LOCUS       NM_001377303            3432 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens L3MBTL histone methyl-lysine binding protein 1
            (L3MBTL1), transcript variant 3, mRNA.
ACCESSION   NM_001377303
VERSION     NM_001377303.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3432)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3432)
  AUTHORS   Wang,Y.X., Yue,L.F., Zhang,J.W., Xiong,Y.W., Hu,J.J., Wang,L.L.,
            Li,Z., Liu,Y., Yang,L. and Sun,L.J.
  TITLE     Expression and DNA Methylation Status of the Imprinted Genes PEG10
            and L3MBTL1 in the Umbilical Cord Blood and Placenta of the
            Offspring of Assisted Reproductive Technology
  JOURNAL   Reprod Sci 28 (4), 1133-1141 (2021)
   PUBMED   33515207
  REMARK    GeneRIF: Expression and DNA Methylation Status of the Imprinted
            Genes PEG10 and L3MBTL1 in the Umbilical Cord Blood and Placenta of
            the Offspring of Assisted Reproductive Technology.
REFERENCE   3  (bases 1 to 3432)
  AUTHORS   Samir,N., Matboli,M., El-Tayeb,H., El-Tawdi,A., Hassan,M.K.,
            Waly,A., El-Akkad,H.A.E., Ramadan,M.G., Al-Belkini,T.N.,
            El-Khamisy,S. and El-Asmar,F.
  TITLE     Competing endogenous RNA network crosstalk reveals novel molecular
            markers in colorectal cancer
  JOURNAL   J Cell Biochem 119 (8), 6869-6881 (2018)
   PUBMED   29737552
  REMARK    GeneRIF: results revealed that the three RNAs-based biomarker
            network (long non-coding intergenic RNA-[lncRNA RP11-909B2.1], Homo
            sapiens microRNA-595 [hsa-miRNA-595], and L3MBTL1 mRNA), had high
            sensitivity and specificity for discriminating CRC from healthy
            controls and also from benign colorectal neoplasm.
REFERENCE   4  (bases 1 to 3432)
  AUTHORS   Nacci,L., Valli,R., Maria Pinto,R., Zecca,M., Cipolli,M.,
            Morini,J., Cesaro,S., Boveri,E., Rosti,V., Corti,P., Ambroni,M.,
            Pasquali,F., Danesino,C., Maserati,E. and Minelli,A.
  TITLE     Parental origin of the deletion del(20q) in Shwachman-Diamond
            patients and loss of the paternally derived allele of the imprinted
            L3MBTL1 gene
  JOURNAL   Genes Chromosomes Cancer 56 (1), 51-58 (2017)
   PUBMED   27553422
  REMARK    GeneRIF: Loss of the paternally derived allele of the imprinted
            L3MBTL1 gene is associated with Shwachman-Diamond syndrome.
REFERENCE   5  (bases 1 to 3432)
  AUTHORS   Perna,F., Vu,L.P., Themeli,M., Kriks,S., Hoya-Arias,R., Khanin,R.,
            Hricik,T., Mansilla-Soto,J., Papapetrou,E.P., Levine,R.L.,
            Studer,L., Sadelain,M. and Nimer,S.D.
  TITLE     The polycomb group protein L3MBTL1 represses a SMAD5-mediated
            hematopoietic transcriptional program in human pluripotent stem
            cells
  JOURNAL   Stem Cell Reports 4 (4), 658-669 (2015)
   PUBMED   25754204
  REMARK    GeneRIF: The polycomb group protein L3MBTL1 represses a
            SMAD5-mediated hematopoietic transcriptional program in human
            pluripotent stem cells.
REFERENCE   6  (bases 1 to 3432)
  AUTHORS   MacGrogan,D., Kalakonda,N., Alvarez,S., Scandura,J.M., Boccuni,P.,
            Johansson,B. and Nimer,S.D.
  TITLE     Structural integrity and expression of the L3MBTL gene in normal
            and malignant hematopoietic cells
  JOURNAL   Genes Chromosomes Cancer 41 (3), 203-213 (2004)
   PUBMED   15334543
  REMARK    GeneRIF: L3MBTL may have a role in myeloid leukemia
REFERENCE   7  (bases 1 to 3432)
  AUTHORS   Li,J., Bench,A.J., Vassiliou,G.S., Fourouclas,N.,
            Ferguson-Smith,A.C. and Green,A.R.
