LOCUS       NM_032438               4206 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens L3MBTL histone methyl-lysine binding protein 3
            (L3MBTL3), transcript variant 1, mRNA.
ACCESSION   NM_032438 XM_027074
VERSION     NM_032438.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4206)
  AUTHORS   Li,Y., Zhang,J., He,J., Chen,X., Zhang,X., Wu,H. and Ding,Y.
  TITLE     Association of the L3MBTL3 rs1125970 and rs4897367 Gene
            Polymorphisms With Coronary Heart Disease Susceptibility in the
            Chinese Population: A Case-Control Study
  JOURNAL   J Cardiovasc Pharmacol 82 (5), 350-363 (2023)
   PUBMED   37523690
  REMARK    GeneRIF: Association of the L3MBTL3 rs1125970 and rs4897367 Gene
            Polymorphisms With Coronary Heart Disease Susceptibility in the
            Chinese Population: A Case-Control Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4206)
  AUTHORS   Hall,D., Giaimo,B.D., Park,S.S., Hemmer,W., Friedrich,T.,
            Ferrante,F., Bartkuhn,M., Yuan,Z., Oswald,F., Borggrefe,T.,
            Rual,J.F. and Kovall,R.A.
  TITLE     The structure, binding and function of a Notch transcription
            complex involving RBPJ and the epigenetic reader protein L3MBTL3
  JOURNAL   Nucleic Acids Res 50 (22), 13083-13099 (2022)
   PUBMED   36477367
  REMARK    GeneRIF: The structure, binding and function of a Notch
            transcription complex involving RBPJ and the epigenetic reader
            protein L3MBTL3.
REFERENCE   3  (bases 1 to 4206)
  AUTHORS   Alcina,A., Fedetz,M., Vidal-Cobo,I., Andres-Leon,E.,
            Garcia-Sanchez,M.I., Barroso-Del-Jesus,A., Eichau,S., Gil-Varea,E.,
            Luisa-Maria,Villar., Saiz,A., Leyva,L., Vandenbroeck,K.,
            Otaegui,D., Izquierdo,G., Comabella,M., Urcelay,E. and Matesanz,F.
  TITLE     Identification of the genetic mechanism that associates L3MBTL3 to
            multiple sclerosis
  JOURNAL   Hum Mol Genet 31 (13), 2155-2163 (2022)
   PUBMED   35088080
  REMARK    GeneRIF: Identification of the genetic mechanism that associates
            L3MBTL3 to multiple sclerosis.
REFERENCE   4  (bases 1 to 4206)
  AUTHORS   Xiong,J., Niu,Y., Liu,W., Zeng,F., Cheng,J.F., Chen,S.Q. and
            Zeng,X.Z.
  TITLE     Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced
            ONFH in Chinese Han population
  JOURNAL   Neurol Sci 43 (4), 2823-2830 (2022)
   PUBMED   34373992
  REMARK    GeneRIF: Effect of L3MBTL3/PTPN9 polymorphisms on risk to
            alcohol-induced ONFH in Chinese Han population.
REFERENCE   5  (bases 1 to 4206)
  AUTHORS   Stielow,B., Zhou,Y., Cao,Y., Simon,C., Pogoda,H.M., Jiang,J.,
            Ren,Y., Phanor,S.K., Rohner,I., Nist,A., Stiewe,T.,
            Hammerschmidt,M., Shi,Y., Bulyk,M.L., Wang,Z. and Liefke,R.
  TITLE     The SAM domain-containing protein 1 (SAMD1) acts as a repressive
            chromatin regulator at unmethylated CpG islands
  JOURNAL   Sci Adv 7 (20) (2021)
   PUBMED   33980486
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4206)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 4206)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   8  (bases 1 to 4206)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   9  (bases 1 to 4206)
  AUTHORS   Lu,J., Ruhf,M.L., Perrimon,N. and Leder,P.
  TITLE     A genome-wide RNA interference screen identifies putative chromatin
            regulators essential for E2F repression
  JOURNAL   Proc Natl Acad Sci U S A 104 (22), 9381-9386 (2007)
   PUBMED   17517653
REFERENCE   10 (bases 1 to 4206)
  AUTHORS   Arai,S. and Miyazaki,T.
