LOCUS       NM_024884               6095 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens L-2-hydroxyglutarate dehydrogenase (L2HGDH),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_024884
VERSION     NM_024884.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6095)
  AUTHORS   Bellad,A., Holla,V.V., Kumari,R., Kamble,N., Yadav,R., Pandey,A.,
            Pal,P.K. and Muthusamy,B.
  TITLE     Loss of function variants in L2HGDH gene causing
            L-2-hydroxyglutaric aciduria
  JOURNAL   Acta Neurol Belg 123 (6), 2315-2323 (2023)
   PUBMED   37378753
  REMARK    GeneRIF: Loss of function variants in L2HGDH gene causing
            L-2-hydroxyglutaric aciduria.
REFERENCE   2  (bases 1 to 6095)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 6095)
  AUTHORS   Qiu,Z., Lin,A.P., Jiang,S., Elkashef,S.M., Myers,J., Srikantan,S.,
            Sasi,B., Cao,J.Z., Godley,L.A., Rakheja,D., Lyu,Y., Zheng,S.,
            Madesh,M., Shiio,Y., Dahia,P.L.M. and Aguiar,R.C.T.
  TITLE     MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and
            Epitranscriptome
  JOURNAL   Cell Chem Biol 27 (5), 538-550 (2020)
   PUBMED   32101699
  REMARK    GeneRIF: MYC Regulation of D2HGDH and L2HGDH Influences the
            Epigenome and Epitranscriptome.
REFERENCE   4  (bases 1 to 6095)
  AUTHORS   Zhang,Y., Wang,C., Yang,K., Wang,S., Tian,G. and Chen,Y.
  TITLE     A novel compound heterozygous mutation of the L2HGDH gene in a
            Chinese boy with L-2-hydroxyglutaric aciduria: case report and
            literature review
  JOURNAL   Neurol Sci 39 (10), 1697-1703 (2018)
   PUBMED   29980873
  REMARK    GeneRIF: The mutations of the L2HGDH gene as the causes of
            L-2-hydroxyglutaric aciduria.
            Review article
REFERENCE   5  (bases 1 to 6095)
  AUTHORS   Peng,W., Ma,X.W., Yang,X., Zhang,W.Q., Yan,L., Wang,Y.X., Liu,X.,
            Wang,Y. and Feng,Z.C.
  TITLE     Two novel L2HGDH mutations identified in a rare Chinese family with
            L-2-hydroxyglutaric aciduria
  JOURNAL   BMC Med Genet 19 (1), 167 (2018)
   PUBMED   30217188
  REMARK    GeneRIF: Two novel L2HGDH mutations were identified in a Chinese
            family with L-2-hydroxyglutaric aciduria.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6095)
  AUTHORS   Rzem,R., Veiga-da-Cunha,M., Noel,G., Goffette,S., Nassogne,M.C.,
            Tabarki,B., Scholler,C., Marquardt,T., Vikkula,M. and Van
            Schaftingen,E.
  TITLE     A gene encoding a putative FAD-dependent L-2-hydroxyglutarate
            dehydrogenase is mutated in L-2-hydroxyglutaric aciduria
  JOURNAL   Proc Natl Acad Sci U S A 101 (48), 16849-16854 (2004)
   PUBMED   15548604
REFERENCE   7  (bases 1 to 6095)
  AUTHORS   Topcu,M., Jobard,F., Halliez,S., Coskun,T., Yalcinkayal,C.,
            Gerceker,F.O., Wanders,R.J., Prud'homme,J.F., Lathrop,M., Ozguc,M.
            and Fischer,J.
  TITLE     L-2-Hydroxyglutaric aciduria: identification of a mutant gene
            C14orf160, localized on chromosome 14q22.1
  JOURNAL   Hum Mol Genet 13 (22), 2803-2811 (2004)
   PUBMED   15385440
  REMARK    GeneRIF: encodes a putative mitochondrial protein with homology to
            FAD-dependent oxidoreductases; a mutant gene is accociated with
            L-2-hydroxyglutaric aciduria.propose to name the gene duranin
REFERENCE   8  (bases 1 to 6095)
  AUTHORS   Jansen,G.A. and Wanders,R.J.
  TITLE     L-2-hydroxyglutarate dehydrogenase: identification of a novel
            enzyme activity in rat and human liver. Implications for
            L-2-hydroxyglutaric acidemia
  JOURNAL   Biochim Biophys Acta 1225 (1), 53-56 (1993)
   PUBMED   8241290
REFERENCE   9  (bases 1 to 6095)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   10 (bases 1 to 6095)
  AUTHORS   Duran,M., Kamerling,J.P., Bakker,H.D., van Gennip,A.H. and
            Wadman,S.K.
