LOCUS       NM_001008661            1815 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kynurenine aminotransferase 3 (KYAT3), transcript
            variant 1, mRNA.
ACCESSION   NM_001008661
VERSION     NM_001008661.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Meng,X., Wang,L., He,M., Yang,Z., Jiao,Y., Hu,Y. and Wang,K.
  TITLE     Cysteine conjugate beta-lyase 2 (CCBL2) expression as a prognostic
            marker of survival in breast cancer patients
  JOURNAL   PLoS One 17 (6), e0269998 (2022)
   PUBMED   35771747
  REMARK    GeneRIF: Cysteine conjugate beta-lyase 2 (CCBL2) expression as a
            prognostic marker of survival in breast cancer patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Matysik-Wozniak,A., Junemann,A., Turski,W.A., Wnorowski,A.,
            Jozwiak,K., Paduch,R., Okuno,E., Moneta-Wielgos,J.,
            Choragiewicz,T., Maciejewski,R. and Rejdak,R.
  TITLE     The presence of kynurenine aminotransferases in the human cornea:
            Evidence from bioinformatics analysis of gene expression and
            immunohistochemical staining
  JOURNAL   Mol Vis 23, 364-371 (2017)
   PUBMED   28706436
  REMARK    GeneRIF: Immunohistochemical analysis revealed the presence of KAT
            I, II, and III in all examined corneal sections.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Pinto,J.T., Krasnikov,B.F., Alcutt,S., Jones,M.E., Dorai,T.,
            Villar,M.T., Artigues,A., Li,J. and Cooper,A.J.
  TITLE     Kynurenine aminotransferase III and glutamine transaminase L are
            identical enzymes that have cysteine S-conjugate beta-lyase
            activity and can transaminate L-selenomethionine
  JOURNAL   J Biol Chem 289 (45), 30950-30961 (2014)
   PUBMED   25231977
  REMARK    GeneRIF: human KAT III/CCBL2 possesses cysteine S-conjugate
            beta-lyase activity, as does mouse KAT II
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Claes,S., Myint,A.M., Domschke,K., Del-Favero,J., Entrich,K.,
            Engelborghs,S., De Deyn,P., Mueller,N., Baune,B. and Rothermundt,M.
  TITLE     The kynurenine pathway in major depression: haplotype analysis of
            three related functional candidate genes
  JOURNAL   Psychiatry Res 188 (3), 355-360 (2011)
   PUBMED   21492941
  REMARK    GeneRIF: The haplotype of KAT III gene CGCTCT may have effect on
            the function of this enzyme in formation of kynurenic acid in some
            patients with major depressive episodes.
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Yu,P., Li,Z., Zhang,L., Tagle,D.A. and Cai,T.
  TITLE     Characterization of kynurenine aminotransferase III, a novel member
            of a phylogenetically conserved KAT family
  JOURNAL   Gene 365, 111-118 (2006)
   PUBMED   16376499
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY028624.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001008661.2.
            
            Summary: This gene encodes an aminotransferase that transaminates
            kynurenine to form kynurenic acid, which is a metabolite of
            tryptophan. Multiple alternatively spliced transcript variants that
            encode different proteins have been described for this gene. This
            gene shares 5' exon structure with the RNA binding motif protein,
            X-linked-like 1 locus on chromosome 1, but the coding sequences are
            non-overlapping. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028624.1, SRR5189652.100848.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260508.9/ ENSP00000260508.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1815              AY028624.1         152-1966
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..1815
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /note="kynurenine aminotransferase 3"
                     /db_xref="GeneID:56267"
                     /db_xref="HGNC:HGNC:33238"
                     /db_xref="MIM:610656"
     exon            1..45
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            46..145
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1411
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /EC_number="2.6.1.7"
                     /EC_number="4.4.1.13"
                     /EC_number="2.6.1.63"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kynurenine--oxoglutarate transaminase 3;
                     cysteine-S-conjugate beta-lyase 2; kynurenine
                     aminotransferase III; kynurenine--oxoglutarate
