LOCUS       NM_173852                523 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens keratinocyte associated protein 2 (KRTCAP2), mRNA.
ACCESSION   NM_173852
VERSION     NM_173852.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Sun,P., Zhang,H., Shi,J., Xu,M., Cheng,T., Lu,B., Yang,L., Zhang,X.
            and Huang,J.
  TITLE     KRTCAP2 as an immunological and prognostic biomarker of
            hepatocellular carcinoma
  JOURNAL   Colloids Surf B Biointerfaces 222, 113124 (2023)
   PUBMED   36634487
  REMARK    GeneRIF: KRTCAP2 as an immunological and prognostic biomarker of
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Shrimal,S., Cherepanova,N.A. and Gilmore,R.
  TITLE     DC2 and KCP2 mediate the interaction between the
            oligosaccharyltransferase and the ER translocon
  JOURNAL   J Cell Biol 216 (11), 3625-3638 (2017)
   PUBMED   28860277
  REMARK    GeneRIF: DC2 and KCP2 mediate the interaction between the
            oligosaccharyltransferase STT3A and the endoplasmic reticulum
            translocon.
REFERENCE   3  (bases 1 to 523)
  AUTHORS   Roboti,P. and High,S.
  TITLE     The oligosaccharyltransferase subunits OST48, DAD1 and KCP2
            function as ubiquitous and selective modulators of mammalian
            N-glycosylation
  JOURNAL   J Cell Sci 125 (Pt 14), 3474-3484 (2012)
   PUBMED   22467853
REFERENCE   4  (bases 1 to 523)
  AUTHORS   Roboti,P. and High,S.
  TITLE     Keratinocyte-associated protein 2 is a bona fide subunit of the
            mammalian oligosaccharyltransferase
  JOURNAL   J Cell Sci 125 (Pt 1), 220-232 (2012)
   PUBMED   22266900
  REMARK    GeneRIF: data strongly support the proposal that KCP2 is a newly
            identified subunit of the N-glycosylation machinery present in a
            subset of eukaryotes
REFERENCE   5  (bases 1 to 523)
  AUTHORS   Shibatani,T., David,L.L., McCormack,A.L., Frueh,K. and Skach,W.R.
  TITLE     Proteomic analysis of mammalian oligosaccharyltransferase reveals
            multiple subcomplexes that contain Sec61, TRAP, and two potential
            new subunits
  JOURNAL   Biochemistry 44 (16), 5982-5992 (2005)
   PUBMED   15835887
REFERENCE   6  (bases 1 to 523)
  AUTHORS   Bonkobara,M., Das,A., Takao,J., Cruz,P.D. and Ariizumi,K.
  TITLE     Identification of novel genes for secreted and membrane-anchored
            proteins in human keratinocytes
  JOURNAL   Br J Dermatol 148 (4), 654-664 (2003)
   PUBMED   12752121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607067.17.
            
            On Dec 2, 2019 this sequence version replaced NM_173852.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB110825.1, CD386005.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000295682.6/
                                                ENSP00000295682.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL607067.17        31398-31481         c
            85-239              AL607067.17        30915-31069         c
            240-303             AL607067.17        30742-30805         c
            304-370             AL607067.17        27968-28034         c
            371-523             AL607067.17        27585-27737         c
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..523
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /note="keratinocyte associated protein 2"
                     /db_xref="GeneID:200185"
                     /db_xref="HGNC:HGNC:28942"
                     /db_xref="MIM:619029"
     exon            1..84
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..491
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /note="keratinocytes associated protein 2; KCP-2;
                     oligosaccharyl transferase subunit KCP2"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit KCP2"
                     /protein_id="NP_776251.2"
                     /db_xref="CCDS:CCDS1096.2"
                     /db_xref="GeneID:200185"
                     /db_xref="HGNC:HGNC:28942"
                     /db_xref="MIM:619029"
                     /translation="MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLG
                     SGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSM
                     VGLYYINKISSTLYQAAAPVLTPAKVTGKSKKRN"
     exon            85..239
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            240..303
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..370
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..523
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      504..509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /note="hexamer: AATAAA"
     polyA_site      523
                     /gene="KRTCAP2"
                     /gene_synonym="KCP2"
                     /note="major polyA site"
ORIGIN      
        1 gcatgcgcat agctaaccgc acccggttca gctcgccttt cttggccaga ggcgccggtt
       61 ggactcacgg gcggggcatg atggtggtgg gtacgggcac ctcgctggcg ctctcctccc
      121 tcctgtccct gctgctcttt gctgggatgc agatgtacag ccgtcagctg gcctccaccg
      181 agtggctcac catccagggc ggcctgcttg gttcgggtct cttcgtgttc tcgctcactg
      241 ccttcaataa tctggagaat cttgtctttg gcaaaggatt ccaagcaaag atcttccctg
      301 agattctcct gtgcctcctg ttggctctct ttgcatctgg cctcatccac cgagtctgtg
      361 tcaccacctg cttcatcttc tccatggttg gtctgtacta catcaacaag atctcctcca
      421 ccctgtacca ggcagcagct ccagtcctca caccagccaa ggtcacaggc aagagcaaga
      481 agagaaactg accctgaatg ttcaataaag ttgattcttt gta
//