  TITLE     L-2-Hydroxyglutaric aciduria: an inborn error of metabolism?
  JOURNAL   J Inherit Metab Dis 3 (4), 109-112 (1980)
   PUBMED   6787330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK022680.1, AY757363.1,
            AL109758.3 and CA424871.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024884.2.
            
            Summary: This gene encodes L-2-hydroxyglutarate dehydrogenase, a
            FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to
            alpha-ketoglutarate in a variety of mammalian tissues. Mutations in
            this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal
            recessive neurometabolic disorder resulting in moderate to severe
            cognitive disability. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022680.1, SRR3476690.1143560.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000267436.9/
                                                  ENSP00000267436.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AK022680.1         1-65
            66-1471             AY757363.1         1-1406
            1472-5545           AL109758.3         182142-186215       c
            5546-6095           CA424871.1         17-566              c
FEATURES             Location/Qualifiers
     source          1..6095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..6095
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /note="L-2-hydroxyglutarate dehydrogenase"
                     /db_xref="GeneID:79944"
                     /db_xref="HGNC:HGNC:20499"
                     /db_xref="MIM:609584"
     exon            1..219
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1471
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /EC_number="1.1.99.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 2-hydroxyglutarate dehydrogenase;
                     alpha-hydroxyglutarate oxidoreductase; alpha-ketoglutarate
                     reductase; L-alpha-hydroxyglutarate dehydrogenase;
                     L-2-hydroxyglutarate dehydrogenase, mitochondrial;
                     duranin"
                     /codon_start=1
                     /product="L-2-hydroxyglutarate dehydrogenase,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_079160.1"
                     /db_xref="CCDS:CCDS9698.1"
                     /db_xref="GeneID:79944"
                     /db_xref="HGNC:HGNC:20499"
                     /db_xref="MIM:609584"
                     /translation="MVPALRYLVGACGRARGLFAGGSPGACGFASGRPRPLCGGSRSA
                     STSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIY
                     YKPESLKAKLCVQGAALLYEYCQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNG
                     VPGLRLIQQEDIKKKEPYCRGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFE
                     VKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDP
                     RIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFK
                     REGYRPFDFSATDVMDIIINSGLIKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEI
                     TISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSIAIS
                     GMIADEVQQRFEL"
     exon            220..335
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            336..487
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            488..619
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            620..782
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            783..817
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            818..985
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1143
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1275
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..6095
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4985..4990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /note="hexamer: AATAAA"
     polyA_site      5012
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /note="major polyA site"
