LOCUS       NM_030975                981 bp    mRNA    linear   PRI 06-FEB-2024
DEFINITION  Homo sapiens keratin associated protein 9-9 (KRTAP9-9), transcript
            variant KRTAP9.5, mRNA.
ACCESSION   NM_030975 XM_926671 XM_937223
VERSION     NM_030975.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 981)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC006070.1.
            
            On Mar 19, 2010 this sequence version replaced NM_030975.1.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the ultrahigh sulfur KAP family and the
            gene is localized to a cluster of KAPs at 17q12-q21. Alternative
            haplotypes of this gene are represented in the GRCh38 reference
            genome assembly. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (KRTAP9.5) lacks an in-frame
            segment of the 5' coding region and includes a base change in the
            3' UTR, compared to variant KRTAP9.9. The encoded isoform
            (KRTAP9.5) is 5 aa shorter than isoform KRTAP9.9. This variant is
            produced from the primary chromosome 17 assembly unit of the GRCh38
            reference genome assembly.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394008.1/ ENSP00000377576.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-981               AC006070.1         50746-51726         c
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..981
                     /gene="KRTAP9-9"
                     /gene_synonym="KAP9.5; KAP9.9; KRTAP9-5; KRTAP9.9"
                     /note="keratin associated protein 9-9"
                     /db_xref="GeneID:81870"
                     /db_xref="HGNC:HGNC:16773"
     exon            1..981
                     /gene="KRTAP9-9"
                     /gene_synonym="KAP9.5; KAP9.9; KRTAP9-5; KRTAP9.9"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..512
                     /gene="KRTAP9-9"
                     /gene_synonym="KAP9.5; KAP9.9; KRTAP9-5; KRTAP9.9"
                     /note="isoform KRTAP9.5 is encoded by transcript variant
                     KRTAP9.5; keratin-associated protein 9-5;
                     keratin-associated protein 9.5; ultrahigh sulfur
                     keratin-associated protein 9.9"
                     /codon_start=1
                     /product="keratin-associated protein 9-9 isoform KRTAP9.5"
                     /protein_id="NP_112237.2"
                     /db_xref="CCDS:CCDS54127.1"
                     /db_xref="GeneID:81870"
                     /db_xref="HGNC:HGNC:16773"
                     /translation="MTHCCSPCCQPTCCRTTCWKPTTVTTCSSTPCCQPSCCVSSCCQ
                     PCCRPACCQNTCCRTTCCQPTCLTSCCQPSCCSTTCCQPICCGSSCCGQTSCGSSCGQ
                     SSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSSCCQPCCRPACCETTCCRTTCFQPTCV
                     SSCCQPSCC"
     regulatory      953..958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP9-9"
                     /gene_synonym="KAP9.5; KAP9.9; KRTAP9-5; KRTAP9.9"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KRTAP9-9"
                     /gene_synonym="KAP9.5; KAP9.9; KRTAP9-5; KRTAP9.9"
     polyA_site      981
                     /gene="KRTAP9-9"
                     /gene_synonym="KAP9.5; KAP9.9; KRTAP9-5; KRTAP9.9"
ORIGIN      
        1 ccatgaccca ctgttgctcc ccttgctgtc agcctacctg ctgcaggacc acctgctgga
       61 agcccaccac tgtgaccacc tgcagcagca caccctgctg ccagccctcc tgctgtgtgt
      121 ctagctgctg ccagccttgc tgccgcccag cttgctgtca aaacacctgc tgcaggacca
      181 cctgctgcca gcccacctgt ctgaccagct gctgccagcc ttcctgctgc agcacaacct
      241 gctgccagcc catctgctgt gggtccagct gctgtggcca aaccagctgt gggtccagct
      301 gtggccagag cagctcctgt gcacctgtgt actgcagaag aacctgctac tacccgacga
      361 ctgtctgcct gcctggttgc ctcaaccaga gctgtggatc cagctgctgc cagccctgct
      421 gccgccccgc ctgctgtgag accacctgct gcaggaccac ttgcttccag cccacctgtg
      481 tgtccagctg ctgccagcct tcttgctgct gatcaagtcc caagagaaca accatcttca
      541 cacaacaacc ttctgctcaa ctgacttatc ttttggagga ctaatttacc ttactgctga
      601 cagcaaccat gttctcaccc aaatttttat gaattctctg catatttaaa atcttgtgaa
      661 tcagcttgag ggagggcaga atacttcatc ctgattctct ttttcttata ccttgtgaat
      721 catgtgccag cttcatgtgt tctcaatttt gagtcatggt ctcagctttg actcaaaagt
      781 caagagcttc attctcttca cttaagaaac ttaagttgct gcaaatgatt aagaatcttc
      841 acaactatgt tttcttttca atatactcat gattcttgta tcctgcttcc ttcttttaat
      901 gatcactttg ggttatctcc ctataaccag ggatcttacc tatatatttc ttaataaata
      961 aatttggaac tattattcat a
//
