LOCUS       NM_144581               1516 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens trans-L-3-hydroxyproline dehydratase (L3HYPDH),
            transcript variant 1, mRNA.
ACCESSION   NM_144581
VERSION     NM_144581.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1516)
  AUTHORS   Visser,W.F., Verhoeven-Duif,N.M. and de Koning,T.J.
  TITLE     Identification of a human trans-3-hydroxy-L-proline dehydratase,
            the first characterized member of a novel family of proline
            racemase-like enzymes
  JOURNAL   J Biol Chem 287 (26), 21654-21662 (2012)
   PUBMED   22528483
  REMARK    GeneRIF: human trans-3-hydroxy-L-proline dehydratase is the first
            characterized member of a novel family of proline racemase-like
            enzymes
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL159140.4 and AK058165.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144581.1.
            
            Summary: The protein encoded by this gene is a dehydratase that
            converts trans-3-hydroxy-L-proline to
            delta(1)-pyrroline-2-carboxylate. This enzyme may function to
            degrade dietary proteins that contain trans-3-hydroxy-L-proline as
            well as other proteins such as collagen IV. The encoded protein can
            be converted to an epimerase by changing a threonine to a cysteine
            at a catalytic site. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1041615.1,
                                           SRR1660807.155725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247194.9/ ENSP00000247194.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL159140.4         148114-148166       c
            54-1434             AK058165.1         1-1381
            1435-1516           AL159140.4         136364-136445       c
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..1516
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="trans-L-3-hydroxyproline dehydratase"
                     /db_xref="GeneID:112849"
                     /db_xref="HGNC:HGNC:20488"
                     /db_xref="MIM:614811"
     exon            1..600
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1157
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /EC_number="4.2.1.77"
                     /note="isoform a is encoded by transcript variant 1;
                     trans-3-hydroxyl-L-proline dehydratase;
                     trans-3-hydroxy-l-proline dehydratase; L-3-hydroxyproline
                     dehydratase (trans-)"
                     /codon_start=1
                     /product="trans-3-hydroxy-L-proline dehydratase isoform a"
                     /protein_id="NP_653182.1"
                     /db_xref="CCDS:CCDS9739.1"
                     /db_xref="GeneID:112849"
                     /db_xref="HGNC:HGNC:20488"
                     /db_xref="MIM:614811"
                     /translation="MESALAVPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSG
                     PTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSS
                     MCGHAVLALGRFALDFGLVPAPPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFH
                     SVPAFVLATDLMVDVPGHGKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASA
                     VTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSG
                     VTARIALQYHKGLLELNQMRAFKSSATGSVFTGKAVREAKCGDFKAVIVEVSGQAHYT
                     GTASFIIEDDDPLRDGFLLK"
     exon            601..770
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /inference="alignment:Splign:2.1.0"
     exon            771..893
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1031
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1516
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="hexamer: AATAAA"
     regulatory      1244..1249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="hexamer: ATTATA"
     polyA_site      1257
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="major polyA site"
     polyA_site      1261
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="major polyA site"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="hexamer: TATAAA"
     polyA_site      1319
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
     regulatory      1414..1419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="hexamer: ATTAAA"
     polyA_site      1438
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="major polyA site"
     regulatory      1478..1483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="hexamer: ATTAAA"
     regulatory      1493..1498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /note="hexamer: AATAAT"
     polyA_site      1499
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
     polyA_site      1516
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
ORIGIN      
        1 agcgtcccgc cctcctcccg cggagtcagt gggtgagggt cgggcttgaa gccatagctg
       61 cgggaccgta ctcgtctccc ccgacgcaga ccatggagag cgcgctggcg gtgccccggc
      121 tgcccccgca tgatccaggg acgccggtgc tgtcggtggt ggacatgcac acgggcggcg
      181 agcccttgcg tatcgtgctg gcggggtgtc cggaggtgtc tgggcccacc ctgctggcca
      241 agcggcgcta catgcgccag caccttgacc acgtgcggcg acggctcatg ttcgagcccc
      301 gagggcaccg ggacatgtac ggggcggtcc tagtcccgag cgagctgccg gacgcgcatc
      361 tgggcgtcct gttcctgcac aacgagggct acagctccat gtgcggccac gcagtgctgg
      421 cgctgggccg cttcgctttg gacttcgggc ttgtgccggc gccccctgcg ggcacccgcg
      481 aggcccgcgt caatatccac tgcccctgcg ggctggtgac cgccttcgtg gcatgcgagg
      541 acggccgcag ccacggaccg gtgcgcttcc acagcgtccc ggccttcgtg ctggccacag
      601 atctcatggt ggatgttcct ggacatggaa aggtgatggt ggacattgca tatggcggtg
      661 cattttatgc atttgttact gctgaaaagt taggactaga catttgttct gcaaagacca
      721 gggaccttgt ggatgcagcg agtgcagtga cagaggcagt gaaagctcag tttaaaatta
      781 atcatcctga tagtgaagac cttgcctttt tatatggaac tatattaaca gatggaaaag
      841 atgcttatac caaggaacca accaccaaca tttgtgtttt tgcagatgaa caggttgaca
      901 gaagtcccac tggctcagga gtgacagccc gaattgcctt acagtatcac aaagggcttc
      961 tggaactgaa ccagatgaga gccttcaaaa gcagtgcaac tggctcagta ttcacaggga
     1021 aagctgtgag ggaagcgaaa tgtggtgatt ttaaagctgt tatagtggaa gtatcaggac
     1081 aagcccatta cacgggtaca gcaagcttta taatagaaga tgacgaccca ttgagggatg
     1141 gatttcttct caagtgactt cttccatgat tttaagggct ttctttttaa agtaatcatt
     1201 atccttaagg actgttttct ctaaattata tgaaaacaaa taaattatac atataaacta
     1261 actctcattc tttgtaaaat actaccctgt ggctaaatat aaagtcatta tacctcgtat
     1321 ttgcaactgt atttgtataa atatcactta tgtctagcat acaaaatgcc agaaattcag
     1381 agtctttttc tagtgattaa cgtatcaggt aaaattaaaa cagtagttac ttttaaaata
     1441 ttgctctata gtaattacta ttaatatcat attttgtatt aaaggctctt cgaataatat
     1501 gtggaattta actgaa
//