  TITLE     Impaired maturation of myeloid progenitors in mice lacking novel
            Polycomb group protein MBT-1
  JOURNAL   EMBO J 24 (10), 1863-1873 (2005)
   PUBMED   15889154
  REMARK    GeneRIF: The mouse MBT-1 protein influences myelopoiesis by
            transiently enhancing p57(KIP2) expression levels.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356579.24, AL583846.9 and
            AL355581.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 8, 2019 this sequence version replaced NM_032438.3.
            
            Summary: This gene encodes a member of the malignant brain tumor
            (MBT) family of chromatin interacting transcriptional repressors.
            Members of this family function as methyl-lysine readers, which
            recognize methylated lysine residues on histone protein tails, and
            are associated with the repression of gene expression. The encoded
            protein may regulate hematopoiesis. Homozygous deletion of this
            gene has been observed in human patients with medulloblastoma.
            [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.27895.1,
                                           SRR14038197.630173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361794.7/ ENSP00000354526.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL356579.24        149035-149118
            85-163              AL356579.24        152681-152759
            164-280             AL583846.9         423-539
            281-392             AL583846.9         7020-7131
            393-467             AL583846.9         7494-7568
            468-627             AL583846.9         8987-9146
            628-760             AL583846.9         10597-10729
            761-845             AL583846.9         12909-12993
            846-937             AL583846.9         15144-15235
            938-1042            AL583846.9         17774-17878
            1043-1178           AL583846.9         24091-24226
            1179-1270           AL583846.9         26068-26159
            1271-1422           AL583846.9         28714-28865
            1423-1499           AL583846.9         36296-36372
            1500-1585           AL583846.9         41358-41443
            1586-1696           AL583846.9         43878-43988
            1697-1811           AL583846.9         50483-50597
            1812-1914           AL583846.9         52003-52105
            1915-2064           AL355581.14        8153-8302
            2065-2144           AL355581.14        24606-24685
            2145-2314           AL355581.14        37179-37348
            2315-2377           AL355581.14        37570-37632
            2378-4206           AL355581.14        43337-45165
FEATURES             Location/Qualifiers
     source          1..4206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.1"
     gene            1..4206
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /note="L3MBTL histone methyl-lysine binding protein 3"
                     /db_xref="GeneID:84456"
                     /db_xref="HGNC:HGNC:23035"
                     /db_xref="MIM:618844"
     exon            1..84
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..163
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..280
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2521
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /note="isoform a is encoded by transcript variant 1;
                     lethal(3)malignant brain tumor-like protein 3;
                     H-l(3)mbt-like protein 3; l(3)mbt-like 3; L3MBTL3, histone
                     methyl-lysine binding protein; L3mbt-like 3"
                     /codon_start=1
                     /product="lethal(3)malignant brain tumor-like protein 3
                     isoform a"
                     /protein_id="NP_115814.1"
                     /db_xref="CCDS:CCDS34537.1"
                     /db_xref="GeneID:84456"
                     /db_xref="HGNC:HGNC:23035"
                     /db_xref="MIM:618844"
