LOCUS       NM_031488               3189 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens L3MBTL histone methyl-lysine binding protein 2
            (L3MBTL2), mRNA.
ACCESSION   NM_031488
VERSION     NM_031488.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3189)
  AUTHORS   Zhong,L., Wang,J., Chen,W., Lv,D., Zhang,R., Wang,X., Zeng,C.,
            He,X., Zheng,L., Gao,Y., Wang,S., Li,M., Wu,Y., Yin,J., Kang,T. and
            Liao,D.
  TITLE     Augmenting L3MBTL2-induced condensates suppresses tumor growth in
            osteosarcoma
  JOURNAL   Sci Adv 9 (47), eadi0889 (2023)
   PUBMED   37992172
  REMARK    GeneRIF: Augmenting L3MBTL2-induced condensates suppresses tumor
            growth in osteosarcoma.
REFERENCE   2  (bases 1 to 3189)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3189)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3189)
  AUTHORS   Nowsheen,S., Aziz,K., Aziz,A., Deng,M., Qin,B., Luo,K.,
            Jeganathan,K.B., Zhang,H., Liu,T., Yu,J., Deng,Y., Yuan,J.,
            Ding,W., van Deursen,J.M. and Lou,Z.
  TITLE     L3MBTL2 orchestrates ubiquitin signalling by dictating the
            sequential recruitment of RNF8 and RNF168 after DNA damage
  JOURNAL   Nat Cell Biol 20 (4), 455-464 (2018)
   PUBMED   29581593
  REMARK    GeneRIF: L3MBTL2 orchestrates ubiquitin signalling by dictating the
            sequential recruitment of RNF8 and RNF168 after DNA damage,
            regulating the DNA damage response pathway.
REFERENCE   5  (bases 1 to 3189)
  AUTHORS   Lo,M.T., Hinds,D.A., Tung,J.Y., Franz,C., Fan,C.C., Wang,Y.,
            Smeland,O.B., Schork,A., Holland,D., Kauppi,K., Sanyal,N.,
            Escott-Price,V., Smith,D.J., O'Donovan,M., Stefansson,H.,
            Bjornsdottir,G., Thorgeirsson,T.E., Stefansson,K., McEvoy,L.K.,
            Dale,A.M., Andreassen,O.A. and Chen,C.H.
  TITLE     Genome-wide analyses for personality traits identify six genomic
            loci and show correlations with psychiatric disorders
  JOURNAL   Nat Genet 49 (1), 152-156 (2017)
   PUBMED   27918536
  REMARK    GeneRIF: L3MBTL2 polymorphism is associated with neuroticism.
REFERENCE   6  (bases 1 to 3189)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   7  (bases 1 to 3189)
  AUTHORS   Ogawa,H., Ishiguro,K., Gaubatz,S., Livingston,D.M. and Nakatani,Y.
  TITLE     A complex with chromatin modifiers that occupies E2F- and
            Myc-responsive genes in G0 cells
  JOURNAL   Science 296 (5570), 1132-1136 (2002)
   PUBMED   12004135
REFERENCE   8  (bases 1 to 3189)
  AUTHORS   Wismar,J.
  TITLE     Molecular characterization of h-l(3)mbt-like: a new member of the
            human mbt family
  JOURNAL   FEBS Lett 507 (1), 119-121 (2001)
   PUBMED   11682070
REFERENCE   9  (bases 1 to 3189)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 3189)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK097052.1, AJ305226.1, BU184979.1 and AJ305227.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031488.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056443.1, SRR1803612.88502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216237.10/ ENSP00000216237.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AK097052.1         31-343
            314-2576            AJ305226.1         302-2564
            2577-2612           BU184979.1         743-778
            2613-3189           AJ305227.1         2706-3282
FEATURES             Location/Qualifiers
     source          1..3189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..3189
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /note="L3MBTL histone methyl-lysine binding protein 2"
                     /db_xref="GeneID:83746"
                     /db_xref="HGNC:HGNC:18594"
                     /db_xref="MIM:611865"
     exon            1..75
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2169
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /note="L3MBTL2, polycomb repressive complex 1 subunit;
                     L(3)mbt-like protein 2; H-l(3)mbt-like protein 2;
                     l(3)mbt-like 2"
                     /codon_start=1
                     /product="lethal(3)malignant brain tumor-like protein 2"
                     /protein_id="NP_113676.2"
                     /db_xref="CCDS:CCDS14011.1"
                     /db_xref="GeneID:83746"
                     /db_xref="HGNC:HGNC:18594"
                     /db_xref="MIM:611865"
                     /translation="MEKPRSIEETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSES
                     SSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAF
                     FSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQG
                     TGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEV
                     LNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAIN
                     SKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDK
                     SQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSE
                     RRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATV
                     CKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTF
                     NWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLL
                     SIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKK
                     QFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEIIAVRVKEEHLDVA
                     SPDKASSPELPVSVENIKQETDD"
     exon            76..313
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            314..447
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            448..571
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            572..651
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            652..769
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            770..904
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            905..993
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1225
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1302
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1407
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1555
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1638
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1873
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1939
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2056
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..3189
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /note="hexamer: ATTAAA"
     polyA_site      3189
                     /gene="L3MBTL2"
                     /gene_synonym="H-l(3)mbt-l; L3MBT"
                     /note="major polyA site"
ORIGIN      
        1 aggccaatat ggcttcctgc acctggtgac gcttggcgaa actgaggtct catggagaag
       61 ccccggagta ttgaggagac cccatcttca gaaccaatgg aggaagagga agatgacgac
      121 ttggagctgt ttggtggcta tgatagtttc cggagttata acagcagtgt gggcagtgag
      181 agcagctcct atctggagga gtcaagtgaa gcagaaaatg aggatcggga agcaggggaa
      241 ctgccgacct ccccgctgca tttgctcagc cctgggactc ctcgctcctt ggatggcagt
      301 ggttctgagc cagctgtctg tgagatgtgt ggtatcgtgg gtacaaggga agccttcttc
      361 tccaagacca agaggttctg cagcgtctcc tgctccagga gctactcctc caactccaag
      421 aaagccagta tcttggctag gttacaggga aaaccaccga ccaaaaaagc caaagtcctg
      481 cacaaggctg cctggtctgc caaaattgga gccttcctcc actctcaagg gacaggacag
      541 ctggcagatg ggacaccaac aggacaagac gctctggtct tgggcttcga ctgggggaag
      601 ttcctgaagg atcacagtta caaggctgct cccgtcagct gtttcaagca cgtcccactc
      661 tatgaccagt gggaggatgt gatgaaaggg atgaaggtgg aggtgctcaa cagtgatgct
      721 gtgctcccca gccgggtgta ctggatcgcc tctgtcatcc agacagcagg gtatcgggtg
      781 ctgcttcggt atgaaggctt tgaaaatgac gccagccatg acttctggtg caacctggga
      841 acagtggatg tccaccccat tggctggtgt gccatcaaca gcaagatcct agtgccccca
      901 cggaccatcc atgccaagtt caccgactgg aagggctacc tcatgaaacg gctggtgggc
      961 tccaggacgc ttcccgtgga tttccacatc aagatggtgg agagcatgaa gtaccccttt
     1021 aggcagggca tgcggctgga agtggtggac aagtcccagg tgtcacgcac tcgcatggct
     1081 gtggtggaca cagtaatcgg gggtcgccta cggctcctct acgaggatgg tgacagtgac
     1141 gacgacttct ggtgccacat gtggagcccc ctgatccacc cagtgggttg gtcacgacgt
     1201 gtgggccacg gcatcaagat gtcagagagg cgaagtgaca tggcccatca ccccaccttc
     1261 cggaagatct actgtgatgc cgttccttac ctcttcaaga aggtacgagc agtctacaca
     1321 gaaggcggtt ggtttgagga agggatgaag ctggaggcca ttgaccccct gaatctgggc
     1381 aacatctgcg tggcaactgt ctgtaaggtt ctcctggatg gatacctgat gatctgtgtg
     1441 gacggggggc cctccacaga tggcttggac tggttctgct accatgcctc ttcccacgcc
     1501 atcttcccgg ccaccttctg tcagaagaat gacattgagc tcacaccgcc aaaaggttat
     1561 gaggcacaga ctttcaactg ggagaactac ttggagaaga ccaagtcgaa agccgctcca
     1621 tcgagactct ttaacatgga ttgcccaaac catggcttca aggtgggcat gaagctggag
     1681 gccgtggacc tgatggagcc ccggctcatc tgtgtggcca cggtgaaacg agtggtgcat
     1741 cggctcctca gcatccactt tgacggctgg gacagcgagt acgaccagtg ggtggactgc
     1801 gagtccccag acatctaccc cgtcggctgg tgtgagctca ccggctacca gctccagcct
     1861 cctgtggccg cagaaccggc cacaccgctg aaggccaaag aggccacaaa gaagaaaaag
     1921 aaacagtttg ggaagaaaag gaaaagaatc ccgcccacta agacgcgacc cctcagacag
     1981 gggtccaaga agcccctgct ggaggacgac cctcagggtg ccaggaagat ctcgtcggag
     2041 cctgttcctg gcgagatcat tgctgtgcgt gtgaaggaag agcatctaga cgtggcctcg
     2101 cccgacaagg cttcaagtcc agagctgcct gtctccgtcg agaacatcaa gcaggaaaca
     2161 gacgactgag ccttcctgcc tccagcctgg cttctagctg gaagccagcc cagcgtttct
     2221 ctaccaccac caccatgcct ccacctgact ttggcttgga gactgatcct ctctgtgtaa
     2281 attctgcccg gtgctgtgaa ggctggacgg tggaggacct gctggggtct cctgggaccc
     2341 gcctgttgct tctgccctcc cctgtggaaa ggtctatatg acgggccgcc tgaggcccca
     2401 gaactcgtct gtgaaccacc ttttccagcc agagttccca aagctggaac gctagctgcc
     2461 tgctcttcct taagatggcc tccccccgac ccgccacggc cctcagttgc cagggatggg
     2521 gccaccactg tcacactgtg gaatacaaga cagtgaactc tgtctgcctg aacgagccat
     2581 gtaaattaag ttctagagca gctctctgag caggataagg tcccctgaca gtgagttgtg
     2641 tggtgggggc agcctctgcc tcaaaaattc accaagcaga atgcctctca gcctcatgtg
     2701 ttggtcctct gctcctccta gctccccagg gatgttgggg acccagcttg tctcggcagc
     2761 taagaagcag tgaccaggat gtggattttg gcgacctgtg tggtggcctt gagctgcttt
     2821 ctgtgtttgt gaggactgac tcccatttcc taaaggaaat gcccccgggg aggacattgg
     2881 gaggaagatg gcctgagtgt gcactttggc tctgctacct gctcctgaag ccccgctaaa
     2941 aataattcat ccaagattcc tttgtagtta aagggtccag ttctgactgg agcctctaga
     3001 gagctgggct tgtatgttct tttggccttt tgttcctacc taaatgaaga aaccatgcct
     3061 ggaggggccg tgaacacaga accctcaaga caaggatgac agagctggag gacacatcta
     3121 gctgccattg caacctcact gggctcccca gactctgtgt gtgagaaatt aaaccccctg
     3181 cttgcttga
//
