LOCUS       NM_001394583            6026 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens kinase suppressor of ras 1 (KSR1), transcript variant
            3, mRNA.
ACCESSION   NM_001394583
VERSION     NM_001394583.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6026)
  AUTHORS   Daley,B.R., Vieira,H.M., Rao,C., Hughes,J.M., Beckley,Z.M.,
            Huisman,D.H., Chatterjee,D., Sealover,N.E., Cox,K., Askew,J.W.,
            Svoboda,R.A., Fisher,K.W., Lewis,R.E. and Kortum,R.L.
  TITLE     SOS1 and KSR1 modulate MEK inhibitor responsiveness to target
            resistant cell populations based on PI3K and KRAS mutation status
  JOURNAL   Proc Natl Acad Sci U S A 120 (47), e2313137120 (2023)
   PUBMED   37972068
  REMARK    GeneRIF: SOS1 and KSR1 modulate MEK inhibitor responsiveness to
            target resistant cell populations based on PI3K and KRAS mutation
            status.
REFERENCE   2  (bases 1 to 6026)
  AUTHORS   Liu,Z., Krstic,A., Neve,A., Casalou,C., Rauch,N., Wynne,K.,
            Cassidy,H., McCann,A., Kavanagh,E., McCann,B., Blanco,A., Rauch,J.
            and Kolch,W.
  TITLE     Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed
            Phenotype of BRAFV600E Mutant Human Melanoma Cells
  JOURNAL   Int J Mol Sci 24 (14), 11821 (2023)
   PUBMED   37511580
  REMARK    GeneRIF: Kinase Suppressor of RAS 1 (KSR1) Maintains the
            Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6026)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6026)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 6026)
  AUTHORS   Zheng,W., Yang,Z., Song,P., Sun,Y., Liu,P., Yue,L., Lv,K., Wang,X.,
            Shen,Y., Si,J., Zhang,X., Ke,Y., Cheng,H. and Hu,W.
  TITLE     SHP2 inhibition mitigates adaptive resistance to MEK inhibitors in
            KRAS-mutant gastric cancer through the suppression of KSR1 activity
  JOURNAL   Cancer Lett 555, 216029 (2023)
   PUBMED   36493900
  REMARK    GeneRIF: SHP2 inhibition mitigates adaptive resistance to MEK
            inhibitors in KRAS-mutant gastric cancer through the suppression of
            KSR1 activity.
REFERENCE   6  (bases 1 to 6026)
  AUTHORS   Matheny,S.A., Chen,C., Kortum,R.L., Razidlo,G.L., Lewis,R.E. and
            White,M.A.
  TITLE     Ras regulates assembly of mitogenic signalling complexes through
            the effector protein IMP
  JOURNAL   Nature 427 (6971), 256-260 (2004)
   PUBMED   14724641
REFERENCE   7  (bases 1 to 6026)
  AUTHORS   Roy,F. and Therrien,M.
  TITLE     MAP kinase module: the Ksr connection
  JOURNAL   Curr Biol 12 (9), R325-R327 (2002)
   PUBMED   12007434
REFERENCE   8  (bases 1 to 6026)
  AUTHORS   Yin,X.L., Chen,S., Yan,J., Hu,Y. and Gu,J.X.
  TITLE     Identification of interaction between MEK2 and A-Raf-1
  JOURNAL   Biochim Biophys Acta 1589 (1), 71-76 (2002)
   PUBMED   11909642
REFERENCE   9  (bases 1 to 6026)
  AUTHORS   Xing,H.R., Lozano,J. and Kolesnick,R.
  TITLE     Epidermal growth factor treatment enhances the kinase activity of
            kinase suppressor of Ras
  JOURNAL   J Biol Chem 275 (23), 17276-17280 (2000)
   PUBMED   10764733
REFERENCE   10 (bases 1 to 6026)
  AUTHORS   Therrien,M., Chang,H.C., Solomon,N.M., Karim,F.D., Wassarman,D.A.
            and Rubin,G.M.
