LOCUS       NM_001402693            5420 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens kinectin 1 (KTN1), transcript variant 18, mRNA.
ACCESSION   NM_001402693
VERSION     NM_001402693.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5420)
  AUTHORS   Niu,X., Shen,Y., Wen,Y., Mi,X., Xie,J., Zhang,Y. and Ding,Z.
  TITLE     KTN1 mediated unfolded protein response protects keratinocytes from
            ionizing radiation-induced DNA damage
  JOURNAL   J Dermatol Sci 114 (1), 24-33 (2024)
   PUBMED   38448340
  REMARK    GeneRIF: KTN1 mediated unfolded protein response protects
            keratinocytes from ionizing radiation-induced DNA damage.
REFERENCE   2  (bases 1 to 5420)
  AUTHORS   Moore,A., Crea,P.W., Makarious,M., Bandres-Ciga,S., Blauwendraat,C.
            and Diez-Fairen,M.
  TITLE     A genetic and transcriptomic assessment of the KTN1 gene in
            Parkinson's disease risk
  JOURNAL   Neurobiol Aging 134, 66-73 (2024)
   PUBMED   37992546
  REMARK    GeneRIF: A genetic and transcriptomic assessment of the KTN1 gene
            in Parkinson's disease risk.
REFERENCE   3  (bases 1 to 5420)
  AUTHORS   Jakob,M., Mattes,L.M., Unger,K., Kueffer,S., Hess,J., Canis,M.,
            Schirmer,M., Spiegel,J.L., Haubner,F., Ihler,F., Weiss,B.G. and
            Kitz,J.
  TITLE     Human microRNA-182-5p and kinectin 1: Potential biomarkers for
            prognosis in oral squamous cell carcinoma
  JOURNAL   Head Neck 43 (12), 3707-3719 (2021)
   PUBMED   34591354
  REMARK    GeneRIF: Human microRNA-182-5p and kinectin 1: Potential biomarkers
            for prognosis in oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 5420)
  AUTHORS   Alberts,A.S., Bouquin,N., Johnston,L.H. and Treisman,R.
  TITLE     Analysis of RhoA-binding proteins reveals an interaction domain
            conserved in heterotrimeric G protein beta subunits and the yeast
            response regulator protein Skn7
  JOURNAL   J Biol Chem 273 (15), 8616-8622 (1998)
   PUBMED   9535835
REFERENCE   5  (bases 1 to 5420)
  AUTHORS   Rao,P.N., Yu,H., Hodge,R., Pettenati,M.J. and Sheetz,M.P.
  TITLE     Assignment of the human kinectin gene (KTN1), encoding a
            kinesin-binding protein, to chromosome 14 band q22.1 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 196-197 (1997)
   PUBMED   9605849
REFERENCE   6  (bases 1 to 5420)
  AUTHORS   Hotta,K., Tanaka,K., Mino,A., Kohno,H. and Takai,Y.
  TITLE     Interaction of the Rho family small G proteins with kinectin, an
            anchoring protein of kinesin motor
  JOURNAL   Biochem Biophys Res Commun 225 (1), 69-74 (1996)
   PUBMED   8769096
REFERENCE   7  (bases 1 to 5420)
  AUTHORS   Print,C.G., Morris,C.M., Spurr,N.K., Rooke,L. and Krissansen,G.W.
  TITLE     The CG-1 gene, a member of the kinectin and ES/130 family, maps to
            human chromosome band 14q22
  JOURNAL   Immunogenetics 43 (4), 227-229 (1996)
   PUBMED   8575822
REFERENCE   8  (bases 1 to 5420)
  AUTHORS   Yu,H., Nicchitta,C.V., Kumar,J., Becker,M., Toyoshima,I. and
            Sheetz,M.P.
