LOCUS       XM_047436991            5732 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens kinase suppressor of ras 1 (KSR1),
            transcript variant X12, mRNA.
ACCESSION   XM_047436991
VERSION     XM_047436991.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..5732
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="kinase suppressor of ras 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 28 ESTs, 372 long SRA reads, 2 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:8844"
                     /db_xref="HGNC:HGNC:6465"
                     /db_xref="MIM:601132"
     CDS             248..2689
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /codon_start=1
                     /product="kinase suppressor of Ras 1 isoform X8"
                     /protein_id="XP_047292947.1"
                     /db_xref="GeneID:8844"
                     /db_xref="HGNC:HGNC:6465"
                     /db_xref="MIM:601132"
                     /translation="MNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDS
                     SWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSP
                     TPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVF
                     QLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSW
                     LSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINN
                     PVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSA
                     TTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISA
                     FAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRP
                     WRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDG
                     HNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKT
                     SLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVR
                     EGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDW
                     PLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDML
                     EKLPKLNRRLSHPGHFWKSADRWRSRYYGKGRYGHPDFKSSCPILEEYINSSKVVPRF
                     ERFGLGVLESSNPKM"
ORIGIN      
        1 attcagtgac tggagaggca gagggaaggg gctcccgggc agtgcgggtt ccaggtgggc
       61 acagctggcg aagctggtcc gttacatttg taagcagagg cagtgcaagc tgagcgtggc
      121 tcccggtgag aggaccccag agctcaacag ctacccccgc ttcagcgact ggctgtacac
      181 tttcaacgtg aggccggagg tggtgcagga gatcccccga gacctcacgc tggatgccct
      241 gctggagatg aatgaggcca aggtgaagga gacgctgcgg cgctgtgggg ccagcgggga
      301 tgagtgtggc cgtctgcagt atgccctcac ctgcctgcgg aaggtgacag gcctgggagg
      361 ggagcacaag gaggactcca gttggagttc attggatgcg cggcgggaaa gtggctcagg
      421 gccttccacg gacaccctct cagcagccag cctgccctgg cccccaggga gctcccagct
      481 gggcagagca ggcaacagcg cccagggccc acgctccatc tccgtgtcag ctctgcccgc
      541 ctcagactcc cccaccccca gcttcagtga gggcctctca gacacctgta ttcccctgca
      601 cgccagcggc cggctgaccc cccgtgccct gcacagcttc atcaccccgc ccaccacacc
      661 ccagctgcga cggcacacca agctgaagcc accacggacg ccccccccac ccagccgcaa
      721 ggtcttccag ctgctgccca gcttccccac actcacccgg agcaagtccc atgagtctca