  TITLE     KSR, a novel protein kinase required for RAS signal transduction
  JOURNAL   Cell 83 (6), 879-888 (1995)
   PUBMED   8521512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069366.8 and AC015688.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000644974.2/ ENSP00000494552.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               AC069366.8         139718-140144       c
            428-568             AC069366.8         45884-46024         c
            569-716             AC069366.8         18953-19100         c
            717-1176            AC069366.8         13487-13946         c
            1177-1181           AC069366.8         10931-10935         c
            1182-1242           AC069366.8         8057-8117           c
            1243-1326           AC069366.8         5698-5781           c
            1327-1388           AC069366.8         4170-4231           c
            1389-1495           AC069366.8         3966-4072           c
            1496-1664           AC015688.11        106376-106544       c
            1665-1706           AC015688.11        102411-102452       c
            1707-1761           AC015688.11        99924-99978         c
            1762-1810           AC015688.11        99084-99132         c
            1811-2190           AC015688.11        97999-98378         c
            2191-2287           AC015688.11        95802-95898         c
            2288-2421           AC015688.11        94483-94616         c
            2422-2553           AC015688.11        93614-93745         c
            2554-2689           AC015688.11        92183-92318         c
            2690-2823           AC015688.11        86384-86517         c
            2824-2904           AC015688.11        82539-82619         c
            2905-6026           AC015688.11        77377-80498         c
FEATURES             Location/Qualifiers
     source          1..6026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..6026
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="kinase suppressor of ras 1"
                     /db_xref="GeneID:8844"
                     /db_xref="HGNC:HGNC:6465"
                     /db_xref="MIM:601132"
     exon            1..427
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2983
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="kinase suppressor of Ras 1 isoform 3"
                     /protein_id="NP_001381512.1"
                     /db_xref="CCDS:CCDS92281.1"
                     /db_xref="GeneID:8844"
                     /db_xref="HGNC:HGNC:6465"
                     /db_xref="MIM:601132"
                     /translation="MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQL
                     QKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPE
                     LNSYPRFSDWLYTFNVRPEVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRL
                     QYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRA
                     GNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQ
                     LRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGS
                     PQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACR
                     ISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSS
                     TTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPDISAF
                     AHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPW
                     RGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGH
                     NQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTS
                     LDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVRE
                     GRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWP
                     LKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLE
                     KLPKLNRRLSHPGHFWKSADRWRSRYYGKGRYGHPDFKSSCPILEEYINSSKVVPRFE
                     RFGLGVLESSNPKM"
     exon            428..568
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..716
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1176
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1181
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1242
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1326
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1388
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1495