  TITLE     Imprinting of the human L3MBTL gene, a polycomb family member
            located in a region of chromosome 20 deleted in human myeloid
            malignancies
  JOURNAL   Proc Natl Acad Sci U S A 101 (19), 7341-7346 (2004)
   PUBMED   15123827
  REMARK    GeneRIF: represents a previously undescribed imprinted locus, a
            vertebrate Polycomb group gene shown to be regulated by this
            mechanism, and has implications for the pathogenesis of myeloid
            malignancies associated with 20q deletions
            Erratum:[Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2101413118.
            doi: 10.1073/pnas.2101413118.. PMID: 33558248]
REFERENCE   8  (bases 1 to 3432)
  AUTHORS   Wang,W.K., Tereshko,V., Boccuni,P., MacGrogan,D., Nimer,S.D. and
            Patel,D.J.
  TITLE     Malignant brain tumor repeats: a three-leaved propeller
            architecture with ligand/peptide binding pockets
  JOURNAL   Structure 11 (7), 775-789 (2003)
   PUBMED   12842041
REFERENCE   9  (bases 1 to 3432)
  AUTHORS   Boccuni,P., MacGrogan,D., Scandura,J.M. and Nimer,S.D.
  TITLE     The human L(3)MBT polycomb group protein is a transcriptional
            repressor and interacts physically and functionally with TEL (ETV6)
  JOURNAL   J Biol Chem 278 (17), 15412-15420 (2003)
   PUBMED   12588862
  REMARK    GeneRIF: The ability of TEL to repress TEL-responsive promoters is
            enhanced by the presence of H-L(3)MBT, an effect dependent on the
            H-L(3)MBT and the TEL interacting domains, which are mapped to
            their respective SPM/SAM domains.
REFERENCE   10 (bases 1 to 3432)
  AUTHORS   Koga,H., Matsui,S., Hirota,T., Takebayashi,S., Okumura,K. and
            Saya,H.
  TITLE     A human homolog of Drosophila lethal(3)malignant brain tumor
            (l(3)mbt) protein associates with condensed mitotic chromosomes
  JOURNAL   Oncogene 18 (26), 3799-3809 (1999)
   PUBMED   10445843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031681.16 and Z98752.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene represents a polycomb group gene. The encoded
            protein functions to regulate gene activity, likely via chromatin
            modification. The encoded protein may also be necessary for
            mitosis. Alternatively spliced transcript variants encoding
            different isoforms have been identified.[provided by RefSeq, Sep
            2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.291137.1,
                                           SRR18074969.1481137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000418998.7/
                                                ENSP00000398516.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AL031681.16        154643-154690
            49-212              AL031681.16        160422-160585
            213-436             AL031681.16        160784-161007
            437-578             AL031681.16        161581-161722
            579-729             AL031681.16        161955-162105
            730-853             AL031681.16        162238-162361
            854-938             AL031681.16        163039-163123
            939-1027            Z98752.16          6054-6142
            1028-1132           Z98752.16          6661-6765
            1133-1268           Z98752.16          7681-7816
            1269-1360           Z98752.16          8195-8286
            1361-1512           Z98752.16          10170-10321
            1513-1589           Z98752.16          10739-10815
            1590-1675           Z98752.16          11405-11490
            1676-1786           Z98752.16          11681-11791
            1787-1901           Z98752.16          12225-12339
            1902-2001           Z98752.16          13234-13333
            2002-2199           Z98752.16          13494-13691
            2200-2249           Z98752.16          13806-13855
            2250-2407           Z98752.16          17548-17705
            2408-2470           Z98752.16          18150-18212
            2471-3432           Z98752.16          18331-19292
FEATURES             Location/Qualifiers
     source          1..3432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..3432