                     transaminase III; kynurenine--glyoxylate transaminase"
                     /codon_start=1
                     /product="kynurenine--oxoglutarate transaminase 3 isoform
                     1"
                     /protein_id="NP_001008661.1"
                     /db_xref="CCDS:CCDS30766.1"
                     /db_xref="GeneID:56267"
                     /db_xref="HGNC:HGNC:33238"
                     /db_xref="MIM:610656"
                     /translation="MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKR
                     IEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFG
                     HPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYD
                     CYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHN
                     PLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIG
                     SAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDD
                     PECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEP
                     YDYKFVKWMTKHKKLSAIPVSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWS
                     VQKS"
     exon            146..204
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            205..349
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            350..499
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            500..586
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            587..712
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            713..833
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            834..910
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1000
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1187
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1261
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1348
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1815
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1794..1799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /note="hexamer: AATAAA"
     polyA_site      1815
                     /gene="KYAT3"
                     /gene_synonym="CCBL2; KAT3; KATIII"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggact cgagcctagg gaggcgaggt tcccgcaccg gatagcatgt ttttggccca
       61 gaggagcctc tgctctctta gcggtagagc aaaattcctg aagacaattt cttcttccaa
      121 aatcctcgga ttctctactt ctgctaaaat gtcactgaaa ttcacaaatg caaaacggat
      181 tgaaggactt gatagtaatg tgtggattga atttaccaaa ttggctgcag acccttctgt
      241 tgtgaatctt ggccaaggct ttccagatat atcccctcct acatatgtaa aagaagaatt
      301 atcaaagatt gcagcaatcg atagcctgaa tcagtataca cgaggctttg gccatccatc
      361 acttgtgaaa gctctgtcct atctgtatga aaagctttat caaaagcaaa ttgattcaaa
      421 taaagaaatc cttgtgacag taggagcata tggatctctt tttaacacca ttcaagcatt
      481 aattgatgag ggagatgaag tcatactaat agtgcctttc tatgactgct atgagcccat
      541 ggtgagaatg gctggagcaa cacctgtttt tattcccctg agatctaaac ctgtttatgg
      601 aaaaagatgg tctagttctg actggacatt agatcctcaa gaactggaaa gtaaatttaa
      661 ttccaaaacc aaagctatta tactaaatac tccacataac ccacttggca aggtgtataa
      721 cagagaggaa ctgcaagtaa ttgctgacct ttgcatcaaa tatgacacac tctgcatcag
      781 cgatgaggtt tatgaatggc ttgtatattc tggaaataag cacttaaaaa tagctacttt
      841 tccaggtatg tgggagagaa caataacaat aggaagtgct ggaaagactt tcagtgtaac
      901 tggctggaag cttggctggt ccattggtcc aaatcatttg ataaaacatt tacagacagt
      961 tcaacaaaac acgatttata cttgtgcaac tcctttacag gaagccttgg ctcaagcttt
     1021 ctggattgac atcaagcgca tggatgaccc agaatgttac tttaattctt tgccaaaaga
     1081 gttagaagta aaaagagatc ggatggtacg tttacttgaa agtgttggcc taaaacccat
     1141 agttcctgat ggaggatact tcatcatcgc tgatgtgtct ttgctagatc cagacctctc
     1201 tgatatgaag aataatgagc cttatgacta taagtttgtg aaatggatga ctaaacataa
     1261 gaaactatca gccatccccg tttcagcatt ctgtaactca gagactaaat cacagtttga
     1321 gaagtttgtg cgtttttgct tcattaaaaa agacagcaca ctggatgctg ctgaagaaat
     1381 catcaaggca tggagtgtac agaagtcttg atttgtgcag aatggattaa tgtttctgtt
     1441 agatgaccta gtatggaatt gttacttagt gctgccacct gctggatgtt aaaaggtatt
     1501 tcagtacaac tggaatttaa atatttccat tgtttttcca aagcagttaa cccaactcct
     1561 aacaacattt tcgggggatc tgaccttttt tttccagttg aaatgtatta acacaccttc
     1621 cacaatcatt ttataagagt cagcataaca tagtggataa gaaatgtgag atgtttaacc
     1681 tctcagtaac tcggttctct cattataaaa taggaataaa atcagtacct gtttcatatg
     1741 aaggtcgttt ctgagaatta aatggactaa tgtatgcaaa aagcctggca aacaataaac
     1801 actcatctga cttta
//
