LOCUS       NM_024069               1344 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens KxDL motif containing 1 (KXD1), transcript variant 2,
            mRNA.
ACCESSION   NM_024069
VERSION     NM_024069.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1344)
  AUTHORS   Tunganuntarat,J., Kanjanasirirat,P., Khumpanied,T.,
            Benjaskulluecha,S., Wongprom,B., Palaga,T., Siregar,T.A.P.,
            Borwornpinyo,S., Chaiprasert,A., Palittapongarnpim,P. and
            Ponpuak,M.
  TITLE     BORC complex specific components and Kinesin-1 mediate autophagy
            evasion by the autophagy-resistant Mycobacterium tuberculosis
            Beijing strain
  JOURNAL   Sci Rep 13 (1), 1663 (2023)
   PUBMED   36717601
  REMARK    GeneRIF: BORC complex specific components and Kinesin-1 mediate
            autophagy evasion by the autophagy-resistant Mycobacterium
            tuberculosis Beijing strain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1344)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1344)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1344)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1344)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1344)
  AUTHORS   Pu,J., Schindler,C., Jia,R., Jarnik,M., Backlund,P. and
            Bonifacino,J.S.
  TITLE     BORC, a multisubunit complex that regulates lysosome positioning
  JOURNAL   Dev Cell 33 (2), 176-188 (2015)
   PUBMED   25898167
REFERENCE   7  (bases 1 to 1344)
  AUTHORS   Yang,Q., He,X., Yang,L., Zhou,Z., Cullinane,A.R., Wei,A., Zhang,Z.,
            Hao,Z., Zhang,A., He,M., Feng,Y., Gao,X., Gahl,W.A., Huizing,M. and
            Li,W.
  TITLE     The BLOS1-interacting protein KXD1 is involved in the biogenesis of
            lysosome-related organelles
  JOURNAL   Traffic 13 (8), 1160-1169 (2012)
   PUBMED   22554196
  REMARK    GeneRIF: KXD1 interacts with BLOS1.
REFERENCE   8  (bases 1 to 1344)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   9  (bases 1 to 1344)
  AUTHORS   Hayes,M.J., Bryon,K., Satkurunathan,J. and Levine,T.P.
  TITLE     Yeast homologues of three BLOC-1 subunits highlight KxDL proteins
            as conserved interactors of BLOC-1
  JOURNAL   Traffic 12 (3), 260-268 (2011)
   PUBMED   21159114
REFERENCE   10 (bases 1 to 1344)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098346.1 and AC005253.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024069.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001080.2, SRR3476690.619265.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222307.9/ ENSP00000222307.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1332              AK098346.1         83-1414
            1333-1344           AC005253.1         23631-23642
FEATURES             Location/Qualifiers
     source          1..1344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1344
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /note="KxDL motif containing 1"
                     /db_xref="GeneID:79036"
                     /db_xref="HGNC:HGNC:28420"
                     /db_xref="MIM:615178"
     exon            1..45
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /inference="alignment:Splign:2.1.0"
     exon            46..167
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..597
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /note="UPF0459 protein C19orf50; BLOC-1 related complex
                     subunit 4"
                     /codon_start=1
                     /product="kxDL motif-containing protein 1"
                     /protein_id="NP_076974.2"
                     /db_xref="CCDS:CCDS12381.1"
                     /db_xref="GeneID:79036"
                     /db_xref="HGNC:HGNC:28420"
                     /db_xref="MIM:615178"
                     /translation="MDLPDSASRVFCGRILSMVNTDDVNAIILAQKNMLDRFEKTNEM
                     LLNFNNLSSARLQQMSERFLHHTRTLVEMKRDLDSIFRRIRTLKGKLARQHPEAFSHI
                     PEASFLEEEDEDPIPPSTTTTIATSEQSTGSCDTSPDTVSPSLSPGFEDLSHVQPGSP
                     AINGRSQTDDEEMTGE"
     exon            168..320
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /inference="alignment:Splign:2.1.0"
     exon            321..367
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /inference="alignment:Splign:2.1.0"
     exon            368..1344
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1313..1318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /note="hexamer: AATAAA"
     polyA_site      1344
                     /gene="KXD1"
                     /gene_synonym="BORCS4; C10orf50; C19orf50; KXDL; MST096;
                     MSTP096"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgcca tcccggaagc gcgagcaagg ccgccagatg tgcaggcagc ggaggaggag
       61 aaagagatgg acctcccgga ctcggcctcg agggtcttct gcggccgcat cctgagcatg
      121 gtgaacacag atgatgtcaa cgccatcatc ctggcccaga agaacatgct ggaccgcttt
      181 gagaagacca atgagatgct gctcaacttc aacaacctgt ccagtgcccg cctgcagcag
      241 atgagcgaac gcttcctgca ccacacgagg accctagtag agatgaaacg ggacctggac
      301 agcatcttcc gccgtatcag gacgctgaaa gggaaactgg ccaggcagca cccagaggcc
      361 ttcagccata tcccagaggc atccttcctg gaggaagagg atgaagaccc catcccaccc
      421 agcaccacga ccaccattgc cacctcagaa cagagcacgg gctcatgtga caccagcccc
      481 gacaccgtct cgccctccct gagccccggc ttcgaggacc tgtcccatgt ccagcctggc
      541 tccccagcca tcaacggccg cagccagaca gatgacgagg agatgacggg cgaatagccc
      601 tgctgcccgg tgccttgagg gggtctcagg gcagcagcat acaaggtggc agcgggtaac
      661 cctgccttgt tctgtcatcc agggctcctt tgctgccccg ttctgtcacc cagggctcct
      721 agggggacaa ggctctctcc cgaggggtgt ggaattcctg ggggggtctt taattctggc
      781 tccttccttc ctcagaacat ctctattctg caagacccct ctgccatgcc agggcacgcc
      841 cattccagct ggagtcgtgg ggctgggcac aggggaattt ttccagagct gagcctgacg
      901 tctgctctga agaatgctta gaaggttccc agacaccaga gccagatgtc ccccaccacc
      961 ggtcaggacc tccttgaggt gcacaagcac ggtctcctct gagttcaccc cagcccaccc
     1021 ccgcacccac taattctgct tttcctgccc cttgctccgt aaaagtatca aatactttct
     1081 ccttggtatc tcaaggaggt ttctgagata ggtagaagtc ttgagacgga ggctggccat
     1141 ccattcagcc ctgagcgtgc tgagttctgt gtttctctga atagaggtgt ggaacctgag
     1201 gggccagcag gcctctctga aggcctccat ggagcaaacg gagccacctc gggaaagagt
     1261 ttaatggaat atttttgtac ccgatgttta cagatgctgt tgggaagtta tcaataaaaa
     1321 gacaccatta ctaaaaaggg aaaa
//