  TITLE     Characterization of kinectin, a kinesin-binding protein: primary
            sequence and N-terminal topogenic signal analysis
  JOURNAL   Mol Biol Cell 6 (2), 171-183 (1995)
   PUBMED   7787244
REFERENCE   9  (bases 1 to 5420)
  AUTHORS   Futterer,A., Kruppa,G., Kramer,B., Lemke,H. and Kronke,M.
  TITLE     Molecular cloning and characterization of human kinectin
  JOURNAL   Mol Biol Cell 6 (2), 161-170 (1995)
   PUBMED   7787243
REFERENCE   10 (bases 1 to 5420)
  AUTHORS   Print,C.G., Leung,E., Harrison,J.E., Watson,J.D. and
            Krissansen,G.W.
  TITLE     Cloning of a gene encoding a human leukocyte protein characterised
            by extensive heptad repeats
  JOURNAL   Gene 144 (2), 221-228 (1994)
   PUBMED   8039706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138499.4.
            
            Summary: This gene encodes an integral membrane protein that is a
            member of the kinectin protein family. The encoded protein is
            primarily localized to the endoplasmic reticulum membrane. This
            protein binds kinesin and may be involved in intracellular
            organelle motility. This protein also binds translation elongation
            factor-delta and may be involved in the assembly of the elongation
            factor-1 complex. Alternate splicing results in multiple transcript
            variants of this gene. [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.182385.1,
                                           SRR14372079.3906380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-887               AL138499.4         79366-80252
            888-1011            AL138499.4         100916-101039
            1012-1564           AL138499.4         111178-111730
            1565-1702           AL138499.4         115676-115813
            1703-1873           AL138499.4         117123-117293
            1874-2004           AL138499.4         118341-118471
            2005-2121           AL138499.4         127071-127187
            2122-2262           AL138499.4         129116-129256
            2263-2369           AL138499.4         132394-132500
            2370-2502           AL138499.4         133685-133817
            2503-2590           AL138499.4         135608-135695
            2591-2757           AL138499.4         136357-136523
            2758-2826           AL138499.4         136938-137006
            2827-2864           AL138499.4         138344-138381
            2865-2955           AL138499.4         139072-139162
            2956-3024           AL138499.4         139533-139601
            3025-3062           AL138499.4         140092-140129
            3063-3144           AL138499.4         140286-140367
            3145-3213           AL138499.4         140851-140919
            3214-3248           AL138499.4         146132-146166
            3249-3339           AL138499.4         147184-147274
            3340-3408           AL138499.4         147961-148029
            3409-3446           AL138499.4         148935-148972
            3447-3537           AL138499.4         149487-149577
            3538-3606           AL138499.4         149728-149796
            3607-3644           AL138499.4         151049-151086
            3645-3735           AL138499.4         152009-152099
            3736-3804           AL138499.4         152176-152244
            3805-3842           AL138499.4         152718-152755
            3843-3933           AL138499.4         155201-155291
            3934-4002           AL138499.4         157705-157773
            4003-4040           AL138499.4         158825-158862
            4041-4131           AL138499.4         160681-160771
            4132-4221           AL138499.4         166400-166489
            4222-4302           AL138499.4         169888-169968
            4303-4392           AL138499.4         170725-170814
            4393-4485           AL138499.4         170944-171036
            4486-4557           AL138499.4         171789-171860
            4558-4641           AL138499.4         172088-172171
            4642-4725           AL138499.4         174994-175077