     regulatory      5099..5104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /note="hexamer: AATAAA"
     polyA_site      5121
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /note="major polyA site"
     regulatory      6075..6080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /note="hexamer: ATTAAA"
     polyA_site      6095
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
ORIGIN      
        1 gctaaagagc gcgggtcctc ggccgtggag ggtcaagtgg cttcttctga gcgctgaggg
       61 aggggagcgt gcgtagggga tggtgccagc gctgcgttat ttggttggtg cctgcggacg
      121 ggcccgcggg cttttcgccg gtggctcccc tggggcgtgc gggttcgcgt ctgggaggcc
      181 aagaccgctg tgtggaggta gccgcagcgc cagcaccagc tcatttgata tagtcatcgt
      241 tggtggcgga attgtggggc ttgcctctgc cagagcactc atcctgcgac atccatcact
      301 ttctattggt gttctggaaa aggagaaaga tttagctgtt caccagactg gacataacag
      361 tggtgtcata catagtggaa tttattataa acctgagtct ctgaaagcca aattatgtgt
      421 acaaggtgca gccctcctct atgagtactg tcagcaaaag ggaatttcct acaagcagtg
      481 tggcaagctt atagtagctg ttgaacaaga agaaattccc agacttcagg ccctatatga
      541 gaaaggcctc cagaatggtg tcccgggcct gaggctgatc cagcaggagg atataaaaaa
      601 gaaggagcca tattgtaggg gtctaatggc tattgattgt ccacatactg gcattgtgga
      661 ctatcggcag gtggctttgt catttgccca ggatttccaa gaagcaggtg gctctgtctt
      721 gaccaatttt gaagtaaaag gtattgaaat ggctaaagaa agtccttcaa gaagtataga
      781 tggaatgcaa tatccaattg ttataaagaa tacaaaggga gaggaaattc gatgtcagta
      841 tgttgtgaca tgtgcaggac tttactcaga ccgtatttca gagttgagtg gctgcactcc
      901 tgatcctcga attgtaccat tccggggaga ttacctgctt ttgaagccag aaaaatgtta
      961 tcttgtaaaa ggaaatattt atccggtccc agatagccgg tttcctttcc taggagttca
     1021 cttcacacca aggatggatg gcagtatttg gctagggcct aatgcagttc ttgcctttaa
     1081 acgagagggt tacagaccct ttgacttcag tgccacagat gttatggata taattatcaa
     1141 tagtggcttg attaaactgg catcccagaa tttttcctat ggagttactg aaatgtataa
     1201 agcatgtttt cttggtgcaa cagtgaagta tcttcaaaaa ttcatccctg aaattactat
     1261 cagtgatata cttaggggcc cagctggagt aagagcccag gccctggata gagatggaaa
     1321 tctggtagaa gattttgtat ttgatgcagg agttggggat attggaaatc gcattcttca
     1381 tgtgagaaat gcaccttctc ctgctgctac ttcttccatt gcaatttctg gaatgattgc
     1441 agatgaagta caacaaagat ttgaattata aataatgaaa ggagctaggt atgcactgta
     1501 atcttcatgt cagcaacaag aatgtactaa ttgcattctt taatttaaaa aatggttttt
     1561 aaactttagt ttttaggtca aagataacca ctgcattgtt aaaatgatgt aacatagaaa
     1621 taataatttt ctacaaaaat tagccaggca tggtggcgca tgcctgtaat ctcagctact
     1681 caggaggctg aggcaggaga atcaattgaa ccgagcagac ggaggtgagc tgagagctga
     1741 gattgcacca ctgcactcca gcctgggtga cagagcaaga aaataataat aataataatt
     1801 ttcaaaatgt taggctgggg gccgtggcca gcactttggg aagccaaggc aggtagattg
     1861 tagcccagga gtttgagaac agcctgggca acatggcaaa accctgtttc tacacaaagt
     1921 tagctgggtc tggtgcctct gtagttccag ctcctcagta ggctgaggtg agaggatcac
     1981 ttgagcccag gaggtctagg ctgcagtgag cttatgttca tgacactgca ttccaggctg
     2041 gatgatagag caagatcttg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa tccagcctgg
     2101 gcaacatagt gaatgaaacc ccatctctac aaaaaataca aaaattagct gggcatgatg
     2161 gtgtgtgcct gtagtcccag ctacttgggg gctgaggcag gaggatcgct tgagcccggg
     2221 agatcaaggc tacagtgagc tgtgttcatg ccactatacc ccagcctggg caacaaagtg
     2281 agtccctgac tcaaaaaata aaaacaacaa caaaaaataa attccatgct tatttacttt
     2341 gcgaataaag aggcaaggta cagttttatc tgtccgaatc cctgactttt atttattttt
     2401 tttttcagac ggagtttcac tcttgttgcc caggcttgag tgcaatggta cgatcttggc
     2461 tcactgcaac ctctgcctcc cgggttccag cgattctctt gcctcaacct cctgagtagc
     2521 tgggattaca ggcgcccacc accatgcctg gctaattttt tgtattttta gtagagacgg
     2581 ggttttgcca tgttggccag gctggtctcg aattcctgac ctcaggtgat ccacctgcct
     2641 cagcctccca aaatgctggg attacaggtg cgagccatca tgctcagccc tgaatccctg
     2701 actttgttaa tgacctgtcc ttaccaacca tgacctagag aagatttggc tttttaagag
     2761 ttttggagaa agatggcata aaaatagatt atttccttaa atcaattttt tagcattacg
     2821 ctacctaagc tcgtttggtc tctcatagac aagaaaatac attatattgt aggttacatt
