LOCUS       NM_173853                872 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens keratinocyte associated protein 3 (KRTCAP3),
            transcript variant 2, mRNA.
ACCESSION   NM_173853
VERSION     NM_173853.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Nikkola,E., Deere,K.A.,
            Cruz-Bautista,I., Arellano-Campos,O., Munoz-Hernandez,L.L.,
            Gomez-Munguia,L., Ordonez-Sanchez,M.L., Reddy,P.M., Lusis,A.J.,
            Matikainen,N., Taskinen,M.R., Riba,L., Cantor,R.M.,
            Sinsheimer,J.S., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Genomic study in Mexicans identifies a new locus for triglycerides
            and refines European lipid loci
  JOURNAL   J Med Genet 50 (5), 298-308 (2013)
   PUBMED   23505323
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   4  (bases 1 to 872)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 872)
  AUTHORS   Bonkobara,M., Das,A., Takao,J., Cruz,P.D. and Ariizumi,K.
  TITLE     Identification of novel genes for secreted and membrane-anchored
            proteins in human keratinocytes
  JOURNAL   Br J Dermatol 148 (4), 654-664 (2003)
   PUBMED   12752121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101689.1 and AY157576.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173853.3.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 - 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY157576.1, ERR279835.232.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288873.7/ ENSP00000288873.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-811               BC101689.1         16-826
            812-872             AY157576.1         797-857
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..872
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /note="keratinocyte associated protein 3"
                     /db_xref="GeneID:200634"
                     /db_xref="HGNC:HGNC:28943"
                     /db_xref="MIM:619261"
     exon            1..60
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..755
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /note="keratinocytes associated protein 3"
                     /codon_start=1
                     /product="keratinocyte-associated protein 3"
                     /protein_id="NP_776252.2"
                     /db_xref="CCDS:CCDS1754.1"
                     /db_xref="GeneID:200634"
                     /db_xref="HGNC:HGNC:28943"
                     /db_xref="MIM:619261"
                     /translation="MRRCSLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVL
                     RHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPPLHWVLLALALVN
                     LLLSVACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIY
                     DTALALWIPSLLMSAGEAALSGYCCVAALTLRGVGPCRKDGLQGQLEEMTELESPKCK
                     RQENEQLLDQNQEIRASQRSWV"
     exon            61..245
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            246..305
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            306..512
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..647
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            648..760
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..872
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /note="hexamer: AATAAA"
     polyA_site      872
                     /gene="KRTCAP3"
                     /gene_synonym="KCP3"
                     /note="major polyA site"
ORIGIN      
        1 acagcggccc tgcggctggc gcggcggacg ggatgaggcg ctgcagtctc tgcgctttcg
       61 acgccgcccg ggggcccagg cggctgatgc gtgtgggcct cgcgctgatc ttggtgggcc
      121 acgtgaacct gctgctgggg gccgtgctgc atggcaccgt cctgcggcac gtggccaatc
      181 cccgcggcgc tgtcacgccg gagtacaccg tagccaatgt catctctgtc ggctcggggc
      241 tgctgagcgt ttccgtggga cttgtggccc tcctggcgtc caggaacctt cttcgccctc
      301 cactgcactg ggtcctgctg gcactagctc tggtgaacct gctcttgtcc gttgcctgct
      361 ccctgggcct ccttcttgct gtgtcactca ctgtggccaa cggtggccgc cgccttattg
      421 ctgactgcca cccaggactg ctggatcctc tggtaccact ggatgagggg ccgggacata
      481 ctgactgccc ctttgacccc acaagaatct atgatacagc cttggctctc tggatccctt
      541 ctttgctcat gtctgcaggg gaggctgctc tatctggtta ctgctgtgtg gctgcactca
      601 ctctacgtgg agttgggccc tgcaggaagg acggacttca ggggcagcta gaggaaatga
      661 cagagcttga atctcctaaa tgtaaaaggc aggaaaatga gcagctactg gatcaaaatc
      721 aagaaatccg ggcatcacag agaagttggg tttaggacag caggtgctgt tccgagactc
      781 agtcctaaag ggtttttttt cccactaagc aaggggccct gacctcggga tgagataaca
      841 aattgtaata aagtaacttc tcttttcttc ta
//