            4726-4818           AL138499.4         177511-177603
            4819-4939           AL138499.4         178724-178844
            4940-5420           AL138499.4         183258-183738
FEATURES             Location/Qualifiers
     source          1..5420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..5420
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="kinectin 1"
                     /db_xref="GeneID:3895"
                     /db_xref="HGNC:HGNC:6467"
                     /db_xref="MIM:600381"
     exon            1..887
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1011
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1564
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     CDS             1042..4944
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="isoform c is encoded by transcript variant 18; CG-1
                     antigen; kinesin receptor"
                     /codon_start=1
                     /product="kinectin isoform c"
                     /protein_id="NP_001389622.1"
                     /db_xref="GeneID:3895"
                     /db_xref="HGNC:HGNC:6467"
                     /db_xref="MIM:600381"
                     /translation="MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKRE
                     QKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL
                     NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAA
                     SKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKT
                     ENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETD
                     KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQL
                     QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQN
                     KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
                     LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRT
                     AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEES
                     LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLA
                     SERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI
                     RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK
                     DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE
                     LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL
                     SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV
                     AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL
                     FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN
                     ERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV
                     LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTI
                     KQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQ
                     LNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESS
                     EKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE"
     exon            1565..1702
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1873
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2004
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2121
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2262
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2369
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2502
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2590
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2757
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2826
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2864
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2955
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3024
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3062
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3144
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3213
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3248
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3339
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3408
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3446