      781 gctggggaac cgcattgatg acgtctcctc gatgaggttt gatctctcgc atggatcccc
      841 acagatggta cggagggata tcgggctgtc ggtgacgcac aggttctcca ccaagtcctg
      901 gctgtcgcag gtctgccacg tgtgccagaa gagcatgata tttggagtga agtgcaagca
      961 ttgcaggttg aagtgtcaca acaaatgtac caaagaagcc cctgcctgta gaatatcctt
     1021 cctgccacta actcggcttc ggaggacaga atctgtcccc tcggacatca acaacccggt
     1081 ggacagagca gccgaacccc attttggaac cctccccaaa gcactgacaa agaaggagca
     1141 ccctccggcc atgaatcacc tggactccag cagcaaccct tcctccacca cctcctccac
     1201 accctcctca ccggcgccct tcccgacatc atccaaccca tccagcgcca ccacgccccc
     1261 caacccctca cctggccagc gggacagcag gttcaacttc ccagctgcct acttcattca
     1321 tcatagacag cagtttatct ttccagtgcc atctgctggc cattgctgga aatgcctcct
     1381 tattgcagaa agtttaaagg aaaacgcttt caacatttca gcctttgcac acgcagcccc
     1441 gctccctgaa gctgccgacg gtacccggct cgatgaccag ccgaaagcag atgtgttgga
     1501 agctcacgaa gcggaggctg aggagccaga ggctggcaag tcagaggcag aagacgatga
     1561 ggacgaggtg gacgacttgc cgagctctcg ccggccctgg cggggcccca tctctcgcaa
     1621 ggccagccag accagcgtgt acctgcagga gtgggacatc cccttcgagc aggtagagct
     1681 gggcgagccc atcgggcagg gccgctgggg ccgggtgcac cgcggccgct ggcatggcga
     1741 ggtggccatt cgcctgctgg agatggacgg ccacaaccag gaccacctga agctcttcaa
     1801 gaaagaggtg atgaactacc ggcagacgcg gcatgagaac gtggtgctct tcatgggggc
     1861 ctgcatgaac ccgccccacc tggccattat caccagcttc tgcaaggggc ggacgttgca
     1921 ctcgtttgtg agggacccca agacgtctct ggacatcaac aagacgaggc aaatcgctca
     1981 ggagatcatc aagggcatgg gatatcttca tgccaagggc atcgtacaca aagatctcaa
     2041 atctaagaac gtcttctatg acaacggcaa ggtggtcatc acagacttcg ggctgtttgg
     2101 gatctcaggc gtggtccgag agggacggcg tgagaaccag ctaaagctgt cccacgactg
     2161 gctgtgctat ctggcccctg agattgtacg cgagatgacc cccgggaagg acgaggatca
     2221 gctgccattc tccaaagctg ctgatgtcta tgcatttggg actgtttggt atgagctgca
     2281 agcaagagac tggcccttga agaaccaggc tgcagaggca tccatctggc agattggaag
     2341 cggggaagga atgaagcgtg tcctgacttc tgtcagcttg gggaaggaag tcagtgagat
     2401 cctgtcggcc tgctgggctt tcgacctgca ggagagaccc agcttcagcc tgctgatgga
     2461 catgctggag aaacttccca agctgaaccg gcggctctcc caccctggac acttctggaa
     2521 gtcagctgat cgctggagga gccgctacta tggaaaagga cgctacggcc accctgactt
     2581 taagagctcc tgtccgattc tggaggaata cattaacagc agcaaagttg taccccggtt
     2641 tgaaaggttt ggcttgggcg tcctggagtc cagtaatcca aagatgtagc cagccatatg
     2701 gtttttcgct gctgatctct ttctttttaa aatgtgtttc tgaaacatcc caacaaccac
     2761 cacgacaaaa aaacactgcc tgcccagcgc tgcaaaccag gagcacacgt cctagattca
     2821 gactgttggc cataaacccc actcgggaga tggagctgca cctgctattt cttaaaatga
     2881 caccaccaac aaccaaacct gtcatgacag acagcaaatg tttacacgta tatttctcct
     2941 gagtgaacct gatgttttac aataggtaat aataaaaaca gtctgtgcag atgcactggc
     3001 actgacggcc aggatggcgg aaatggccat cccctctgag gaccttgtag gcggtgaggg
     3061 acccatgctg ggccagaagg aagacaaaca tggtaattgc agctgttctt ggggtagggc
     3121 ggggagccca gaaggtctga tctggcctct gctttttggc ccaagactcc atcagggaaa
     3181 tctatctagg gctctcccct tgtcctttca aagggatact gccccttcct cgtcttgcag