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /note="L3MBTL histone methyl-lysine binding protein 1"
                     /db_xref="GeneID:26013"
                     /db_xref="HGNC:HGNC:15905"
                     /db_xref="MIM:608802"
     exon            1..48
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            49..212
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2665
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     lethal(3)malignant brain tumor-like protein 1; lethal (3)
                     malignant brain tumor l(3); l(3)mbt protein homolog;
                     l(3)mbt-like 1; L3MBTL1, histone methyl-lysine binding
                     protein"
                     /codon_start=1
                     /product="lethal(3)malignant brain tumor-like protein 1
                     isoform 3"
                     /protein_id="NP_001364232.1"
                     /db_xref="CCDS:CCDS93043.1"
                     /db_xref="GeneID:26013"
                     /db_xref="HGNC:HGNC:15905"
                     /db_xref="MIM:608802"
                     /translation="MEGHAEMEMLRTLKGPSTGEVSMHLVAGDSPGSGPHLPATAFII
                     PASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTV
                     RLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDG
                     EAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQER
                     SVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTAST
                     PESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKL
                     EGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHK
                     LQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPS
                     LVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPD
                     PDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVED
                     HRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPL
                     SYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAEL
                     SDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSAL
                     SAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDE
                     ARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSF
                     ASDSQY"
     exon            213..436
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            437..578
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            579..729
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            730..853
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..938
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1027
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1132
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1268
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1360
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1512
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1589
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1675
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1786
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1901
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2001
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2199
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2249
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2407
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2470
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..3432
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2704..2709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /note="hexamer: ATTAAA"
     polyA_site      2726
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /note="major polyA site"
     regulatory      3409..3414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /note="hexamer: AATAAA"
     polyA_site      3432
                     /gene="L3MBTL1"
                     /gene_synonym="dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3"
                     /note="major polyA site"
ORIGIN      
        1 ggctcggacc gtagctaggc gctgggcggc caccggctgg ccaggcaggc ctgccaggat
       61 ggaggggcat gctgggatgg aggggcatgc tgaaatggag atgctgagga cactgaaggg
