LOCUS       NM_031961               1005 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens keratin associated protein 9-2 (KRTAP9-2), mRNA.
ACCESSION   NM_031961
VERSION     NM_031961.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1005)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1005)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1005)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 1005)
  AUTHORS   Rogers,M.A., Langbein,L., Winter,H., Ehmann,C., Praetzel,S.,
            Korn,B. and Schweizer,J.
  TITLE     Characterization of a cluster of human high/ultrahigh sulfur
            keratin-associated protein genes embedded in the type I keratin
            gene domain on chromosome 17q12-21
  JOURNAL   J Biol Chem 276 (22), 19440-19451 (2001)
   PUBMED   11279113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Michael Rogers. The reference sequence was
            derived from AC006070.1.
            
            On May 17, 2019 this sequence version replaced NM_031961.2.
            
            Summary: This protein is a member of the keratin-associated protein
            (KAP) family. The KAP proteins form a matrix of keratin
            intermediate filaments which contribute to the structure of hair
            fibers. KAP family members appear to have unique, family-specific
            amino- and carboxyl-terminal regions and are subdivided into three
            multi-gene families according to amino acid composition: the high
            sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.
            This protein is a member of the ultrahigh sulfur KAP family and the
            gene is localized to a cluster of KAPs at 17q12-q21. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ406946.1, SRR5189667.365758.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377721.3/ ENSP00000366950.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1005              AC006070.1         79458-80462         c
FEATURES             Location/Qualifiers
     source          1..1005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1005
                     /gene="KRTAP9-2"
                     /gene_synonym="KAP9.2; KRTAP9.2"
                     /note="keratin associated protein 9-2"
                     /db_xref="GeneID:83899"
                     /db_xref="HGNC:HGNC:16926"
     exon            1..1005
                     /gene="KRTAP9-2"
                     /gene_synonym="KAP9.2; KRTAP9.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..532
                     /gene="KRTAP9-2"
                     /gene_synonym="KAP9.2; KRTAP9.2"
                     /note="ultrahigh sulfur keratin-associated protein 9.2"
                     /codon_start=1
                     /product="keratin-associated protein 9-2"
                     /protein_id="NP_114167.2"
                     /db_xref="CCDS:CCDS32651.1"
                     /db_xref="GeneID:83899"
                     /db_xref="HGNC:HGNC:16926"
                     /translation="MTHCCSPCCQPTCCRTTCCRTTCWKPTTVTTCSSTPCCQPACCV
                     SSCCQPCCRPTCCQNTCCRTTCCQPTCVTSCCQPSCCSTPCCQPTCCGSSCCGQTSCG
                     SSCGQSSSCAPVYCRRTCYYPTTVCLPGCLNQSCGSNCCQPCCRPACCETTCCRTTCF
                     QPTCVSSCCQPSCC"
ORIGIN      
        1 tgacaccatg acccactgtt gctccccttg ctgtcagcct acctgctgca ggaccacctg
       61 ctgcaggacc acctgctgga agcccaccac tgtgaccacc tgcagcagca caccctgctg
      121 ccagcccgcc tgctgtgtgt ccagctgctg ccagccttgc tgccgcccaa cttgctgtca
      181 aaacacctgc tgtaggacca cctgctgcca gcccacctgt gtgaccagct gctgccagcc
      241 ttcctgctgc agcacaccct gctgccagcc cacctgctgt gggtccagct gctgtggcca
      301 aaccagctgt gggtccagct gtggccagag cagctcctgt gcacctgtgt actgcagaag
      361 aacctgctac taccccacga ctgtctgcct gcctggttgc ctaaaccaga gctgtggctc
      421 caactgctgc cagccctgct gccgcccagc ctgctgtgag accacctgct gcaggaccac
      481 ttgcttccag cccacctgtg tgtccagctg ctgccagcct tcttgctgct gatcacgttc
      541 caagagaacc accatcctca cacaacaaat ttctgctcaa ctgactcatc ttttggggga
      601 ctaatttaat ttgctgctga cagccaccat gctctcaccc aaatttttat gaattctcta
      661 catgtttaaa atcttggaaa tctgcttgag ggagggcaga atacttcatc ctgattctct
      721 ttttccttac accttgtgga tcatgtgcca gcttcatctg ttctcaagtt tgagtcatgg
      781 tctcagcttt gactctaaag tcaagagctt cattccctgc ttctaaggaa tttaggtttc
      841 tgcaactgat cgatgatctt tgcaatcttt tttttgtttt caatatcctc ctcatcgttc
      901 ttgtatcctt ctttcttctt ttcatgataa atttgtgttg tgtccctggt agcagaaatc
      961 cttacctata tgtttctgaa taaattctga accatcctca tctca
//
