LOCUS       NM_001278116            5138 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens L1 cell adhesion molecule (L1CAM), transcript variant
            4, mRNA.
ACCESSION   NM_001278116
VERSION     NM_001278116.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5138)
  AUTHORS   Mannan,R., Wang,X., Mahapatra,S., Wang,S., Chinnaiyan,A.K.,
            Skala,S.L., Zhang,Y., McMurry,L.M., Zelenka-Wang,S., Cao,X.,
            Sangoi,A.R., Dadhania,V., Picken,M.M., Menon,S., Al-Ahmadie,H.,
            Chinnaiyan,A.M., Dhanasekaran,S.M. and Mehra,R.
  TITLE     Expression of L1 Cell Adhesion Molecule, a Nephronal Principal Cell
            Marker, in Nephrogenic Adenoma
  JOURNAL   Mod Pathol 37 (8), 100540 (2024)
   PUBMED   38901674
  REMARK    GeneRIF: Expression of L1 Cell Adhesion Molecule, a Nephronal
            Principal Cell Marker, in Nephrogenic Adenoma.
REFERENCE   2  (bases 1 to 5138)
  AUTHORS   Hauser,S., Bickel,L., Weinspach,D., Gerg,M., Schafer,M.K.,
            Pfeifer,M., Hazin,J., Schelter,F., Weidle,U.H., Ramser,J.,
            Volkmann,J., Meindl,A., Schmitt,M., Schrotzlmair,F., Altevogt,P.
            and Kruger,A.
  TITLE     Full-length L1CAM and not its Delta2Delta27 splice variant promotes
            metastasis through induction of gelatinase expression
  JOURNAL   PLoS One 6 (4), e18989 (2011)
   PUBMED   21541352
  REMARK    GeneRIF: Metastasis formation upon up-regulation of full
            length-L1CAM correlated with increased invasive potential and
            elevated Matrix metalloproteinase (MMP)-2 and -9 expression and
            activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5138)
  AUTHORS   Pfeifer,M., Schirmer,U., Geismann,C., Schafer,H., Sebens,S. and
            Altevogt,P.
  TITLE     L1CAM expression in endometrial carcinomas is regulated by usage of
            two different promoter regions
  JOURNAL   BMC Mol Biol 11, 64 (2010)
   PUBMED   20799950
  REMARK    GeneRIF: Results suggest that the L1CAM gene has two functionally
            active promoter sites that are used in a cell-type specific manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5138)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
REFERENCE   5  (bases 1 to 5138)
  AUTHORS   Stumpel,C. and Vos,Y.J.
  TITLE     L1 Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301657
REFERENCE   6  (bases 1 to 5138)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
REFERENCE   7  (bases 1 to 5138)
  AUTHORS   Rosenthal,A., Jouet,M. and Kenwrick,S.
  TITLE     Aberrant splicing of neural cell adhesion molecule L1 mRNA in a
            family with X-linked hydrocephalus
  JOURNAL   Nat Genet 2 (2), 107-112 (1992)
   PUBMED   1303258
  REMARK    Erratum:[Nat Genet 1993 Mar;3(3):273]
REFERENCE   8  (bases 1 to 5138)
  AUTHORS   Kobayashi,M., Miura,M., Asou,H. and Uyemura,K.
  TITLE     Molecular cloning of cell adhesion molecule L1 from human nervous
            tissue: a comparison of the primary sequences of L1 molecules of
            different origin
  JOURNAL   Biochim Biophys Acta 1090 (2), 238-240 (1991)
   PUBMED   1932117
REFERENCE   9  (bases 1 to 5138)
  AUTHORS   Hlavin,M.L. and Lemmon,V.
  TITLE     Molecular structure and functional testing of human L1CAM: an
            interspecies comparison
  JOURNAL   Genomics 11 (2), 416-423 (1991)
   PUBMED   1769655
REFERENCE   10 (bases 1 to 5138)
  AUTHORS   Djabali,M., Mattei,M.G., Nguyen,C., Roux,D., Demengeot,J.,
            Denizot,F., Moos,M., Schachner,M., Goridis,C. and Jordan,B.R.
