LOCUS       NM_001079521            4728 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens kinectin 1 (KTN1), transcript variant 2, mRNA.
ACCESSION   NM_001079521
VERSION     NM_001079521.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   Niu,X., Shen,Y., Wen,Y., Mi,X., Xie,J., Zhang,Y. and Ding,Z.
  TITLE     KTN1 mediated unfolded protein response protects keratinocytes from
            ionizing radiation-induced DNA damage
  JOURNAL   J Dermatol Sci 114 (1), 24-33 (2024)
   PUBMED   38448340
  REMARK    GeneRIF: KTN1 mediated unfolded protein response protects
            keratinocytes from ionizing radiation-induced DNA damage.
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Moore,A., Crea,P.W., Makarious,M., Bandres-Ciga,S., Blauwendraat,C.
            and Diez-Fairen,M.
  TITLE     A genetic and transcriptomic assessment of the KTN1 gene in
            Parkinson's disease risk
  JOURNAL   Neurobiol Aging 134, 66-73 (2024)
   PUBMED   37992546
  REMARK    GeneRIF: A genetic and transcriptomic assessment of the KTN1 gene
            in Parkinson's disease risk.
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Jakob,M., Mattes,L.M., Unger,K., Kueffer,S., Hess,J., Canis,M.,
            Schirmer,M., Spiegel,J.L., Haubner,F., Ihler,F., Weiss,B.G. and
            Kitz,J.
  TITLE     Human microRNA-182-5p and kinectin 1: Potential biomarkers for
            prognosis in oral squamous cell carcinoma
  JOURNAL   Head Neck 43 (12), 3707-3719 (2021)
   PUBMED   34591354
  REMARK    GeneRIF: Human microRNA-182-5p and kinectin 1: Potential biomarkers
            for prognosis in oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Alberts,A.S., Bouquin,N., Johnston,L.H. and Treisman,R.
  TITLE     Analysis of RhoA-binding proteins reveals an interaction domain
            conserved in heterotrimeric G protein beta subunits and the yeast
            response regulator protein Skn7
  JOURNAL   J Biol Chem 273 (15), 8616-8622 (1998)
   PUBMED   9535835
REFERENCE   5  (bases 1 to 4728)
  AUTHORS   Rao,P.N., Yu,H., Hodge,R., Pettenati,M.J. and Sheetz,M.P.
  TITLE     Assignment of the human kinectin gene (KTN1), encoding a
            kinesin-binding protein, to chromosome 14 band q22.1 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 196-197 (1997)
   PUBMED   9605849
REFERENCE   6  (bases 1 to 4728)
  AUTHORS   Hotta,K., Tanaka,K., Mino,A., Kohno,H. and Takai,Y.
  TITLE     Interaction of the Rho family small G proteins with kinectin, an
            anchoring protein of kinesin motor
  JOURNAL   Biochem Biophys Res Commun 225 (1), 69-74 (1996)
   PUBMED   8769096
REFERENCE   7  (bases 1 to 4728)
  AUTHORS   Print,C.G., Morris,C.M., Spurr,N.K., Rooke,L. and Krissansen,G.W.
  TITLE     The CG-1 gene, a member of the kinectin and ES/130 family, maps to
            human chromosome band 14q22
  JOURNAL   Immunogenetics 43 (4), 227-229 (1996)
   PUBMED   8575822
REFERENCE   8  (bases 1 to 4728)
  AUTHORS   Yu,H., Nicchitta,C.V., Kumar,J., Becker,M., Toyoshima,I. and
            Sheetz,M.P.
  TITLE     Characterization of kinectin, a kinesin-binding protein: primary
            sequence and N-terminal topogenic signal analysis
  JOURNAL   Mol Biol Cell 6 (2), 171-183 (1995)
   PUBMED   7787244
REFERENCE   9  (bases 1 to 4728)
  AUTHORS   Futterer,A., Kruppa,G., Kramer,B., Lemke,H. and Kronke,M.