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3537
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3606
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3644
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3735
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3804
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3842
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3933
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4002
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4040
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4131
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4221
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..4302
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4392
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4393..4485
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4486..4557
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4641
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..4725
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4726..4818
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..4939
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5420
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5396..5401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="hexamer: AATAAA"
     polyA_site      5420
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="major polyA site"
ORIGIN      
        1 gaagccgccc gtttcctgcc gagcggcgcg acggcacctg agcgactgcg gcggcggcgg
       61 cggcggcggc ggcgcctcgg agcgggcggc ccgggctgta gtgccggcgc cgccgcgtct
      121 tcccggtctc ctttcccggc cgcacagggt gagggagagc aggccgcacc gggacgggcg
      181 ccggcggcgg ggagcgcggg gggaggcggc gccggccgcg gggtcctggg gcaggcggga
      241 gggccgcgcc gggcgggggg gcgcggccgc ggggcccgga cgccgcccgc tgggtaggcc
      301 tcgggcatcc ggttgccgcc gcggggctct tgttggggcc gggacgccgc agggggcggg
      361 ctcggaggga cctcctcggc ctcgcggggc cgctctgggc ccgaccccgg ctctgtcgcg
      421 gcacccgggg cgcggccgag ggacaccccc caccctcccc aaggacgact ctcccgaagg
      481 cgaggtcgac ccgagcgggc cctggggtga ccgaggcacc tatttttagc caagcctgag
      541 ggcccccggg agggaaggcg gattaccgcc tcctcggccg gtggacggag gcagcgcgtc
      601 tccggcggcg tccccgggcc ggagctgggc cacacttacg ccatgctgga gttccagtcc
      661 tcgccgctgc ctccggcggt ctgggcgctc gcccccttcc ccggcgcccc tcccgctgcc
      721 ctttgcgagt ccccaggtca gggcgggagg cggttgggca cggaaagcag catgaggggg
      781 gactttggaa aaatccatgg accactctcg acaccggcga agttatccct tcctgtcccc
      841 gaggggtgtg tcctagcgat tcggcctgac cccttcagtt tccaaaagta gattttcgtt
      901 ccgtcaccca ggctggagtg cagtggtgtg accttggctt gctgcaaccc tttgcctcct
      961 gggttcaagt gattctcatt gcctcagcct cctaagtagc tgggattaca ggttttatag
     1021 gatcacattg acaaaagtac catggagttt tatgagtcag catattttat tgttcttatt
     1081 ccttcaatag ttattacagt aattttcctc ttcttctggc ttttcatgaa agaaacatta
     1141 tatgatgaag ttcttgcaaa acagaaaaga gaacaaaagc ttattcctac caaaacagat
     1201 aaaaagaaag cagaaaagaa aaagaataaa aagaaagaaa tccagaatgg aaacctccat
     1261 gaatccgact ctgagagtgt acctcgagac tttaaattat cagatgcttt ggcagtagaa
     1321 gatgatcaag ttgcacctgt tccattgaat gtcgttgaaa cttcaagtag tgttagggaa
     1381 agaaaaaaga aggaaaagaa acaaaagcct gtgcttgaag agcaggtcat caaagaaagt
     1441 gacgcatcaa agattcctgg caaaaaagta gaacctgtcc cagttactaa acagcccacc
     1501 cctccctctg aagcagctgc ctcgaagaag aaaccagggc agaagaagtc taaaaatgga
     1561 agcgatgacc aggataaaaa ggtggaaact ctcatggtac catcaaaaag gcaagaagca
     1621 ttgcccctcc accaagagac taaacaagaa agtggatcag ggaagaagaa agcttcatca
     1681 aagaaacaaa agacagaaaa tgtcttcgta gatgaacccc ttattcatgc aactacttat
     1741 attcctttga tggataatgc tgactcaagt cctgtggtag ataagagaga ggttattgat
     1801 ttgcttaaac ctgaccaagt agaagggatc cagaaatctg ggactaaaaa actgaagacc
     1861 gaaactgaca aagaaaatgc tgaagtgaag tttaaagatt ttcttctgtc cttgaagact
     1921 atgatgtttt ctgaagatga ggctctttgt gttgtagact tgctaaagga gaagtctggt
     1981 gtaatacaag atgctttaaa gaagtcaagt aagggagaat tgactacgct tatacatcag
     2041 cttcaagaaa aggacaagtt actcgctgct gtgaaggaag atgctgctgc tacaaaggat
     2101 cggtgtaagc agttaaccca ggaaatgatg acagagaaag aaagaagcaa tgtggttata
