LOCUS       NM_001394584            5491 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens kinase suppressor of ras 1 (KSR1), transcript variant
            4, mRNA.
ACCESSION   NM_001394584
VERSION     NM_001394584.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5491)
  AUTHORS   Daley,B.R., Vieira,H.M., Rao,C., Hughes,J.M., Beckley,Z.M.,
            Huisman,D.H., Chatterjee,D., Sealover,N.E., Cox,K., Askew,J.W.,
            Svoboda,R.A., Fisher,K.W., Lewis,R.E. and Kortum,R.L.
  TITLE     SOS1 and KSR1 modulate MEK inhibitor responsiveness to target
            resistant cell populations based on PI3K and KRAS mutation status
  JOURNAL   Proc Natl Acad Sci U S A 120 (47), e2313137120 (2023)
   PUBMED   37972068
  REMARK    GeneRIF: SOS1 and KSR1 modulate MEK inhibitor responsiveness to
            target resistant cell populations based on PI3K and KRAS mutation
            status.
REFERENCE   2  (bases 1 to 5491)
  AUTHORS   Liu,Z., Krstic,A., Neve,A., Casalou,C., Rauch,N., Wynne,K.,
            Cassidy,H., McCann,A., Kavanagh,E., McCann,B., Blanco,A., Rauch,J.
            and Kolch,W.
  TITLE     Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed
            Phenotype of BRAFV600E Mutant Human Melanoma Cells
  JOURNAL   Int J Mol Sci 24 (14), 11821 (2023)
   PUBMED   37511580
  REMARK    GeneRIF: Kinase Suppressor of RAS 1 (KSR1) Maintains the
            Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5491)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5491)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 5491)
  AUTHORS   Zheng,W., Yang,Z., Song,P., Sun,Y., Liu,P., Yue,L., Lv,K., Wang,X.,
            Shen,Y., Si,J., Zhang,X., Ke,Y., Cheng,H. and Hu,W.
  TITLE     SHP2 inhibition mitigates adaptive resistance to MEK inhibitors in
            KRAS-mutant gastric cancer through the suppression of KSR1 activity
  JOURNAL   Cancer Lett 555, 216029 (2023)
   PUBMED   36493900
  REMARK    GeneRIF: SHP2 inhibition mitigates adaptive resistance to MEK
            inhibitors in KRAS-mutant gastric cancer through the suppression of
            KSR1 activity.
REFERENCE   6  (bases 1 to 5491)
  AUTHORS   Matheny,S.A., Chen,C., Kortum,R.L., Razidlo,G.L., Lewis,R.E. and
            White,M.A.
  TITLE     Ras regulates assembly of mitogenic signalling complexes through
            the effector protein IMP
  JOURNAL   Nature 427 (6971), 256-260 (2004)
   PUBMED   14724641
REFERENCE   7  (bases 1 to 5491)
  AUTHORS   Roy,F. and Therrien,M.
  TITLE     MAP kinase module: the Ksr connection
  JOURNAL   Curr Biol 12 (9), R325-R327 (2002)
   PUBMED   12007434
REFERENCE   8  (bases 1 to 5491)
  AUTHORS   Yin,X.L., Chen,S., Yan,J., Hu,Y. and Gu,J.X.
  TITLE     Identification of interaction between MEK2 and A-Raf-1
  JOURNAL   Biochim Biophys Acta 1589 (1), 71-76 (2002)
   PUBMED   11909642
REFERENCE   9  (bases 1 to 5491)
  AUTHORS   Xing,H.R., Lozano,J. and Kolesnick,R.
  TITLE     Epidermal growth factor treatment enhances the kinase activity of
            kinase suppressor of Ras
  JOURNAL   J Biol Chem 275 (23), 17276-17280 (2000)
   PUBMED   10764733
REFERENCE   10 (bases 1 to 5491)
  AUTHORS   Therrien,M., Chang,H.C., Solomon,N.M., Karim,F.D., Wassarman,D.A.
            and Rubin,G.M.