  TITLE     The gene encoding L1, a neural adhesion molecule of the
            immunoglobulin family, is located on the X chromosome in mouse and
            man
  JOURNAL   Genomics 7 (4), 587-593 (1990)
   PUBMED   2387585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA122729.1, BC126229.1 and
            BC025843.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001278116.1.
            
            Summary: The protein encoded by this gene is an axonal glycoprotein
            belonging to the immunoglobulin supergene family. The ectodomain,
            consisting of several immunoglobulin-like domains and
            fibronectin-like repeats (type III), is linked via a single
            transmembrane sequence to a conserved cytoplasmic domain. This cell
            adhesion molecule plays an important role in nervous system
            development, including neuronal migration and differentiation.
            Mutations in the gene cause X-linked neurological syndromes known
            as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic
            paraplegia and hydrocephalus). Alternative splicing of this gene
            results in multiple transcript variants, some of which include an
            alternate exon that is considered to be specific to neurons.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and its 5' UTR structure is inferred based on
            experimental data in PMID 20799950. Variants 1 and 4 encode the
            same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK289754.1, M77640.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370060.7/ ENSP00000359077.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               DA122729.1         3-112
            111-4305            BC126229.1         4-4198
            4306-5138           BC025843.1         1667-2499
FEATURES             Location/Qualifiers
     source          1..5138
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..5138
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /note="L1 cell adhesion molecule"
                     /db_xref="GeneID:3897"
                     /db_xref="HGNC:HGNC:6470"
                     /db_xref="MIM:308840"
     exon            1..109
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..293
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3991
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; neural cell adhesion molecule L1; antigen
                     identified by monoclonal antibody R1"
                     /codon_start=1
                     /product="neural cell adhesion molecule L1 isoform 1
                     precursor"
                     /protein_id="NP_001265045.1"
                     /db_xref="CCDS:CCDS14733.1"
                     /db_xref="GeneID:3897"
                     /db_xref="HGNC:HGNC:6470"
                     /db_xref="MIM:308840"
                     /translation="MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRR
                     LVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNS
                     NFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNP
                     PPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRT
                     IIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKW
                     LRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY
                     WLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILS
                     NVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKA
                     FGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTI
                     MANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDS
                     DKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLH
                     LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPY
                     VHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW
                     MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGP
                     EPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREG
                     SQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTP
                     EGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRD
                     PELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGEN
                     YSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEI
                     HLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRS
                     KGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGS
                     DDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE"
     exon            294..308
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..414
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..617
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..740
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..911
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1023
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1208
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1340
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1484
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1596
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1763
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1920
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2045
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2156
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2354
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2425
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2648
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2764
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2966
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3089
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3263
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3383
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3539
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3674
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3747
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3759
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..5138
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5120..5125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /note="hexamer: AATAAA"
     polyA_site      5138
                     /gene="L1CAM"
                     /gene_synonym="CAML1; CD171; HSAS; HSAS1; HYCX; MASA;
                     MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1"
                     /note="major polyA site"
ORIGIN      
        1 acagccgctg ctgccgcagc atcggcatcg cagacgcgct cgggcggcgg gtccgaggcc
       61 ggcgtgcgcg gaggctgggc gggcagcccg agcggtggcc gcagcgcagt gcccccactc
      121 ccaactcccg ccccaagccg cccaccagcc cccttcccct ccggccggag cctgaaccga
      181 gcccggctgg ctgtgctgcg cggtgccgcc gggaaagatg gtcgtggcgc tgcggtacgt
      241 gtggcctctc ctcctctgca gcccctgcct gcttatccag atccccgagg aatatgaagg
      301 acaccatgtg atggagccac ctgtcatcac ggaacagtct ccacggcgcc tggttgtctt
      361 ccccacagat gacatcagcc tcaagtgtga ggccagtggc aagcccgaag tgcagttccg
      421 ctggacgagg gatggtgtcc acttcaaacc caaggaagag ctgggtgtga ccgtgtacca
      481 gtcgccccac tctggctcct tcaccatcac gggcaacaac agcaactttg ctcagaggtt
      541 ccagggcatc taccgctgct ttgccagcaa taagctgggc accgccatgt cccatgagat
      601 ccggctcatg gccgagggtg cccccaagtg gccaaaggag acagtgaagc ccgtggaggt
      661 ggaggaaggg gagtcagtgg ttctgccttg caaccctccc ccaagtgcag agcctctccg
      721 gatctactgg atgaacagca agatcttgca catcaagcag gacgagcggg tgacgatggg
      781 ccagaacggc aacctctact ttgccaatgt gctcacctcc gacaaccact cagactacat
      841 ctgccacgcc cacttcccag gcaccaggac catcattcag aaggaaccca ttgacctccg
      901 ggtcaaggcc accaacagca tgattgacag gaagccgcgc ctgctcttcc ccaccaactc
      961 cagcagccac ctggtggcct tgcaggggca gccattggtc ctggagtgca tcgccgaggg
     1021 ctttcccacg cccaccatca aatggctgcg ccccagtggc cccatgccag ccgaccgtgt
     1081 cacctaccag aaccacaaca agaccctgca gctgctgaaa gtgggcgagg aggatgatgg
     1141 cgagtaccgc tgcctggccg agaactcact gggcagtgcc cggcatgcgt actatgtcac
     1201 cgtggaggct gccccgtact ggctgcacaa gccccagagc catctatatg ggccaggaga
     1261 gactgcccgc ctggactgcc aagtccaggg caggccccaa ccagaggtca cctggagaat
     1321 caacgggatc cctgtggagg agctggccaa agaccagaag taccggattc agcgtggcgc
     1381 cctgatcctg agcaacgtgc agcccagtga cacaatggtg acccaatgtg aggcccgcaa
     1441 ccggcacggg ctcttgctgg ccaatgccta catctacgtt gtccagctgc cagccaagat
     1501 cctgactgcg gacaatcaga cgtacatggc tgtccagggc agcactgcct accttctgtg
     1561 caaggccttc ggagcgcctg tgcccagtgt tcagtggctg gacgaggatg ggacaacagt
     1621 gcttcaggac gaacgcttct tcccctatgc caatgggacc ctgggcattc gagacctcca