     3241 aggaaaccct ggctaggaac tgagctagtt tatggagtct ggaattcctg gagagcttgg
     3301 gttcaccttc tcacccctgt aatccaggct gctcctgctg gaaaagtaga aacagaatcc
     3361 aaaaaaggtc tggactcacc cggtggttcc cagccagggt ttctgctgca aggtgaggaa
     3421 acatccatgg cttgtacaga tgtgagtctt tgatgaagcc cccaggcagg caccaaggtg
     3481 atgggactca gggccttggc ttttagatac atcccagtcc ctgactgaca tctgaccatg
     3541 agggctggat gggtgggaac aaggaggagt agatggcaaa agtacctgag cccacttccc
     3601 agccacaggg tgaccctggc actgtaaaaa ccctttgtca gtcatgccag aaggttctag
     3661 aactgcccac ctcttccatt tcagtcctgc tgaaacccct tagcctattt ccgactcctc
     3721 tgtccatgct ctgagttcag ctgggcagtg tgtgggctat cacccctttc atttagacct
     3781 acctagctgg cccccatctg cagagccttc cttagcacca ttaggccttc tacttgtgtc
     3841 catttgaagc aggaggggct ggatttggaa aagtctttga agtgagagca ccacgcttgt
     3901 cttcgttaga aactcttaac tgcagaaaaa agttccagat ggcaagggag cccttaagtg
     3961 gagattaggt tgcattagac tccaaaacca gaaaggaaaa agggtgatgg gagtggagac
     4021 gtgattggat tcaggcccag aacctgtgac catgctctga gctcagactt ggggagggag
     4081 gggtgtggct cccacccctt ccagttaaga cctgcctagc agagccccag tctccagccc
     4141 cttccctagc accagagtct ggtcaaaatg ccacagaaaa tgagctgctc tgccagcaag
     4201 ctgtggagct gcctcctctc caggcctggc atcccttggt cagcccctcc tgggagggca
     4261 cagccgtatt acagtgccag tgtgcctggc catcagcatc ttcacccttc ccagtctgtg
     4321 tggggaggct gtaaaccccg tggattcagc tccgtgtgga gtttctgtgc tatggtggga
     4381 ctgctcattt tgccccatca tccctttggc ctcccacaca cctgcccctt cccagggatc
     4441 acgtgtgtct ccagcctttc acctttctat tgcaatggtg gcctttgtcc aggcaagagc
     4501 aggcctgatg gatgtactgg tgagccccac agttggatgt cagctcagcc gtccaactgg
     4561 gaggaacagt aggctcagtt cctccctgac ccctgacacc aggccgcagt gggcatgcac
     4621 aggcccacag aaagtcagtc tgggttttgc ttttctcgtg agcatcacag ttaaagaagc
     4681 gctcattgag caactacagt gcacttggtc ttctgcaagt gctgggcacc tagagatagg
     4741 aacagtcatg gtccctgctc ttaaggaact gatgacctgg tggggccctg ttgtcttcaa
     4801 ggaacccaga agccactggg ccccaaaggt ggaactgaag gactgggggc agctggctct
     4861 cagcctgcca cctctgcact gcctgccttt aaagaacccc accccacccc atgatggccc
     4921 cctctgttcc ccttgtattt cagtgactgt gaattgaggt taggaaggca cacctgccct
     4981 tctgtgtgct ctctccacac gaaggatgac agatactgtg aattcagccc tcacggccaa
     5041 ctgtgaaggg gatggagaag gctgggaggg ctcggggaga gctcttaggg gctgcggaag
     5101 tccccacggg ggtctgagag tggagcccaa gctttggccc tccaggcatc cccagtttcc
     5161 agcctcacct ctgaagccct gctgccttta accaccagag ccgcagcccc ctgggtttct
     5221 gtctaactcg aagtcttgaa tcctagctag tttggggttg tgagcagtgt gtagcaaagt
     5281 tgatctctcc atgtcaccaa atcaaaacac cctctgtcat cctacggcat ttcctcttga
     5341 ggtcacagag aggaatggca agccctggaa acctgtgtta ttctgtgttg atttggtgtg
     5401 gggggagggt ggagacgtaa atgtgaagcc agttggagtt tgtgctatgc agcagtgtta
     5461 gccaggatct catcagcgtg caaacctagc atcttctgtg gccacaagcc acacacttgc
     5521 tttttttgaa tgtgatgtaa aatttgtaca gtaaagtttt tatattttct atcaactaca
     5581 tttgtcttcc agacatgcta ttaatttaaa ttaaaatggt tagtattaac aaacatgctg
     5641 tatcgggttt ttttgccact ggcaagaaca tgccctctgt gctaagccag gcctgggtgt
     5701 ctggagtttg tgaataaagt tataccaagg tg
//