  TITLE     KSR, a novel protein kinase required for RAS signal transduction
  JOURNAL   Cell 83 (6), 879-888 (1995)
   PUBMED   8521512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069366.8 and AC015688.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142670,
                              SAMEA2142853 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC069366.8         36136-36254         c
            120-267             AC069366.8         18953-19100         c
            268-727             AC069366.8         13487-13946         c
            728-788             AC069366.8         8057-8117           c
            789-872             AC069366.8         5698-5781           c
            873-934             AC069366.8         4170-4231           c
            935-1041            AC069366.8         3966-4072           c
            1042-1210           AC015688.11        106376-106544       c
            1211-1252           AC015688.11        102411-102452       c
            1253-1307           AC015688.11        99924-99978         c
            1308-1356           AC015688.11        99084-99132         c
            1357-1736           AC015688.11        97999-98378         c
            1737-1833           AC015688.11        95802-95898         c
            1834-1967           AC015688.11        94483-94616         c
            1968-2099           AC015688.11        93614-93745         c
            2100-2235           AC015688.11        92183-92318         c
            2236-2369           AC015688.11        86384-86517         c
            2370-5491           AC015688.11        77377-80498         c
FEATURES             Location/Qualifiers
     source          1..5491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..5491
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="kinase suppressor of ras 1"
                     /db_xref="GeneID:8844"
                     /db_xref="HGNC:HGNC:6465"
                     /db_xref="MIM:601132"
     exon            1..119
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            120..267
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..727
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..788
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     CDS             751..2448
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /EC_number="2.7.11.1"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="kinase suppressor of Ras 1 isoform 4"
                     /protein_id="NP_001381513.1"
                     /db_xref="GeneID:8844"
                     /db_xref="HGNC:HGNC:6465"
                     /db_xref="MIM:601132"
                     /translation="MVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKC
                     HNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPA
                     MNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHH
                     RQQFIFPDISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDED
                     EVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG
                     EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGR
                     TLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITD
                     FGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFG
                     TVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQE
                     RPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM"
     exon            789..872
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..934
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1041
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1210
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1252
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1307
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1356
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1736