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1664
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1706
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1761
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1810
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..2190
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2287
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2421
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2553
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2689
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2823
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2904
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..6026
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5904..5909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="hexamer: ATTAAA"
     polyA_site      5927
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
     regulatory      6007..6012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="hexamer: AATAAA"
     polyA_site      6026
                     /gene="KSR1"
                     /gene_synonym="KSR; RSU2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccgcgg ctttcgcttt gctgccgcgg ctgggagggt ggaagcggca gactcagcgg
       61 ccggctctac cggcgtcccg gctcgggcag cgccgagggg cgctcctggt ccagctctcc
      121 tggctcgggg gttccttgcc gaggcgcccg cgccccgggc tcccagcctc ggccgccgcg
      181 gccccgatgc cgaggcatgg atagagcagc gctgcgcgcg gcggcgatgg gagagaagaa
      241 ggagggcggt ggcggggggg atgcggcggc cgcggaggga ggcgcagggg ccgcggccag
      301 ccgggcgctg cagcagtgcg ggcagctcca gaagctcatc gacatctcca tcggcagcct
      361 gcgcgggctg cgcaccaagt gcgctgtgtc caacgacctc acccagcagg agatacggac
      421 cctggaggcg aagctggtcc gttacatttg taagcagagg cagtgcaagc tgagcgtggc
      481 tcccggtgag aggaccccag agctcaacag ctacccccgc ttcagcgact ggctgtacac
      541 tttcaacgtg aggccggagg tggtgcagga gatcccccga gacctcacgc tggatgccct
      601 gctggagatg aatgaggcca aggtgaagga gacgctgcgg cgctgtgggg ccagcgggga
      661 tgagtgtggc cgtctgcagt atgccctcac ctgcctgcgg aaggtgacag gcctgggagg
      721 ggagcacaag gaggactcca gttggagttc attggatgcg cggcgggaaa gtggctcagg
      781 gccttccacg gacaccctct cagcagccag cctgccctgg cccccaggga gctcccagct
      841 gggcagagca ggcaacagcg cccagggccc acgctccatc tccgtgtcag ctctgcccgc
      901 ctcagactcc cccaccccca gcttcagtga gggcctctca gacacctgta ttcccctgca
      961 cgccagcggc cggctgaccc cccgtgccct gcacagcttc atcaccccgc ccaccacacc
     1021 ccagctgcga cggcacacca agctgaagcc accacggacg ccccccccac ccagccgcaa
     1081 ggtcttccag ctgctgccca gcttccccac actcacccgg agcaagtccc atgagtctca
     1141 gctggggaac cgcattgatg acgtctcctc gatgaggttt gatctctcgc atggatcccc
     1201 acagatggta cggagggata tcgggctgtc ggtgacgcac aggttctcca ccaagtcctg
     1261 gctgtcgcag gtctgccacg tgtgccagaa gagcatgata tttggagtga agtgcaagca
     1321 ttgcaggttg aagtgtcaca acaaatgtac caaagaagcc cctgcctgta gaatatcctt
     1381 cctgccacta actcggcttc ggaggacaga atctgtcccc tcggacatca acaacccggt
     1441 ggacagagca gccgaacccc attttggaac cctccccaaa gcactgacaa agaaggagca
     1501 ccctccggcc atgaatcacc tggactccag cagcaaccct tcctccacca cctcctccac
     1561 accctcctca ccggcgccct tcccgacatc atccaaccca tccagcgcca ccacgccccc
     1621 caacccctca cctggccagc gggacagcag gttcaacttc ccagctgcct acttcattca
     1681 tcatagacag cagtttatct ttccagacat ttcagccttt gcacacgcag ccccgctccc
     1741 tgaagctgcc gacggtaccc ggctcgatga ccagccgaaa gcagatgtgt tggaagctca
     1801 cgaagcggag gctgaggagc cagaggctgg caagtcagag gcagaagacg atgaggacga
     1861 ggtggacgac ttgccgagct ctcgccggcc ctggcggggc cccatctctc gcaaggccag
     1921 ccagaccagc gtgtacctgc aggagtggga catccccttc gagcaggtag agctgggcga
     1981 gcccatcggg cagggccgct ggggccgggt gcaccgcggc cgctggcatg gcgaggtggc
     2041 cattcgcctg ctggagatgg acggccacaa ccaggaccac ctgaagctct tcaagaaaga
     2101 ggtgatgaac taccggcaga cgcggcatga gaacgtggtg ctcttcatgg gggcctgcat
     2161 gaacccgccc cacctggcca ttatcaccag cttctgcaag gggcggacgt tgcactcgtt
     2221 tgtgagggac cccaagacgt ctctggacat caacaagacg aggcaaatcg ctcaggagat
     2281 catcaagggc atgggatatc ttcatgccaa gggcatcgta cacaaagatc tcaaatctaa
     2341 gaacgtcttc tatgacaacg gcaaggtggt catcacagac ttcgggctgt ttgggatctc
     2401 aggcgtggtc cgagagggac ggcgtgagaa ccagctaaag ctgtcccacg actggctgtg
     2461 ctatctggcc cctgagattg tacgcgagat gacccccggg aaggacgagg atcagctgcc
     2521 attctccaaa gctgctgatg tctatgcatt tgggactgtt tggtatgagc tgcaagcaag