      121 gccttccaca ggggaggtca gcatgcactt ggtggccgga gacagccccg gttctggtcc
      181 tcacctgccc gcaactgcct tcatcattcc agccagttcg gccaccctcg gcctgcccag
      241 cagtgccctg gatgtgtctt gctttccccg ggagccaatc catgtgggtg ccccggagca
      301 agtggccggc tgcgaaccag tttctgccac cgtcctgccg cagcttagcg ccgggccggc
      361 cagctccagc accagcacag tgcggcttct ggaatggaca gaggccgcgg ccccgccccc
      421 agggggcggc ctgcggttcc ggataagcga gtataagccg ctgaacatgg cgggagtgga
      481 gcagcccccg agccccgagc tgcggcagga aggcgtgacc gaatacgaag atggcggggc
      541 cccggcggga gatggcgagg cgggccccca acaggcggag gaccaccccc agaatcctcc
      601 agaagatccc aatcaggacc ccccagagga tgatagcacc tgtcagtgcc aggcgtgcgg
      661 gcctcaccaa gccgcgggtc cagatcttgg ttcctctaat gatggctgcc ctcagctgtt
      721 ccaggagcgg tcagtcatag tggagaactc ctcaggctct accagcgctt ctgagctcct
      781 caaacccatg aagaagagga agcgcaggga ataccagagc ccatcagagg aggagtcgga
      841 gccagaggcc atggagaagc aagaagaagg aaaggaccca gagggacaac ccactgctag
      901 caccccagag agtgaggagt ggagcagcag ccagcctgca acaggtgaga agaaggaatg
      961 ctggtcgtgg gagtcctacc tagaggagca gaaggccatt actgctccag tcagcctctt
     1021 ccaggactcc caggcagtca ctcacaacaa gaatggcttc aaactgggca tgaagttgga
     1081 aggcattgac cctcaacacc cgtccatgta cttcatcctc accgtggctg aggtatgtgg
     1141 ctatcgccta cgcctgcact ttgatgggta ttctgagtgc catgacttct gggtcaatgc
     1201 caactcccct gacattcacc ctgctggctg gttcgagaag acgggccaca agctgcagcc
     1261 tcccaaaggt tacaaggagg aggagttcag ctggagccag tacctgcgca gcacaagagc
     1321 tcaggctgcc cccaagcacc tgtttgtgag ccagagccac agtcccccac ccctgggctt
     1381 ccaggtgggc atgaagctgg aggctgttga ccgcatgaac ccgtcccttg tctgcgtggc
     1441 cagtgtgacc gatgtggtgg acagccgctt cctggtgcac tttgacaact gggatgatac
     1501 ttatgactac tggtgtgatc ccagcagccc ctacatccac ccagtgggct ggtgccagaa
     1561 gcaaggaaag cccctcaccc ctccacaaga ctacccagac cctgataact tctgttggga
     1621 gaaatatctg gaagaaactg gggcctctgc tgtccccacc tgggccttca aggtgcgacc
     1681 ccctcacagc ttcctggtca atatgaagct ggaggctgtg gaccgcagga acccagccct
     1741 gattcgcgtg gccagcgtgg aggatgtgga ggaccatcgg ataaagatcc actttgatgg
     1801 ctggagtcat ggctatgatt tctggatcga cgctgaccac ccagacatcc accctgccgg
     1861 ctggtgctcc aagacaggac atcccctgca gcctcctctc ggacccagag agcccagctc
     1921 tgcctcccct gggggctgtc cccctctcag ctataggagc ctgccccaca ctaggacctc
     1981 caaatacagc tttcaccacc ggaagtgccc cactcctggt tgcgacggct ctggccatgt
     2041 cacaggcaag ttcacagctc accattgcct ctcaggctgc ccactggctg agaggaacca
     2101 gagccggctg aaagcggagc tgtctgactc ggaggcctca gcccgcaaga agaacctctc
     2161 aggcttctcc ccaaggaaga agcctcgcca tcacggccga attggacgcc ctccgaagta
     2221 tcgaaagatt ccgcaggaag atttccagac cctcacgccc gatgtcgtgc accagtccct
     2281 cttcatgtca gccctgtcgg cccaccctga ccgctcactc tcagtgtgct gggagcagca
     2341 ctgcaagctc ctgccaggag tagcgggcat ctcagcctcg acagtcgcca agtggaccat
     2401 cgatgaggtc ttcggctttg ttcagaccct gacaggttgt gaggaccaag cacgcctctt
     2461 caaagacgag gcaagaatag tcagagtgac ccatgtatct gggaagactc tagtctggac
     2521 tgtggcccag cttggggacc ttgtgtgctc agatcatctt caggaaggaa aaggcatcct
     2581 ggagacagga gtccattcac tcctctgctc tctacccact catttgcttg ccaaacttag
     2641 ctttgccagt gatagtcaat attaaagtgt acttttttcc cctttaatcc aatatagttg
     2701 ataattaaag tgtattttga atgacacaga tattgtgatt tactgcaagg atcctaacac
     2761 acacttaaaa tcaagagcca aggagtagtg agttgtagat aaaaaaagaa tgtcagcttt
     2821 ggagacagtc tgggtttaaa tcccagttct gtcaatttga gctgtttact gtctctgagc
     2881 ctacatcttc ttgtctgtaa aatggagata aaatgggttt aatgaggtct accttgcaga
     2941 gccattgtga gcattggaaa tgatgaatga atcataccag aacgtctagt ataattacag
     3001 tcatgcattg cttaacgatg gggatacatt cttagaaatg tgtcactagg caattctgtc
     3061 attgtgtaaa cattatagaa tgtacttaca caaacctaga tgttatatgt atttttattt
     3121 acatgtatat tttcacatga aataccaaat gtcacagcat tattactgaa tgtcagtcat
     3181 ttcccctact tgatctgcaa tgccaatatc aagggccatg tatcaggttt ctgtatatgt
     3241 tccactataa tcttatggga ccatggtttt aaatgtggaa tcattgacag aaatgtcttt
     3301 atgtagcata tggctgtgta tcactagtat ataatagagc aatattatgg aggaatatgt
     3361 agatccaatc actttaccta tacaaaatga ctgctatggt gggaacacaa taaacaccag
     3421 ttttgacttt ta
//