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1833
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1967
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2099
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2235
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2369
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..5491
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5369..5374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="hexamer: ATTAAA"
     polyA_site      5392
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
     regulatory      5472..5477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="hexamer: AATAAA"
     polyA_site      5491
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="major polyA site"
ORIGIN      
        1 agttctagct gggagaggtg ggtgctgcag agtctgggat tccagggtga aagccacagg
       61 ttcccctgaa taagctctta ctgctggtgg ttcctgaact gaagatgcag gcggatctgg
      121 agatcccccg agacctcacg ctggatgccc tgctggagat gaatgaggcc aaggtgaagg
      181 agacgctgcg gcgctgtggg gccagcgggg atgagtgtgg ccgtctgcag tatgccctca
      241 cctgcctgcg gaaggtgaca ggcctgggag gggagcacaa ggaggactcc agttggagtt
      301 cattggatgc gcggcgggaa agtggctcag ggccttccac ggacaccctc tcagcagcca
      361 gcctgccctg gcccccaggg agctcccagc tgggcagagc aggcaacagc gcccagggcc
      421 cacgctccat ctccgtgtca gctctgcccg cctcagactc ccccaccccc agcttcagtg
      481 agggcctctc agacacctgt attcccctgc acgccagcgg ccggctgacc ccccgtgccc
      541 tgcacagctt catcaccccg cccaccacac cccagctgcg acggcacacc aagctgaagc
      601 caccacggac gcccccccca cccagccgca aggtcttcca gctgctgccc agcttcccca
      661 cactcacccg gagcaagtcc catgagtctc agctggggaa ccgcattgat gacgtctcct
      721 cgatgagatc tctcgcatgg atccccacag atggtacgga gggatatcgg gctgtcggtg
      781 acgcacaggt tctccaccaa gtcctggctg tcgcaggtct gccacgtgtg ccagaagagc
      841 atgatatttg gagtgaagtg caagcattgc aggttgaagt gtcacaacaa atgtaccaaa
      901 gaagcccctg cctgtagaat atccttcctg ccactaactc ggcttcggag gacagaatct
      961 gtcccctcgg acatcaacaa cccggtggac agagcagccg aaccccattt tggaaccctc
     1021 cccaaagcac tgacaaagaa ggagcaccct ccggccatga atcacctgga ctccagcagc
     1081 aacccttcct ccaccacctc ctccacaccc tcctcaccgg cgcccttccc gacatcatcc
     1141 aacccatcca gcgccaccac gccccccaac ccctcacctg gccagcggga cagcaggttc
     1201 aacttcccag ctgcctactt cattcatcat agacagcagt ttatctttcc agacatttca
     1261 gcctttgcac acgcagcccc gctccctgaa gctgccgacg gtacccggct cgatgaccag
     1321 ccgaaagcag atgtgttgga agctcacgaa gcggaggctg aggagccaga ggctggcaag
     1381 tcagaggcag aagacgatga ggacgaggtg gacgacttgc cgagctctcg ccggccctgg
     1441 cggggcccca tctctcgcaa ggccagccag accagcgtgt acctgcagga gtgggacatc
     1501 cccttcgagc aggtagagct gggcgagccc atcgggcagg gccgctgggg ccgggtgcac
     1561 cgcggccgct ggcatggcga ggtggccatt cgcctgctgg agatggacgg ccacaaccag
     1621 gaccacctga agctcttcaa gaaagaggtg atgaactacc ggcagacgcg gcatgagaac
     1681 gtggtgctct tcatgggggc ctgcatgaac ccgccccacc tggccattat caccagcttc
     1741 tgcaaggggc ggacgttgca ctcgtttgtg agggacccca agacgtctct ggacatcaac
     1801 aagacgaggc aaatcgctca ggagatcatc aagggcatgg gatatcttca tgccaagggc
     1861 atcgtacaca aagatctcaa atctaagaac gtcttctatg acaacggcaa ggtggtcatc
     1921 acagacttcg ggctgtttgg gatctcaggc gtggtccgag agggacggcg tgagaaccag
     1981 ctaaagctgt cccacgactg gctgtgctat ctggcccctg agattgtacg cgagatgacc
     2041 cccgggaagg acgaggatca gctgccattc tccaaagctg ctgatgtcta tgcatttggg
     2101 actgtttggt atgagctgca agcaagagac tggcccttga agaaccaggc tgcagaggca
     2161 tccatctggc agattggaag cggggaagga atgaagcgtg tcctgacttc tgtcagcttg
     2221 gggaaggaag tcagtgagat cctgtcggcc tgctgggctt tcgacctgca ggagagaccc
     2281 agcttcagcc tgctgatgga catgctggag aaacttccca agctgaaccg gcggctctcc
     2341 caccctggac acttctggaa gtcagctgac attaacagca gcaaagttgt accccggttt
     2401 gaaaggtttg gcttgggcgt cctggagtcc agtaatccaa agatgtagcc agccatatgg
