LOCUS       NM_207392                426 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens keratinocyte differentiation associated protein
            (KRTDAP), transcript variant 1, mRNA.
ACCESSION   NM_207392
VERSION     NM_207392.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 426)
  AUTHORS   Tsuchida,S., Bonkobara,M., McMillan,J.R., Akiyama,M., Yudate,T.,
            Aragane,Y., Tezuka,T., Shimizu,H., Cruz,P.D. Jr. and Ariizumi,K.
  TITLE     Characterization of Kdap, a protein secreted by keratinocytes
  JOURNAL   J Invest Dermatol 122 (5), 1225-1234 (2004)
   PUBMED   15140226
  REMARK    GeneRIF: Kdap may serve as a soluble regulator of keratinocyte
            differentiation.
REFERENCE   2  (bases 1 to 426)
  AUTHORS   Oomizu,S., Sahuc,F., Asahina,K., Inamatsu,M., Matsuzaki,T.,
            Sasaki,M., Obara,M. and Yoshizato,K.
  TITLE     Kdap, a novel gene associated with the stratification of the
            epithelium
  JOURNAL   Gene 256 (1-2), 19-27 (2000)
   PUBMED   11054531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC130501.1, AY359007.1 and
            AI184682.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_207392.2.
            
            Summary: This gene encodes a protein which may function in the
            regulation of keratinocyte differentiation and maintenance of
            stratified epithelia. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX112106.1, AJ293408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338897.4/ ENSP00000339251.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC130501.1         68-77
            11-424              AY359007.1         1-414
            425-426             AI184682.1         8-9                 c
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..426
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /note="keratinocyte differentiation associated protein"
                     /db_xref="GeneID:388533"
                     /db_xref="HGNC:HGNC:16313"
                     /db_xref="MIM:617212"
     exon            1..109
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..322
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; KIPV467"
                     /codon_start=1
                     /product="keratinocyte differentiation-associated protein
                     isoform 1 precursor"
                     /protein_id="NP_997275.1"
                     /db_xref="CCDS:CCDS12462.1"
                     /db_xref="GeneID:388533"
                     /db_xref="HGNC:HGNC:16313"
                     /db_xref="MIM:617212"
                     /translation="MKIPVLPAVVLLSLLVLHSAQGATLGGPEEESTIENYASRPEAF
                     NTPFLNIDKLRSAFKADEFLNWHALFESIKRKLPFLNWDAFPKLKGLRSATPDAQ"
     exon            110..148
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /inference="alignment:Splign:2.1.0"
     exon            149..190
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /inference="alignment:Splign:2.1.0"
     exon            191..235
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /inference="alignment:Splign:2.1.0"
     exon            236..283
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /inference="alignment:Splign:2.1.0"
     exon            284..426
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /inference="alignment:Splign:2.1.0"
     regulatory      404..409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /note="hexamer: AATAAA"
     polyA_site      410
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
     polyA_site      426
                     /gene="KRTDAP"
                     /gene_synonym="KDAP; UNQ467"
                     /note="major polyA site"
ORIGIN      
        1 agagcacccc aaacttgacg ccatgaagat cccggtcctt cctgccgtgg tgctcctctc
       61 cctcctggtg ctccactctg cccagggagc caccctgggt ggtcctgagg aagaaagcac
      121 cattgagaat tatgcgtcac gacccgaggc ctttaacacc ccgttcctga acatcgacaa
      181 attgcgatct gcgtttaagg ctgatgagtt cctgaactgg cacgccctct ttgagtctat
      241 caaaaggaaa cttcctttcc tcaactggga tgcctttcct aagctgaaag gactgaggag
      301 cgcaactcct gatgcccagt gaccatgacc tccactggaa gagggggcta gcgtgagcgc
      361 tgattctcaa cctaccataa ctctttcctg cctcaggaac tccaataaaa cattttccat
      421 ccaaca
//