     2581 agactggccc ttgaagaacc aggctgcaga ggcatccatc tggcagattg gaagcgggga
     2641 aggaatgaag cgtgtcctga cttctgtcag cttggggaag gaagtcagtg agatcctgtc
     2701 ggcctgctgg gctttcgacc tgcaggagag acccagcttc agcctgctga tggacatgct
     2761 ggagaaactt cccaagctga accggcggct ctcccaccct ggacacttct ggaagtcagc
     2821 tgatcgctgg aggagccgct actatggaaa aggacgctac ggccaccctg actttaagag
     2881 ctcctgtccg attctggagg aatacattaa cagcagcaaa gttgtacccc ggtttgaaag
     2941 gtttggcttg ggcgtcctgg agtccagtaa tccaaagatg tagccagcca tatggttttt
     3001 cgctgctgat ctctttcttt ttaaaatgtg tttctgaaac atcccaacaa ccaccacgac
     3061 aaaaaaacac tgcctgccca gcgctgcaaa ccaggagcac acgtcctaga ttcagactgt
     3121 tggccataaa ccccactcgg gagatggagc tgcacctgct atttcttaaa atgacaccac
     3181 caacaaccaa acctgtcatg acagacagca aatgtttaca cgtatatttc tcctgagtga
     3241 acctgatgtt ttacaatagg taataataaa aacagtctgt gcagatgcac tggcactgac
     3301 ggccaggatg gcggaaatgg ccatcccctc tgaggacctt gtaggcggtg agggacccat
     3361 gctgggccag aaggaagaca aacatggtaa ttgcagctgt tcttggggta gggcggggag
     3421 cccagaaggt ctgatctggc ctctgctttt tggcccaaga ctccatcagg gaaatctatc
     3481 tagggctctc cccttgtcct ttcaaaggga tactgcccct tcctcgtctt gcagaggaaa
     3541 ccctggctag gaactgagct agtttatgga gtctggaatt cctggagagc ttgggttcac
     3601 cttctcaccc ctgtaatcca ggctgctcct gctggaaaag tagaaacaga atccaaaaaa
     3661 ggtctggact cacccggtgg ttcccagcca gggtttctgc tgcaaggtga ggaaacatcc
     3721 atggcttgta cagatgtgag tctttgatga agcccccagg caggcaccaa ggtgatggga
     3781 ctcagggcct tggcttttag atacatccca gtccctgact gacatctgac catgagggct
     3841 ggatgggtgg gaacaaggag gagtagatgg caaaagtacc tgagcccact tcccagccac
     3901 agggtgaccc tggcactgta aaaacccttt gtcagtcatg ccagaaggtt ctagaactgc
     3961 ccacctcttc catttcagtc ctgctgaaac cccttagcct atttccgact cctctgtcca
     4021 tgctctgagt tcagctgggc agtgtgtggg ctatcacccc tttcatttag acctacctag
     4081 ctggccccca tctgcagagc cttccttagc accattaggc cttctacttg tgtccatttg
     4141 aagcaggagg ggctggattt ggaaaagtct ttgaagtgag agcaccacgc ttgtcttcgt
     4201 tagaaactct taactgcaga aaaaagttcc agatggcaag ggagccctta agtggagatt
     4261 aggttgcatt agactccaaa accagaaagg aaaaagggtg atgggagtgg agacgtgatt
     4321 ggattcaggc ccagaacctg tgaccatgct ctgagctcag acttggggag ggaggggtgt
     4381 ggctcccacc ccttccagtt aagacctgcc tagcagagcc ccagtctcca gccccttccc
     4441 tagcaccaga gtctggtcaa aatgccacag aaaatgagct gctctgccag caagctgtgg
     4501 agctgcctcc tctccaggcc tggcatccct tggtcagccc ctcctgggag ggcacagccg
     4561 tattacagtg ccagtgtgcc tggccatcag catcttcacc cttcccagtc tgtgtgggga
     4621 ggctgtaaac cccgtggatt cagctccgtg tggagtttct gtgctatggt gggactgctc
     4681 attttgcccc atcatccctt tggcctccca cacacctgcc ccttcccagg gatcacgtgt
     4741 gtctccagcc tttcaccttt ctattgcaat ggtggccttt gtccaggcaa gagcaggcct
     4801 gatggatgta ctggtgagcc ccacagttgg atgtcagctc agccgtccaa ctgggaggaa
     4861 cagtaggctc agttcctccc tgacccctga caccaggccg cagtgggcat gcacaggccc
     4921 acagaaagtc agtctgggtt ttgcttttct cgtgagcatc acagttaaag aagcgctcat
     4981 tgagcaacta cagtgcactt ggtcttctgc aagtgctggg cacctagaga taggaacagt
     5041 catggtccct gctcttaagg aactgatgac ctggtggggc cctgttgtct tcaaggaacc
     5101 cagaagccac tgggccccaa aggtggaact gaaggactgg gggcagctgg ctctcagcct
     5161 gccacctctg cactgcctgc ctttaaagaa ccccacccca ccccatgatg gccccctctg
     5221 ttccccttgt atttcagtga ctgtgaattg aggttaggaa ggcacacctg cccttctgtg
     5281 tgctctctcc acacgaagga tgacagatac tgtgaattca gccctcacgg ccaactgtga
     5341 aggggatgga gaaggctggg agggctcggg gagagctctt aggggctgcg gaagtcccca
     5401 cgggggtctg agagtggagc ccaagctttg gccctccagg catccccagt ttccagcctc
     5461 acctctgaag ccctgctgcc tttaaccacc agagccgcag ccccctgggt ttctgtctaa
     5521 ctcgaagtct tgaatcctag ctagtttggg gttgtgagca gtgtgtagca aagttgatct
     5581 ctccatgtca ccaaatcaaa acaccctctg tcatcctacg gcatttcctc ttgaggtcac
     5641 agagaggaat ggcaagccct ggaaacctgt gttattctgt gttgatttgg tgtgggggga
     5701 gggtggagac gtaaatgtga agccagttgg agtttgtgct atgcagcagt gttagccagg
     5761 atctcatcag cgtgcaaacc tagcatcttc tgtggccaca agccacacac ttgctttttt
     5821 tgaatgtgat gtaaaatttg tacagtaaag tttttatatt ttctatcaac tacatttgtc
     5881 ttccagacat gctattaatt taaattaaaa tggttagtat taacaaacat gctgtatcgg
     5941 gtttttttgc cactggcaag aacatgccct ctgtgctaag ccaggcctgg gtgtctggag
     6001 tttgtgaata aagttatacc aaggtg
//