     2881 cttttaattt tgaagagtca caaaactcac attatttaga gcaacaatat ttgtatttgg
     2941 aaattaaaaa ttcatgattt caagaaaata cataaaattt acatttttga gtagtttgaa
     3001 taagtttcta tcttaattat aatatttgta ggaaataaca aaacaaactc aaagccttta
     3061 ttatttccag tctctttgta actgatgtgg tatggtatca tcatgaaatc taaacagtgg
     3121 tacactgagt ggttgtcctg ttcttcaatc tctgtggctg agaactgaaa taacttagaa
     3181 gagacagatt tttatgagag cagttttaga atcctgacac tgatgtatag aactccaatt
     3241 taaaaaagtt atttatctat tatatctctg atctttagtc acactaaggc tctcaaaatg
     3301 ttggccaaga ttggtaatga ttcatacgta cttgattttt cagggctcct ataaacttgt
     3361 atagggatat ttttccattt ttgataaata tctaactttg aggcattcac ttttgtaaac
     3421 cgcgaaagtg ccttacattc acctcatgag tattttaagt tgatgcccag tgctgtggta
     3481 tatcctgtat atatgtgttt tgtggtatct atcgaaatta ttcttataat ttagaaagtt
     3541 agaaaataga aattgtaaat gaaaatgtgg cgacctgact gcagaacttt gagtactgaa
     3601 ccacatttag gtgaggcatt ttcatccatt ctctctgatt tgctctctca ggattcatct
     3661 tctactgtgt atgtcttctt tcctcttagc tctccaaagc tgtatgatgg atgggtgaga
     3721 aggatgtgca ttttggttga taggaaaaat gtttctgttt tcttcctttt cccctcactt
     3781 caagcattga tgattacatt gattgagcta cctcatccat taatttgaaa ggctacactt
     3841 catcagctca tgtttaagaa gtagcacatc ccaggtaaac agagtaggcc attattcaac
     3901 tcttaggatg agtatattaa aagcattcag atatcaatga cagaagaaac aagccctaat
     3961 gtttctttat aacagctgat tcctgcaaga aatgcaaaca caggatattt ttctgttcca
     4021 ttacaagatt actaagagat ggaaaatatt atcattctgt attttgtcag tagtacgatt
     4081 gcatacatac taagttgtaa acattgaatt acaaaaaatg attgtcctaa ttgaagcagt
     4141 cctcaatcca tttgagtctg tacaataccc tgaaaaggaa acaacaggtg ctggagagga
     4201 tgtggagaaa taggaacact tttacactgt tggtgggact gtaaactagt tcaaccattg
     4261 tggaagtcag tgtggcgatt cctcagggat ctggaactag aaataccatt tgacccagcc
     4321 atcccattac tgggtatata cccaagggac tataaatcat gctgctataa agacacatgc
     4381 acacgtatgt ttattgtggc actattcaca atagtaaaga cttggaacca acccaaatgt
     4441 ccaacaacga tagactggat taagaaaatg tggcacatat acaccatgga atactatgca
     4501 gccataaaaa atgatgagtt catgtccttt gtagggacat ggatgaaatt ggaaatcatc
     4561 attctcagta aactatcgca agaacaaaaa accaaacacc gcatgttctc actcatagat
     4621 gggaattgaa caatgagaac acatggacac aggaagggga acatcacact ctggggactg
     4681 ttgtggggtg gggggagggg ggagggatag cattaggaga tatacctaat gctaaatgac
     4741 gagttaatgg gtgcagcaca ccagcacggc acatgtatac atatgtaact aacctgcaca
     4801 ttgtgcacat gtaccctaaa acttaaagta taataataaa caatatatat atatatatat
     4861 atataaaata ccctgaaaaa taaaaatgaa aaatttgttg aaagtgtttt gaatatgtag
     4921 gttattctgc ttgtaaaacg ttttatatgt atgtcaatag ggtttttttg tttaatactg
     4981 atataataaa gttttatgta tttctgacag aagaaatgta tattaatatt taaaatattt
     5041 taatgagcct tggtgttgta gagaacatat tttttagttc cataaaaact tttatgcaaa
     5101 taaatttttt tatgtgtaaa acataaactg tttgctttag atagatagca gccaaccttt
     5161 ttaaaaaact catttctgtg ttagtatata atacaaaatg aggttgagtc atttatattt
     5221 tgggtaaaaa gtggagcatt ttagatttta acttcagagt gtttgtgagg aactcttgat
     5281 gtaccagcaa gtatattttt ggtgtttcat gttacgtagc ttaactcttt tatccataca
     5341 tatatgtgta tatcaaagtc cttcccttga tcctctcagc attagcactg tttggggagt
     5401 tgcctttact gttggcagaa ttccactttc cctgaggcca tttggaaatc tacctagtag
     5461 cctgtgggat aaccttaact cttagaactt tcttcaaagg atggtggtga gaatggggta
     5521 tactgccagg ccctggccta cgggagtttg tagggcctac ttttggaggc aatccaaccc
     5581 tgatggctgt acctatgagc tatccctgta aacacaggag acatggtgtc tatattgttt
     5641 aaggactggc tctgccctcc tgggccctta atctgtgtct agacttcttg gtcagaggtt
     5701 tcctcatctt tctgcgcata cactattatc taaagatctt gtaaacattt ttgagttgta
     5761 atcgtaaagt cagtttctaa gcttttctaa cacactcaaa gggagttttt gaaatctctt
     5821 catcagggct taaggtagaa ggacagggtg aaatggttgg gaaagcaaaa gctgcctcga
     5881 gatgttttca aatagtttgt actcattaaa tagcttaaga atggaaataa accctgaagc
     5941 cctgaaggga agaacagtgt tgataccaac caactctact tttctggcct caaatcctag
     6001 aaagtattgt gggtttgttg ttgttgttga tgttgttaat tgcttgtatt ttctgcttat
     6061 gggaaggatc tcacattaaa gttatcttat tttaa
//