                     /translation="MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALE
                     VITDENEMENVKKATATTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKT
                     GMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEE
                     DNEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSA
                     VLKQGLPPKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPE
                     HQSVYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKG
                     YKEEEFNWQTYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVAT
                     VTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSW
                     DKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVH
                     FDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELMEASEHGGCSTPGCKGI
                     GHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGEMPPASPSFPRNKRTDANESSS
                     SPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEPTVQQAQRRSAVFLSFKSPIPC
                     LPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAF
                     LLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL"
     exon            281..392
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..467
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..627
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..760
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..845
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..937
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1042
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1178
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1270
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1422
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1499
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1585
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1696
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1811
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1914
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2064
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2144
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2314
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2377
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..4206
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /note="hexamer: AATAAA"
     polyA_site      3253
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /note="hexamer: AATAAA"
     polyA_site      4206
                     /gene="L3MBTL3"
                     /gene_synonym="MBT-1; MBT1"
                     /note="major polyA site"
ORIGIN      
        1 gcacatgcgc attgcgcccg cagccctgga ccatttgtca ggactactcg tgagacggag
       61 aaaaaaaaaa gagaaaattt ggggaaccct taggagaaat cttgagagtg gacagcaatt
      121 gtgaagatcg ccagagagtt ctgtgtttca tcaccgccga aaggttaaaa aataaatcat
      181 gactgaatct gcctctagca caagtggtca agagtttgat gtgttcagtg ttatggactg
      241 gaaagatgga gtgggcacgt taccaggaag tgacttaaag tttcgggtaa atgagtttgg
      301 agccctggaa gttattacag atgagaatga gatggaaaat gttaaaaaag caactgctac
      361 caccacttgg atggtaccaa ctgctcaaga agccccgacc tctcccccga gctccaggcc
      421 cgtatttcca cctgcctact ggacatctcc acctggatgt cccacagtct tttcagagaa
      481 gactgggatg cctttcaggt tgaaggatcc agtgaaagta gaagggcttc agttctgtga
      541 gaactgttgt cagtatggca acgtagatga gtgtctttct ggaggaaact attgcagcca
      601 gaattgtgct cggcacatca aagataaaga tcagaaggaa gaaagggacg tagaagaaga
      661 caatgaggaa gaagatccta agtgtagtcg gaagaaaaaa ccaaaattat ctctgaaagc
      721 tgacaccaag gaggatggag aagagagaga tgatgaaatg gagaacaaac aagatgtaag
      781 aatcctgagg ggttcgcaga gagcacggag gaaaagacga ggggattcgg ctgtactaaa
      841 gcagggtttg cctcctaaag gaaagaaagc gtggtgctgg gcatcctacc tggaagagga
      901 gaaagcggtg gcagtgccgg cgaagctgtt caaggagcat caatcctttc catataacaa
      961 aaatggattc aaagttggca tgaaattaga aggcgtggat cctgagcatc agtctgtgta