     2161 acaaggatga aagatcgaat tggaacatta gaaaaggaac ataatgtatt tcaaaacaaa
     2221 atacatgtca gttatcaaga gactcaacag atgcagatga agtttcagca agttcgtgag
     2281 cagatggagg cagagatagc tcacttgaag caggaaaatg gtatactgag agatgcagtc
     2341 agcaacacta caaatcaact ggaaagcaag cagtctgcag aactaaataa actacgccag
     2401 gattatgcta ggttggtgaa tgagctgact gagaaaacag gaaagctaca gcaagaggaa
     2461 gtccaaaaga agaatgctga gcaagcagct actcagttga aggttcaact acaagaagct
     2521 gagagaaggt gggaagaagt tcagagctac atcaggaaga gaacagcgga acatgaggca
     2581 gcacagcaag atttacagag taaatttgtg gccaaagaaa atgaagtaca gagtctgcat
     2641 agtaagctta cagatacctt ggtatcaaaa caacagttgg agcaaagact aatgcagtta
     2701 atggaatcag agcagaaaag ggtgaacaaa gaagagtctc tacaaatgca ggttcaggat
     2761 attttggagc agaatgaggc tttgaaagct caaattcagc agttccattc ccagatagca
     2821 gcccagacct ccgcttcagt tctagcagaa gaattacata aagtgattgc agaaaaggat
     2881 aagcagataa aacagactga agattcttta gcaagtgaac gtgatcgttt aacaagtaaa
     2941 gaagaggaac ttaaggatat acagaatatg aatttcttat taaaagctga agtgcagaaa
     3001 ttacaggccc tggcaaatga gcaggctgct gctgcacatg aattggagaa gatgcaacaa
     3061 agtgtttatg ttaaagatga taaaataaga ttgctggaag agcaactaca acatgaaatt
     3121 tcaaacaaaa tggaagaatt taagattcta aatgaccaaa acaaagcatt aaaatcagaa
     3181 gttcagaagc tacagactct tgtttctgaa cagcctaata aggatgttgt ggaacaaatg
     3241 gaaaaatgca ttcaagaaaa agatgagaag ttaaagactg tggaagaatt acttgaaact
     3301 ggacttattc aggtggcaac taaagaagag gagctgaatg caataagaac agaaaattca
     3361 tctctgacaa aagaagttca agacttaaaa gctaagcaaa atgatcaggt ttcttttgcc
     3421 tctctagttg aagaacttaa gaaagtgatc catgagaaag atggaaagat caagtctgta
     3481 gaagagcttc tggaggcaga acttctcaaa gttgctaaca aggagaaaac tgttcaggat
     3541 ttgaaacagg aaataaaggc tctaaaagaa gaaataggaa atgtccagct tgaaaaggct
     3601 caacagttat ctatcacttc caaagttcag gagcttcaga acttattaaa aggaaaagag
     3661 gaacagatga ataccatgaa ggctgttttg gaagagaaag agaaagacct agccaataca
     3721 gggaagtggt tacaggatct tcaagaagaa aatgaatctt taaaagcaca tgttcaggaa
     3781 gtagcacaac ataacttgaa agaggcctct tctgcatcac agtttgaaga acttgagatt
     3841 gtgttgaaag aaaaggaaaa tgaattgaag aggttagaag ccatgctaaa agagagggag
     3901 agtgatcttt ctagcaaaac acagctgtta caggatgtac aagatgaaaa caaattgttt
     3961 aagtcccaaa ttgagcagct taaacaacaa aactaccaac aggcatcttc ttttccccct
     4021 catgaagaat tattaaaagt aatttcagaa agagagaaag aaataagtgg tctctggaat
     4081 gagttagatt ctttgaagga tgcagttgaa caccagagga agaaaaacaa tgaaaggcag
     4141 caacaggtgg aagctgttga gttggaggct aaagaagttc tcaaaaaatt atttccaaag
     4201 gtgtctgtcc cttctaattt gagttatggt gaatggttgc atggatttga aaaaaaggca
     4261 aaagaatgta tggctggaac ttcagggtca gaggaggtta aggttctaga gcacaagttg
     4321 aaagaagctg atgaaatgca cacattgtta cagctagagt gtgaaaaata caaatccgtc
     4381 cttgcagaaa cagaaggaat tttacagaag ctacagagaa gtgttgagca agaagaaaat
     4441 aaatggaaag ttaaggtcga tgaatcacac aagactatta aacagatgca gtcatcattt
     4501 acatcttcag aacaagagct agagcgatta agaagcgaaa ataaggatat tgaaaatctg
     4561 agaagagaac gagaacattt ggaaatggaa ctagaaaagg cagagatgga acgatctacc
     4621 tatgttacag aagtcagaga gttgaaggca cagttaaatg aaacactcac aaaacttaga
     4681 actgaacaaa atgaaagaca gaaggtagct ggtgatttgc ataaggctca acagtcactg
     4741 gagcttatcc agtcaaaaat agtaaaagct gctggagaca ctactgttat tgaaaatagt
     4801 gatgtttccc cagaaacgga gtcttctgag aaggagacaa tgtctgtaag tctaaatcag
     4861 actgtaacac agttacagca gttgcttcag gcggtaaacc aacagctcac aaaggagaaa
     4921 gagcactacc aggtgttaga gtgaagtaat tgggaaactg ttcatttgag gataaaaaag
     4981 gcattgtatt atattttgcc aaattaaagc cttatttatg ttttcaccct ttctactttg
     5041 tcagaaacac tgaacagagt tttgtctttt ctaatccttg ttagactact gatttaaaga
     5101 aggaaaaaaa aaagccaact ctgtagacac cttcagagtt tagttttata ataaaaactg
     5161 tttgaataat tagaccttta cattcctgaa gataaacatg taatctttta tcttattttg
     5221 ctcaataaaa ttgttcagaa gatcaaagtg gtaaagacaa tgtaaaattt aacattttaa
     5281 tactgatgtt gtacactgtt ttacttaaca ttttgggaag taactgcctc tgacttcaac
     5341 tcaagaaaac acttttttgt tgctaatgta atcggttttt gtaatggcgt cagcaaataa
     5401 aaggatgctt attattcaaa
//
