc tgaagaactg gatacagaga ctataaataa caaggttccc ccaagaggaa
     1561 tcattgtttc tatcatatgt aacatgcaat ctgttggcct caatagcacc gctttgaaga
     1621 ttgcccttga atttgataaa gacagatcag actgataacc ttaacaccat aggtgcaaaa
     1681 tgagttgttc tgaggttttt ttgaaacatt aaagttccaa aacatgacat ttttaagaat
     1741 aaatttgaaa tagagtataa ctgaatgcag agaattatgt acctctaatt gcttaatttt
     1801 gtaatggtct tttattgtag aattggttct ttatactcag ggaagtaatt atattgtttt
     1861 tactttttga aaaaagtgtt aactcttgaa ataaaatatt ctgataaaat a
//