  TITLE     Molecular cloning and characterization of human kinectin
  JOURNAL   Mol Biol Cell 6 (2), 161-170 (1995)
   PUBMED   7787243
REFERENCE   10 (bases 1 to 4728)
  AUTHORS   Print,C.G., Leung,E., Harrison,J.E., Watson,J.D. and
            Krissansen,G.W.
  TITLE     Cloning of a gene encoding a human leukocyte protein characterised
            by extensive heptad repeats
  JOURNAL   Gene 144 (2), 221-228 (1994)
   PUBMED   8039706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA769269.1, Z22551.1,
            AL138499.4, AY536375.1 and BQ014936.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001079521.1.
            
            Summary: This gene encodes an integral membrane protein that is a
            member of the kinectin protein family. The encoded protein is
            primarily localized to the endoplasmic reticulum membrane. This
            protein binds kinesin and may be involved in intracellular
            organelle motility. This protein also binds translation elongation
            factor-delta and may be involved in the assembly of the elongation
            factor-1 complex. Alternate splicing results in multiple transcript
            variants of this gene. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.138589.1,
                                           SRR1803612.12872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395314.8/ ENSP00000378725.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               DA769269.1         1-110
            111-804             Z22551.1           2-695
            805-807             AL138499.4         115779-115781
            808-1296            Z22551.1           696-1184
            1297-1315           AL138499.4         129154-129172
            1316-2993           Z22551.1           1204-2881
            2994-4725           AY536375.1         1207-2938
            4726-4728           BQ014936.1         23-25               c
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..4728
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="kinectin 1"
                     /db_xref="GeneID:3895"
                     /db_xref="HGNC:HGNC:6467"
                     /db_xref="MIM:600381"
     exon            1..148
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            149..701
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4252
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="isoform a is encoded by transcript variant 2; CG-1
                     antigen; kinesin receptor"
                     /codon_start=1
                     /product="kinectin isoform a"
                     /protein_id="NP_001072989.1"
                     /db_xref="CCDS:CCDS41957.1"
                     /db_xref="GeneID:3895"
                     /db_xref="HGNC:HGNC:6467"
                     /db_xref="MIM:600381"
                     /translation="MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKRE
                     QKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPL
                     NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAA
                     SKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKT
                     ENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETD
                     KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQL
                     QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQN
                     KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
                     LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRT
                     AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEES
                     LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLA
                     SERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI
                     RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK
                     DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE
                     LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL
                     SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV
                     AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL
                     FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN
                     DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
                     LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET
                     EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR
                     EREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQL
                     NETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
                     KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE"
     exon            702..839
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1010
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1141
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1258
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1399
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1506
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1639
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1727
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1894
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1963
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2001
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2092
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2161
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2199
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2281
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2350
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2385
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2476
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2545
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2583
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2674
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2743
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2781
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2872
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2941
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..2979
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3070
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3139
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3177
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3268
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3355
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3445
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3526
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3616
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3709
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3781
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3865
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..3949
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4033
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4126
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4247
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4728
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4704..4709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="hexamer: AATAAA"
     polyA_site      4728
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /note="major polyA site"
ORIGIN      
        1 gaagccgccc gtttcctgcc gagcggcgcg acggcacctg agcgactgcg gcggcggcgg
       61 cggcggcggc ggcgcctcgg agcgggcggc ccgggctgta gtgccggcgc cgccgcgtct
      121 tcccggtctc ctttcccggc cgcacagggt tttataggat cacattgaca aaagtaccat
      181 ggagttttat gagtcagcat attttattgt tcttattcct tcaatagtta ttacagtaat
      241 tttcctcttc ttctggcttt tcatgaaaga aacattatat gatgaagttc ttgcaaaaca
      301 gaaaagagaa caaaagctta ttcctaccaa aacagataaa aagaaagcag aaaagaaaaa
      361 gaataaaaag aaagaaatcc agaatggaaa cctccatgaa tccgactctg agagtgtacc
      421 tcgagacttt aaattatcag atgctttggc agtagaagat gatcaagttg cacctgttcc
      481 attgaatgtc gttgaaactt caagtagtgt tagggaaaga aaaaagaagg aaaagaaaca
      541 aaagcctgtg cttgaagagc aggtcatcaa agaaagtgac gcatcaaaga ttcctggcaa
      601 aaaagtagaa cctgtcccag ttactaaaca gcccacccct ccctctgaag cagctgcctc
      661 gaagaagaaa ccagggcaga agaagtctaa aaatggaagc gatgaccagg ataaaaaggt
      721 ggaaactctc atggtaccat caaaaaggca agaagcattg cccctccacc aagagactaa
      781 acaagaaagt ggatcaggga agaagaaagc ttcatcaaag aaacaaaaga cagaaaatgt
      841 cttcgtagat gaacccctta ttcatgcaac tacttatatt cctttgatgg ataatgctga
      901 ctcaagtcct gtggtagata agagagaggt tattgatttg cttaaacctg accaagtaga
      961 agggatccag aaatctggga ctaaaaaact gaagaccgaa actgacaaag aaaatgctga
     1021 agtgaagttt aaagattttc ttctgtcctt gaagactatg atgttttctg aagatgaggc
     1081 tctttgtgtt gtagacttgc taaaggagaa gtctggtgta atacaagatg ctttaaagaa
     1141 gtcaagtaag ggagaattga ctacgcttat acatcagctt caagaaaagg acaagttact