     1681 ggccaatgac accggacgct acttctgcct ggctgccaat gaccaaaaca atgttaccat
     1741 catggctaac ctgaaggtta aagatgcaac tcagatcact caggggcccc gcagcacaat
     1801 cgagaagaaa ggttccaggg tgaccttcac gtgccaggcc tcctttgacc cctccttgca
     1861 gcccagcatc acctggcgtg gggacggtcg agacctccag gagcttgggg acagtgacaa
     1921 gtacttcata gaggatgggc gcctggtcat ccacagcctg gactacagcg accagggcaa
     1981 ctacagctgc gtggccagta ccgaactgga tgtggtggag agtagggcac agctcttggt
     2041 ggtggggagc cctgggccgg tgccacggct ggtgctgtcc gacctgcacc tgctgacgca
     2101 gagccaggtg cgcgtgtcct ggagtcctgc agaagaccac aatgccccca ttgagaaata
     2161 tgacattgaa tttgaggaca aggaaatggc gcctgaaaaa tggtacagtc tgggcaaggt
     2221 tccagggaac cagacctcta ccaccctcaa gctgtcgccc tatgtccact acacctttag
     2281 ggttactgcc ataaacaaat atggccccgg ggagcccagc ccggtctctg agactgtggt
     2341 cacacctgag gcagccccag agaagaaccc tgtggatgtg aagggggaag gaaatgagac
     2401 caccaatatg gtcatcacgt ggaagccgct ccggtggatg gactggaacg ccccccaggt
     2461 tcagtaccgc gtgcagtggc gccctcaggg gacacgaggg ccctggcagg agcagattgt
     2521 cagcgacccc ttcctggtgg tgtccaacac gtccaccttc gtgccctatg agatcaaagt
     2581 ccaggccgtc aacagccagg gcaagggacc agagccccag gtcactatcg gctactctgg
     2641 agaggactac ccccaggcaa tccctgagct ggaaggcatt gaaatcctca actcaagtgc
     2701 cgtgctggtc aagtggcggc cggtggacct ggcccaggtc aagggccacc tccgcggata
     2761 caatgtgacg tactggaggg agggcagtca gaggaagcac agcaagagac atatccacaa
     2821 agaccatgtg gtggtgcccg ccaacaccac cagtgtcatc ctcagtggct tgcggcccta
     2881 tagctcctac cacctggagg tgcaggcctt taacgggcga ggatcggggc ccgccagcga
     2941 gttcaccttc agcaccccag agggagtgcc tggccacccc gaggcgttgc acctggagtg
     3001 ccagtcgaac accagcctgc tgctgcgctg gcagccccca ctcagccaca acggcgtgct
     3061 caccggctac gtgctctcct accaccccct ggatgagggg ggcaaggggc aactgtcctt
     3121 caaccttcgg gaccccgaac ttcggacaca caacctgacc gatctcagcc cccacctgcg
     3181 gtaccgcttc cagcttcagg ccaccaccaa agagggccct ggtgaagcca tcgtacggga
     3241 aggaggcact atggccttgt ctgggatctc agattttggc aacatctcag ccacagcggg
     3301 tgaaaactac agtgtcgtct cctgggtccc caaggagggc cagtgcaact tcaggttcca
     3361 tatcttgttc aaagccttgg gagaagagaa gggtggggct tccctttcgc cacagtatgt
     3421 cagctacaac cagagctcct acacgcagtg ggacctgcag cctgacactg actacgagat
     3481 ccacttgttt aaggagagga tgttccggca ccaaatggct gtgaagacca atggcacagg
     3541 ccgcgtgagg ctccctcctg ctggcttcgc cactgagggc tggttcatcg gctttgtgag
     3601 tgccatcatc ctcctgctcc tcgtcctgct catcctctgc ttcatcaagc gcagcaaggg
     3661 cggcaaatac tcagtgaagg ataaggagga cacccaggtg gactctgagg cccgaccgat
     3721 gaaagatgag accttcggcg agtacaggtc cctggagagt gacaacgagg agaaggcctt
     3781 tggcagcagc cagccatcgc tcaacgggga catcaagccc ctgggcagtg acgacagcct
     3841 ggccgattat gggggcagcg tggatgttca gttcaacgag gatggttcgt tcattggcca
     3901 gtacagtggc aagaaggaga aggaggcggc agggggcaat gacagctcag gggccacttc
     3961 ccccatcaac cctgccgtgg ccctagaata gtggagtcca ggacaggaga tgctgtgccc
     4021 ctggccttgg gatccaggcc cctccctctc cagcaggccc atgggaggct ggagttgggg
     4081 cagaggagaa cttgctgcct cggatcccct tcctaccacc cggtccccac tttattgcca
     4141 aaacccagct gcaccccttc ctgggcacac gctgctctgc cccagcttgg gcagatctcc
     4201 cacatgccag gggcctttgg gtgctgtttt gccagcccat ttgggcagag aggctgtggt
     4261 ttgggggaga agaagtaggg gtggcccgaa agggtctccg aaatgctgtc tttcttgctc
     4321 cctgactggg ggcagacatg gtggggtctc ctcaggacca gggttggcac cttccccctc
     4381 ccccagccac tccccagcca gcctggctgg gactgggaac agaactcggt gtccccacca
     4441 tctgctgtct tttctttgcc atctctgctc caaccgggat gggagccggg caaactggcc
     4501 gcgggggcag gggaggccat ctggagagcc cagagtcccc ccactcccag catcgcactc
     4561 tggcagcacc gcctcttccc gccgcccagc ccaccccatg gccggctttc aggagctcca
     4621 tacacacgct gccttcggta cccaccacac aacatccaag tggcctccgt cactacctgg
     4681 ctgcggggcg ggcacacctc ctcccactgc ccactggccg gcctcttcca gccgccccca
     4741 ccccccagga ccccttagca gccctgccct ccctatcgtc tgaacagttg tcttcctcag
     4801 cctcctcccg cccccacctt gggaatgtaa atacaccgtg actttgaaag tttgtacccc
     4861 tgtccttccc tttacgccac tagtgtgtag gcagatgtct gagtccctag gtggtttcta
     4921 ggattgatag caattagctt tgatgaaccc atcccaggaa aaataaaaac agacaaaaaa
     4981 aaaggaaaga ttggttctcc cagcactgct cagcagccac agcctccctg tatgcctgtg
     5041 cttggtctac tgataagccc tctacaaaaa aacaaaagta tatatatata tgtacataat
     5101 atcagaatta taacaggcaa ataaaacctg aaaatcaa
//