     2461 tttttcgctg ctgatctctt tctttttaaa atgtgtttct gaaacatccc aacaaccacc
     2521 acgacaaaaa aacactgcct gcccagcgct gcaaaccagg agcacacgtc ctagattcag
     2581 actgttggcc ataaacccca ctcgggagat ggagctgcac ctgctatttc ttaaaatgac
     2641 accaccaaca accaaacctg tcatgacaga cagcaaatgt ttacacgtat atttctcctg
     2701 agtgaacctg atgttttaca ataggtaata ataaaaacag tctgtgcaga tgcactggca
     2761 ctgacggcca ggatggcgga aatggccatc ccctctgagg accttgtagg cggtgaggga
     2821 cccatgctgg gccagaagga agacaaacat ggtaattgca gctgttcttg gggtagggcg
     2881 gggagcccag aaggtctgat ctggcctctg ctttttggcc caagactcca tcagggaaat
     2941 ctatctaggg ctctcccctt gtcctttcaa agggatactg ccccttcctc gtcttgcaga
     3001 ggaaaccctg gctaggaact gagctagttt atggagtctg gaattcctgg agagcttggg
     3061 ttcaccttct cacccctgta atccaggctg ctcctgctgg aaaagtagaa acagaatcca
     3121 aaaaaggtct ggactcaccc ggtggttccc agccagggtt tctgctgcaa ggtgaggaaa
     3181 catccatggc ttgtacagat gtgagtcttt gatgaagccc ccaggcaggc accaaggtga
     3241 tgggactcag ggccttggct tttagataca tcccagtccc tgactgacat ctgaccatga
     3301 gggctggatg ggtgggaaca aggaggagta gatggcaaaa gtacctgagc ccacttccca
     3361 gccacagggt gaccctggca ctgtaaaaac cctttgtcag tcatgccaga aggttctaga
     3421 actgcccacc tcttccattt cagtcctgct gaaacccctt agcctatttc cgactcctct
     3481 gtccatgctc tgagttcagc tgggcagtgt gtgggctatc acccctttca tttagaccta
     3541 cctagctggc ccccatctgc agagccttcc ttagcaccat taggccttct acttgtgtcc
     3601 atttgaagca ggaggggctg gatttggaaa agtctttgaa gtgagagcac cacgcttgtc
     3661 ttcgttagaa actcttaact gcagaaaaaa gttccagatg gcaagggagc ccttaagtgg
     3721 agattaggtt gcattagact ccaaaaccag aaaggaaaaa gggtgatggg agtggagacg
     3781 tgattggatt caggcccaga acctgtgacc atgctctgag ctcagacttg gggagggagg
     3841 ggtgtggctc ccaccccttc cagttaagac ctgcctagca gagccccagt ctccagcccc
     3901 ttccctagca ccagagtctg gtcaaaatgc cacagaaaat gagctgctct gccagcaagc
     3961 tgtggagctg cctcctctcc aggcctggca tcccttggtc agcccctcct gggagggcac
     4021 agccgtatta cagtgccagt gtgcctggcc atcagcatct tcacccttcc cagtctgtgt
     4081 ggggaggctg taaaccccgt ggattcagct ccgtgtggag tttctgtgct atggtgggac
     4141 tgctcatttt gccccatcat ccctttggcc tcccacacac ctgccccttc ccagggatca
     4201 cgtgtgtctc cagcctttca cctttctatt gcaatggtgg cctttgtcca ggcaagagca
     4261 ggcctgatgg atgtactggt gagccccaca gttggatgtc agctcagccg tccaactggg
     4321 aggaacagta ggctcagttc ctccctgacc cctgacacca ggccgcagtg ggcatgcaca
     4381 ggcccacaga aagtcagtct gggttttgct tttctcgtga gcatcacagt taaagaagcg
     4441 ctcattgagc aactacagtg cacttggtct tctgcaagtg ctgggcacct agagatagga
     4501 acagtcatgg tccctgctct taaggaactg atgacctggt ggggccctgt tgtcttcaag
     4561 gaacccagaa gccactgggc cccaaaggtg gaactgaagg actgggggca gctggctctc
     4621 agcctgccac ctctgcactg cctgccttta aagaacccca ccccacccca tgatggcccc
     4681 ctctgttccc cttgtatttc agtgactgtg aattgaggtt aggaaggcac acctgccctt
     4741 ctgtgtgctc tctccacacg aaggatgaca gatactgtga attcagccct cacggccaac
     4801 tgtgaagggg atggagaagg ctgggagggc tcggggagag ctcttagggg ctgcggaagt
     4861 ccccacgggg gtctgagagt ggagcccaag ctttggccct ccaggcatcc ccagtttcca
     4921 gcctcacctc tgaagccctg ctgcctttaa ccaccagagc cgcagccccc tgggtttctg
     4981 tctaactcga agtcttgaat cctagctagt ttggggttgt gagcagtgtg tagcaaagtt
     5041 gatctctcca tgtcaccaaa tcaaaacacc ctctgtcatc ctacggcatt tcctcttgag
     5101 gtcacagaga ggaatggcaa gccctggaaa cctgtgttat tctgtgttga tttggtgtgg
     5161 ggggagggtg gagacgtaaa tgtgaagcca gttggagttt gtgctatgca gcagtgttag
     5221 ccaggatctc atcagcgtgc aaacctagca tcttctgtgg ccacaagcca cacacttgct
     5281 ttttttgaat gtgatgtaaa atttgtacag taaagttttt atattttcta tcaactacat
     5341 ttgtcttcca gacatgctat taatttaaat taaaatggtt agtattaaca aacatgctgt
     5401 atcgggtttt tttgccactg gcaagaacat gccctctgtg ctaagccagg cctgggtgtc
     5461 tggagtttgt gaataaagtt ataccaaggt g
//