     1021 ctgtgtcctc accgtcgcgg aggtttgtgg ataccggata aagcttcact ttgatgggta
     1081 ttctgattgc tatgacttct gggtgaatgc agacgctctg gatatccacc cagttgggtg
     1141 gtgtgagaaa accggccaca aactccatcc tccaaaaggg tataaagaag aagaattcaa
     1201 ttggcagacc tatcttaaga catgtaaagc tcaagctgct cctaagtcat tatttgaaaa
     1261 tcagaatata acagtgatcc catcgggctt tcgagttggt atgaagcttg aggcagtaga
     1321 caaaaagaat ccctcattca tctgtgttgc tacggtaaca gatatggtgg acaatcgttt
     1381 cctggtacat tttgacaact gggatgagag ctatgactat tggtgtgaag catcaagtcc
     1441 acatattcat ccagttggtt ggtgtaagga acatagaaga acccttatta ctccaccagg
     1501 ttatccaaat gtgaaacatt tttcttggga taaatactta gaagaaacca attctttacc
     1561 tgctcctgca agagctttca aagtgaaacc tcctcatgga ttccagaaaa aaatgaagct
     1621 tgaggttgta gacaaaagga accctatgtt tattagagta gcaactgtgg cagacacaga
     1681 tgatcaccgg gtaaaagttc actttgatgg ctggaacaat tgctatgatt actggataga
     1741 tgcagattct cctgatattc accctgtagg ctggtgttca aaaacaggac atccccttca
     1801 gcctcctttg agccccttag aattaatgga agcttcagaa catggtggat gctcaacccc
     1861 gggatgtaaa gggattggcc atttcaagag agcgagacat ctgggccctc acagtgctgc
     1921 caactgtccc tattcagaaa tcaatttgaa taaagaccgt atttttccag accgcttaag
     1981 tggtgagatg cctccggcta gtccgtcatt tccaagaaat aaaaggacag atgcaaatga
     2041 aagctcttct tcccctgaaa tcagagacca gcatgctgat gatgtcaaag aagactttga
     2101 agagagaaca gaaagtgaaa tgagaacatc acatgaagcc agaggtgccc gggaagaacc
     2161 caccgtccag caggcacagc gtcggtcagc tgtctttctg tcctttaagt ccccaattcc
     2221 atgtctgccc ttgcgctggg agcagcaaag caaacttctt ccaactgtcg caggaatccc
     2281 tgccagtaaa gtttccaaat ggagcacaga cgaggtgtca gaatttatac agagcttacc
     2341 tgggtgtgaa gaacatggaa aggtatttaa agatgaacaa attgatggag aagcatttct
     2401 acttatgact caaacagaca ttgttaaaat tatgagcatt aaactgggcc ctgctctcaa
     2461 aattttcaat tccatcctga tgttcaaagc tgcagagaag aattctcaca atgaactttg
     2521 aagatggtga attctgaata ccatcagcat tctgctttaa agctcatgtt ttattcaaag
     2581 cacaaggacg gttataactc ctaagtgaga agtctccaaa actcaaaaga gcaacactat
     2641 cggattattt atattactca agagacaata tatatgaatt cttatgaaag tgcttgagct
     2701 tttaaccagg tactgtctaa caacagtcat cttttggttc tgttcactga gctaaattta
     2761 tctttgtaaa tctttttgag tctggggggt ggggggaagg ggggcttcat taattattta
     2821 tggtaatggg gggcagagta agaacttttg gcattttgta aacattgttg aattctcttt
     2881 catgtacact gtttcttttt caatactttc agaaaccttt ttatataatc aaatttcaat
     2941 ttaaaccaaa ttagtcgaaa cctggctaag tttagccagt aggactgtta tctgtattgt
     3001 taattttgtg ccatattttg aattgcaaca ttatgctaag tataactttg caagtcatga
     3061 tattgcctaa ctgcttgtca taattgtcag ggctgaatag ttgtaagaat gacttttctt
     3121 tgaatcagta tttttccttt tgcacgcatt atgaaatgtt aaacaaatta cttttcacca
     3181 gcatctttac tataattacc aaaaacatgt atataaaaga atgaaattga aaaataaaat
     3241 atataaacat aaataaatta ggtagtgtat tttgagtggc atcagtctca ctcatcttgg
     3301 tgccccggtg tttacaagag ccagatggtg tcagaggagt acgcagttgt atgcagttat
     3361 ggttgggggg aatgtttgtg agggtcttga actatttatg agatgatctt gagcttctaa
     3421 ttttcattga tgaaattgtg gtggtttaca gagactaaga gctcattctg tcaacagaaa
     3481 cactaatctg tacagagcgc tgtctcaggt catgcattgt cctccaaacc caaaggtttt
     3541 tttcagggtt ggctagagag cgagtattgt gattttgctg aaaagacaag gtgtgaagga
     3601 gcaacttcag ttgacacaaa atttgaaatg ctcacagatc agggaggtga tttcccaaag
     3661 taattgccca agaacctccg ttttggaagg attccttttt ctgtagaata ctttgcctcg
     3721 atatataagc atacagatgc actttaaatg aaaacccttg attataaatt gatagctggt
     3781 agtgtttctt ttgcaagaat gcatttctaa ggcaaaaggt aaattatttt gtccgtcttt
     3841 tgatgtactt tctgattcca ggattggata tttattcaag gactatttta aaaatagaaa
     3901 gtaagtttgt agcatgctgt ctgaattctg gggtaagttc cacctcttct ttagttgctt
     3961 tcgtttttta tgatgtagga cttcctttga tatccctgtt ggaagtccat tagcagtcct
     4021 ttgcatttgc caattcaagg taaaacaggg tcagtgacat ctgcagtgtc ccagtcattt
     4081 atttgcatga atctgcttaa ataagttttt tgttgctgtt ttttcttttt tatgttttgt
     4141 tcagaatttg tacattcaag ttgtacttgt tatatctgac atgaatgaaa taaaatctta
     4201 attaca
//