     1201 cgctgctgtg aaggaagatg ctgctgctac aaaggatcgg tgtaagcagt taacccagga
     1261 aatgatgaca gagaaagaaa gaagcaatgt ggttataaca aggatgaaag atcgaattgg
     1321 aacattagaa aaggaacata atgtatttca aaacaaaata catgtcagtt atcaagagac
     1381 tcaacagatg cagatgaagt ttcagcaagt tcgtgagcag atggaggcag agatagctca
     1441 cttgaagcag gaaaatggta tactgagaga tgcagtcagc aacactacaa atcaactgga
     1501 aagcaagcag tctgcagaac taaataaact acgccaggat tatgctaggt tggtgaatga
     1561 gctgactgag aaaacaggaa agctacagca agaggaagtc caaaagaaga atgctgagca
     1621 agcagctact cagttgaagg ttcaactaca agaagctgag agaaggtggg aagaagttca
     1681 gagctacatc aggaagagaa cagcggaaca tgaggcagca cagcaagatt tacagagtaa
     1741 atttgtggcc aaagaaaatg aagtacagag tctgcatagt aagcttacag ataccttggt
     1801 atcaaaacaa cagttggagc aaagactaat gcagttaatg gaatcagagc agaaaagggt
     1861 gaacaaagaa gagtctctac aaatgcaggt tcaggatatt ttggagcaga atgaggcttt
     1921 gaaagctcaa attcagcagt tccattccca gatagcagcc cagacctccg cttcagttct
     1981 agcagaagaa ttacataaag tgattgcaga aaaggataag cagataaaac agactgaaga
     2041 ttctttagca agtgaacgtg atcgtttaac aagtaaagaa gaggaactta aggatataca
     2101 gaatatgaat ttcttattaa aagctgaagt gcagaaatta caggccctgg caaatgagca
     2161 ggctgctgct gcacatgaat tggagaagat gcaacaaagt gtttatgtta aagatgataa
     2221 aataagattg ctggaagagc aactacaaca tgaaatttca aacaaaatgg aagaatttaa
     2281 gattctaaat gaccaaaaca aagcattaaa atcagaagtt cagaagctac agactcttgt
     2341 ttctgaacag cctaataagg atgttgtgga acaaatggaa aaatgcattc aagaaaaaga
     2401 tgagaagtta aagactgtgg aagaattact tgaaactgga cttattcagg tggcaactaa
     2461 agaagaggag ctgaatgcaa taagaacaga aaattcatct ctgacaaaag aagttcaaga
     2521 cttaaaagct aagcaaaatg atcaggtttc ttttgcctct ctagttgaag aacttaagaa
     2581 agtgatccat gagaaagatg gaaagatcaa gtctgtagaa gagcttctgg aggcagaact
     2641 tctcaaagtt gctaacaagg agaaaactgt tcaggatttg aaacaggaaa taaaggctct
     2701 aaaagaagaa ataggaaatg tccagcttga aaaggctcaa cagttatcta tcacttccaa
     2761 agttcaggag cttcagaact tattaaaagg aaaagaggaa cagatgaata ccatgaaggc
     2821 tgttttggaa gagaaagaga aagacctagc caatacaggg aagtggttac aggatcttca
     2881 agaagaaaat gaatctttaa aagcacatgt tcaggaagta gcacaacata acttgaaaga
     2941 ggcctcttct gcatcacagt ttgaagaact tgagattgtg ttgaaagaaa aggaaaatga
     3001 attgaagagg ttagaagcca tgctaaaaga gagggagagt gatctttcta gcaaaacaca
     3061 gctgttacag gatgtacaag atgaaaacaa attgtttaag tcccaaattg agcagcttaa
     3121 acaacaaaac taccaacagg catcttcttt tccccctcat gaagaattat taaaagtaat
     3181 ttcagaaaga gagaaagaaa taagtggtct ctggaatgag ttagattctt tgaaggatgc
     3241 agttgaacac cagaggaaga aaaacaatga ccttcgggag aaaaactggg aagcaatgga
     3301 agcattggca tcaactgaaa aaatgctgca ggacaaagtg aacaagactt ccaaggaaag
     3361 gcagcaacag gtggaagctg ttgagttgga ggctaaagaa gttctcaaaa aattatttcc
     3421 aaaggtgtct gtcccttcta atttgagtta tggtgaatgg ttgcatggat ttgaaaaaaa
     3481 ggcaaaagaa tgtatggctg gaacttcagg gtcagaggag gttaaggttc tagagcacaa
     3541 gttgaaagaa gctgatgaaa tgcacacatt gttacagcta gagtgtgaaa aatacaaatc
     3601 cgtccttgca gaaacagaag gaattttaca gaagctacag agaagtgttg agcaagaaga
     3661 aaataaatgg aaagttaagg tcgatgaatc acacaagact attaaacaga tgcagtcatc
     3721 atttacatct tcagaacaag agctagagcg attaagaagc gaaaataagg atattgaaaa
     3781 tctgagaaga gaacgagaac atttggaaat ggaactagaa aaggcagaga tggaacgatc
     3841 tacctatgtt acagaagtca gagagctgaa agatctgttg actgaattgc agaaaaaact
     3901 tgatgattca tattctgaag cagtaagaca gaatgaagag ctaaatttgt tgaaggcaca
     3961 gttaaatgaa acactcacaa aacttagaac tgaacaaaat gaaagacaga aggtagctgg
     4021 tgatttgcat aaggctcaac agtcactgga gcttatccag tcaaaaatag taaaagctgc
     4081 tggagacact actgttattg aaaatagtga tgtttcccca gaaacggagt cttctgagaa
     4141 ggagacaatg tctgtaagtc taaatcagac tgtaacacag ttacagcagt tgcttcaggc
     4201 ggtaaaccaa cagctcacaa aggagaaaga gcactaccag gtgttagagt gaagtaattg
     4261 ggaaactgtt catttgagga taaaaaaggc attgtattat attttgccaa attaaagcct
     4321 tatttatgtt ttcacccttt ctactttgtc agaaacactg aacagagttt tgtcttttct
     4381 aatccttgtt agactactga tttaaagaag gaaaaaaaaa agccaactct gtagacacct
     4441 tcagagttta gttttataat aaaaactgtt tgaataatta gacctttaca ttcctgaaga
     4501 taaacatgta atcttttatc ttattttgct caataaaatt gttcagaaga tcaaagtggt
     4561 aaagacaatg taaaatttaa cattttaata ctgatgttgt acactgtttt acttaacatt
     4621 ttgggaagta actgcctctg acttcaactc aagaaaacac ttttttgttg ctaatgtaat
     4681 cggtttttgt aatggcgtca gcaaataaaa ggatgcttat tattcaaa
//
